Publications

Selected Publications

• Gbedande, K., Ibitokou, S.A., Ong, M.L., Brown, M.G. and Stephens, R. (2024) Heightened Innate Immune State Induced by Viral Vector Leads to Enhanced T cell Response to Challenge and Prolongs Malaria Vaccine Protection. iScience. In press.
• Wessel, R., Ageeb, N., Obeid, J., Mauldin, I., Goundry, K., Hossain, M., Lehman, C., Gentzler, R.D., Wages, N.A., Slingluff, C.L., Bullock, T.N.J., Dolatshahi, S., and Brown, M.G. (2024) Spatial colocalization and combined survival benefit of natural killer and CD8 T cells despite profound MHC class I loss in non-small cell lung cancer. J. Immu-noTher. Cancer. PMID: 39299754 PMCID: PMC11418484.
• Annis, J., and Brown, M.G. (2024) Inflammation and Macrophage Loss Mark Increased Susceptibility in a Genetic Model of Acute Viral Infection Induced Tissue Damage. J. Immunol. 213:853-864. PMID: 39046317 PMCID: PMC11371500.
• Annis, J.L., Duncan, J.B.W., Billcheck, H.O., Kuzma, A.G., Crittenden, R.B. and Brown, M.G. (2024) Multiple Immune and Genetic Mechanisms Contribute to Cmv5s-Driven Susceptibility and Tissue Damage during Acute MCMV Infection. J. Immunol. PMID: 38224204 PMCID: PMC10922835.
• Lindsay, R.S., Melssen, M.M., Stasiak, K., Annis, J.L., Woods, A.N., Rodriguez, A.B., Brown, M.G., Engelhard, V.H. (2022) NK cells reduce anergic T cell development in early-stage tumors by promoting myeloid cell maturation. Frontiers in Oncology. PMID: 36531040 PMCID: PMC9755581
• Cronk, J.M., Dziewulska, K.H., Crittenden, R.B., Xie, X., Hammarskjöld, M.L., and Brown, M.G. (2022) Altered-self virus sensing via educated NK cells drives antiviral immunity during MCMV infection. J. Immunology 209:1 PMID: 36165178 PMCID: PMC9529956
• Nozaki, K., Maltez, V.I., Rayamajhi, M., Tubbs, A.L., Mitchell, J.E., Lacey, C.A., Harvest, C.K., Li, L., Nash, W.T., Larson, H.N., McGlaughon, B.D., Moorman, N.J., Brown, M.G., Whitmire, J.K., and Miao, E.A. (2022) Caspase-7 activates ASM to repair gasdermin and perforin pores. Nature 606:960 PMID: 35705808 PMCID: PMC9247046
• Cronk, J., Fafoutis, E. and Brown, M.G. (2021) Licensing natural killers for antiviral immunity. Pathogens 10:908 PMID: 34358058 PMCID: PMC8308748.
• Gamache, A.E., Cronk, J., Nash, W., Puchalski, P., Gillespie, A., Wei, H., Gray, L., Hammarskjold, M.L., Xu, W., and Brown, M.G. (2019) Ly49R activation receptor drives self-MHC-educated NK cell immunity against cytomegalovirus infection. Proc. Natl. Acad. Sci. USA. PMID: 31843910. PMCID: PMC6936569
• Shi, L., Li, K., Guo, Y., Banerjee, A., Wang, Q., Lorenz, U. M., Parlak, M., Sullivan, L. C., Onyema, O. O., Arefanian, S., Stelow, E. B., Brautigan, D. L., Bullock, T. N. J., Brown, M.G., Krupnick, A. S. (2018) Modulation of NKG2D, NKp46 and Ly49C/I facilitates natural killer cell-mediated control of lung cancer. Proc. Natl. Acad. Sci. USA. 115:11808-11813. PMID: 30381460 PMCID: PMC6243255.
• Brown, M.G., Gamache, A., Nash, W.T. and Cronk, J. (2018) Natural selection for killer receptors and their MHC class I ligands: In pursuit of gene pairs that fit well in tandem. J Leuk Biol. 105:489-495. PMID 30500089 PMCID: PMC7837754.
• Nash, W., Gillespie, A.L., and Brown, M.G. (2017) Murine cytomegalovirus disrupts splenic dendritic cell subsets via type I interferon-dependent and independent mechanisms. Frontiers in Immunology, PMID: 28337202 PMCID: PMC5343017.
• Gillespie, A., Lee, H., Robertson, C., Cabot, M., and Brown, M.G. (2017) Genome-wide exome analysis of Cmv5-disparate mouse strains that differ in host resistance to murine cytomegalovirus infection. G3: Genes, Genomes, Genetics 7:1979-1984. PMID: 28450376 PMCID: PMC5473773.
• Krueger, P., Narayanan, S., Brown, M.G., Sung, S.J. and Hahn, Y. (2017) Murine liver-resident group 1 innate lymphoid cells regulate optimal priming of anti-viral CD8+ T cells. J Leuk Biol, 101:329-338. PMID: 27493244 PMCID: PMC6608037.
• Teoh, J., Gamache, A., Gillespie, A., Stadnisky, M.D., Yagita, H., Bullock, T.N. and Brown, M.G. (2016) Acute virus control mediated by licensed NK cells sets primary CD8+ T cell dependence on CD27 costimulation. J Immunol, 197: 4360-4370. PMID: 27798162 PMCID: PMC5123769.
• Gillespie, A., Teoh, J., Lee, H., Prince, J., Stadnisky, M.D., Anderson, M., Nash, W., Rival, C., Wei, H., Gamache, A., Farber, C., Tung, K. and Brown, M.G. (2016) Genomic modifiers of natural killer cells, immune responsiveness and lymphoid tissue remodeling together increase host resistance to viral infection. PLOS Pathogens. 12:e1005419. doi: 10.1371/journal.ppat.1005419, PMID: 26845690 PMCID: PMC4742223.
• Wei, H., Nash, W., Makrigiannis, A. and Brown, M.G. (2014) Impaired NK cell education diminishes resistance to murine CMV infection. Eur J Immunol. 44: 3273-3282. PMID: 25187217 PMCID: PMC4233007.
• Prince, J., Lundgren, A., Stadnisky, M.D., Nash, W., Beeber, A., Turner, S.D. and Brown, M.G. (2013) Multiparametric analysis of host response to murine cytomegalovirus in MHC class I-disparate mice reveals primacy of licensed Ly49G2+ NK cells in viral control. J. Immunol. 191:4709-4719. PMID: 24068668 PMCID: PMC3820117.
• Carroll, V.A., Lundgren, A., Wei, H., Sainz, S., Tung, K.S. and Brown, M.G. (2012) Natural Killer Cells Regulate murine CMV-induced Sialadenitis and salivary gland disease. J. Virol. 86:2132-2142. PMID: 22156514 PMCID: PMC3302420.
• Stadnisky, M.D., Xie, X., Coats, E.R., Bullock, T.N. and Brown, M.G. (2011) Self-MHC class I-licensed NK cells enhance adaptive CD8 T-cell viral immunity. Blood 117(19):5133-5141. PMID: 21436069 PMCID: PMC3109538.
• Xie, X., Stadnisky, M.D., Coats, E.R., Rahim, M., Lundgren, A., Xu, W., Makrigiannis, A. P. and Brown, M.G. (2010) MHC class I Dk expression in hematopoietic and non-hematopoietic cells confers natural killer cell resistance to murine cytomegalovirus. Proc. Natl. Acad. Sci. USA 107(19):8754-8759. PMID: 20421478 PMCID: PMC2889336.
• Xie, X., Stadnisky, M. and Brown, M.G. (2009) MHC class I Dk locus and Ly49G2+ NK cells confer H-2k resistance to murine cytomegalovirus. J. Immunol. 182: 7163-7171. PMID: 19454713 PMCID: PMC2730597.
• Xie, X., Dighe, A., Clark, P., Sabastian, P., Buss, S. and Brown, M.G. (2007) Deficient major histocompatibility complex-linked innate murine cytomegalovirus immunity in MA/My.L-H2b mice and viral down-regulation of H-2k class I proteins. J. Virol. 81:229-236. PMID: 17050600 PMCID: PMC1797260.
• Dighe, A., Rodriguez, M., Sabastian, P., Xie, X., McVoy, M. and Brown, M.G. (2005) Requisite H2k role in NK cell-mediated resistance in acute murine CMV infected MA/My mice. J. Immunol. 175: 6820-6828.
• Rodriguez, M., Sabastian, P., Clark, P. and Brown, M.G. (2004) Cmv1-independent antiviral role of NK cells revealed in murine cytomegalovirus-infected New Zealand White mice. J. Immunol. 173: 6312-6318.
• Wheat, R., Clark, P.Y. and Brown, M.G. (2003) Quantitative measurement of infectious murine cytomegalovirus genomes in real-time PCR. J. Virol. Meth. 112:107-113.
• Brown, M.G., Scalzo, A.A., Stone, L.R., Clark, P.Y., Du, Y., Palanca, B., Yokoyama, W.M. (2001) Natural killer gene complex (Nkc) allelic variability in inbred mice: Evidence for Nkc haplotypes. Immunogenetics 53:584-591.
• Brown, M.G., Dokun, A.O., Heusel, J., Smith, H.R.C., Beckman, D.L., Blattenberger, E.A., Dubbelde, C.E., Stone, L.R., Scalzo, A.A., Yokoyama, W.M. (2001) Vital involvement of a natural killer cell activation receptor in resistance to viral infection. Science 292:934-937.
• Brown, M.G., Fulmek, S., Matsumoto, K., Cho, R., Lyons, P.A., Levy, E.R., Scalzo, A. A., Yokoyama, W.M. (1997) A 2-Mb YAC Contig and Physical Map of the Natural Killer Gene Complex on Mouse Chromosome 6. Genomics 42:16-25.
• Driscoll, J., Brown, M.G., Finley, D., and Monaco, J.J. (1993) MHC-linked Lmp gene products specifically alter the peptidase activities of the proteasome. Nature 365:262-264.
• Brown, M.G., Driscoll, J., and Monaco, J.J. (1991) Structural and serological similarity of the MHC-linked LMP and proteasome (multicatalytic proteinase) complexes. Nature 353:355-357.

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A comprehensive list of Dr. Michael Brown’s publications can be found on the NIH National Center for Biotech-nology Information (NCBI) website: http://www.ncbi.nlm.nih.gov/myncbi/browse/collection/40346979/?sort=date&direction=descending