Jayakrishna Ambati

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  • Phone: 434-924-7876
  • Fax: 434-924-9416

Primary Appointment

Professor, Ophthalmology

Education

  • Fellowship, Retina Clinical & Research, Massachusetts Eye & Ear Infirmary
  • Residency, Ophthalmology, University of Rochester
  • MD, Medicine, SUNY Downstate Medical Center College of Medicine

Research Disciplines

Biomedical Engineering, Experimental Pathology, Immunology, Microbiology, Neuroscience

Research Interests

Understanding the Molecular Basis of Macular Degeneration in Order to Hasten the Eradication of Blindness

Research Description

Alu RNA transcripts promote advanced dry age-related macular degeneration:
Geographic atrophy (GA) is the advanced form of dry age-related macular degeneration and is a leading cause of blindness in the Unites States. Currently, there is no FDA approved therapy for the over 1 million Americans with GA. One major goal of the laboratory was to identify novel molecular targets to fight this major unmet health need. We recently identified a class of RNA molecules - Alu RNA transcripts - cause RPE degeneration, which is a critical step in the pathogenesis of GA (Kaneko et al., Nature 2011). We further identified a new protective role for the enzyme Dicer1 whereby it cleaves Alu RNA transcripts, rendering them innocuous. In GA, the abundance of Dicer1 is reduced which leads to accumulation of cytotoxic Alu RNAs and RPE degeneration. This work was highlighted by commentaries in Cell (2011) and Nature (2011), and will serve as the foundation for the rational design of therapeutics for treating this pervasive disease.


Vascular Heterogeneity in the Eye:
The main goal of the laboratory is to elucidate molecular mechanisms that fundamentally regulate vascular growth in normal and diseased states in the eye. In 2006, we answered the foremost outstanding question in vascular biology: "What is responsible for avascularity of the cornea?" This work (Ambati et al., Nature 2006) demonstrated that, contrary to prevailing dogma that a multitude of anti-angiogenic molecules was required for corneal avascularity, a single protein - soluble VEGF receptor-1 - was uniquely responsible. This work was hailed by Science as a âSignaling Breakthrough of the Yearâ (Adler et al., Science STKE 2007), and is far-reaching because the cornea is the default platform for testing therapies for cancer, atherosclerosis, and other diseases driven by angiogenesis. In 2009 this work was extended to the lymphatic vasculature with our discovery and characterization of a similar, soluble, splice variant of VEGF receptor-2 (Albuquerque et al., Nature Med 2009) which sequesters VEGF-C and is responsible, specifically, for the alymphatic cornea.


Paradigms in Ocular Angiogenesis:
Several corneal and retinal diseases are hallmarked by neovascularization that often leads to irreversible blindness. We seek to identify the specific mediators for such pathologic responses in order to develop targeted therapeutics to reverse and prevent these devastating disorders. Our laboratory was the first to demonstrate the presence of in situ complement activation in the retina and choroid of patients with age-related macular degeneration (AMD). We showed (Nozaki et al., PNAS 2006) that this complement activation triggers the angiogenic switch that transforms the disease state from an atrophic to a neovascular phenotype. This vital observation has now resulted in the initiation of pre-clinical/Phase I clinical trials of complement inhibitors in AMD by more than a dozen pharmaceutical/biotech companies. Crucial to this translational advance was our labâs report of the first animal model of AMD (Ambati et al., Nature Med 2003). This data in conjunction with several other studies has supported a major paradigm shift towards inflammatory and immunologic mediators playing a significant role in the development of AMD and its progression to choroidal neovascularization.


The Interface of Immunity and Vascular Response in the Eye:
How does the omnipresent immune system induce pathologic vascular responses in the eye? Given the fundamental lack of knowledge on the molecular basis of immune regulated angiogenesis, our lab is committed to unraveling these complex biologic interactions. We recently identified (Kleinman et al., Nature 2008) the immune receptor TLR3 as a surprising signaling receptor for small interfering RNAs (siRNAs) in a sequence-independent manner. We showed that siRNAs "generically" suppress angiogenesis in multiple mouse models by activating cell surface TLR3 rather than by triggering RNA interference. These findings, which were covered in commentaries by Nature Medicine (2008) and Nature Biotechnology (2008), advance the nascent understanding of the multifunctional aspects of the immune system within the eye. We will continue our investigations into immunovascular biology with the goal of mapping this critical interface while creating more effective and tolerable medicines to treat neovascular diseases.


Our lab made a major breakthrough in this field by identifying CCR3, a chemokine receptor which has been implicated to be a key player in allergic inflammatory processes, as a biomarker and potential therapeutic target for choroidal neovascularization in age related macular degeneration (Takeda et al., Nature 2009). Of special importance, we were able to detect abnormal blood vessels in vivo in the eyes of mice that spontaneously develop CNV, prior to invasion of the retina, by attaching anti-CCR3 antibodies to tiny semiconductor nanocrystals, or "quantum dots." The discovery of this target may some day enable detection and treatment of neovascular age-related macular degeneration before blood vessels invade the retina and damage eyesight.


Selected Publications

2023

Gelfand, B. D., Argyle, D. A., Olivieri, J. J., & Ambati, J. (2023). Survey of commercial antibodies targeting Y chromosome-encoded genes.. MedComm - Future medicine, 2(4), e62. doi:10.1002/mef2.62

Ambati, J., & Gelfand, B. D. (2024). Response to 'Early Onset Drusen and RPE Dysfunction in a Patient with NLRP3-AID'. OCULAR IMMUNOLOGY AND INFLAMMATION, 32(5), 778. doi:10.1080/09273948.2023.2191710

Magagnoli, J., Pereira, F., Narendran, S., Huang, P., Cummings, T., Hardin, J. W., . . . Ambati, J. (2023). Anti-HIV Drugs Reduce Risk of Prediabetes and Progression to Type 2 Diabetes in HIV-Infected Patients.. MedComm - Future medicine, 2(2), e37. doi:10.1002/mef2.37

Wang, S. -B., Nagasaka, Y., Argyle, D., Nagasaka, A., Yerramothu, P., Gelfand, B. D., & Ambati, J. (2023). Targeting the m6A mRNA demethylase FTO suppresses vascular endothelial growth factor release and choroidal neovascularization. SIGNAL TRANSDUCTION AND TARGETED THERAPY, 8(1). doi:10.1038/s41392-022-01277-4

2022

Tan, A. C. S., Schwartz, R., Anaya, D., Chatziralli, I., Yuan, M., Cicinelli, M. V., . . . Loewenstein, A. (2022). Are intravitreal injections essential during the COVID-19 pandemic? Global preferred practice patterns and practical recommendations. INTERNATIONAL JOURNAL OF RETINA AND VITREOUS, 8(1). doi:10.1186/s40942-022-00380-6

Huang, P., Narendran, S., Pereira, F., Fukuda, S., Nagasaka, Y., Apicella, I., . . . Ambati, J. (2022). Subretinal injection in mice to study retina physiology and disease. NATURE PROTOCOLS, 17(6), 1468-+. doi:10.1038/s41596-022-00689-4

Huang, P., Narendran, S., Pereira, F., Fukuda, S., Nagasaka, Y., Apicella, I., . . . Ambati, J. (2022). The Learning Curve of Murine Subretinal Injection Among Clinically Trained Ophthalmic Surgeons. TRANSLATIONAL VISION SCIENCE & TECHNOLOGY, 11(3). doi:10.1167/tvst.11.3.13

Palko, S. I., Saba, N. J., Mullane, E., Nicholas, B. D., Nagasaka, Y., Ambati, J., . . . Mohan, R. (2022). Compartmentalized citrullination in Muller glial endfeet during retinal degeneration. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119(9). doi:10.1073/pnas.2121875119

2021

Pierre, M., Mainguy, A., Chatziralli, I., Pakzad-Vaezi, K., Ruiz-Medrano, J., Bodaghi, B., . . . Touhami, S. (2021). Macular Hemorrhage Due to Age-Related Macular Degeneration or Retinal Arterial Macroaneurysm: Predictive Factors of Surgical Outcome. JOURNAL OF CLINICAL MEDICINE, 10(24). doi:10.3390/jcm10245787

Wang, S. -B., Narendran, S., Hirahara, S., Varshney, A., Pereira, F., Apicella, I., . . . Ambati, J. (2021). DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs. SCIENCE IMMUNOLOGY, 6(66). doi:10.1126/sciimmunol.abi4493

Banerjee, D., Langberg, K., Abbas, S., Odermatt, E., Yerramothu, P., Volaric, M., . . . Kerur, N. (2021). A non-canonical, interferon-independent signaling activity of cGAMP triggers DNA damage response signaling. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-26240-9

Fukuda, S., Narendran, S., Varshney, A., Nagasaka, Y., Wang, S. -B., Ambati, K., . . . Ambati, J. (2021). Alu complementary DNA is enriched in atrophic macular degeneration and triggers retinal pigmented epithelium toxicity via cytosolic innate immunity. SCIENCE ADVANCES, 7(40). doi:10.1126/sciadv.abj3658

Uehara, H., Zhang, X., Pereira, F., Narendran, S., Choi, S., Bhuvanagiri, S., . . . Ambati, B. K. (2021). Start codon disruption with CRISPR/Cas9 prevents murine Fuchs' endothelia corneal dystrophy. ELIFE, 10. doi:10.7554/eLife.55637

Narendran, S., Pereira, F., Yerramothu, P., Apicella, I., Wang, S. -B., Ambati, K., . . . Ambati, J. (2021). Nucleoside reverse transcriptase inhibitors and Kamuvudines inhibit amyloid-β induced retinal pigmented epithelium degeneration. SIGNAL TRANSDUCTION AND TARGETED THERAPY, 6(1). doi:10.1038/s41392-021-00537-z

Fukuda, S., Varshney, A., Fowler, B. J., Wang, S. -B., Narendran, S., Ambati, K., . . . Ambati, J. (2021). Cytoplasmic synthesis of endogenous Alu complementary DNA via reverse transcription and implications in age-related macular degeneration. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 118(6). doi:10.1073/pnas.2022751118

2020

Narendran, S., Pereira, F., & Ambati, J. (2020). NLRP3 Inflammasome Inhibition A Potential Therapeutic Strategy to Attenuate Postinfarction Adverse Cardiac Remodeling. JACC-BASIC TO TRANSLATIONAL SCIENCE, 5(12), 1225-1227. doi:10.1016/j.jacbts.2020.11.004

Ambati, J., Magagnoli, J., Leung, H., Wang, S. -B., Andrews, C. A., Fu, D., . . . Gelfand, B. D. (2020). Repurposing anti-inflammasome NRTIs for improving insulin sensitivity and reducing type 2 diabetes development. NATURE COMMUNICATIONS, 11(1). doi:10.1038/s41467-020-18528-z

Narendran, S., Pereira, F., Yerramothu, P., Apicella, I., Wang, S. -B., Varshney, A., . . . Ambati, J. (2020). A Clinical Metabolite of Azidothymidine Inhibits Experimental Choroidal Neovascularization and Retinal Pigmented Epithelium Degeneration. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 61(10). doi:10.1167/iovs.61.10.4

Stanescu-Segall, D., de Gauzy, T. S., Reynolds, R., Faes, L., Pohlmann, D., Pakzad-Vaezi, K., . . . Touhami, S. (2020). Expert opinion on the management and follow-up of uveitis patients during SARS-CoV-2 outbreak. EXPERT REVIEW OF CLINICAL IMMUNOLOGY, 16(7), 651-657. doi:10.1080/1744666X.2020.1791086

Magagnoli, J., Narendran, S., Pereira, F., Cummings, T. H., Hardin, J. W., Sutton, S. S., & Ambati, J. (2020). Outcomes of Hydroxychloroquine Usage in United States Veterans Hospitalized with COVID-19. MED, 1(1), 114-+. doi:10.1016/j.medj.2020.06.001

Makin, R. D., Argyle, D., Hirahara, S., Nagasaka, Y., Zhang, M., Yan, Z., . . . Gelfand, B. D. (2020). Voluntary Exercise Suppresses Choroidal Neovascularization in Mice. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 61(5). doi:10.1167/iovs.61.5.52

Magagnoli, J., Narendran, S., Pereira, F., Cummings, T., Hardin, J. W., Sutton, S. S., & Ambati, J. (2020). Outcomes of hydroxychloroquine usage in United States veterans hospitalized with Covid-19.. medRxiv. doi:10.1101/2020.04.16.20065920

Wright, C. B., Uehara, H., Kim, Y., Yasuma, T., Yasuma, R., Hirahara, S., . . . Gelfand, B. D. (2020). Chronic Dicer1 deficiency promotes atrophic and neovascular outer retinal pathologies in mice. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 117(5), 2579-2587. doi:10.1073/pnas.1909761117

2019

De Cecco, M., Ito, T., Petrashen, A. P., Elias, A. E., Skvir, N. J., Criscione, S. W., . . . Sedivy, J. M. (2019). Author Correction: L1 drives IFN in senescent cells and promotes age-associated inflammation.. Nature, 572(7767), E5. doi:10.1038/s41586-019-1350-9

De Cecco, M., Ito, T., Petrashen, A. P., Elias, A. E., Skvir, N. J., Criscione, S. W., . . . Sedivy, J. M. (2019). L1 drives IFN in senescent cells and promotes age-associated inflammation. NATURE, 566(7742), 73-+. doi:10.1038/s41586-018-0784-9

2018

Makin, R. D., Apicella, I., Nagasaka, Y., Kaneko, H., Turner, S. D., Kerur, N., . . . Gelfand, B. D. (2018). RF/6A Chorioretinal Cells Do Not Display Key Endothelial Phenotypes. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 59(15), 5795-5802. doi:10.1167/iovs.18-25215

Al-Khalidi, R., Panicucci, C., Cox, P., Chira, N., Rog, J., Young, C. N. J., . . . Gorecki, D. C. (2018). Zidovudine ameliorates pathology in the mouse model of Duchenne muscular dystrophy via P2RX7 purinoceptor antagonism. ACTA NEUROPATHOLOGICA COMMUNICATIONS, 6. doi:10.1186/s40478-018-0530-4

Kerur, N., Fukuda, S., Banerjee, D., Kim, Y., Fu, D., Apicella, I., . . . Ambati, J. (2018). cGAS drives noncanonical-inflammasome activation in age-related macular degeneration (vol 24, pg 50, 2017). NATURE MEDICINE, 24(1). Retrieved from https://www.webofscience.com/

Whitcup, S. M., Cidlowski, J. A., Csaky, K. G., & Ambati, J. (2018). Pharmacology of Corticosteroids for Diabetic Macular Edema. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 59(1), 1-12. doi:10.1167/iovs.17-22259

2017

Kerur, N., Fukuda, S., Banerjee, D., Kim, Y., Fu, D., Apicella, I., . . . Ambati, J. (2018). cGAS drives noncanonical-inflammasome activation in age-related macular degeneration. NATURE MEDICINE, 24(1), 50-+. doi:10.1038/nm.4450

Di Ruocco, F., Basso, V., Rivoire, M., Mehlen, P., Ambati, J., De Falco, S., & Tarallo, V. (2018). Alu RNA accumulation induces epithelial-to-mesenchymal transition by modulating miR-566 and is associated with cancer progression. ONCOGENE, 37(5), 627-637. doi:10.1038/onc.2017.369

Ambati, J. (2017). The Foundation of the American Society of Retina Specialists Presidentsâ Young Investigator Award Lecture. Journal of VitreoRetinal Diseases, 1(1), 24-26. doi:10.1177/2474126416683850

2016

Wright, C. B., & Ambati, J. (2017). Dry Age-Related Macular Degeneration Pharmacology. PHARMACOLOGIC THERAPY OF OCULAR DISEASE, 242, 321-336. doi:10.1007/164_2016_36

Gelfand, B. D., & Ambati, J. (2016). A Revised Hemodynamic Theory of Age-Related Macular Degeneration. TRENDS IN MOLECULAR MEDICINE, 22(8), 656-670. doi:10.1016/j.molmed.2016.06.009

Bogdanovich, S., Kim, Y., Mizutani, T., Yasuma, R., Tudisco, L., Cicatiello, V., . . . Ambati, J. (2016). Human IgG1 antibodies suppress angiogenesis in a target-independent manner. SIGNAL TRANSDUCTION AND TARGETED THERAPY, 1. doi:10.1038/sigtrans.2015.1

Yasuma, R., Cicatiello, V., Mizutani, T., Tudisco, L., Kim, Y., Tarallo, V., . . . Ambati, J. (2016). Intravenous immune globulin suppresses angiogenesis in mice and humans. SIGNAL TRANSDUCTION AND TARGETED THERAPY, 1. doi:10.1038/sigtrans.2015.2

2015

Mizutani, T., Fowler, B. J., Kim, Y., Yasuma, R., Krueger, L. A., Gelfand, B. D., & Ambati, J. (2015). Nucleoside Reverse Transcriptase Inhibitors Suppress Laser-Induced Choroidal Neovascularization in Mice. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 56(12), 7122-7129. doi:10.1167/iovs.15-17440

Kleinman, M. E., & Ambati, J. (2016). Complement Activation and Inhibition in Retinal Diseases. RETINAL PHARMACOTHERAPEUTICS, 55, 46-56. doi:10.1159/000431141

Gelfand, B. D., Wright, C. B., Kim, Y., Yasuma, T., Yasuma, R., Li, S., . . . Ambati, J. (2015). Iron Toxicity in the Retina Requires Alu RNA and the NLRP3 Inflammasome. CELL REPORTS, 11(11), 1686-1693. doi:10.1016/j.celrep.2015.05.023

Cicatiello, V., Apicella, I., Tudisco, L., Tarallo, V., Formisano, L., Sandomenico, A., . . . De Falco, S. (2015). Powerful anti-tumor and anti-angiogenic activity of a new anti-vascular endothelial growth factor receptor 1 peptide in colorectal cancer models. ONCOTARGET, 6(12), 10563-10576. doi:10.18632/oncotarget.3384

Gelfand, B. D., Wright, C. B., & Ambati, J. (2015). A novel mouse model of neovascular AMD due to Dicer1 deficiency. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 56(7). Retrieved from https://www.webofscience.com/

2014

Hirano, Y., Yasuma, T., Mizutani, T., Fowler, B. J., Tarallo, V., Yasuma, R., . . . Ambati, J. (2014). IL-18 is not therapeutic for neovascular age-related macular degeneration. NATURE MEDICINE, 20(12), 1372-1375. doi:10.1038/nm.3671

Fowler, B. J., Gelfand, B. D., Kim, Y., Kerur, N., Tarallo, V., Hirano, Y., . . . Ambati, J. (2014). Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity. SCIENCE, 346(6212), 1000-1003. doi:10.1126/science.1261754

Kim, Y., Tarallo, V., Kerur, N., Yasuma, T., Gelfand, B. D., Bastos-Carvalho, A., . . . Ambati, J. (2014). DICER1/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-related macular degeneration. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111(45), 16082-16087. doi:10.1073/pnas.1403814111

Rahman, M. S., Ambati, J., Joshi, S., & Rankin, S. E. (2014). Incorporation of isolated Ti sites into mesoporous silica thin films by sugar surfactant complexation. MICROPOROUS AND MESOPOROUS MATERIALS, 190, 74-83. doi:10.1016/j.micromeso.2014.01.025

2013

Kerur, N., Hirano, Y., Tarallo, V., Fowler, B. J., Bastos-Carvalho, A., Yasuma, T., . . . Ambati, J. (2013). TLR-Independent and P2X7-Dependent Signaling Mediate Alu RNA-Induced NLRP3 Inflammasome Activation in Geographic Atrophy. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 54(12), 7395-7401. doi:10.1167/iovs.13-12500

Chavala, S. H., Kim, Y., Tudisco, L., Cicatiello, V., Milde, T., Kerur, N., . . . Ambati, J. (2013). Retinal angiogenesis suppression through small molecule activation of p53. JOURNAL OF CLINICAL INVESTIGATION, 123(10), 4170-4181. doi:10.1172/JCI67315

Luo, L., Uehara, H., Zhang, X., Das, S. K., Olsen, T., Holt, D., . . . Ambati, B. K. (2013). Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1. ELIFE, 2. doi:10.7554/eLife.00324

Ambati, J., Atkinson, J. P., & Gelfand, B. D. (2013). Immunology of age-related macular degeneration. NATURE REVIEWS IMMUNOLOGY, 13(6), 438-451. doi:10.1038/nri3459

Luo, L., Zhang, X., Hirano, Y., Tyagi, P., Barabas, P., Uehara, H., . . . Ambati, B. K. (2013). Targeted Intraceptor Nanoparticle Therapy Reduces Angiogenesis and Fibrosis in Primate and Murine Macular Degeneration. ACS NANO, 7(4), 3264-3275. doi:10.1021/nn305958y

Kim, Y., Kerur, N., Li, S., & Ambati, J. (2013). HMGB1 is a potent inducer of choroidal angiogenesis through a MyD88-dependent manner. ACTA OPHTHALMOLOGICA, 91. doi:10.1111/j.1755-3768.2013.F061.x

2012

Kleinman, M. E., & Ambati, J. (2013). Clocking in on Diabetic Retinopathy. DIABETES, 62(1), 29-30. doi:10.2337/db12-1151

Tarallo, V., Bogdanovich, S., Hirano, Y., Tudisco, L., Zentilin, L., Giacca, M., . . . De Falco, S. (2012). Inhibition of Choroidal and Corneal Pathologic Neovascularization by Plgf1-de Gene Transfer. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 53(13), 7989-7996. doi:10.1167/iovs.12-10658

Shibata, M. -A., Ambati, J., Shibata, E., Yoshidome, K., & Harada-Shiba, M. (2012). Mammary cancer gene therapy targeting lymphangiogenesis: VEGF-C siRNA and soluble VEGF receptor-2, a splicing variant. MEDICAL MOLECULAR MORPHOLOGY, 45(4), 179-184. doi:10.1007/s00795-012-0576-5

Uehara, H., Cho, Y., Simonis, J., Cahoon, J., Archer, B., Luo, L., . . . Ambati, B. K. (2013). Dual suppression of hemangiogenesis and lymphangiogenesis by splice-shifting morpholinos targeting vascular endothelial growth factor receptor 2 (KDR). FASEB JOURNAL, 27(1), 76-85. doi:10.1096/fj.12-213835

Dridi, S., Hirano, Y., Tarallo, V., Kim, Y., Fowler, B. J., Ambati, B. K., . . . Ambati, J. (2012). ERK1/2 activation is a therapeutic target in age-related macular degeneration. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(34), 13781-13786. doi:10.1073/pnas.1206494109

Ambati, J., & Fowler, B. J. (2012). Mechanisms of Age-Related Macular Degeneration. NEURON, 75(1), 26-39. doi:10.1016/j.neuron.2012.06.018

Tarallo, V., Hirano, Y., Gelfand, B. D., Dridi, S., Kerur, N., Kim, Y., . . . Ambati, J. (2012). DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88. CELL, 149(4), 847-859. doi:10.1016/j.cell.2012.03.036

Ambati, J., Saiyed, H., & Rankin, S. E. (2012). DFT investigation of NH3 physisorption on CuSO4 impregnated SiO2. PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 14(18), 6617-6627. doi:10.1039/c2cp22539e

Ambati, J., Lopez, A. M., Cochran, D., Wattamwar, P., Bean, K., Dziubla, T. D., & Rankin, S. E. (2012). Engineered silica nanocarriers as a high-payload delivery vehicle for antioxidant enzymes. ACTA BIOMATERIALIA, 8(6), 2096-2103. doi:10.1016/j.actbio.2012.02.012

Ambati, J., Song, Y., Rankin, S. E., & Lehmler, H. -J. (2012). Density Functional Theory Study of Semiquinone Radical Anions of Polychlorinated Biphenyls in the Syn- and Anti-like Conformation. JOURNAL OF PHYSICAL CHEMISTRY A, 116(6), 1586-1595. doi:10.1021/jp2077193

2011

Kleinman, M. E., & Ambati, J. (2012). A Window to Innate Neuroimmunity: Toll-Like Receptor-Mediated Cell Responses in the Retina. RETINAL DEGENERATIVE DISEASES, 723, 3-9. doi:10.1007/978-1-4614-0631-0_1

Kleinman, M. E., Kaneko, H., Cho, W. G., Dridi, S., Fowler, B. J., Blandford, A. D., . . . Ambati, J. (2012). Short-interfering RNAs Induce Retinal Degeneration via TLR3 and IRF3. MOLECULAR THERAPY, 20(1), 101-108. doi:10.1038/mt.2011.212

Song, Y., Ambati, J., Parkin, S., Rankin, S. E., Robertson, L. W., & Lehmler, H. -J. (2011). Crystal structure and density functional theory studies of toxic quinone metabolites of polychlorinated biphenyls. CHEMOSPHERE, 85(3), 386-392. doi:10.1016/j.chemosphere.2011.07.004

Ambati, J., & Rankin, S. E. (2011). Reaction-induced phase separation of bis(triethoxysilyl)ethane upon sot-gel polymerization in acidic conditions. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 362(2), 345-353. doi:10.1016/j.jcis.2011.06.064

Ambati, J. (2011). Age-Related Macular Degeneration and the Other Double Helix The Cogan Lecture. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 52(5), 2166-2169. doi:10.1167/iovs.11-7328

Kaneko, H., Dridi, S., Tarallo, V., Gelfand, B. D., Fowler, B. J., Cho, W. G., . . . Ambati, J. (2011). DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. NATURE, 471(7338), 325-+. doi:10.1038/nature09830

2010

Ye, Z., Uittenbogaard, A. M., Cohen, D. A., Kaplan, A. M., Ambati, J., & Straley, S. C. (2011). Distinct CCR2+ Gr1+ Cells Control Growth of the Yersinia pestis ÎyopM Mutant in Liver and Spleen during Systemic Plague. INFECTION AND IMMUNITY, 79(2), 674-687. doi:10.1128/IAI.00808-10

Ambati, J., & Rankin, S. E. (2010). Determination of 29Si-1H Spin-Spin Coupling Constants in Organoalkoxysilanes with Nontrivial Scalar Coupling Patterns. JOURNAL OF PHYSICAL CHEMISTRY A, 114(48), 12613-12621. doi:10.1021/jp105644p

Shibata, M. -A., Ambati, J., Shibata, E., Albuquerque, R. J. C., Morimoto, J., Ito, Y., & Otsuki, Y. (2010). The endogenous soluble VEGF receptor-2 isoform suppresses lymph node metastasis in a mouse immunocompetent mammary cancer model. BMC MEDICINE, 8. doi:10.1186/1741-7015-8-69

Pavlakovic, H., Becker, J., Albuquerque, R., Wilting, J., & Ambati, J. (2010). Soluble VEGFR-2: an antilymphangiogenic variant of VEGF receptors. LYMPHATICS IN THE DIGESTIVE SYSTEM: PHYSIOLOGY, HEALTH, AND DISEASE, 1207, E7-E15. doi:10.1111/j.1749-6632.2010.05714.x

Kleinman, M. E., Westhouse, S. J., Ambati, J., Pearson, P. A., & Halperin, L. S. (2010). Triamcinolone crystal size.. Ophthalmology, 117(8), 1654-1654.e4. doi:10.1016/j.ophtha.2010.01.052

Ambati, J., & Rankin, S. E. (2010). DFT Calculations of Indirect 29Si-1H Spin-Spin Coupling Constants in Organoalkoxysilanes. JOURNAL OF PHYSICAL CHEMISTRY A, 114(16), 5279-5286. doi:10.1021/jp911327a

Becker, J., Pavlakovic, H., Ludewig, F., Wilting, F., Weich, H. A., Albuquerque, R., . . . Wilting, J. (2010). Neuroblastoma Progression Correlates with Downregulation of the Lymphangiogenesis Inhibitor sVEGFR-2. CLINICAL CANCER RESEARCH, 16(5), 1431-1441. doi:10.1158/1078-0432.CCR-09-1936

Kleinman, M. E., Baffi, J. Z., & Ambati, J. (2010). The Multifactorial Nature of Retinal Vascular Disease. OPHTHALMOLOGICA, 224, 16-24. doi:10.1159/000315152