Loren D. Erickson

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Primary Appointment

Associate Professor, Microbiology, Immunology, and Cancer Biology

Education

  • BS, Biology, Seattle Pacific University
  • PhD, Immunology, The University of Iowa
  • Postdoc, Immunology, Dartmouth Medical School

Research Disciplines

Cancer Biology, Experimental Pathology, Immunology, Microbiology, Translational Science

Research Interests

Immune mechanisms of pathogenic antibody production in allergy and autoimmunity

Research Description

CURRENT PROJECTS:
- Using mouse genetics to identify the susceptibility factors that control B cell tolerance, differentiation and survival, leading to autoantibody production.
- Defining the mechanisms by which autoimmune susceptibility elicits inflammation and recruitment of innate immune cells in secondary lymphoid organs that affect B cell function.
- Characterizing the regulation and activity of extracellular vesicles derived from B cells to control autoimmune responses.
- Characterizing the development and persistence of IgE antibodies to food allergens using red meat allergy as a model system.

Personal Statement

The Erickson laboratory studies the host immune response in autoimmunity both in experimental mouse models of lupus and in human lupus patients. Most of our efforts have focused on the response of B cells in lupus and the signals that affect B cell tolerance and the differentiation and survival of autoreactive memory B cells and plasma cells. While much of the focus of our research has been on the development of pathogenic IgG-producing B cells we have recently broadened our horizons to examine mechanisms underlying antibody production in two areas: 1) Investigating the immunophenotypes of B cells that produce pathogenic IgE in allergy since little is known about the origin and mechanisms of tolerance of IgE antibodies. 2) Investigating the role that extracellular vesicles derived from B cells may play in immune protection and disease, such as lupus and allergy. We have extensive experience with in vivo mouse models, working with human specimens, and functional analyses of mouse/human B cells.
Go to Loren Erickson's Lab Site for detailed information about his lab and his research.

Training

  • Biodefense & Infectious Diseases Short-Term Training to Increase Diversity in Biomedical Sciences
  • Interdisciplinary Training Program in Immunology
  • Training in Cell and Molecular Biology

Selected Publications

2024

Rival, C., Mandal, M., Cramton, K., Qiao, H., Arish, M., Sun, J., . . . Erickson, L. D. (2024). B cells secrete functional antigen-specific IgG antibodies on extracellular vesicles. SCIENTIFIC REPORTS, 14(1). doi:10.1038/s41598-024-67912-y

Dennis, E., Murach, M., Blackburn, C. M. R., Marshall, M., Root, K., Pattarabanjird, T., . . . McNamara, C. A. (2024). Loss of TET2 increases B-1 cell number and IgM production while limiting CDR3 diversity. FRONTIERS IN IMMUNOLOGY, 15. doi:10.3389/fimmu.2024.1380641

2023

Beydoun, H. A., Beydoun, M. A., Meirelles, O., Erickson, L. D., Gamaldo, A. A., Weiss, J., . . . Zonderman, A. B. (2023). Cardiovascular health, infection burden, and incident dementia in the UK Biobank.. Alzheimer's & dementia : the journal of the Alzheimer's Association, 19(10), 4475-4487. doi:10.1002/alz.13405

2021

Mauldin, I. S., Jo, J., Wages, N. A., Yogendran, L. V., Mahmutovic, A., Young, S. J., . . . Fadul, C. E. (2021). Proliferating CD8+ T Cell Infiltrates Are Associated with Improved Survival in Glioblastoma. CELLS, 10(12). doi:10.3390/cells10123378

Keshavarz, B., Erickson, L. D. D., Platts-Mills, T. A. E., & Wilson, J. M. M. (2021). Lessons in Innate and Allergic Immunity From Dust Mite Feces and Tick Bites. FRONTIERS IN ALLERGY, 2. doi:10.3389/falgy.2021.692643

Pattarabanjird, T., Wilson, J. M., Erickson, L. D., Workman, L. J., Qiao, H., Ghosheh, Y., . . . McNamara, C. A. (2022). Chemokine Receptor Activation Enhances Memory B Cell Class Switching Linked to IgE Sensitization to Alpha Gal and Cardiovascular Disease. FRONTIERS IN CARDIOVASCULAR MEDICINE, 8. doi:10.3389/fcvm.2021.791028

2020

Rovin, B. H., & Erickson, L. D. (2020). Variability in the B cell-receptor repertoire across immune-mediated diseases. KIDNEY INTERNATIONAL, 98(3), 536-538. doi:10.1016/j.kint.2020.04.029

Chandrasekhar, J. L., Cox, K. M., & Erickson, L. D. (2020). B Cell Responses in the Development of Mammalian Meat Allergy. FRONTIERS IN IMMUNOLOGY, 11. doi:10.3389/fimmu.2020.01532

2019

Chandrasekhar, J. L., Cox, K. M., Loo, W. M., Qiao, H., Tung, K. S., & Erickson, L. D. (2019). Cutaneous Exposure to Clinically Relevant Lone Star Ticks Promotes IgE Production and Hypersensitivity through CD4+ T Cell- and MyD88-Dependent Pathways in Mice.. Journal of immunology (Baltimore, Md. : 1950), 203(4), 813-824. doi:10.4049/jimmunol.1801156

Cox, K. M., Commins, S. P., Capaldo, B. J., Workman, L. J., Platts-Mills, T. A. E., Amir, E. -A. D., . . . Erickson, L. D. (2019). An integrated framework using high-dimensional mass cytometry and fluorescent flow cytometry identifies discrete B cell subsets in patients with red meat allergy. CLINICAL AND EXPERIMENTAL ALLERGY, 49(5), 615-625. doi:10.1111/cea.13322

2017

Cox, K. M., & Erickson, L. D. (2017). Editorial: Masters of fate: the APC cytokine milieu as a key regulator of distinct Tfh cell subsets. JOURNAL OF LEUKOCYTE BIOLOGY, 101(1), 1-3. doi:10.1189/jlb.1CE0816-351R

2016

van Opstal, E., Kolling, G. L., Mooreii, J. H., Coquery, C. M., Wade, N. S., Loo, W. M., . . . Warren, C. A. (2016). Vancomycin Treatment Alters Humoral Immunity and Intestinal Microbiota in an Aged Mouse Model of Clostridium difficile Infection. JOURNAL OF INFECTIOUS DISEASES, 214(1), 130-139. doi:10.1093/infdis/jiw071

2015

Commins, S. P., Jerath, M. R., Cox, K., Erickson, L. D., & Platts-Mills, T. (2016). Delayed anaphylaxis to alpha-gal, an oligosaccharide in mammalian meat. ALLERGOLOGY INTERNATIONAL, 65(1), 16-20. doi:10.1016/j.alit.2015.10.001

Brown, M. G., & Erickson, L. D. (2015). Editorial: NK cell reaping of Tfh cells: reckless slaughter or sensible pruning?. JOURNAL OF LEUKOCYTE BIOLOGY, 98(2), 139-142. doi:10.1189/jlb.4CE0415-175R

Coquery, C. M., Loo, W. M., Wade, N. S., Bederman, A. G., Tung, K. S., Lewis, J. E., . . . Erickson, L. D. (2015). BAFF Regulates Follicular Helper T Cells and Affects Their Accumulation and Interferon-γ Production in Autoimmunity. ARTHRITIS & RHEUMATOLOGY, 67(3), 773-784. doi:10.1002/art.38950

2014

Coquery, C. M., Wade, N. S., Loo, W. M., Kinchen, J. M., Cox, K. M., Jiang, C., . . . Erickson, L. D. (2014). Neutrophils Contribute to Excess Serum BAFF Levels and Promote CD4+ T Cell and B Cell Responses in Lupus-Prone Mice. PLOS ONE, 9(7). doi:10.1371/journal.pone.0102284

2013

Peperzak, V., Vikström, I., Walker, J., Glaser, S. P., LePage, M., Coquery, C. M., . . . Tarlinton, D. M. (2013). Erratum: Corrigendum: Mcl-1 is essential for the survival of plasma cells. Nature Immunology, 14(8), 877. doi:10.1038/ni0813-877c

Peperzak, V., Vikstroem, I., Walker, J., Glaser, S. P., LePage, M., Coquery, C. M., . . . Tarlinton, D. M. (2013). Mcl-1 is essential for the survival of plasma cells. NATURE IMMUNOLOGY, 14(3), 290-297. doi:10.1038/ni.2527

2012

Coquery, C. M., Loo, W., Buszko, M., Lannigan, J., & Erickson, L. D. (2012). Optimized protocol for the isolation of spleen-resident murine neutrophils. CYTOMETRY PART A, 81A(9), 806-814. doi:10.1002/cyto.a.22096

Coquery, C. M., & Erickson, L. D. (2012). Regulatory Roles of the Tumor Necrosis Factor Receptor BCMA. CRITICAL REVIEWS IN IMMUNOLOGY, 32(4), 287-305. Retrieved from https://www.webofscience.com/

2011

Panchanathan, R., Liu, H., Liu, H., Fang, C. -M., Erickson, L. D., Pitha, P. M., & Choubey, D. (2012). Distinct Regulation of Murine Lupus Susceptibility Genes by the IRF5/Blimp-1 Axis. JOURNAL OF IMMUNOLOGY, 188(1), 270-278. doi:10.4049/jimmunol.1102311

Ernst, P. B., Erickson, L. D., Loo, W. M., Scott, K. G., Wiznerowicz, E. B., Brown, C. C., . . . Tung, K. S. (2012). Spontaneous autoimmune gastritis and hypochlorhydria are manifest in the ileitis-prone SAMP1/YitFcs mice. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 302(1), G105-G115. doi:10.1152/ajpgi.00194.2011

Wolf, A. I., Mozdzanowska, K., Quinn, W. J. I. I. I., Metzgar, M., Williams, K. L., Caton, A. J., . . . Erikson, J. (2011). Protective antiviral antibody responses in a mouse model of influenza virus infection require TACI. JOURNAL OF CLINICAL INVESTIGATION, 121(10), 3954-3964. doi:10.1172/JCI57362

Panchanathan, R., Shen, H., Duan, X., Rathinam, V. A. K., Erickson, L. D., Fitzgerald, K. A., & Choubey, D. (2011). Aim2 Deficiency in Mice Suppresses the Expression of the Inhibitory Fcγ Receptor (FcγRIIB) through the Induction of the IFN-Inducible p202, a Lupus Susceptibility Protein. JOURNAL OF IMMUNOLOGY, 186(12), 6762-6770. doi:10.4049/jimmunol.1003638

Jiang, C., Loo, W. M., Greenley, E. J., Tung, K. S., & Erickson, L. D. (2011). B Cell Maturation Antigen Deficiency Exacerbates Lymphoproliferation and Autoimmunity in Murine Lupus. JOURNAL OF IMMUNOLOGY, 186(11), 6136-6147. doi:10.4049/jimmunol.1001931

2010

Panchanathan, R., Duan, X., Shen, H., Rathinam, V. A. K., Erickson, L. D., Fitzgerald, K. A., & Choubey, D. (2010). Aim2 Deficiency Stimulates the Expression of IFN-Inducible Ifi202, a Lupus Susceptibility Murine Gene within the Nba2 Autoimmune Susceptibility Locus. JOURNAL OF IMMUNOLOGY, 185(12), 7385-7393. doi:10.4049/jimmunol.1002468