Chaofan Li
- Email: djp5yp@virginia.edu
Primary Appointment
Assistant Professor, Medicine- Infectious Diseases and International Health
Education
- PhD, Pathogenic Organisms, Fudan University
Research Disciplines
Infectious Diseases/Biodefense
Research Interests
Infectious Diseases
Research Description
Selected Publications
2024
Son, Y. M., Cheon, I. S., Li, C., & Sun, J. (2024). Persistent B Cell-Derived MHC Class II Signaling Is Required for the Optimal Maintenance of Tissue-Resident Helper T Cells.. ImmunoHorizons, 8(2), 163-171. doi:10.4049/immunohorizons.2300093
2023
Jie, S., Narasimhan, H., Cheon, I. S., Qian, W., Hu, S., Parimon, T., . . . Chen, P. (2023). Proximal immune-epithelial progenitor interactions drive chronic tissue sequelae post COVID-19. doi:10.21203/rs.3.rs-3587418/v1
Narasimhan, H., Cheon, I. S., Qian, W., Hu, S., Parimon, T., Li, C., . . . Sun, J. (2023). Proximal immune-epithelial progenitor interactions drive chronic tissue sequelae post COVID-19.. bioRxiv. doi:10.1101/2023.09.13.557622
Zhu, B., Wei, X., Narasimhan, H., Qian, W., Zhang, R., Cheon, I. S., . . . Sun, J. (2023). Inhibition of the mitochondrial pyruvate carrier simultaneously mitigates hyperinflammation and hyperglycemia in COVID-19. SCIENCE IMMUNOLOGY, 8(82). doi:10.1126/sciimmunol.adf0348
Bingham, G. C., Muehling, L. M., Li, C., Huang, Y., Ma, S. -F., Abebayehu, D., . . . Bonham, C. A. (2024). High-dimensional comparison of monocytes and T cells in post-COVID and idiopathic pulmonary fibrosis. FRONTIERS IN IMMUNOLOGY, 14. doi:10.3389/fimmu.2023.1308594
2022
Tang, J., Zeng, C., Cox, T. M., Li, C., Son, Y. M., Cheon, I. S., . . . Sun, J. (2022). Respiratory mucosal immunity against SARS-CoV-2 after mRNA vaccination. SCIENCE IMMUNOLOGY, 7(76). doi:10.1126/sciimmunol.add4853
Gao, X., Zhu, B., Wu, Y., Li, C., Zhou, X., Tang, J., & Sun, J. (2022). TFAM-Dependent Mitochondrial Metabolism Is Required for Alveolar Macrophage Maintenance and Homeostasis. JOURNAL OF IMMUNOLOGY, 208(6), 1456-1466. doi:10.4049/jimmunol.2100741
2021
Cheon, I. S., Li, C., Son, Y. M., Goplen, N. P., Wu, Y., Cassmann, T., . . . Sun, J. (2021). Immune signatures underlying post-acute COVID-19 lung sequelae. SCIENCE IMMUNOLOGY, 6(65). doi:10.1126/sciimmunol.abk1741
2020
Zhang, S., Zhao, G., Su, C., Li, C., Zhou, X., Zhao, W., . . . Wang, B. (2020). Neonatal priming and infancy boosting with a novel respiratory syncytial virus vaccine induces protective immune responses without concomitant respiratory disease upon RSV challenge. HUMAN VACCINES & IMMUNOTHERAPEUTICS, 16(3), 664-672. doi:10.1080/21645515.2019.1671134
Goplen, N. P., Wu, Y., Son, Y. M., Li, C., Wang, Z., Cheon, I. S., . . . Sun, J. (2020). Tissue-resident CD8+ T cells drive age-associated chronic lung sequelae after viral pneumonia. SCIENCE IMMUNOLOGY, 5(53). doi:10.1126/sciimmunol.abc4557
2019
Li, C., Zhu, B., Son, Y. M., Wang, Z., Jiang, L., Xiang, M., . . . Sun, J. (2019). The Transcription Factor Bhlhe40 Programs Mitochondria! Regulation of Resident CD8+ T Cell Fitness and Functionality. IMMUNITY, 51(3), 491-+. doi:10.1016/j.immuni.2019.08.013
Wang, Z., Wang, S., Goplen, N. P., Li, C., Cheon, I. S., Dai, Q., . . . Sun, J. (2019). PD-1hi CD8+ resident memory T cells balance immunity and fibrotic sequelae. SCIENCE IMMUNOLOGY, 4(36). doi:10.1126/sciimmunol.aaw1217
Goplen, N. P., Huang, S., Zhu, B., Cheon, I. S., Son, Y. M., Wang, Z., . . . Sun, J. (2019). Tissue-Resident Macrophages Limit Pulmonary CD8 Resident Memory T Cell Establishment. FRONTIERS IN IMMUNOLOGY, 10. doi:10.3389/fimmu.2019.02332
Zhu, B., Zhang, R., Li, C., Jiang, L., Xiang, M., Ye, Z., . . . Sun, J. (2019). BCL6 modulates tissue neutrophil survival and exacerbates pulmonary inflammation following influenza virus infection. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116(24), 11888-11893. doi:10.1073/pnas.1902310116
Huang, S., Goplen, N. P., Zhu, B., Cheon, I. S., Son, Y., Wang, Z., . . . Sun, J. (2019). Macrophage PPAR-γ suppresses long-term lung fibrotic sequelae following acute influenza infection. PLOS ONE, 14(10). doi:10.1371/journal.pone.0223430
2017
Zhou, C., Li, C., Gong, G. -Z., Wang, S., Zhang, J. -M., Xu, D. -Z., . . . Wang, B. (2017). Analysis of immunological mechanisms exerted by HBsAg-HBIG therapeutic vaccine combined with Adefovir in chronic hepatitis B patients. HUMAN VACCINES & IMMUNOTHERAPEUTICS, 13(9), 1989-1996. doi:10.1080/21645515.2017.1335840
2016
Li, C., Zhou, X., Zhong, Y., Li, C., Dong, A., He, Z., . . . Wang, B. (2016). A Recombinant G Protein Plus Cyclosporine A-Based Respiratory Syncytial Virus Vaccine Elicits Humoral and Regulatory T Cell Responses against Infection without Vaccine-Enhanced Disease. JOURNAL OF IMMUNOLOGY, 196(4), 1721-1731. doi:10.4049/jimmunol.1502103
2015
Geng, S., Zhang, H., Zhou, X., He, Y., Zhang, X., Xie, X., . . . Wang, B. (2015). Diabetes tolerogenic vaccines targeting antigen-specific inflammation. HUMAN VACCINES & IMMUNOTHERAPEUTICS, 11(2), 522-530. doi:10.1080/21645515.2014.1004024
2014
Wang, S., Yu, Y., Geng, S., Wang, D., Zhang, L., Xie, X., . . . Wang, B. (2014). A coimmunization vaccine of Aβ42 ameliorates cognitive deficits without brain inflammation in an Alzheimer's disease model. ALZHEIMERS RESEARCH & THERAPY, 6(3). doi:10.1186/alzrt256
Xie, X., Geng, S., Liu, H., Li, C., Yang, Y., & Wang, B. (2014). Cimetidine synergizes with Praziquantel to enhance the immune response of HBV DNA vaccine via activating cytotoxic CD8+ T cell. HUMAN VACCINES & IMMUNOTHERAPEUTICS, 10(6), 1688-1699. doi:10.4161/hv.28517
2012
Geng, S., Zhong, Y., Wang, S., Liu, H., Zou, Q., Xie, X., . . . Wang, B. (2012). Amiloride Enhances Antigen Specific CTL by Faciliting HBV DNA Vaccine Entry into Cells. PLOS ONE, 7(3). doi:10.1371/journal.pone.0033015