Larry C. Borish

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  • Phone: 434-243-2610

Primary Appointment

Professor, Medicine- Asthma, Allergy and Immunology

Research Interests

Innate immune mechanisms of rhinovirus (RV)-induced asthma exacerbations. Immune and cellular mechanisms of asthma. Immune mechanisms in chronic hyperplastic eosinophilic sinusitis (CHES).

Research Description

(1) The current research being performed in my laboratory focuses on the innate immune mechanisms involved in the ability of rhinovirus (RV) to induce asthma exacerbations. These studies are based upon the observations that most asthma exacerbations in children and young adults result from RV infections; however, the etiology of these RV-induced exacerbations remain poorly understood. We hypothesize that the immune responses generated in the nose of asthmatics underlie subsequent systemic modulation of the immune system, and that  in susceptible individuals (i.e., those with pre-existing asthma)  this modified nasal milieu is responsible for the asthma exacerbation. Specifically, we proposed that this modification produces a distinct pattern of immune responsiveness to RV in the upper airway of asthmatics, which triggers the development of a Th2 cytokine Âsignature state that drives the adverse outcome of RV infection in the lower airway of asthmatics. In addition, we proposed that the intensity of this Th2-inducing nasal airway milieu is further exaggerated in these allergic asthmatics, by a concomitant defect in the development and expression of effective anti-RV immune responses, leading to greater susceptibility to RV and more severe viral infections. To support this mechanism, we will confirm in these studies our prediction that similar reactions will occur in the nose and circulation of patients with just allergic rhinitis (AR), but that in the absence of asthma no lower airway manifestations develop. Ultimately determining the etiology of rhinovirus-induced asthma exacerbations will identify specific targets to prevent and treat these episodes.
(2) Immune and molecular mechanisms in aspirin-exacerbated respiratory disease (AERD):
We are investigating the role of cysteinyl leukotrienes and cytokines in the development of aspirin-exacerbated respiratory disease (AERD). We hypothesize that cysteinyl leukotrienes and other arachidonate metabolites promote eosinophil, fibroblast and fibrocyte proliferation, secretion of proinflammatory cytokines, and the aggressive remodeling characteristic of asthma, sinusitis and nasal polyposis. Concentrations of cysteinyl leukotrienes (CysLTs) and their receptors are significantly higher in tissue obtained from subjects with AERD as compared to aspirin tolerant asthma or the healthy airway. AERD is characterized by upregulation of CysLT synthesis pathways and CysLT receptors, including novel receptors that are targeted by CysLTE4, occurring concomitantly with downregulation of PgE2 synthesis (cox2 and mPGES1) and responsiveness (EP2) pathways. These aberrations are controlled by cytokines including IL-4 and IL-13 acting through the transcription factor pStat6 but AERD is also characterized by prominent expression of IFN-gamma. Therapeutic aspirin desensitization functions, at least in part, through blocking gene transcription mediated through diminished expression of pStat6 in the nucleus. Our current studies emphasize the role of CysLTs acting through this putative CysLTE4 receptor pathway, in particular on eosinophils, as well as aberrant signaling mechanisms involving PgE2. These studies involve transcriptome screening, proteomics, and genome-wide searches to identify unique molecular pathways responsible for the development of aspirin-exacerbated respiratory disease.

Training

  • Biodefense & Infectious Diseases Short-Term Training to Increase Diversity in Biomedical Sciences
  • Interdisciplinary Training Program in Immunology

Selected Publications

2024

Harris, D., & Borish, L. (2024). How we treat type 2 low asthma. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 133(1), 43-46. doi:10.1016/j.anai.2024.04.013

Borish, L. (2024). The never-ending challenge of using clinical criteria to diagnose and assess severity of chronic rhinosinusitis. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 132(3), 257-258. doi:10.1016/j.anai.2023.09.010

Conway, A. E., White, A. A., Borish, L., Shaker, M., & Lee, M. W. (2024). Eicosanoids, innate immunity, and alarmins in aspirin-exacerbated respiratory disease. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 133(1), 13-15. doi:10.1016/j.anai.2024.02.024

Altamirano, C. D., Breidenbaugh, M., & Borish, L. (2024). Don't lose sleep over chronic rhinosinusitis with nasal polyps. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 132(1), 5-6. doi:10.1016/j.anai.2023.09.012

2023

Spergel, J., Borish, L., Grayson, M. H., Greenhawt, M. J., Leung, D. Y. M., Levi-Schaffer, F., . . . Stukus, D. R. (2024). For allergists, the solution is never violence!. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 132(2), 117-118. doi:10.1016/j.anai.2023.10.012

Borish, L. (2023). Insights into mechanisms of immunotherapy circa 1943: "What has been will be again". ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 131(2), 277-278. doi:10.1016/j.anai.2023.01.035

Mehta, A. M., Lee, I., Li, G., Jones, M. K., Hanson, L., Lonabaugh, K., . . . Albon, D. P. (2023). The impact of CFTR modulator triple therapy on type 2 inflammatory response in patients with cystic fibrosis. ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY, 19(1). doi:10.1186/s13223-023-00822-2

Medernach, J. G., Li, R. -C., Zhao, X. -Y., Yin, B., Noonan, E. A., Etter, E. F., . . . McGowan, E. C. (2023). Immunoglobulin G4 in eosinophilic esophagitis: Immune complex formation and correlation with disease activity. ALLERGY, 78(12), 3193-3203. doi:10.1111/all.15826

Noonan, E., Straesser, M. D., Makin, T., Williams, A., Al-Hazaymeh, A., Routes, J. M., . . . Lawrence, M. G. (2023). Impaired Response to Polysaccharide Vaccine in Selective IgE Deficiency. JOURNAL OF CLINICAL IMMUNOLOGY, 43(6), 1448-1454. doi:10.1007/s10875-023-01501-y

Mehta, A. M., Lee, I., Jones, M., Hanson, L., Lonabaugh, K., List, R., . . . Albon, D. P. (2023). The Impact of CFTR Modulator Triple Therapy on Type 2 Inflammatory Response in Patients With Cystic Fibrosis. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 207. Retrieved from https://www.webofscience.com/

Albon, D., Zhang, L., Patrie, J., Jones, M., Li, Z. G., Noonan, E., & Borish, L. (2023). Association between Cystic Fibrosis exacerbations, lung function, T2 inflammation and microbiological colonization. ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY, 19(1). doi:10.1186/s13223-023-00760-z

Borish, L., Teague, W. G., Patrie, J. T., Wavell, K. W., Barros, A. J., Malpass, H. C., & Lawrence, M. G. (2023). Further evidence of a type 2 inflammatory signature in chronic obstructive pulmonary disease or emphysema. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 130(5), 617-+. doi:10.1016/j.anai.2023.01.024

Oppenheimer, J., & Borish, L. (2023). Operationalization of dynamic dosing in asthma. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 130(4), 425-426. doi:10.1016/j.anai.2023.01.007

Luu, L. A., Makin, T. A., Borish, L., Snavely, E. A., Meyer, J. S., Zlotoff, B. J., & Zeichner, S. L. (2023). Fever, Rash, and Cough in a 7-Year-Old Boy. PEDIATRICS, 151(2). doi:10.1542/peds.2022-058194

Corren, J., Jackson, D. J., Casale, T. B., Borish, L., Rabe, K. F., Busse, W. W., . . . Deniz, Y. (2023). Dupilumab Efficacy in Patients with Uncontrolled Moderate-to-Severe Type 2 Asthma Regardless of Perennial Aeroallergen Sensitization. JOURNAL OF ASTHMA AND ALLERGY, 16, 249-260. doi:10.2147/JAA.S385645

2022

Makin, T., Breidenbaugh, M., & Borish, L. (2022). Novel insights into pathogenic mechanisms of severe exacerbation-prone asthma and their impact on clinical management. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 129(6), 651-652. doi:10.1016/j.anai.2022.09.003

Lieberman, J. A., & Borish, L. (2022). Update in primary immune deficiencies for the practicing allergist/clinical immunologist. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 129(5), 537-538. doi:10.1016/j.anai.2022.07.034

Tang, J., Zeng, C., Cox, T. M., Li, C., Son, Y. M., Cheon, I. S., . . . Sun, J. (2022). Respiratory mucosal immunity against SARS-CoV-2 after mRNA vaccination. SCIENCE IMMUNOLOGY, 7(76). doi:10.1126/sciimmunol.add4853

Eid, R., Noonan, E., Borish, L., Barnes, B. H., Stelow, E. B., Sauer, B., & McGowan, E. C. (2022). High prevalence of gastrointestinal symptoms and undiagnosed eosinophilic esophagitis among allergic adults. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 10(12), 3325-+. doi:10.1016/j.jaip.2022.09.028

Borish, L., & Eschenbacher, W. (2022). Nasal polyposis: A neovascularization disorder?. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 129(1), 9-10. doi:10.1016/j.anai.2022.04.033

Lawrence, M. G., & Borish, L. (2022). Specific antibody deficiency: pearls and pitfalls for diagnosis. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 129(5), 572-578. doi:10.1016/j.anai.2022.05.028

Borish, L., Cohen, N. A., Chupp, G., Hopkins, C., Wagenmann, M., Sousa, A. R., . . . Fokkens, W. (2022). Evaluating enrollment and outcome criteria in trials of biologics for chronic rhinosinusitis with nasal polyps. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 129(2), 160-168. doi:10.1016/j.anai.2022.04.004

Borish, L. (2022). Rethinking the central role of mast cells in virally mediated asthma exacerbations. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 129(6), 676-678. doi:10.1016/j.anai.2022.03.029

Grayson, M. H., Borish, L., Castells, M. C., Greenhawt, M. J., Leung, D. Y. M., Lieberman, J. A., . . . Stukus, D. R. (2022). Annals editors on the war in Ukraine. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 128(6), 619-620. doi:10.1016/j.anai.2022.03.018

Eschenbacher, W., Kim, M., Mattos, J., Lawrence, M., Payne, S., & Borish, L. (2022). Activation of platelet-adherent basophils in chronic rhinosinusitis with alcohol hypersensitivity. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 128(4), 443-450. doi:10.1016/j.anai.2022.01.013

Feng, X., Lawrence, M. G., Payne, S. C., Mattos, J., Etter, E., Negri, J. A., . . . Borish, L. (2022). Lower viral loads in subjects with rhinovirus-challenged allergy despite reduced innate immunity. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 128(4), 414-+. doi:10.1016/j.anai.2022.01.007

Chen, W., He, S., Xie, X., Yang, X., Duan, C., Ye, P., . . . Feng, X. (2022). Over-expression of CRTH2 indicates eosinophilic inflammation and poor prognosis in recurrent nasal polyps. FRONTIERS IN IMMUNOLOGY, 13. doi:10.3389/fimmu.2022.1046426

Ye, P., He, S., Tang, S., Xie, X., Duan, C., Zhang, L., . . . Feng, X. (2022). Improvement of Subjective Olfactory Dysfunction in Chronic Rhinosinusitis With Nasal Polyps After Endoscopic Sinus Surgery. FRONTIERS IN SURGERY, 9. doi:10.3389/fsurg.2022.870682

2021

Kuster, J. K., Unlu, S., Makin, T. A., Par-Young, J., Simonov, M., Shafi, S., . . . Shin, J. J. (2022). Low IgG trough and lymphocyte subset counts are associated with hospitalization for COVID-19 in patients with primary antibody deficiency. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 10(2), 633-+. doi:10.1016/j.jaip.2021.11.030

Borish, L., Baroody, F. M., Kim, M. S., Lieberman, J. A., Peters, A., Stevens, W. W., & Bernstein, J. A. (2022). Yardstick for the medical management of chronic rhinosinusitis. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 128(2), 118-128. doi:10.1016/j.anai.2021.10.014

Lawrence, M. G., Teague, W. G., Feng, X., Welch, C., Etter, E., Negri, J., . . . Borish, L. (2022). Interleukin-5 receptor alpha (CD125) expression on human blood and lung neutrophils. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 128(1), 53-+. doi:10.1016/j.anai.2021.08.004

Eid, R., Yan, C. H., Stevens, W., Doherty, T. A., & Borish, L. (2021). Innate immune cell dysregulation drives inflammation and disease in aspirin-exacerbated respiratory disease. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 148(2), 309-318. doi:10.1016/j.jaci.2021.06.016

Eid, R., & Borish, L. (2021). Eosinophils in antiviral immunity and (perhaps) a benefit of having asthma during the SARS-CoV2 pandemic. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 127(1), 3-4. doi:10.1016/j.anai.2021.03.017

Al-Hazaymeh, A., Patrie, J., Adams, J. C., Borish, L., & McGowan, E. C. (2021). Asthma-related outcomes during the SARS-CoV2 pandemic: A single-center observational study. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 9(9), 3483-+. doi:10.1016/j.jaip.2021.05.034

Teague, W. G., Lawrence, M. G., Williams, S., Garrod, A. S., Froh, D., Early, S. V., . . . Borish, L. (2021). Novel Treatment-Refractory Preschool Wheeze Phenotypes Identified by Cluster Analysis of Lung Lavage Constituents. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 9(7), 2792-+. doi:10.1016/j.jaip.2021.03.059

Patel, J., Borish, L., & Gurrola, J. I. I. (2021). When medical treatments fail Surgical interventions for allergic rhinitis. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 127(2), 161-162. doi:10.1016/j.anai.2021.03.006

Eschenbacher, W., Eid, R., & Borish, L. (2021). Recent discoveries regarding the pathogenesis of chronic rhinosinusitis and their implications for future therapies. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 126(2), 107-108. doi:10.1016/j.anai.2020.11.006

2020

Stevens, W. W., Jerschow, E., Baptist, A. P., Borish, L., Bosso, J. V., Buchheit, K. M., . . . White, A. A. (2021). The role of aspirin desensitization followed by oral aspirin therapy in managing patients with aspirin-exacerbated respiratory disease: A Work Group Report from the Rhinitis, Rhinosinusitis and Ocular Allergy Committee of the American Academy of Allergy, Asthma & Immunology. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 147(3), 827-844. doi:10.1016/j.jaci.2020.10.043

Straesser, M., Keshavarz, B., Borish, L., Khokhar, D., Holian, A., Charlton, N. P., . . . Wilson, J. M. (2021). α-Gal on Crotalidae-polyvalent Fab antivenom (CroFab): Investigating the relevance to immediate hypersensitivity reactions. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 9(2), 1015-+. doi:10.1016/j.jaip.2020.10.026

Borish, L. (2020). Insights into how innocuous foods or proteins deserving of immune ignorance can become allergens. JOURNAL OF CLINICAL INVESTIGATION, 130(10), 5118-5120. doi:10.1172/JCI141950

Eschenbacher, W., Straesser, M., Knoeddler, A., Li, R. -C., & Borish, L. (2020). Biologics for the Treatment of Allergic Rhinitis, Chronic Rhinosinusitis, and Nasal Polyposis. IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA, 40(4), 539-547. doi:10.1016/j.iac.2020.06.001

Steinke, J. W., Lawrence, M. G., Teague, W. G., Braciale, T. J., Patrie, J. T., & Borish, L. (2021). Bronchoalveolar lavage cytokine patterns in children with severe neutrophilic and paucigranulocytic asthma. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 147(2), 686-+. doi:10.1016/j.jaci.2020.05.039

Lal, D., Borish, L., Detwiller, K. Y., Gray, S. T., Joshi, S., Kern, R. C., . . . Rank, M. A. (2020). A case for multidisciplinary management of chronic rhinosinusitis with nasal polyposis. INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY, 10(7), 795-797. doi:10.1002/alr.22557

Eschenbacher, W., & Borish, L. (2020). Our evolving understanding of the pathogenesis and presentations of chronic rhinosinusitis Implications for therapeutic options. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 124(4), 303-304. doi:10.1016/j.anai.2020.02.005

Lal, D., Borish, L., Detwiller, K. Y., Gray, S. T., Joshi, S., Kern, R. C., . . . Rank, M. A. (2020). The Rationale for Multidisciplinary Management of Chronic Rhinosinusitis with Nasal Polyposis. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 8(5), 1565-1566. doi:10.1016/j.jaip.2020.03.001

Naclerio, R., Baroody, F., Bachert, C., Bleier, B., Borish, L., Brittain, E., . . . Togias, A. (2020). Clinical Research Needs for the Management of Chronic Rhinosinusitis with Nasal Polyps in the New Era of Biologics: A National Institute of Allergy and Infectious Diseases Workshop. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 8(5), 1532-+. Retrieved from https://www.webofscience.com/

Heymann, P. W., Platts-Mills, T. A. E., Woodfolk, J. A., Borish, L., Murphy, D. D., Carper, H. T., . . . Turner, R. B. (2020). Understanding the asthmatic response to an experimental rhinovirus infection: Exploring the effects of blocking IgE. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 146(3), 545-554. doi:10.1016/j.jaci.2020.01.035

Eccles, J. D., Turner, R. B., Kirk, N. A., Muehling, L. M., Borish, L., Steinke, J. W., . . . Woodfolk, J. A. (2020). T-bet plus Memory B Cells Link to Local Cross-Reactive IgG upon Human Rhinovirus Infection. CELL REPORTS, 30(2), 351-+. doi:10.1016/j.celrep.2019.12.027

Zhang, L., Borish, L., Smith, A., Somerville, L., & Albon, D. (2020). Use of mepolizumab in adult patients with cystic fibrosis and an eosinophilic phenotype: case series. ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY, 16(1). doi:10.1186/s13223-019-0397-3

2019

Borish, L. (2019). Aspirin-exacerbated Respiratory Disease: A Syndrome of Mast Cell-mediated PgD2 Overproduction. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 200(6), 651-652. doi:10.1164/rccm.201904-0716ED

Pal, K., Ramsden, M., Shim, Y. M., Borish, L., Payne, S. C., & Steinke, J. W. (2019). Suppression of aspirin-mediated eosinophil activation by prostaglandin E2 Relevance to aspirin and nonsteroidal anti-inflammatory drug hypersensitivity. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 123(5), 503-506. doi:10.1016/j.anai.2019.09.003

Eschenbacher, W. H., & Borish, L. (2019). Nasal polyposis and future risk of sinonasal malignancy. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 144(4), 933-934. doi:10.1016/j.jaci.2019.08.015

Feng, X., Payne, S. C., Borish, L., & Steinke, J. W. (2019). Differential Expression of Extracellular Matrix Components in Nasal Polyp Endotypes. AMERICAN JOURNAL OF RHINOLOGY & ALLERGY, 33(6), 665-670. doi:10.1177/1945892419860634

Kennedy, J. L., Pham, S., & Borish, L. (2019). Rhinovirus and Asthma Exacerbations. IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA, 39(3), 335-+. doi:10.1016/j.iac.2019.03.003

Pal, K., Feng, X., Steinke, J. W., Burdick, M. D., Shim, Y. M., Sung, S. -S., . . . Borish, L. (2019). Leukotriene A4 Hydrolase Activation and Leukotriene B4 Production by Eosinophils in Severe Asthma. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 60(4), 413-419. doi:10.1165/rcmb.2018-0175OC

Hamed, A., Preston, D. C., Eschenbacher, W., Khokhar, D., Workman, L., Steinke, J. W., . . . Borish, L. (2019). Nasal IgE production in allergic rhinitis: Impact of rhinovirus infection. CLINICAL AND EXPERIMENTAL ALLERGY, 49(6), 847-852. doi:10.1111/cea.13372

Borish, L., & Hamilos, D. L. (2019). Endotype-Phenotype Correlation in Chronic Rhinosinusitis: Is It Time to Think Beyond Polyposis?. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 7(8), 2821-2822. doi:10.1016/j.jaip.2019.07.024

Gorski, S. A., Lawrence, M. G., Hinkelman, A., Spano, M. M., Steinke, J. W., Borish, L., . . . Braciale, T. J. (2019). Expression of IL-5 receptor alpha by murine and human lung neutrophils. PLOS ONE, 14(8). doi:10.1371/journal.pone.0221113

Teague, W. G., & Borish, L. C. (2019). Low Serum IgG: A Novel Predictor of Virus-Induced Asthma Exacerbations?. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 7(5), 1514-1515. doi:10.1016/j.jaip.2019.03.003

Teague, W. G., Lawrence, M. G., Shirley, D. -A. T., Garrod, A. S., Early, S. V., Payne, J. B., . . . Borish, L. (2019). Lung Lavage Granulocyte Patterns and Clinical Phenotypes in Children with Severe, Therapy-Resistant Asthma. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 7(6), 1803-+. doi:10.1016/j.jaip.2018.12.027

Pollack, K., Zlotoff, B. J., Borish, L. C., Commins, S. P., Platts-Mills, T. A. E., & Wilson, J. M. (2019). α-Gal Syndrome vs Chronic Urticaria. JAMA DERMATOLOGY, 155(1), 115-116. doi:10.1001/jamadermatol.2018.3970

2018

Oppenheimer, J. J., & Borish, L. (2018). Asthma Yardstick Update Practical recommendations for a sustained step-up in asthma therapy for poorly controlled asthma. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 121(6), 660-661. doi:10.1016/j.anai.2018.08.018

Lawrence, M. G., Palacios-Kibler, T. V., Workman, L. J., Schuyler, A. J., Steinke, J. W., Payne, S. C., . . . Borish, L. (2018). Low Serum IgE Is a Sensitive and Specific Marker for Common Variable Immunodeficiency (CVID). JOURNAL OF CLINICAL IMMUNOLOGY, 38(3), 225-233. doi:10.1007/s10875-018-0476-0

Lawrence, M. G., Steinke, J. W., & Borish, L. (2018). Cytokine-targeting biologics for allergic diseases. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 120(4), 376-381. doi:10.1016/j.anai.2018.01.009

2017

Straesser, M. D., Oliver, E., Palacios, T., Kyin, T., Patrie, J., Borish, L., . . . Lawrence, M. G. (2018). Serum IgE as an immunological marker to predict response to omalizumab treatment in symptomatic chronic urticaria. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 6(4), 1386-+. doi:10.1016/j.jaip.2017.10.030

Gurrola, J. I. I., & Borish, L. (2017). Chronic rhinosinusitis: Endotypes, biomarkers, and treatment response. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 140(6), 1499-1508. doi:10.1016/j.jaci.2017.10.006

Turner, R. B., Woodfolk, J. A., Borish, L., Steinke, J. W., Patrie, J. T., Muehling, L. M., . . . Lehtinen, M. J. (2017). Effect of probiotic on innate inflammatory response and viral shedding in experimental rhinovirus infection - a randomised controlled trial. BENEFICIAL MICROBES, 8(2), 207-215. doi:10.3920/BM2016.0160

Steinke, J. W., Smith, A. R., Carpenter, D. J., Patrie, J. T., Payne, S. C., & Borish, L. (2017). Lack of Efficacy of Symptoms and Medical History in Distinguishing the Degree of Eosinophilia in Nasal Polyps. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 5(6), 1582-+. doi:10.1016/j.jaip.2017.04.009

2016

Kennedy, J. L., Steinke, J. W., Liu, L., Negri, J., Borish, L., & Payne, S. C. (2016). Failure of itraconazole to prevent T-helper type 2 cell immune deviation: Implications for chronic rhinosinusitis. AMERICAN JOURNAL OF RHINOLOGY & ALLERGY, 30(6), 379-384. doi:10.2500/ajra.2016.30.4362

Kennedy, J. L., Stoner, A. N., & Borish, L. (2016). Aspirin-exacerbated respiratory disease: Prevalence, diagnosis, treatment, and considerations for the future. AMERICAN JOURNAL OF RHINOLOGY & ALLERGY, 30(6), 407-413. doi:10.2500/ajra.2016.30.4370

Steinke, J. W., & Borish, L. (2016). Immune Responses in Rhinovirus-Induced Asthma Exacerbations. CURRENT ALLERGY AND ASTHMA REPORTS, 16(11). doi:10.1007/s11882-016-0661-2

Borish, L. (2016). Rethinking chronic rhinosinusitis phenotypes. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 138(5), 1354-1355. doi:10.1016/j.jaci.2016.08.013

Steinke, J. W., Payne, S. C., & Borish, L. (2016). Eosinophils and Mast Cells in Aspirin-Exacerbated Respiratory Disease. IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA, 36(4), 719-+. doi:10.1016/j.iac.2016.06.008

Steinke, J. W., & Borish, L. (2016). Chronic rhinosinusitis phenotypes. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 117(3), 234-240. doi:10.1016/j.anai.2016.06.006

Borish, L. (2016). The immunology of asthma Asthma phenotypes and their implications for personalized treatment. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 117(2), 108-114. doi:10.1016/j.anai.2016.04.022

Lawrence, M. G., Steinke, J. W., & Borish, L. (2016). Basic science for the clinician: Mechanisms of sublingual and subcutaneous immunotherapy. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 117(2), 138-142. doi:10.1016/j.anai.2016.06.027

Feng, X., Ramsden, M. K., Negri, J., Baker, M. G., Payne, S. C., Borish, L., & Steinke, J. W. (2016). Eosinophil production of prostaglandin D2 in patients with aspirin-exacerbated respiratory disease. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 138(4), 1089-U479. doi:10.1016/j.jaci.2016.04.042

Lal, D., Jategaonkar, A. A., Borish, L., Chambliss, L. R., Gnagi, S. H., Hwang, P. H., . . . Lund, V. J. (2016). Management of rhinosinusitis during pregnancy: systematic review and expert panel recommendations.. Rhinology, 54(2), 99-104. doi:10.4193/rhino15.228

Borish, L. (2016). Non-specific airway hyperreactivity in asthma: a clinical correlate to ... what exactly?. CLINICAL AND EXPERIMENTAL ALLERGY, 46(2), 189-191. doi:10.1111/cea.12637

Lal, D., Jategaonkar, A. A., Borish, L., Chambliss, L. R., Gnagi, S. H., Hwang, P. H., . . . Lund, V. J. (2016). Management of rhinosinusitis during pregnancy: systematic review and expert panel recommendations. RHINOLOGY, 54(2), 99-104. doi:10.4193/Rhin15.228

Hoyt, A. E. W., Borish, L., Gurrola, J., & Payne, S. (2016). Allergic Fungal Rhinosinusitis. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 4(4), 599-604. doi:10.1016/j.jaip.2016.03.010

2015

Palacios, T., Stillman, L., Borish, L., & Lawrence, M. (2016). Lack of basophil CD203c-upregulating activity as an immunological marker to predict response to treatment with omalizumab in patients with symptomatic chronic urticaria. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 4(3), 529-530. doi:10.1016/j.jaip.2015.11.025

Borish, L. (2015). Chronic Rhinosinusitis: More Than Just "Asthma of the Upper Airway". AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 192(6), 647-648. doi:10.1164/rccm.201506-1201ED

Palacios, T., Bartelt, L., Scheld, W., Lopes, M. B., Kelting, S. M., Holland, S., . . . Lawrence, M. (2015). Fatal Coxsackie meningoencephalitis in a patient with B-cell lymphopenia and hypogammaglobulinemia following rituximab therapy. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 115(2), 148-150. doi:10.1016/j.anai.2015.05.007

Patterson, M. F., Borish, L., & Kennedy, J. L. (2015). The past, present, and future of monoclonal antibodies to IL-5 and eosinophilic asthma: a review. JOURNAL OF ASTHMA AND ALLERGY, 8, 125-134. doi:10.2147/JAA.S74178

Steinke, J. W., Liu, L., Turner, R. B., Braciale, T. J., & Borish, L. (2015). Immune Surveillance by Rhinovirus-Specific Circulating CD4+ and CD8+ T Lymphocytes. PLOS ONE, 10(1). doi:10.1371/journal.pone.0115271

Steinke, J. W., & Borish, L. (2015). Factors driving the aspirin exacerbated respiratory disease phenotype. AMERICAN JOURNAL OF RHINOLOGY & ALLERGY, 29(1), 35-40. doi:10.2500/ajra.2015.29.4123

2014

Baker, M. G., Cronin, J. A., Borish, L., & Lawrence, M. G. (2014). Evaluation of a skin testing protocol for diagnosing perioperative anaphylaxis due to isosulfan blue allergy. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 113(3), 330-331. doi:10.1016/j.anai.2014.07.002

Steinke, J. W., Negri, J., Liu, L., Payne, S. C., & Borish, L. (2014). Aspirin Activation of Eosinophils and Mast Cells: Implications in the Pathogenesis of Aspirin-Exacerbated Respiratory Disease. JOURNAL OF IMMUNOLOGY, 193(1), 41-47. doi:10.4049/jimmunol.1301753

Steinke, J. W., Negri, J., Payne, S. C., & Borish, L. (2014). Biological effects of leukotriene E4 on eosinophils. PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 91(3), 105-110. doi:10.1016/j.plefa.2014.02.006

Kennedy, J. L., Shaker, M., McMeen, V., Gern, J., Carper, H., Murphy, D., . . . Heymann, P. W. (2014). Comparison of Viral Load in Individuals with and without Asthma during Infections with Rhinovirus. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 189(5), 532-539. doi:10.1164/rccm.201310-1767OC

Kennedy, J. L., Schroeder, N., Palacios, T., Rosen, L. B., Martinez, B., Browne, S., & Borish, L. (2014). Fifty-five-year-old man with chronic yeast infections. ALLERGY AND ASTHMA PROCEEDINGS, 35(5), 415-422. doi:10.2500/aap.2014.35.3776

Kennedy, J. L., Borish, L., Christophel, J., & Payne, S. C. (2014). Letters to the Editor: Assessing the cost-effectiveness of allergen immunotherapy in allergic rhinitis. AMERICAN JOURNAL OF RHINOLOGY & ALLERGY, 28(4), 353-354. doi:10.2500/ajra.2014.28.0715

Kennedy, J. L., Robinson, D., Christophel, J., Borish, L., & Payne, S. (2014). Decision-making analysis for allergen immunotherapy versus nasal steroids in the treatment of nasal steroid-responsive allergic rhinitis. AMERICAN JOURNAL OF RHINOLOGY & ALLERGY, 28(1), 59-64. doi:10.2500/ajra.2014.28.3998

2013

Ma, L., Danoff, T. M., & Borish, L. (2014). Case fatality and population mortality associated with anaphylaxis in the United States. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 133(4), 1075-1083. doi:10.1016/j.jaci.2013.10.029

Kennedy, J. L., Hubbard, M. A., Huyett, P., Patrie, J. T., Borish, L., & Payne, S. C. (2013). Sino-nasal outcome test (SNOT-22): A predictor of postsurgical improvement in patients with chronic sinusitis. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 111(4), 246-U90. doi:10.1016/j.anai.2013.06.033

Steinke, J. W., Liu, L., Huyett, P., Negri, J., Payne, S. C., & Borish, L. (2013). Prominent role of IFN-γ in patients with aspirin-exacerbated respiratory disease. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 132(4), 856-+. doi:10.1016/j.jaci.2013.05.008

Kennedy, J. L., & Borish, L. (2013). Chronic sinusitis pathophysiology: The role of allergy. AMERICAN JOURNAL OF RHINOLOGY & ALLERGY, 27(5), 367-371. doi:10.2500/ajra.2013.27.3906

Settipane, R. A., Peters, A. T., & Borish, L. (2013). Immunomodulation of allergic sinonasal disease. AMERICAN JOURNAL OF RHINOLOGY & ALLERGY, 27, S59-S62. doi:10.2500/ajra.2013.27.3930

Settipane, R. A., Borish, L., & Peters, A. T. (2013). Determining the role of allergy in sinonasal disease. AMERICAN JOURNAL OF RHINOLOGY & ALLERGY, 27, S56-S58. doi:10.2500/ajra.2013.27.3929

Kennedy, J. L., & Borish, L. (2013). Chronic rhinosinusitis and antibiotics: The good, the bad, and the ugly. AMERICAN JOURNAL OF RHINOLOGY & ALLERGY, 27(6), 467-472. doi:10.2500/ajra.2013.27.3960

2012

Tilles, S. A., Borish, L., & Cohen, J. P. (2013). Management of hereditary angioedema in 2012: scientific and pharmacoeconomic perspectives. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 110(2), 70-74. doi:10.1016/j.anai.2012.11.014

Juncadella, I. J., Kadl, A., Sharma, A. K., Shim, Y. M., Hochreiter-Hufford, A., Borish, L., & Ravichandran, K. S. (2013). Apoptotic cell clearance by bronchial epithelial cells critically influences airway inflammation. NATURE, 493(7433), 547-+. doi:10.1038/nature11714

Chipps, B. E., Zeiger, R. S., Dorenbaum, A., Borish, L., Wenzel, S. E., Miller, D. P., . . . Haselkorn, T. (2012). Assessment of asthma control and asthma exacerbations in the epidemiology and natural history of asthma: outcomes and treatment regimens (TENOR) observational cohort. CURRENT PULMONOLOGY REPORTS, 1(4), 259-269. doi:10.1007/s13665-012-0025-x

Steinke, J. W., Payne, S. C., Chen, P. G., Negri, J., Stelow, E. B., & Borish, L. (2012). Etiology of Nasal Polyps in Cystic Fibrosis: Not a Unimodal Disease. ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, 121(9), 579-586. doi:10.1177/000348941212100904

Chipps, B. E., Zeiger, R. S., Borish, L., Wenzel, S. E., Yegin, A., Hayden, M. L., . . . Haselkorn, T. (2012). Key findings and clinical implications from The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 130(2), 332-+. doi:10.1016/j.jaci.2012.04.014

Posthumus, J., Tinana, A., Mozena, J. D., Steinke, J. W., & Borish, L. (2012). Autoimmune mechanisms in chronic idiopathic urticaria. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 130(3), 814-+. doi:10.1016/j.jaci.2012.04.037

Kennedy, J. L., Turner, R. B., Braciale, T., Heymann, P. W., & Borish, L. (2012). Pathogenesis of rhinovirus infection. CURRENT OPINION IN VIROLOGY, 2(3), 287-293. doi:10.1016/j.coviro.2012.03.008

Borish, L., & Steinke, J. W. (2012). The promise and obstacles of asthma genetics research. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 108(6), 388-389. doi:10.1016/j.anai.2012.03.017

Raveendran, R., Clough-Paabo, E., Borish, L., & Erwin, E. (2012). Using Objective Tools to Evaluate Pediatric Patients with Chronic Rhinitis. Journal of Allergy and Clinical Immunology, 129(2), AB113. doi:10.1016/j.jaci.2011.12.552

Tilles, S. A., & Borish, L. (2012). Hereditary angioedema: implications of treating a rare disease Response. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 109(2), 151. doi:10.1016/j.anai.2012.05.020

Posthumus, J., & Borish, L. (2012). A 71-year-old man with anaphylaxis after eating grits. ALLERGY AND ASTHMA PROCEEDINGS, 33(1), 110-113. doi:10.2500/aap.2012.33.3476

Steinke, J. W., Payne, S. C., & Borish, L. (2012). Interleukin-4 in the Generation of the AERD Phenotype: Implications for Molecular Mechanisms Driving Therapeutic Benefit of Aspirin Desensitization.. Journal of allergy, 2012, 182090. doi:10.1155/2012/182090

2011

Payne, S. C., Early, S. B., Huyett, P., Han, J. K., Borish, L., & Steinke, J. W. (2011). Evidence for Distinct Histologic Profile of Nasal Polyps With and Without Eosinophilia. LARYNGOSCOPE, 121(10), 2262-2267. doi:10.1002/lary.21969

Payne, S. C., Borish, L., & Steinke, J. W. (2011). Genetics and phenotyping in chronic sinusitis. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 128(4), 710-722. doi:10.1016/j.jaci.2011.05.022

Payne, S. C., Chen, P. G., & Borish, L. (2011). Local class switching in nonallergic rhinitis. CURRENT OPINION IN OTOLARYNGOLOGY & HEAD AND NECK SURGERY, 19(3), 193-198. doi:10.1097/MOO.0b013e328345005c

Tilles, S. A., & Borish, L. (2011). A new generation of hereditary angioedema treatments: remarkable advances clash with disturbing economic reality. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 106(4), 264-266. doi:10.1016/j.anai.2011.01.025

Baye, T. M., Kovacic, M. B., Myers, J. M. B., Martin, L. J., Lindsey, M., Patterson, T. L., . . . Hershey, G. K. K. (2011). Differences in Candidate Gene Association between European Ancestry and African American Asthmatic Children. PLOS ONE, 6(2). doi:10.1371/journal.pone.0016522

Laidlaw, T. M., Steinke, J. W., Tinana, A. M., Feng, C., Xing, W., Lam, B. K., . . . Borish, L. (2011). Characterization of a novel human mast cell line that responds to stem cell factor and expresses functional FcâRI. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 127(3), 815-U499. doi:10.1016/j.jaci.2010.12.1101

Wisniewski, J. A., & Borish, L. (2011). Novel cytokines and cytokine-producing T cells in allergic disorders. ALLERGY AND ASTHMA PROCEEDINGS, 32(2), 83-94. doi:10.2500/aap.2011.32.3428

Erwin, E. A., Faust, R. A., Platts-Mills, T. A. E., & Borish, L. (2011). Epidemiological analysis of chronic rhinitis in pediatric patients. AMERICAN JOURNAL OF RHINOLOGY & ALLERGY, 25(5), 327-332. doi:10.2500/ajra.2011.25.3640

2010

Borish, L., Ayars, A. G., & Kirkpatrick, C. H. (2011). Common variable immunodeficiency presenting as herpes simplex virus encephalitis. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 127(2), 541-543. doi:10.1016/j.jaci.2010.11.004

Haselkorn, T., Szefler, S. J., Simons, F. E. R., Zeiger, R. S., Mink, D. R., Chipps, B. E., . . . Wong, D. A. (2010). Allergy, total serum immunoglobulin E, and airflow in children and adolescents in TENOR. PEDIATRIC ALLERGY AND IMMUNOLOGY, 21(8), 1157-1165. doi:10.1111/j.1399-3038.2010.01065.x

Borish, L., & Steinke, J. W. (2011). Interleukin-33 in Asthma: How Big of a Role Does It Play?. CURRENT ALLERGY AND ASTHMA REPORTS, 11(1), 7-11. doi:10.1007/s11882-010-0153-8

Borish, L. (2010). IL-4 and IL-13 Dual Antagonism A Promising Approach to the Dilemma of Generating Effective Asthma Biotherapeutics. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 181(8), 769-770. doi:10.1164/rccm.201002-0147ED

Mozena, J. D., Tinana, A., Negri, J., Steinke, J. W., & Borish, L. (2010). Lack of a Role for Cross-Reacting Anti-Thyroid Antibodies in Chronic Idiopathic Urticaria. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 130(7), 1860-1865. doi:10.1038/jid.2010.35