David Kittlesen


Primary Appointment

Associate Professor of Biology, General Faculty, Biology


  • BA, Biology, St. Olaf College
  • PhD, Immunology, Washington University
  • Postdoc, Tumor immunology, University of Virginia
  • Postdoc, Viral immunology, University of Virginia

Research Disciplines


Research Interests

Pedagogical innovation in undergraduate biology

Research Description

Following postdoctoral work with CIC Professors Slingluff and Hahn, I moved to the Department of Biology where I have been teaching Introduction to Immunology (Biol 3240) and Biological Therapy of Cancer (Biol 4390) since 1998. I also teach the cell biology and genetics semester of Introduction to Biology (Biol 2100), Microbiology lab (Biol 3270), and a small seminar for first semester undergrads titled, Why Havenât We Cured Cancer? (COLA 1500).

Selected Publications

Slingluff CL, Yamshchikov G, Neese P, Galavotti H, Eastham S, Engelhard VH, Kittlesen D, Deacon D, Hibbitts S, Grosh WW, Petroni G, Cohen R, Wiernasz C, Patterson JW, Conway BP, Ross WG, Phase I trial of a melanoma vaccine with gp100(280-288) peptide and tetanus helper peptide in adjuvant: immunologic and clinical outcomes., 2001; Clinical cancer research : an official journal of the American Association for Cancer Research. 7(10) 3012-24. PMID: 11595689

Yang S, Kittlesen D, Slingluff CL, Vervaert CE, Seigler HF, Darrow TL, Dendritic cells infected with a vaccinia vector carrying the human gp100 gene simultaneously present multiple specificities and elicit high-affinity T cells reactive to multiple epitopes and restricted by HLA-A2 and -A3., 2001; Journal of immunology (Baltimore, Md. : 1950). 164(8) 4204-11. PMID: 10754316

Slingluff CL, Colella TA, Thompson L, Graham DD, Skipper JC, Caldwell J, Brinckerhoff L, Kittlesen DJ, Deacon DH, Oei C, Harthun NL, Huczko EL, Hunt DF, Darrow TL, Engelhard VH, Melanomas with concordant loss of multiple melanocytic differentiation proteins: immune escape that may be overcome by targeting unique or undefined antigens., 2001; Cancer immunology, immunotherapy : CII. 48(12) 661-72. PMID: 10752474

Kittlesen DJ, Chianese-Bullock KA, Yao ZQ, Braciale TJ, Hahn YS, Interaction between complement receptor gC1qR and hepatitis C virus core protein inhibits T-lymphocyte proliferation., 2000; The Journal of clinical investigation. 106(10) 1239-49. PMID: 11086025 | PMCID: PMC381434

Large MK, Kittlesen DJ, Hahn YS, Suppression of host immune response by the core protein of hepatitis C virus: possible implications for hepatitis C virus persistence., 1999; Journal of immunology (Baltimore, Md. : 1950). 162(2) 931-8. PMID: 9916717

Kittlesen DJ, Thompson LW, Gulden PH, Skipper JC, Colella TA, Shabanowitz J, Hunt DF, Engelhard VH, Slingluff CL, Shabanowitz JA, Human melanoma patients recognize an HLA-A1-restricted CTL epitope from tyrosinase containing two cysteine residues: implications for tumor vaccine development., 1998; Journal of immunology (Baltimore, Md. : 1950). 160(5) 2099-106. PMID: 9498746

Mosse CA, Meadows L, Luckey CJ, Kittlesen DJ, Huczko EL, Slingluff CL, Shabanowitz J, Hunt DF, Engelhard VH, The class I antigen-processing pathway for the membrane protein tyrosinase involves translation in the endoplasmic reticulum and processing in the cytosol., 1998; The Journal of experimental medicine. 187(1) 37-48. PMID: 9419209 | PMCID: PMC2199193

Skipper JC, Kittlesen DJ, Hendrickson RC, Deacon DD, Harthun NL, Wagner SN, Hunt DF, Engelhard VH, Slingluff CL, Shared epitopes for HLA-A3-restricted melanoma-reactive human CTL include a naturally processed epitope from Pmel-17/gp100., 1996; Journal of immunology (Baltimore, Md. : 1950). 157(11) 5027-33. PMID: 8943411

Kittlesen DJ, Brown LR, Braciale VL, Sambrook JP, Gething MJ, Braciale TJ, Presentation of newly synthesized glycoproteins to CD4+ T lymphocytes. An analysis using influenza hemagglutinin transport mutants., 1993; The Journal of experimental medicine. 177(4) 1021-30. PMID: 8096235 | PMCID: PMC2190981