Judith A. Woodfolk
- Email: jaw4m@Virginia.EDU
- Phone: 434-924-1293 / 434-982-3958
- Fax: 434-924-1251
Primary Appointment
Professor, Medicine- Asthma, Allergy and Immunology
Education
- MBChB, Medicine, Sheffield University
- PhD, Microbiology, University of Virginia
Research Disciplines
Immunology, Microbiology, Molecular Biology, Translational Science
Research Interests
The immune response to common cold and allergens in health and disease.
Research Description
Current projects include: (1) Understanding mechanisms of cross-protective immunity to human rhinovirus in an experimental human infection model; (2) Defining pathogenic T cell responses to rhinovirus in asthma (3) Identifying immune determinants of severe outcomes in COVID-19 patients, including those that link to chronic lung damage.
Ongoing work uses novel tools and state-of-the-art technologies to provide a systems biology perspective of immune activation in humans. Our approach involves a high degree of collaboration with clinical experts in asthma, pulmonary and critical care medicine, and infectious diseases, as well as with basic scientists in virology, biochemistry, transcriptomics, and single-cell analytics.
Personal Statement
Training
- Biodefense & Infectious Diseases Short-Term Training to Increase Diversity in Biomedical Sciences
- Interdisciplinary Training Program in Immunology
Selected Publications
2024
Bingham, G. C., Muehling, L. M., Li, C., Huang, Y., Ma, S. -F., Abebayehu, D., . . . Bonham, C. A. (2024). High-dimensional comparison of monocytes and T cells in post-COVID and idiopathic pulmonary fibrosis. FRONTIERS IN IMMUNOLOGY, 14. doi:10.3389/fimmu.2023.1308594
2023
Narasimhan, H., Cheon, I. S., Qian, W., Hu, S., Parimon, T., Li, C., . . . Sun, J. (2023). Proximal immune-epithelial progenitor interactions drive chronic tissue sequelae post COVID-19.. bioRxiv. doi:10.1101/2023.09.13.557622
Jie, S., Narasimhan, H., Cheon, I. S., Qian, W., Hu, S., Parimon, T., . . . Chen, P. (2023). Proximal immune-epithelial progenitor interactions drive chronic tissue sequelae post COVID-19. doi:10.21203/rs.3.rs-3587418/v1
Ayers, E., Canderan, G., Williams, M. E., Keshavarz, B., Portell, C. A., Wilson, J. M., & Woodfolk, J. A. (2023). In-depth cellular and humoral dynamics of the response to COVID-19 vaccine booster in patients with chronic B-cell neoplasms. BLOOD CANCER JOURNAL, 13(1). doi:10.1038/s41408-023-00884-w
2022
Brooks, B., Tancredi, C., Song, Y., Mogus, A. T., Huang, M. -L. W., Zhu, H., . . . Zeichner, S. L. (2022). Epstein-Barr Virus and Human Herpesvirus-6 Reactivation in Acute COVID-19 Patients. VIRUSES-BASEL, 14(9). doi:10.3390/v14091872
Muehling, L. M., Heymann, P. W., Carper, H., Murphy, D. D., Rajadhyaksha, E., Kennedy, J., . . . Woodfolk, J. A. (2022). Cluster analysis of nasal cytokines during rhinovirus infection identifies different immunophenotypes in both children and adults with allergic asthma. CLINICAL AND EXPERIMENTAL ALLERGY, 52(10), 1169-1182. doi:10.1111/cea.14176
Keshavarz, B., Richards, N. E., Workman, L. J., Patel, J., Muehling, L. M., Canderan, G., . . . Wilson, J. M. (2022). Trajectory of IgG to SARS-CoV-2 After Vaccination With BNT162b2 or mRNA-1273 in an Employee Cohort and Comparison With Natural Infection. FRONTIERS IN IMMUNOLOGY, 13. doi:10.3389/fimmu.2022.850987
2021
Barone, S. M., Paul, A. G. A., Muehling, L. M., Lannigan, J. A., Kwok, W. W., Turner, R. B., . . . Irish, J. M. (2021). Unsupervised machine learning reveals key immune cell subsets in COVID-19 rhinovirus infection, and cancer therapy. ELIFE, 10. doi:10.7554/eLife.64653
Keshavarz, B., Wiencek, J. R., Workman, L. J., Straesser, M. D., Muehling, L. M., Canderan, G., . . . Wilson, J. M. (2021). Quantitative Measurement of IgG to Severe Acute Respiratory Syndrome Coronavirus-2 Proteins Using ImmunoCAP. INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 182(5), 417-424. doi:10.1159/000514203
Keshavarz, B., Wiencek, J., Bazydlo, L., Straesser, M., Workman, L., Platts-Mills, T., & Wilson, J. (2021). Quantitative Measurement of IgG to SARS-CoV-2 Proteins Using the Phadia ImmunoCAP 250. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 147(2), AB150.
2020
Barone, S. M., Paul, A. G. A., Muehling, L. M., Lannigan, J. A., Kwok, W. W., Turner, R. B., . . . Irish, J. M. (2020). Unsupervised machine learning reveals key immune cell subsets in COVID-19, rhinovirus infection, and cancer therapy.. bioRxiv. doi:10.1101/2020.07.31.190454
Roberts, G., Almqvist, C., Boyle, R., Crane, J., Hogan, S. P., Marsland, B., . . . Woodfolk, J. A. (2020). Developments allergy in 2019 through the eyes of Clinical and Experimental Allergy, Part II clinical allergy. CLINICAL AND EXPERIMENTAL ALLERGY, 50(12), 1302-1312. doi:10.1111/cea.13778
Roberts, G., Almqvist, C., Boyle, R., Crane, J., Hogan, S. P., Marsland, B., . . . Woodfolk, J. A. (2020). Developments allergy in 2019 through the eyes of clinical and experimental allergy, part I mechanisms. CLINICAL AND EXPERIMENTAL ALLERGY, 50(12), 1294-1301. doi:10.1111/cea.13777
Muehling, L. M., Heymann, P. W., Wright, P. W., Eccles, J. D., Agrawal, R., Carper, H. T., . . . Woodfolk, J. A. (2020). Human TH1 and TH2 cells targeting rhinovirus and allergen coordinately promote allergic asthma. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 146(3), 555-570. doi:10.1016/j.jaci.2020.03.037
Heymann, P. W., Platts-Mills, T. A. E., Woodfolk, J. A., Borish, L., Murphy, D. D., Carper, H. T., . . . Turner, R. B. (2020). Understanding the asthmatic response to an experimental rhinovirus infection: Exploring the effects of blocking IgE. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 146(3), 545-554. doi:10.1016/j.jaci.2020.01.035
Eccles, J. D., Turner, R. B., Kirk, N. A., Muehling, L. M., Borish, L., Steinke, J. W., . . . Woodfolk, J. A. (2020). T-bet plus Memory B Cells Link to Local Cross-Reactive IgG upon Human Rhinovirus Infection. CELL REPORTS, 30(2), 351-+. doi:10.1016/j.celrep.2019.12.027
2019
Roberts, G., Almqvist, C., Boyle, R., Crane, J., Hogan, S. P., Marsland, B., . . . Woodfolk, J. A. (2019). Developments in the mechanisms of allergy in 2018 through the eyes of Clinical and Experimental Allergy, Part I. CLINICAL AND EXPERIMENTAL ALLERGY, 49(12), 1541-1549. doi:10.1111/cea.13532
Roberts, G., Almqvist, C., Boyle, R., Crane, J., Hogan, S. P., Marsland, B., . . . Woodfolk, J. A. (2019). Developments in the field of clinical allergy in 2018 through the eyes of Clinical and Experimental Allergy, Part II. CLINICAL AND EXPERIMENTAL ALLERGY, 49(12), 1550-1557. doi:10.1111/cea.13535
Glesner, J., Kapingidza, A. B., Godzwon, M., Offermann, L. R., Mueller, G. A., DeRose, E. F., . . . Pomes, A. (2019). A Human IgE Antibody Binding Site on Der p 2 for the Design of a Recombinant Allergen for Immunotherapy. JOURNAL OF IMMUNOLOGY, 203(9), 2545-2556. doi:10.4049/jimmunol.1900580
Paul, A. G. A., Muehling, L. M., Eccles, J. D., & Woodfolk, J. A. (2019). T cells in severe childhood asthma. CLINICAL AND EXPERIMENTAL ALLERGY, 49(5), 564-581. doi:10.1111/cea.13374
Rosen, D. A., Seki, S. M., Fernandez-Castaneda, A., Beiter, R. M., Eccles, J. D., Woodfolk, J. A., & Gaultier, A. (2019). Modulation of the sigma-1 receptor-IRE1 pathway is beneficial in preclinical models of inflammation and sepsis. SCIENCE TRANSLATIONAL MEDICINE, 11(478). doi:10.1126/scitranslmed.aau5266
Davidson, W. F., Leung, D. Y. M., Beck, L. A., Berin, C. M., Boguniewicz, M., Busse, W. W., . . . Plaut, M. (2019). Report from the National Institute of Allergy and Infectious Diseases workshop on "Atopic dermatitis and the atopic march: Mechanisms and interventions''. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 143(3), 894-913. doi:10.1016/j.jaci.2019.01.003
2018
Roberts, G., Almqvist, C., Boyle, R., Crane, J., Hogan, S. P., Marsland, B., . . . Woodfolk, J. A. (2018). Developments in the field of allergy in 2017 through the eyes of Clinical and Experimental Allergy. CLINICAL AND EXPERIMENTAL ALLERGY, 48(12), 1606-1621. doi:10.1111/cea.13318
Muehling, L. M., Turner, R. B., Brown, K. B., Wright, P. W., Patrie, J. T., Lahtinen, S. J., . . . Woodfolk, J. A. (2018). Single-Cell Tracking Reveals a Role for Pre-Existing CCR5+ Memory Th1 Cells in the Control of Rhinovirus-A39 After Experimental Challenge in Humans. JOURNAL OF INFECTIOUS DISEASES, 217(3), 381-392. doi:10.1093/infdis/jix514
Wisniewski, J. A., Muehling, L. M., Eccles, J. D., Capaldo, B. J., Agrawal, R., Shirley, D. -A., . . . Woodfolk, J. A. (2018). TH1 signatures are present in the lower airways of children with severe asthma, regardless of allergic status. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 141(6), 2048-+. doi:10.1016/j.jaci.2017.08.020
Lotfi-Emran, S., Ward, B. R., Le, Q. T., Pozez, A. L., Manjili, M. H., Woodfolk, J. A., & Schwartz, L. B. (2018). Human mast cells present antigen to autologous CD4+ T cells. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 141(1), 311-+. doi:10.1016/j.jaci.2017.02.048
2017
Roberts, G., Boyle, R., Crane, J., Hogan, S. P., Saglani, S., Wickman, M., & Woodfolk, J. A. (2017). Developments in the field of allergy in 2016 through the eyes of Clinical and Experimental Allergy. CLINICAL AND EXPERIMENTAL ALLERGY, 47(12), 1512-1525. doi:10.1111/cea.13049
Platts-Mills, T. A. E., & Woodfolk, J. A. (2017). Mite Avoidance as a Logical Treatment for Severe Asthma in Childhood. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 196(2), 119-121. doi:10.1164/rccm.201703-0450ED
Heymann, P. W., Huyen-Tran, N., Steinke, J. W., Turner, R. B., Woodfolk, J. A., Platts-Mills, T. A. E., . . . Hershey, G. K. K. (2017). Rhinovirus infection results in stronger and more persistent genomic dysregulation: Evidence for altered innate immune response in asthmatics at baseline, early in infection, and during convalescence. PLOS ONE, 12(5). doi:10.1371/journal.pone.0178096
Muehling, L. M., Lawrence, M. G., & Woodfolk, J. A. (2017). Pathogenic CD4+ T cells in patients with asthma. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 140(6), 1523-1540. doi:10.1016/j.jaci.2017.02.025
Turner, R. B., Woodfolk, J. A., Borish, L., Steinke, J. W., Patrie, J. T., Muehling, L. M., . . . Lehtinen, M. J. (2017). Effect of probiotic on innate inflammatory response and viral shedding in experimental rhinovirus infection - a randomised controlled trial. BENEFICIAL MICROBES, 8(2), 207-215. doi:10.3920/BM2016.0160
Lawrence, M. G., Woodfolk, J. A., Schuyler, A. J., Stillman, L. C., Chapman, M. D., & Platts-Mills, T. A. E. (2017). Half-life of IgE in serum and skin: Consequences for anti-IgE therapy in patients with allergic disease. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 139(2), 422-428. doi:10.1016/j.jaci.2016.04.056
2016
Roberts, G., Boyle, R., Bryce, P. J., Crane, J., Hogan, S. P., Saglani, S., . . . Woodfolk, J. A. (2016). Developments in the field of clinical allergy in 2015 through the eyes of Clinical and Experimental Allergy. CLINICAL AND EXPERIMENTAL ALLERGY, 46(11), 1389-1397. doi:10.1111/cea.12831
Roberts, G., Boyle, R., Bryce, P. J., Crane, J., Hogan, S. P., Saglani, S., . . . Woodfolk, J. A. (2016). Developments in the field of allergy mechanisms in 2015 through the eyes of Clinical & Experimental Allergy. CLINICAL AND EXPERIMENTAL ALLERGY, 46(10), 1248-1257. doi:10.1111/cea.12823
Muehling, L. M., Mai, D. T., Kwok, W. W., Heymann, P. W., Pomes, A., & Woodfolk, J. A. (2016). Circulating Memory CD4+ T Cells Target Conserved Epitopes of Rhinovirus Capsid Proteins and Respond Rapidly to Experimental Infection in Humans. JOURNAL OF IMMUNOLOGY, 197(8), 3214-3224. doi:10.4049/jimmunol.1600663
Platts-Mills, T. A. E., Schuyler, A. J., Erwin, E. A., Commins, S. P., & Woodfolk, J. A. (2016). IgE in the diagnosis and treatment of allergic disease. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 137(6), 1662-1670. doi:10.1016/j.jaci.2016.04.010
Platts-Mills, T. A. E., Heymann, P. W., Commins, S. P., & Woodfolk, J. A. (2016). The discovery of IgE 50 years later. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 116(3), 179-182. doi:10.1016/j.anai.2016.01.003
Woodfolk, J. A. (2016). Benign TH2 immunity in children: A fresh perspective on control of the allergic response. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 137(2), 388-389. doi:10.1016/j.jaci.2015.12.1153
Woodfolk, J. A., Glesner, J., Wright, P. W., Kepley, C. L., Li, M., Himly, M., . . . Pomes, A. (2016). Antigenic Determinants of the Bilobal Cockroach Allergen Bla g 2. JOURNAL OF BIOLOGICAL CHEMISTRY, 291(5), 2288-2301. doi:10.1074/jbc.M115.702324
2015
Woodfolk, J. A., Commins, S. P., Schuyler, A. J., Erwin, E. A., & Platts-Mills, T. A. E. (2015). Allergens, sources, particles, and molecules: Why do we make IgE responses?. ALLERGOLOGY INTERNATIONAL, 64(4), 295-303. doi:10.1016/j.alit.2015.06.001
Wisniewski, J. A., Commins, S. P., Agrawal, R., Hulse, K. E., Yu, M. D., Cronin, J., . . . Woodfolk, J. A. (2015). Analysis of cytokine production by peanut-reactive T cells identifies residual Th2 effectors in highly allergic children who received peanut oral immunotherapy. CLINICAL AND EXPERIMENTAL ALLERGY, 45(7), 1201-1213. doi:10.1111/cea.12537
2014
Romeo, M. J., Agrawal, R., Pomes, A., & Woodfolk, J. A. (2014). A molecular perspective on TH2-promoting cytokine receptors in patients with allergic disease. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 133(4), 952-+. doi:10.1016/j.jaci.2013.08.006
Romeo, M. J., Agrawal, R., Pomes, A., & Woodfolk, J. A. (2014). Gene silencing and related oligonucleotide therapies for TH2-promoting cytokines Reply. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 134(3), 762-763. doi:10.1016/j.jaci.2014.06.009
Erwin, E. A., Woodfolk, J. A., James, H. R., Satinover, S. M., & Platts-Mills, T. A. E. (2014). Changes in cat specific IgE and IgG antibodies with decreased cat exposure. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 112(6), 545-U164. doi:10.1016/j.anai.2014.03.007
Agrawal, R., & Woodfolk, J. A. (2014). Skin Barrier Defects in Atopic Dermatitis. CURRENT ALLERGY AND ASTHMA REPORTS, 14(5). doi:10.1007/s11882-014-0433-9
Agrawal, R., Wisniewski, J., Yu, M. D., Kennedy, J. L., Platts-Mills, T., Heymann, P. W., & Woodfolk, J. A. (2014). Infection with human rhinovirus 16 promotes enhanced IgE responsiveness in basophils of atopic asthmatics. CLINICAL AND EXPERIMENTAL ALLERGY, 44(10), 1266-1273. doi:10.1111/cea.12390
2013
Agrawal, R., Hulse, K., & Woodfolk, J. A. (2013). Targeting antibody receptors as an approach towards immunotherapy.. Arbeiten aus dem Paul-Ehrlich-Institut (Bundesinstitut fur Impfstoffe und biomedizinische Arzneimittel) Langen/Hessen, 97, 153-156.
Wisniewski, J., Agrawal, R., & Woodfolk, J. A. (2013). Mechanisms of tolerance induction in allergic disease: integrating current and emerging concepts. CLINICAL AND EXPERIMENTAL ALLERGY, 43(2), 164-176. doi:10.1111/cea.12016
Wisniewski, J. A., Agrawal, R., Minnicozzi, S., Xin, W., Patrie, J., Heymann, P. W., . . . Woodfolk, J. A. (2013). Sensitization to food and inhalant allergens in relation to age and wheeze among children with atopic dermatitis. CLINICAL AND EXPERIMENTAL ALLERGY, 43(10), 1160-1170. doi:10.1111/cea.12169
Allakhverdi, Z., Comeau, M. R., Arment, M., Agrawal, R., Woodfolk, J. A., Sehmi, R., . . . Delespesse, G. (2013). Mast cell-activated bone marrow mesenchymal stromal cells regulate proliferation and lineage commitment of CD34+ progenitor cells. FRONTIERS IN IMMUNOLOGY, 4. doi:10.3389/fimmu.2013.00461
2012
Cornmins, S. P., Kelly, L. A., Ronmark, E., James, H. R., Pochan, S. L., Peters, E. J., . . . Platts-Mills, T. A. E. (2012). Galactose-α-1,3-Galactose-Specific IgE Is Associated with Anaphylaxis but Not Asthma. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 185(7), 723-730. doi:10.1164/rccm.201111-2017OC
2011
Agrawal, R., Wisniewski, J. A., & Woodfolk, J. A. (2011). The Role of Regulatory T Cells in Atopic Dermatitis. PATHOGENESIS AND MANAGEMENT OF ATOPIC DERMATITIS, 41, 112-124.
Erwin, E. A., Woodfolk, J. A., Ronmark, E., Perzanowski, M., & Platts-Mills, T. A. E. (2011). The long-term protective effects of domestic animals in the home. CLINICAL AND EXPERIMENTAL ALLERGY, 41(7), 920-922. doi:10.1111/j.1365-2222.2011.03787.x
Platts-Mills, T. A. E., & Woodfolk, J. A. (2011). Allergens and their role in the allergic immune response. IMMUNOLOGICAL REVIEWS, 242, 51-68. doi:10.1111/j.1600-065X.2011.01021.x
2010
Reefer, A. J., Hulse, K. E., Lannigan, J. A., Solga, M. D., Wright, P. W., Kelly, L. A., . . . Woodfolk, J. A. (2010). Flow cytometry imaging identifies rare TH2 cells expressing thymic stromal lymphopoietin receptor in a "proallergic" milieu. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 126(5), 1049-U241. doi:10.1016/j.jaci.2010.07.023
Hulse, K. E., Reefer, A. J., Engelhard, V. H., Patrie, J. T., Ziegler, S. F., Chapman, M. D., & Woodfolk, J. A. (2010). Targeting allergen to FcγRI reveals a novel TH2 regulatory pathway linked to thymic stromal lymphopoietin receptor. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 125(1), 247-256. doi:10.1016/j.jaci.2009.10.027