Sanja Arandjelovic

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Primary Appointment

Assistant Professor of Medicine, Medicine- Nephrology

Education

  • PhD, Biochemistry, University of Virginia

Research Disciplines

Immunology

Research Interests

Innate immunity, Cell clearance, Inflammatory and autoimmune disease

Research Description

The Arandjelovic laboratory research focus is on cell clearance in inflammatory disease, using rheumatoid arthritis (RA) and multiple sclerosis (MS) as model systems. Inflammatory states are associated with high rates of cell death, mostly through apoptosis, and the clearance of apoptotic cells is a critical step in disease pathology. However, the cellular identity of phagocytes and the molecular events that contribute to the clearance of apoptotic cells has been understudied in many inflammatory diseases. In other words, âwhoâ are the cleaning crew and which âtoolsâ are they using?

Selected Publications

2022

Lucas, C. D., Medina, C. B., Bruton, F. A., Dorward, D. A., Raymond, M. H., Tufan, T., . . . Ravichandran, K. S. (2022). Pannexin 1 drives efficient epithelial repair after tissue injury. SCIENCE IMMUNOLOGY, 7(71). doi:10.1126/sciimmunol.abm4032

2021

Arandjelovic, S., Perry, J. S. A., Zhou, M., Ceroi, A., Smirnov, I., Walk, S. F., . . . Ravichandran, K. S. (2021). ELMO1 signaling is a promoter of osteoclast function and bone loss. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-25239-6

Shankman, L. S., Fleury, S. T., Evans, W. B., Penberthy, K. K., Arandjelovic, S., Blumberg, R. S., . . . Ravichandran, K. S. (2021). Efferocytosis by Paneth cells within the intestine. CURRENT BIOLOGY, 31(11), 2469-+. doi:10.1016/j.cub.2021.03.055

2020

Medina, C. B., Mehrotra, P., Arandjelovic, S., Perrys, J. S. A., Guo, Y., Morioka, S., . . . Ravichandran, K. S. (2020). Metabolites released from apoptotic cells act as tissue messengers. NATURE, 580(7801), 130-+. doi:10.1038/s41586-020-2121-3

2019

Rival, C. M., Xu, W., Shankman, L. S., Morioka, S., Arandjelovic, S., Lee, C. S., . . . Ravichandran, K. S. (2019). Phosphatidylserine on viable sperm and phagocytic machinery in oocytes regulate mammalian fertilization. NATURE COMMUNICATIONS, 10. doi:10.1038/s41467-019-12406-z

Arandjelovic, S., Perry, J. S. A., Lucas, C. D., Penberthy, K. K., Kim, T. -H., Zhou, M., . . . Ravichandran, K. S. (2019). A noncanonical role for the engulfment gene ELMO1 in neutrophils that promotes inflammatory arthritis. NATURE IMMUNOLOGY, 20(2), 141-+. doi:10.1038/s41590-018-0293-x

2017

Seki, S. M., Stevenson, M., Rosen, A. M., Arandjelovic, S., Gemta, L., Bullock, T. N. J., & Gaultier, A. (2017). Lineage-Specific Metabolic Properties and Vulnerabilities of T Cells in the Demyelinating Central Nervous System. JOURNAL OF IMMUNOLOGY, 198(12), 4607-4617. doi:10.4049/jimmunol.1600825

Penberthy, K. K., Buckley, M. W., Arandjelovic, S., & Ravichandran, K. (2017). Ex vivo modulation of the Foxo1 phosphorylation state does not lead to dysfunction of T regulatory cells. PLOS ONE, 12(3). doi:10.1371/journal.pone.0173386

Weaver, J. L., Arandjelovic, S., Brown, G., Mendu, S. K., Schappe, M. S., Buckley, M. W., . . . Bayliss, D. A. (2017). Hematopoietic pannexin 1 function is critical for neuropathic pain. SCIENTIFIC REPORTS, 7. doi:10.1038/srep42550

2015

Arandjelovic, S., & Ravichandran, K. S. (2015). Phagocytosis of apoptotic cells in homeostasis. NATURE IMMUNOLOGY, 16(9), 907-917. doi:10.1038/ni.3253

Buckley, M. W., Trampont, P. C., Arandjelovic, S., Fond, A. M., Juncadella, I. J., & Ravichandran, K. S. (2015). ShcA Regulates Late Stages of T Cell Development and Peripheral CD4(+) T Cell Numbers. JOURNAL OF IMMUNOLOGY, 194(4), 1665-1676. doi:10.4049/jimmunol.1401728

Hochreiter-Hufford, A. E., Arandjelovic, S., & Ravichandran, K. S. (2015). Using Phosphatidylserine Exposure on Apoptotic Cells to Stimulate Myoblast Fusion. CELL FUSION: OVERVIEWS AND METHODS, 2ND EDITION, 141-148. doi:10.1007/978-1-4939-2703-6_10

2014

Buckley, M. W., Arandjelovic, S., Trampont, P. C., Kim, T. S., Braciale, T. J., & Ravichandran, K. S. (2014). Unexpected Phenotype of Mice Lacking Shcbp1, a Protein Induced during T Cell Proliferation. PLOS ONE, 9(8). doi:10.1371/journal.pone.0105576

2013

Arandjelovic, S., & Ravichandran, K. S. (2013). A MERry Response After Myocardial Infarction. CIRCULATION RESEARCH, 113(8), 949-951. doi:10.1161/CIRCRESAHA.113.302155

Hochreiter-Hufford, A. E., Lee, C. S., Kinchen, J. M., Sokolowski, J. D., Arandjelovic, S., Call, J. A., . . . Ravichandran, K. S. (2013). Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion. NATURE, 497(7448), 263-+. doi:10.1038/nature12135

Fernandez-Castaneda, A., Arandjelovic, S., Stiles, T. L., Schlobach, R. K., Mowen, K. A., Gonias, S. L., & Gaultier, A. (2013). Identification of the Low Density Lipoprotein (LDL) Receptor-related Protein-1 Interactome in Central Nervous System Myelin Suggests a Role in the Clearance of Necrotic Cell Debris. JOURNAL OF BIOLOGICAL CHEMISTRY, 288(7), 4538-4548. doi:10.1074/jbc.M112.384693

2012

Arandjelovic, S., McKenney, K. R., Leming, S. S., & Mowen, K. A. (2012). ATP Induces Protein Arginine Deiminase 2-Dependent Citrullination in Mast Cells through the P2X7 Purinergic Receptor. JOURNAL OF IMMUNOLOGY, 189(8), 4112-4122. doi:10.4049/jimmunol.1201098

Rohrbach, A. S., Hemmers, S., Arandjelovic, S., Corr, M., & Mowen, K. A. (2012). PAD4 is not essential for disease in the K/BxN murine autoantibody-mediated model of arthritis. ARTHRITIS RESEARCH & THERAPY, 14(3). doi:10.1186/ar3829

2011

Hemmers, S., Teijaro, J. R., Arandjelovic, S., & Mowen, K. A. (2011). PAD4-Mediated Neutrophil Extracellular Trap Formation Is Not Required for Immunity against Influenza Infection. PLOS ONE, 6(7). doi:10.1371/journal.pone.0022043

2010

Arandjelovic, S., Wickramarachchi, D., Hemmers, S., Leming, S. S., Kono, D. H., & Mowen, K. A. (2010). Mast cell function is not altered by Coronin-1A deficiency. JOURNAL OF LEUKOCYTE BIOLOGY, 88(4), 737-745. doi:10.1189/jlb.0310131