McNamara Lab

Beirne B. Carter Center for Immunology Research
Department of Medicine: Cardiovascular Medicine
University of Virginia School of Medicine

Publications

  1. Pattarabanjird T, Marshall M, Upadhye A, Srikakulapu P, Garmey J, Haider A, Taylor AM, Lutgens E, McNamara CA. B-1b Cells Possess Unique bHLH-Driven P62-Dependent Self-Renewal and Atheroprotection. Circ Res. 2022 Feb 25:CIRCRESAHA121320436. doi: 10.1161/CIRCRESAHA.121.320436. Epub ahead of print. PMID: 35209718.

  2. Pattarabanjird T, Wilson JM, Erickson LD, Workman LJ, Qiao H, Ghosheh Y, Gulati R, Durant C, Vallejo J, Saigusa R, Platts-Mills TAE, Taylor AM, Ley K, McNamara CA. Chemokine Receptor Activation Enhances Memory B Cell Class Switching Linked to IgE Sensitization to Alpha Gal and Cardiovascular Disease. Front Cardiovasc Med. 2022 Jan 13;8:791028. doi: 10.3389/fcvm.2021.791028. PMID: 35097011; PMCID: PMC8793803.

  3. Osinski V, Srikakulapu P, Haider YM, Marshall MA, Ganta VC, Annex BH, McNamara CA. Loss of Id3 (Inhibitor of Differentiation 3) Increases the Number of IgM-Producing B-1b Cells in Ischemic Skeletal Muscle Impairing Blood Flow Recovery During Hindlimb Ischemia. Arterioscler Thromb Vasc Biol. 2022 Jan;42(1):6-18. doi: 10.1161/ATVBAHA.120.315501. Epub 2021 Nov 23. PMID: 34809449; PMCID: PMC8702457.

  4. Spinosa MD, Montgomery WG, Lempicki M, Srikakulapu P, Johnsrude MJ, McNamara CA, Upchurch GR Jr, Ailawadi G, Leitinger N, Meher AK. B Cell-Activating Factor Antagonism Attenuates the Growth of Experimental Abdominal Aortic Aneurysm. Am J Pathol. 2021 Dec;191(12):2231-2244. doi: 10.1016/j.ajpath.2021.08.012. Epub 2021 Sep 9. PMID: 34509440; PMCID: PMC8647430.

  5. Kothari H, Williams CM, McSkimming C, Drago F, Marshall MA, Garmey J, Vigneshwar M, Zunder ER, McNamara CA. Identification of human immune cell subtypes most responsive to IL-1β-induced inflammatory signaling using mass cytometry. Sci Signal. 2021 Mar 9;14(673):eabc5763. doi: 10.1126/scisignal.abc5763. PMID: 33688079; PMCID: PMC8491136.

  6. Srikakulapu P, Upadhye A, Drago F, Perry HM, Bontha SV, McSkimming C, Marshall MA, Taylor AM, McNamara CA. Chemokine Receptor-6 Promotes B-1 Cell Trafficking to Perivascular Adipose Tissue, Local IgM Production and Atheroprotection. Front Immunol. 2021 Feb 19;12:636013. doi: 10.3389/fimmu.2021.636013. PMID: 33679793; PMCID: PMC7933012.

  7. Misiou A, Garmey JC, Hensien JM, Harmon DB, Osinski V, McSkimming C, Marshall MA, Fischer JW, Grandoch M, McNamara CA. Helix-Loop-Helix Factor Id3 (Inhibitor of Differentiation 3): A Novel Regulator of Hyaluronan-Mediated Adipose Tissue Inflammation. Arterioscler Thromb Vasc Biol. 2021 Feb;41(2):796-807. doi: 10.1161/ATVBAHA.120.315588. Epub 2020 Dec 31. PMID: 33380173; PMCID: PMC8105274.

  8. Osinski V, Klibanov AL, McNamara CA. Preparation, Administration, and Assessment of In vivo Tissue-Specific Cellular Uptake of Fluorescent Dye-Labeled Liposomes. J Vis Exp. 2020 Jul 30;(161). doi: 10.3791/61585. PMID: 32804164.

  9. Srikakulapu P, McNamara CA. B Lymphocytes and Adipose Tissue Inflammation. Arterioscler Thromb Vasc Biol. 2020 May;40(5):1110-1122. doi: 10.1161/ATVBAHA.119.312467. Epub 2020 Mar 5. PMID: 32131612; PMCID: PMC7398177.

  10. Osinski V, Bauknight DK, Dasa SSK, Harms MJ, Kroon T, Marshall MA, Garmey JC, Nguyen AT, Hartman J, Upadhye A, Srikakulapu P, Zhou A, O'Mahony G, Klibanov AL, Kelly KA, Boucher J, McNamara CA. In vivo liposomal delivery of PPARα/γ dual agonist tesaglitazar in a model of obesity enriches macrophage targeting and limits liver and kidney drug effects. Theranostics. 2020 Jan 1;10(2):585-601. doi: 10.7150/thno.36572. PMID: 31903139; PMCID: PMC6929996.

  11. Upadhye A, Sturek JM, McNamara CA. 2019 Russell Ross Memorial Lecture in Vascular Biology: B Lymphocyte-Mediated Protective Immunity in Atherosclerosis. Arterioscler Thromb Vasc Biol. 2020 Feb;40(2):309-322. doi: 10.1161/ATVBAHA.119.313064. Epub 2019 Dec 19. PMID: 31852222; PMCID: PMC7398219.

  12. Bauknight DK, Osinski V, Dasa SSK, Nguyen AT, Marshall MA, Hartman J, Harms M, O'Mahony G, Boucher J, Klibanov AL, McNamara CA, Kelly KA. Importance of thorough tissue and cellular level characterization of targeted drugs in the evaluation of pharmacodynamic effects. PLoS One. 2019 Nov 14;14(11):e0224917. doi: 10.1371/journal.pone.0224917. PMID: 31725756; PMCID: PMC6855449.

  13. Gaddis DE, Padgett LE, Wu R, Nguyen A, McSkimming C, Dinh HQ, Araujo DJ, Taylor AM, McNamara CA, Hedrick CC. Atherosclerosis Impairs Naive CD4 T-Cell Responses via Disruption of Glycolysis. Arterioscler Thromb Vasc Biol. 2021 Sep;41(9):2387-2398. doi: 10.1161/ATVBAHA.120.314189. Epub 2021 Jul 29. PMID: 34320835.

  14. Kassiteridi C, Cole JE, Griseri T, Falck-Hansen M, Goddard ME, Seneviratne AN, Green PA, Park I, Shami AG, Pattarabanjird T, Upadhye A, Taylor AM, Handa A, Channon KM, Lutgens E, McNamara CA, Williams RO, Monaco C. CD200 Limits Monopoiesis and Monocyte Recruitment in Atherosclerosis. Circ Res. 2021 Jul 9;129(2):280-295. doi: 10.1161/CIRCRESAHA.119.316062. Epub 2021 May 12. PMID: 33975450; PMCID: PMC8260471.

  15. Keshavarz B, Wiencek JR, Workman LJ, Straesser MD, Muehling LM, Canderan G, Drago F, Bonham CA, Sturek JM, Ramani C, McNamara CA, Woodfolk JA, Kadl A, Platts-Mills TAE, Wilson JM. Quantitative Measurement of IgG to Severe Acute Respiratory Syndrome Coronavirus-2 Proteins Using ImmunoCAP. Int Arch Allergy Immunol. 2021;182(5):417-424. doi: 10.1159/000514203. Epub 2021 Feb 23. PMID: 33621972; PMCID: PMC8018212.

  16. Padgett LE, Dinh HQ, Wu R, Gaddis DE, Araujo DJ, Winkels H, Nguyen A, McNamara CA, Hedrick CC. Naive CD8+ T Cells Expressing CD95 Increase Human Cardiovascular Disease Severity. Arterioscler Thromb Vasc Biol. 2020 Dec;40(12):2845-2859. doi: 10.1161/ATVBAHA.120.315106. Epub 2020 Oct 15. Erratum in: Arterioscler Thromb Vasc Biol. 2021 Jun;41(6):e383. PMID: 33054398; PMCID: PMC8184121.

  17. Alencar GF, Owsiany KM, Karnewar S, Sukhavasi K, Mocci G, Nguyen AT, Williams CM, Shamsuzzaman S, Mokry M, Henderson CA, Haskins R, Baylis RA, Finn AV, McNamara CA, Zunder ER, Venkata V, Pasterkamp G, Björkegren J, Bekiranov S, Owens GK. Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate Complex SMC Phenotypic Changes Critical in Late-Stage Atherosclerotic Lesion Pathogenesis. Circulation. 2020 Nov 24;142(21):2045-2059. doi: 10.1161/CIRCULATIONAHA.120.046672. Epub 2020 Jul 17. PMID: 32674599; PMCID: PMC7682794.

  18. Zernecke A, Winkels H, Cochain C, Williams JW, Wolf D, Soehnlein O, Robbins CS, Monaco C, Park I, McNamara CA, Binder CJ, Cybulsky MI, Scipione CA, Hedrick CC, Galkina EV, Kyaw T, Ghosheh Y, Dinh HQ, Ley K. Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas. Circ Res. 2020 Jul 17;127(3):402-426. doi: 10.1161/CIRCRESAHA.120.316903. Epub 2020 Jul 16. PMID: 32673538; PMCID: PMC7371244.

  19. Cherepanova OA, Srikakulapu P, Greene ES, Chaklader M, Haskins RM, McCanna ME, Bandyopadhyay S, Ban B, Leitinger N, McNamara CA, Owens GK. Novel Autoimmune IgM Antibody Attenuates Atherosclerosis in IgM Deficient Low-Fat Diet-Fed, but Not Western Diet-Fed Apoe-/- Mice. Arterioscler Thromb Vasc Biol. 2020 Jan;40(1):206-219. doi: 10.1161/ATVBAHA.119.312771. Epub 2019 Oct 24. PMID: 31645128; PMCID: PMC7006879.

  20. Upadhye A, Srikakulapu P, Gonen A, Hendrikx S, Perry HM, Nguyen A, McSkimming C, Marshall MA, Garmey JC, Taylor AM, Bender TP, Tsimikas S, Holodick NE, Rothstein TL, Witztum JL, McNamara CA. Diversification and CXCR4-Dependent Establishment of the Bone Marrow B-1a Cell Pool Governs Atheroprotective IgM Production Linked to Human Coronary Atherosclerosis. Circ Res. 2019 Oct 25;125(10):e55-e70. doi: 10.1161/CIRCRESAHA.119.315786. Epub 2019 Sep 24. PMID: 31549940; PMCID: PMC6830526.

  21. Upadhye A, Srikakulapu P, McNamara CA. Cell- and Sex-Specific Role of FcγR (Fcγ Receptor) IIb in Experimental Atherosclerosis. Arterioscler Thromb Vasc Biol. 2019 Jul;39(7):1269-1271. doi: 10.1161/ATVBAHA.119.312916. Epub 2019 Jun 26. PMID: 31242029; PMCID: PMC7863628.

  22. Shikatani EA, Besla R, Ensan S, Upadhye A, Khyzha N, Li A, Emoto T, Chiu F, Degousee N, Moreau JM, Perry HM, Thayaparan D, Cheng HS, Pacheco S, Smyth D, Noyan H, Zavitz CCJ, Bauer CMT, Hilgendorf I, Libby P, Swirski FK, Gommerman JL, Fish JE, Stampfli MR, Cybulsky MI, Rubin BB, Paige CJ, Bender TP, McNamara CA, Husain M, Robbins CS. c-Myb Exacerbates Atherosclerosis through Regulation of Protective IgM-Producing Antibody-Secreting Cells. Cell Rep. 2019 May 21;27(8):2304-2312.e6. doi: 10.1016/j.celrep.2019.04.090. PMID: 31116977.

  23. Wilson JM, McNamara CA, Platts-Mills TAE. IgE, α-Gal and atherosclerosis. Aging (Albany NY). 2019 Apr 5;11(7):1900-1902. doi: 10.18632/aging.101894. PMID: 30958794; PMCID: PMC6503887.

  24. Hamers AAJ, Dinh HQ, Thomas GD, Marcovecchio P, Blatchley A, Nakao CS, Kim C, McSkimming C, Taylor AM, Nguyen AT, McNamara CA, Hedrick CC. Human Monocyte Heterogeneity as Revealed by High-Dimensional Mass Cytometry. Arterioscler Thromb Vasc Biol. 2019 Jan;39(1):25-36. doi: 10.1161/ATVBAHA.118.311022. PMID: 30580568; PMCID: PMC6697379.

  25. Gonen A, Choi SH, Miu P, Agatisa-Boyle C, Acks D, Taylor AM, McNamara CA, Tsimikas S, Witztum JL, Miller YI. A monoclonal antibody to assess oxidized cholesteryl esters associated with apoAI and apoB-100 lipoproteins in human plasma. J Lipid Res. 2019 Feb;60(2):436-445. doi: 10.1194/jlr.D090852. Epub 2018 Dec 18. Erratum in: J Lipid Res. 2019 Nov;60(11):1979. PMID: 30563909; PMCID: PMC6358287.

  26. Wilson JM, Nguyen AT, Schuyler AJ, Commins SP, Taylor AM, Platts-Mills TAE, McNamara CA. IgE to the Mammalian Oligosaccharide Galactose-α-1,3-Galactose Is Associated With Increased Atheroma Volume and Plaques With Unstable Characteristics-Brief Report. Arterioscler Thromb Vasc Biol. 2018 Jul;38(7):1665-1669. doi: 10.1161/ATVBAHA.118.311222. Epub 2018 Jun 14. PMID: 29903734; PMCID: PMC6039405.

  27. Gaddis DE, Padgett LE, Wu R, McSkimming C, Romines V, Taylor AM, McNamara CA, Kronenberg M, Crotty S, Thomas MJ, Sorci-Thomas MG, Hedrick CC. Apolipoprotein AI prevents regulatory to follicular helper T cell switching during atherosclerosis. Nat Commun. 2018 Mar 15;9(1):1095. doi: 10.1038/s41467-018-03493-5. PMID: 29545616; PMCID: PMC5854619.

  28. Kothari H, Nguyen AT, Yang X, Hisada Y, Tsimikas S, Mackman N, Taylor A, McNamara CA. Association of D-dimer with Plaque Characteristics and Plasma Biomarkers of Oxidation-Specific Epitopes in Stable Subjects with Coronary Artery Disease. J Cardiovasc Transl Res. 2018 Jun;11(3):221-229. doi: 10.1007/s12265-018-9790-4. Epub 2018 Jan 17. PMID: 29344841.

  29. Srikakulapu P, Upadhye A, Rosenfeld SM, Marshall MA, McSkimming C, Hickman AW, Mauldin IS, Ailawadi G, Lopes MBS, Taylor AM, McNamara CA. Perivascular Adipose Tissue Harbors Atheroprotective IgM-Producing B Cells. Front Physiol. 2017 Sep 22;8:719. doi: 10.3389/fphys.2017.00719. PMID: 28970806; PMCID: PMC5609437.

  30. Marcovecchio PM, Thomas GD, Mikulski Z, Ehinger E, Mueller KAL, Blatchley A, Wu R, Miller YI, Nguyen AT, Taylor AM, McNamara CA, Ley K, Hedrick CC. Scavenger Receptor CD36 Directs Nonclassical Monocyte Patrolling Along the Endothelium During Early Atherogenesis. Arterioscler Thromb Vasc Biol. 2017 Nov;37(11):2043-2052. doi: 10.1161/ATVBAHA.117.309123. Epub 2017 Sep 21. PMID: 28935758; PMCID: PMC5930003.

  31. Thomas GD, Hamers AAJ, Nakao C, Marcovecchio P, Taylor AM, McSkimming C, Nguyen AT, McNamara CA, Hedrick CC. Human Blood Monocyte Subsets: A New Gating Strategy Defined Using Cell Surface Markers Identified by Mass Cytometry. Arterioscler Thromb Vasc Biol. 2017 Aug;37(8):1548-1558. doi: 10.1161/ATVBAHA.117.309145. Epub 2017 Jun 8. PMID: 28596372; PMCID: PMC5828170.

  32. Srikakulapu P, McNamara CA. B cells and atherosclerosis. Am J Physiol Heart Circ Physiol. 2017 May 1;312(5):H1060-H1067. doi: 10.1152/ajpheart.00859.2016. Epub 2017 Mar 17. PMID: 28314764; PMCID: PMC5451581.

  33. Kohlgrüber S, Upadhye A, Dyballa-Rukes N, McNamara CA, Altschmied J. Regulation of Transcription Factors by Reactive Oxygen Species and Nitric Oxide in Vascular Physiology and Pathology. Antioxid Redox Signal. 2017 May 1;26(13):679-699. doi: 10.1089/ars.2016.6946. Epub 2017 Jan 4. PMID: 27841660; PMCID: PMC5421514.

  34. Srikakulapu P, Hu D, Yin C, Mohanta SK, Bontha SV, Peng L, Beer M, Weber C, McNamara CA, Grassia G, Maffia P, Manz RA, Habenicht AJ. Artery Tertiary Lymphoid Organs Control Multilayered Territorialized Atherosclerosis B-Cell Responses in Aged ApoE-/- Mice. Arterioscler Thromb Vasc Biol. 2016 Jun;36(6):1174-85. doi: 10.1161/ATVBAHA.115.306983. Epub 2016 Apr 21. Erratum in: Arterioscler Thromb Vasc Biol. 2016 Jul;36(7):e62. PMID: 27102965; PMCID: PMC4894775.

  35. Harmon DB, Srikakulapu P, Kaplan JL, Oldham SN, McSkimming C, Garmey JC, Perry HM, Kirby JL, Prohaska TA, Gonen A, Hallowell P, Schirmer B, Tsimikas S, Taylor AM, Witztum JL, McNamara CA. Protective Role for B-1b B Cells and IgM in Obesity-Associated Inflammation, Glucose Intolerance, and Insulin Resistance. Arterioscler Thromb Vasc Biol. 2016 Apr;36(4):682-91. doi: 10.1161/ATVBAHA.116.307166. Epub 2016 Feb 11. PMID: 26868208; PMCID: PMC4808436.

  36. Kaplan JL, Marshall MA, C McSkimming C, Harmon DB, Garmey JC, Oldham SN, Hallowell P, McNamara CA. Adipocyte progenitor cells initiate monocyte chemoattractant protein-1-mediated macrophage accumulation in visceral adipose tissue. Mol Metab. 2015 Aug 12;4(11):779-94. doi: 10.1016/j.molmet.2015.07.010. PMID: 26629403; PMCID: PMC4632113.

  37. Rosenfeld SM, Perry HM, Gonen A, Prohaska TA, Srikakulapu P, Grewal S, Das D, McSkimming C, Taylor AM, Tsimikas S, Bender TP, Witztum JL, McNamara CA. B-1b Cells Secrete Atheroprotective IgM and Attenuate Atherosclerosis. Circ Res. 2015 Jul 17;117(3):e28-39. doi: 10.1161/CIRCRESAHA.117.306044. Epub 2015 Jun 16. PMID: 26082558; PMCID: PMC4527334.

  38. Manichaikul A, Rich SS, Perry H, Yeboah J, Law M, Davis M, Parker M, Ragosta M, Connelly JJ, McNamara CA, Taylor AM. A functionally significant polymorphism in ID3 is associated with human coronary pathology. PLoS One. 2014 Mar 6;9(3):e90222. doi: 10.1371/journal.pone.0090222. Erratum in: PLoS One. 2014;9(9):e109222. PMID: 24603695; PMCID: PMC3946163.

  39. Morris-Rosenfeld S, Lipinski MJ, McNamara CA. Understanding the role of B cells in atherosclerosis: potential clinical implications. Expert Rev Clin Immunol. 2014 Jan;10(1):77-89. doi: 10.1586/1744666X.2014.857602. Epub 2013 Dec 2. PMID: 24308836; PMCID: PMC4358742.

  40. Perry HM, Oldham SN, Fahl SP, Que X, Gonen A, Harmon DB, Tsimikas S, Witztum JL, Bender TP, McNamara CA. Helix-loop-helix factor inhibitor of differentiation 3 regulates interleukin-5 expression and B-1a B cell proliferation. Arterioscler Thromb Vasc Biol. 2013 Dec;33(12):2771-9. doi: 10.1161/ATVBAHA.113.302571. Epub 2013 Oct 10. PMID: 24115031; PMCID: PMC4003558.

  41. Perry HM, Bender TP, McNamara CA. B cell subsets in atherosclerosis. Front Immunol. 2012 Dec 11;3:373. doi: 10.3389/fimmu.2012.00373. PMID: 23248624; PMCID: PMC3518786.

  42. Lipinski MJ, Campbell KA, Duong SQ, Welch TJ, Garmey JC, Doran AC, Skaflen MD, Oldham SN, Kelly KA, McNamara CA. Loss of Id3 increases VCAM-1 expression, macrophage accumulation, and atherogenesis in Ldlr-/- mice. Arterioscler Thromb Vasc Biol. 2012 Dec;32(12):2855-61. doi: 10.1161/ATVBAHA.112.300352. Epub 2012 Oct 4. PMID: 23042815; PMCID: PMC3509414.

  43. Perry HM, McNamara CA. Refining the role of B cells in atherosclerosis. Arterioscler Thromb Vasc Biol. 2012 Jul;32(7):1548-9. doi: 10.1161/ATVBAHA.112.249235. PMID: 22699274.

  44. Campbell KA, Lipinski MJ, Doran AC, Skaflen MD, Fuster V, McNamara CA. Lymphocytes and the adventitial immune response in atherosclerosis. Circ Res. 2012 Mar 16;110(6):889-900. doi: 10.1161/CIRCRESAHA.111.263186. PMID: 22427326; PMCID: PMC3373006.

  45. Cutchins A, Harmon DB, Kirby JL, Doran AC, Oldham SN, Skaflen M, Klibanov AL, Meller N, Keller SR, Garmey J, McNamara CA. Inhibitor of differentiation-3 mediates high fat diet-induced visceral fat expansion. Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):317-24. doi: 10.1161/ATVBAHA.111.234856. Epub 2011 Nov 10. PMID: 22075252; PMCID: PMC3262109.

  46. Doran AC, Lipinski MJ, Oldham SN, Garmey JC, Campbell KA, Skaflen MD, Cutchins A, Lee DJ, Glover DK, Kelly KA, Galkina EV, Ley K, Witztum JL, Tsimikas S, Bender TP, McNamara CA. B-cell aortic homing and atheroprotection depend on Id3. Circ Res. 2012 Jan 6;110(1):e1-12. doi: 10.1161/CIRCRESAHA.111.256438. Epub 2011 Oct 27. PMID: 22034493; PMCID: PMC3253259.

  47. Lipinski MJ, Perry HM, Doran AC, Oldham SN, McNamara CA. Comment on "Conventional B2 B cell depletion ameliorates whereas its adoptive transfer aggravates atherosclerosis". J Immunol. 2011 Jan 1;186(1):4; author reply 6. doi: 10.4049/jimmunol.1090119. PMID: 21172871.

  48. Doran AC, Lehtinen AB, Meller N, Lipinski MJ, Slayton RP, Oldham SN, Skaflen MD, Yeboah J, Rich SS, Bowden DW, McNamara CA. Id3 is a novel atheroprotective factor containing a functionally significant single-nucleotide polymorphism associated with intima-media thickness in humans. Circ Res. 2010 Apr 16;106(7):1303-11. doi: 10.1161/CIRCRESAHA.109.210294. Epub 2010 Feb 25. PMID: 20185798; PMCID: PMC2860382.

  49. Doran AC, Meller N, Cutchins A, Deliri H, Slayton RP, Oldham SN, Kim JB, Keller SR, McNamara CA. The helix-loop-helix factors Id3 and E47 are novel regulators of adiponectin. Circ Res. 2008 Sep 12;103(6):624-34. doi: 10.1161/CIRCRESAHA.108.175893. Epub 2008 Jul 31. PMID: 18669923; PMCID: PMC2746666.

  50. Doran AC, Meller N, McNamara CA. Role of smooth muscle cells in the initiation and early progression of atherosclerosis. Arterioscler Thromb Vasc Biol. 2008 May;28(5):812-9. doi: 10.1161/ATVBAHA.107.159327. Epub 2008 Feb 14. PMID: 18276911; PMCID: PMC2734458.