Ukpong Bassey Eyo

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Primary Appointment

Associate Professor of Neuroscience, Neuroscience

Education

  • BS, Biology: Pre-Professional Zoology, Northwest Missouri State
  • PhD, Biology: Neuroscience, University of Iowa
  • Postdoc, Microglia-Neuron Interactions, Rutgers University, NJ
  • Postdoc, Microglia-Neuron Interactions, Mayo Clinic, Rochester, MN

Research Disciplines

Development, Stem Cells & Regeneration, Neuroimmunology, Neuroscience

Research Interests

Neuroscience

Research Description

Microglia in neurodevelopment and neurodevelopment disorders

Personal Statement

I am broadly interested in microglial behaviors in the healthy and diseased mammalian brain especially during development. During my graduate training, I developed a keen interest in microglial biology. There, I focused on understanding and elucidating microglial dynamics during early postnatal development in the mammalian hippocampus both under normal conditions and during simulated ischemia in acute brain slices using confocal microscopy. For my postdoctoral training, I turned my attention to microglial interactions with neurons in living tissues to elucidate some of the interesting bi-directional communication that occurs between these two brain cell types in the healthy brain. As an independent investigator I will combine my graduate and postgraduate training to study microglial roles in and interactions with the nervous system elements during development and developmental disorders such as seizures. I am confident that my studies will help provide significant insights into the function of microglial cells in the mammalian brain.

Training

  • Basic Cardiovascular Research Training Grant
  • Predoctoral Training in Neuroscience
  • Training in Cell and Molecular Biology

Selected Publications

2024

Uweru, O. J., Okojie, A. K., Trivedi, A., Benderoth, J., Thomas, L. S., Davidson, G., . . . Eyo, U. B. (2024). A P2RY12 deficiency results in sex-specific cellular perturbations and sexually dimorphic behavioral anomalies. JOURNAL OF NEUROINFLAMMATION, 21(1). doi:10.1186/s12974-024-03079-7

Li, H., & Eyo, U. B. (2024). The diversity, destiny, and memory of DAMs. IMMUNITY, 57(2), 200-202. doi:10.1016/j.immuni.2024.01.004

2023

Lopez-Ortiz, A. O., & Eyo, U. B. (2023). Astrocytes and microglia in the coordination of CNS development and homeostasis. JOURNAL OF NEUROCHEMISTRY. doi:10.1111/jnc.16006

Okojie, A. K., Uweru, J. O., Coburn, M. A., Li, S., Cao-Dao, V. D., & Eyo, U. B. (2023). Distinguishing the effects of systemic CSF1R inhibition by PLX3397 on microglia and peripheral immune cells. JOURNAL OF NEUROINFLAMMATION, 20(1). doi:10.1186/s12974-023-02924-5

Gibbs-Shelton, S., Benderoth, J., Gaykema, R. P., Straub, J., Okojie, K. A., Uweru, J. O., . . . Eyo, U. B. (2023). Microglia play beneficial roles in multiple experimental seizure models. GLIA, 71(7), 1699-1714. doi:10.1002/glia.24364

2022

Gu, N., Yi, M. -H., Murugan, M., Xie, M., Parusel, S., Peng, J., . . . Wu, L. -J. (2022). Spinal microglia contribute to sustained inflammatory pain via amplifying neuronal activity. MOLECULAR BRAIN, 15(1). doi:10.1186/s13041-022-00970-3

Mills, W. A. I. I. I., & Eyo, U. B. (2023). TREMble Before TREM2: The Mighty Microglial Receptor Conferring Neuroprotective Properties in TDP-43 Mediated Neurodegeneration. NEUROSCIENCE BULLETIN, 39(1), 163-166. doi:10.1007/s12264-022-00944-4

Mills, W. A. I. I. I., Coburn, M. A., & Eyo, U. B. (2022). The emergence of the calvarial hematopoietic niche in health and disease. IMMUNOLOGICAL REVIEWS, 311(1), 26-38. doi:10.1111/imr.13120

Lukens, J. R., & Eyo, U. B. (2022). Microglia and Neurodevelopmental Disorders. ANNUAL REVIEW OF NEUROSCIENCE, 45, 425-445. doi:10.1146/annurev-neuro-110920-023056

Mills, W. A. I. I. I., Woo, A. M., Jiang, S., Martin, J., Surendran, D., Bergstresser, M., . . . Sontheimer, H. (2022). Astrocyte plasticity in mice ensures continued endfoot coverage of cerebral blood vessels following injury and declines with age. NATURE COMMUNICATIONS, 13(1). doi:10.1038/s41467-022-29475-2

2021

Bisht, K., Okojie, K. A., Sharma, K., Lentferink, D. H., Sun, Y. -Y., Chen, H. -R., . . . Eyo, U. B. (2021). Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-25590-8

Eyo, U. B., Haruwaka, K., Mo, M., Campos-Salazar, A. B., Wang, L., Speros, X. S., . . . Wu, L. -J. (2021). Microglia provide structural resolution to injured dendrites after severe seizures. CELL REPORTS, 35(5). doi:10.1016/j.celrep.2021.109080

Melssen, M. M., Lindsay, R. S., Stasiak, K., Rodriguez, A. B., Briegel, A. M., Cyranowski, S., . . . Engelhard, V. H. (2021). Differential Expression of CD49a and CD49b Determines Localization and Function of Tumor-Infiltrating CD8+ T Cells. CANCER IMMUNOLOGY RESEARCH, 9(5), 583-597. doi:10.1158/2326-6066.CIR-20-0427

Sharma, K., Bisht, K., & Eyo, U. B. (2021). A Comparative Biology of Microglia Across Species. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 9. doi:10.3389/fcell.2021.652748

2020

Badimon, A., Strasburger, H. J., Ayata, P., Chen, X., Nair, A., Ikegami, A., . . . Schaefer, A. (2020). Negative feedback control of neuronal activity by microglia. NATURE, 586(7829), 417-+. doi:10.1038/s41586-020-2777-8

Bisht, K., Sharma, K., & Eyo, U. B. (2020). Precise Brain Mapping to Perform Repetitive In Vivo Imaging of Neuro-Immune Dynamics in Mice. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, (162). doi:10.3791/61454

Sharma, K., Wu, L. -J., & Eyo, U. B. (2020). Calming Neurons with a Microglial Touch. TRENDS IN NEUROSCIENCES, 43(4), 197-199. doi:10.1016/j.tins.2020.01.008

2019

Liu, Y. U., Ying, Y., Li, Y., Eyo, U. B., Chen, T., Zheng, J., . . . Wu, L. -J. (2019). Neuronal network activity controls microglial process surveillance in awake mice via norepinephrine signaling. NATURE NEUROSCIENCE, 22(11), 1771-+. doi:10.1038/s41593-019-0511-3

Mo, M., Eyo, U. B., Xie, M., Peng, J., Bosco, D. B., Umpierre, A. D., . . . Wu, L. -J. (2019). Microglial P2Y12 Receptor Regulates Seizure-Induced Neurogenesis and Immature Neuronal Projections. JOURNAL OF NEUROSCIENCE, 39(47), 9453-9464. doi:10.1523/JNEUROSCI.0487-19.2019

Eyo, U. B., & Wu, L. -J. (2019). Microglia: Lifelong patrolling immune cells of the brain. PROGRESS IN NEUROBIOLOGY, 179. doi:10.1016/j.pneurobio.2019.04.003

Zhou, L. -J., Peng, J., Xu, Y. -N., Zeng, W. -J., Zhang, J., Wei, X., . . . Wu, L. -J. (2019). Microglia Are Indispensable for Synaptic Plasticity in the Spinal Dorsal Horn and Chronic Pain. CELL REPORTS, 27(13), 3844-+. doi:10.1016/j.celrep.2019.05.087

Uweru, J. O., & Eyo, U. B. (2019). A decade of diverse microglial-neuronal physical interactions in the brain (2008-2018). NEUROSCIENCE LETTERS, 698, 33-38. doi:10.1016/j.neulet.2019.01.001

2018

Bosco, D. B., Zheng, J., Xu, Z., Peng, J., Eyo, U. B., Tang, K., . . . Wu, L. -J. (2018). RNAseq analysis of hippocampal microglia after kainic acid-induced seizures. MOLECULAR BRAIN, 11. doi:10.1186/s13041-018-0376-5

Eyo, U. B., Mo, M., Yi, M. -H., Murugan, M., Liu, J., Yarlagadda, R., . . . Wu, L. -J. (2018). P2Y12R-Dependent Translocation Mechanisms Gate the Changing Microglial Landscape. CELL REPORTS, 23(4), 959-966. doi:10.1016/j.celrep.2018.04.001

Zhao, X., Eyo, U. B., Murugan, M., & Wu, L. -J. (2018). Microglial interactions with the neurovascular system in physiology and pathology. DEVELOPMENTAL NEUROBIOLOGY, 78(6), 604-617. doi:10.1002/dneu.22576

Eyo, U. B., Bispo, A., Liu, J., Sabu, S., Wu, R., DiBona, V. L., . . . Wu, L. -J. (2018). The GluN2A Subunit Regulates Neuronal NMDA receptor-Induced Microglia-Neuron Physical Interactions. SCIENTIFIC REPORTS, 8. doi:10.1038/s41598-018-19205-4

2017

Tian, D. -S., Peng, J., Murugan, M., Feng, L. -J., Liu, J. -L., Eyo, U. B., . . . Wu, L. -J. (2017). Chemokine CCL2-CCR2 Signaling Induces Neuronal Cell Death via STAT3 Activation and IL-1β Production after Status Epilepticus. JOURNAL OF NEUROSCIENCE, 37(33), 7878-7892. doi:10.1523/JNEUROSCI.0315-17.2017

2016

Gu, N., Peng, J., Murugan, M., Wang, X., Eyo, U. B., Sun, D., . . . Wu, L. -J. (2016). Spinal Microgliosis Due to Resident Microglial Proliferation Is Required for Pain Hypersensitivity after Peripheral Nerve Injury. CELL REPORTS, 16(3), 605-614. doi:10.1016/j.celrep.2016.06.018

Peng, J., Gu, N., Zhou, L., Eyo, U. B., Murugan, M., Gan, W. -B., & Wu, L. -J. (2016). Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury. NATURE COMMUNICATIONS, 7. doi:10.1038/ncomms12029

Eyo, U. B., Murugan, M., & Wu, L. -J. (2017). Microglia-Neuron Communication in Epilepsy. GLIA, 65(1), 5-18. doi:10.1002/glia.23006

Swiatkowski, P., Murugan, M., Eyo, U. B., Wang, Y., Rangaraju, S., Oh, S. B., & Wu, L. -J. (2016). ACTIVATION OF MICROGLIAL P2Y12 RECEPTOR IS REQUIRED FOR OUTWARD POTASSIUM CURRENTS IN RESPONSE TO NEURONAL INJURY. NEUROSCIENCE, 318, 22-33. doi:10.1016/j.neuroscience.2016.01.008

Eyo, U. B., Peng, J., Murugan, M., Mo, M., Lalani, A., Xie, P., . . . Wu, L. -J. (2016). Regulation of Physical Microglia-Neuron Interactions by Fractalkine Signaling after Status Epilepticus. ENEURO, 3(6). doi:10.1523/ENEURO.0209-16.2016

2015

Gu, N., Eyo, U. B., Murugan, M., Peng, J., Matta, S., Dong, H., & Wu, L. -J. (2016). Microglial P2Y12 receptors regulate microglial activation and surveillance during neuropathic pain. BRAIN BEHAVIOR AND IMMUNITY, 55, 82-92. doi:10.1016/j.bbi.2015.11.007

Eyo, U. B., Miner, S. A., Weiner, J. A., & Dailey, M. E. (2016). Developmental changes in microglial mobilization are independent of apoptosis in the neonatal mouse hippocampus. BRAIN BEHAVIOR AND IMMUNITY, 55, 49-59. doi:10.1016/j.bbi.2015.11.009

Liu, J., Tian, D., Murugan, M., Eyo, U. B., Dreyfus, C. F., Wang, W., & Wu, L. -J. (2015). Microglial Hv1 proton channel promotes cuprizone-induced demyelination through oxidative damage. JOURNAL OF NEUROCHEMISTRY, 135(2), 347-356. doi:10.1111/jnc.13242

Eyo, U. B., Gu, N., De, S., Dong, H., Richardson, J. R., & Wu, L. -J. (2015). Modulation of Microglial Process Convergence Toward Neuronal Dendrites by Extracellular Calcium. JOURNAL OF NEUROSCIENCE, 35(6), 2417-2422. doi:10.1523/JNEUROSCI.3279-14.2015

2014

Eyo, U. B., Peng, J., Swiatkowski, P., Mukherjee, A., Bispo, A., & Wu, L. -J. (2014). Neuronal Hyperactivity Recruits Microglial Processes via Neuronal NMDA Receptors and Microglial P2Y12 Receptors after Status Epilepticus. JOURNAL OF NEUROSCIENCE, 34(32), 10528-10540. doi:10.1523/JNEUROSCI.0416-14.2014

2013

Dailey, M. E., Eyo, U., Eyo, U., Fuller, L., Hass, J., & Kurpius, D. (2013). Imaging microglia in brain slices and slice cultures.. Cold Spring Harbor protocols, 2013(12), 1142-1148. doi:10.1101/pdb.prot079483

Eyo, U. B., Miner, S. A., Ahlers, K. E., Wu, L. -J., & Dailey, M. E. (2013). P2X7 receptor activation regulates microglial cell death during oxygen-glucose deprivation. NEUROPHARMACOLOGY, 73, 311-319. doi:10.1016/j.neuropharm.2013.05.032

Eyo, U. B., & Dailey, M. E. (2013). Microglia: Key Elements in Neural Development, Plasticity, and Pathology. JOURNAL OF NEUROIMMUNE PHARMACOLOGY, 8(3), 494-509. doi:10.1007/s11481-013-9434-z

Eyo, U. B., & Wu, L. -J. (2013). Bidirectional Microglia-Neuron Communication in the Healthy Brain. NEURAL PLASTICITY, 2013. doi:10.1155/2013/456857

2012

Eyo, U., & Dailey, M. E. (2012). Effects of oxygen-glucose deprivation on microglial mobility and viability in developing mouse hippocampal tissues. GLIA, 60(11), 1747-1760. doi:10.1002/glia.22394