Jeffrey M Sturek

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Primary Appointment

Associate Professor, Pharmacology

Research Interests

Pharmacology

Selected Publications

2025

2024

Acetaminophen for Prevention and Treatment of Organ Dysfunction in Critically Ill Patients With Sepsis: The ASTER Randomized Clinical Trial
Journal of the American Medical Association. 2024; 332(5): 390. DOI:10.1001/JAMA.2024.8772.

An aberrant immuneâepithelial progenitor niche drives viral lung sequelae
Nature. 2024; 634(8035): 961 - 969. DOI:10.1038/S41586-024-07926-8.

Analysis of National Institutes of Health Funding for the COVID-19 Pandemic
Open Forum Infectious Diseases. 2024; 11(3):. DOI:10.1093/OFID/OFAE064.

Conjugation of ILâ33 to Microporous Annealed Particle Scaffolds Enhances Type 2âLike Immune Responses In Vitro and In Vivo
Advanced Healthcare Materials. 2024; DOI:10.1002/ADHM.202400249.

Early trajectories of virological and immunological biomarkers and clinical outcomes in patients admitted to hospital for COVID-19: an international, prospective cohort study
The Lancet Microbe. 2024; 5(6): e559 - e569. DOI:10.1016/S2666-5247(24)00015-6.

Effect of Neutralizing Monoclonal Antibody Treatment on Early Trajectories of Virologic and Immunologic Biomarkers in Patients Hospitalized With COVID-19
Journal of Infectious Diseases. 2024; 229(3): 671 - 679. DOI:10.1093/INFDIS/JIAD446.

Fostamatinib for Hospitalized Adults With COVID-19 and Hypoxemia: A Randomized Clinical Trial
JAMA Network Open. 2024; 7(12): e2448215. DOI:10.1001/JAMANETWORKOPEN.2024.48215.

Local, Quantitative Morphometry of Fibroproliferative Lung Injury Using Laminin
American Journal of Respiratory Cell and Molecular Biology. 2024; 71(1): 23 - 29. DOI:10.1165/RCMB.2023-0294MA.

Machine Learning-based Analysis of Publications Funded by the National Institutes of Health's Initial COVID-19 Pandemic Response
Open Forum Infectious Diseases. 2024; 11(4):. DOI:10.1093/OFID/OFAE156.

Pulmonary Function and Survival 1 Year After Dupilumab Treatment of Acute Moderate to Severe Coronavirus Disease 2019: A Follow-up Study From a Phase 2a Trial
Open Forum Infectious Diseases. 2024; 11(2):. DOI:10.1093/OFID/OFAD630.

Viral and Host Factors Are Associated With Mortality in Hospitalized Patients With COVID-19
Clinical Infectious Diseases. 2024; 78(6): 1490 - 1503. DOI:10.1093/CID/CIAD780.

2023

Assessment of Symptom, Disability, and Financial Trajectories in Patients Hospitalized for COVID-19 at 6 Months
JAMA Network Open. 2023; 6(2): e2255795. DOI:10.1001/JAMANETWORKOPEN.2022.55795.

Discrete T-Cell and Inflammatory Profiles in the Blood Define Pulmonary Phenotypes After COVID-19 Illness.
Journal of Allergy and Clinical Immunology. 2023; 151(2): AB339. DOI:10.1016/J.JACI.2022.12.793.

Dysregulated immune networks define distinct respiratory phenotypes of post-acute sequelae of COVID-19
Journal of immunology. 2023; 210(Supplement_1): 234.20 - 234.20. DOI:10.4049/JIMMUNOL.210.SUPP.234.20.

Improved survival of SARS COV-2-infected K18-hACE2 mice treated with adenosine A2AR agonist
Heliyon. 2023; 9(8): e19226. DOI:10.1016/J.HELIYON.2023.E19226.

Inhibition of the mitochondrial pyruvate carrier simultaneously mitigates hyperinflammation and hyperglycemia in COVID-19
Science Immunology. 2023; 8(82):. DOI:10.1126/SCIIMMUNOL.ADF0348.

Renin-Angiotensin System Modulation With Synthetic Angiotensin (1-7) and Angiotensin II Type 1 ReceptorâBiased Ligand in Adults With COVID-19: Two Randomized Clinical Trials
Journal of the American Medical Association. 2023; 329(14): 1170. DOI:10.1001/JAMA.2023.3546.

2022

Convalescent Plasma for Preventing Critical Illness in COVID-19: a Phase 2 Trial and Immune Profile
Microbiology Spectrum. 2022; 10(1):. DOI:10.1128/SPECTRUM.02560-21.

COVID-19 patients exhibit unique transcriptional signatures indicative of disease severity
Frontiers in Immunology. 2022; 13:. DOI:10.3389/FIMMU.2022.989556.

Efficacy and Safety of Ensovibep for Adults Hospitalized With COVID-19: A Randomized Controlled Trial
Annals of Internal Medicine. 2022; 175(9): 1266 - 1274. DOI:10.7326/M22-1503.

Efficacy and safety of two neutralising monoclonal antibody therapies, sotrovimab and BRII-196 plus BRII-198, for adults hospitalised with COVID-19 (TICO): a randomised controlled trial
Lancet Infectious Diseases. 2022; 22(5): 622 - 635. DOI:10.1016/S1473-3099(21)00751-9.

Organization of Outpatient Care After COVID-19 Hospitalization
Chest. 2022; 161(6): 1485 - 1489. DOI:10.1016/J.CHEST.2022.01.034.

Pleural Fluid Analysis in Neutropenia
Annals of the American Thoracic Society. 2022; 19(11): 1946 - 1948. DOI:10.1513/ANNALSATS.202204-331RL.

Responses to a Neutralizing Monoclonal Antibody for Hospitalized Patients With COVID-19 According to Baseline Antibody and Antigen Levels: A Randomized Controlled Trial
Annals of Internal Medicine. 2022; 175(2): 234 - 243. DOI:10.7326/M21-3507.

Safety and Efficacy of Dupilumab for the Treatment of Hospitalized Patients With Moderate to Severe Coronavirus Disease 2019: A Phase 2a Trial
Open Forum Infectious Diseases. 2022; 9(8):. DOI:10.1093/OFID/OFAC343.

Survivors Of Severe COVID-19 With Long-Haul Respiratory Symptoms Display Enhanced Activation of Circulating T Cells
Journal of Allergy and Clinical Immunology. 2022; 149(2): AB58. DOI:10.1016/J.JACI.2021.12.222.

The Association of Baseline Plasma SARS-CoV-2 Nucleocapsid Antigen Level and Outcomes in Patients Hospitalized With COVID-19
Annals of Internal Medicine. 2022; 175(10): 1401 - 1410. DOI:10.7326/M22-0924.

2021

2020

2019 Russell Ross Memorial Lecture in Vascular Biology: B LymphocyteâMediated Protective Immunity in Atherosclerosis
Arteriosclerosis, Thrombosis, and Vascular Biology. 2020; 40(2): 309 - 322. DOI:10.1161/ATVBAHA.119.313064.

Evaluation of K18-hACE2 Mice as a Model of SARS-CoV-2 Infection
American Journal of Tropical Medicine and Hygiene. 2020; 103(3): 1215 - 1219. DOI:10.4269/AJTMH.20-0762.

2019

2018

18F-NaF and 18F-FDG as molecular probes in the evaluation of atherosclerosis
European Journal of Nuclear Medicine and Molecular Imaging. 2018; 45(12): 2190 - 2200. DOI:10.1007/S00259-018-4078-0.

2017