Thomas P Loughran, Jr.


Primary Appointment

F. Palmer Weber-Smithfield Foods Professor of Oncology Research & Professor of Medicine, Medicine- Hematology and Oncology


  • Clinical Fellowship, Oncology, Fred Hutchinson Cancer Research Center
  • MD, Hahnemann Medical College
  • Residency, Thomas Jefferson University Hospital, Philadelphia, PA

Research Disciplines

Bioinformatics and Genomics, Cancer Biology, Computational Biology, Immunology, Molecular Biology, Translational Science

Research Interests

Hematologic malignancies; bone marrow disorders; leukemia; large granular lymphocyte (LGL)

Research Description

Dr. Loughran's current research includes:
current research includes:
⢠R01 grant from the NIHâs National Cancer Institute to identify and characterize the LGL leukemia virus and understand how it might cause leukemia;
⢠NCI RO1 grant to study the pathogenesis of LGL leukemia;
⢠translational research grant from the Leukemia & Lymphoma Society to investigate new treatments for LGL leukemia;
⢠program project grant from the NCI aimed at developing new therapeutics for acute myelogenous leukemia.

Personal Statement

Thomas P. Loughran, Jr., MD, is the director of the University of Virginia Cancer Center, F. Palmer Weber-Smithfield Foods Professor of Oncology Research and Professor of Medicine. From July 2003 to August 2013, he served as the founding director of the Penn State Hershey Cancer Institute and Professor of Medicine at the Penn State College of Medicine. He previously served as program leader of hematologic malignancies at the H. Lee Moffitt Cancer Center and Research Institute at the University of South Florida, associate director of the Bone Marrow Transplant Program at SUNY Health Science Center, and chief of hematology at the Syracuse Veteran's Affairs Medical Center in Syracuse, N.Y. He completed his fellowship in medical oncology at the Fred Hutchinson Cancer Research Center under direction of Nobel Laureate, Dr. E.D. Thomas and remained on faculty there for seven years.
His career as a physician scientist is a testament to translational research beginning with his discovery of large granular lymphocyte (LGL) leukemia. He has published numerous articles in high impact peer-reviewed journals including The New England Journal of Medicine, Annals of Internal Medicine, Lancet, Journal of Clinical Investigation, Journal of Clinical Oncology, and Blood. He and his wife, Kenna, have two daughters, Kathleen and Kelly.


  • Cancer Research Training in Molecular Biology
  • Interdisciplinary Training Program in Immunology
  • Training in the Pharmacological Sciences

Selected Publications


Ung, J., Tan, S. -F., Fox, T. E., Shaw, J. J. P., Vass, L. R., Costa-Pinheiro, P., . . . Loughran, T. P. (2022). Harnessing the power of sphingolipids: Prospects for acute myeloid leukemia. BLOOD REVIEWS, 55. doi:10.1016/j.blre.2022.100950

Cheon, H., Elghawy, O., Shemo, B. C., Feith, D. J., & Loughran, T. P. (2022). LGL leukemia patients exhibit substantial protective humoral responses following SARS-CoV-2 vaccination.. EJHaem, 3(3), 919-923. doi:10.1002/jha2.472

Fries, C., Evans, A. G., Cheon, H., Korones, D. N., Jr, L. T. P., & Andolina, J. R. (2022). Allogeneic Bone Marrow Transplant as a Cure for Refractory T-Cell Large Granular Lymphocytic Leukemia in an Adolescent. JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 44(6), E960-E963. doi:10.1097/MPH.0000000000002390

Cheon, H., Xing, J. C., Moosic, K. B., Ung, J., Chan, V. W., Chung, D. S., . . . Loughran Jr, T. P. (2022). Genomic landscape of TCR alpha beta and TCR gamma delta T-large granular lymphocyte leukemia. BLOOD, 139(20), 3058-3072. doi:10.1182/blood.2021013164

Moosic, K. B., Ananth, K., Andrade, F., Feith, D. J., Darrah, E., & Loughran, T. P. (2022). Intersection Between Large Granular Lymphocyte Leukemia and Rheumatoid Arthritis. FRONTIERS IN ONCOLOGY, 12. doi:10.3389/fonc.2022.869205

Baer, C., Kimura, S., Rana, M. S., Kleist, A. B., Flerlage, T., Feith, D. J., . . . Mullighan, C. G. (2022). CCL22 mutations drive natural killer cell lymphoproliferative disease by deregulating microenvironmental crosstalk. NATURE GENETICS, 54(5), 637-+. doi:10.1038/s41588-022-01059-2

Huuhtanen, J., Bhattacharya, D., Lonnberg, T., Kankainen, M., Kerr, C., Theodoropoulos, J., . . . Mustjoki, S. (2022). Single-cell characterization of leukemic and non-leukemic immune repertoires in CD8(+) T-cell large granular lymphocytic leukemia. NATURE COMMUNICATIONS, 13(1). doi:10.1038/s41467-022-29173-z

Assmann, J. L. J. C., Leon, L. G., Stavast, C. J., van den Bogaerdt, S. E., Schilperoord-Vermeulen, J., Sandberg, Y., . . . Langerak, A. W. (2022). miR-181a is a novel player in the STAT3-mediated survival network of TCR alpha beta+CD8+T large granular lymphocyte leukemia. LEUKEMIA, 36(4), 983-993. doi:10.1038/s41375-021-01480-2

Mundy-Bosse, B. L., Weigel, C., Wu, Y. -Z., Abdelbaky, S., Youssef, Y., Casas, S. B., . . . Oakes, C. C. (2022). Identification and Targeting of the Developmental Blockade in Extranodal Natural Killer/T-cell Lymphoma. BLOOD CANCER DISCOVERY, 3(2), 154-169. doi:10.1158/2643-3230.BCD-21-0098

Fisher-Wellman, K. H., Hagen, J. T., Kassai, M., Kao, L. -P., Nelson, M. A. M., McLaughlin, K. L., . . . Cabot, M. C. (2022). Alterations in sphingolipid composition and mitochondrial bioenergetics represent synergistic therapeutic vulnerabilities linked to multidrug resistance in leukemia. FASEB JOURNAL, 36(1). doi:10.1096/fj.202101194RRR


Golla, U., Ehudin, M. A., Annageldiyev, C., Zeng, Z., Bastihalli Tukaramrao, D., Tarren, A., . . . Sharma, A. (2021). DJ4 Targets the Rho-Associated Protein Kinase Pathway and Attenuates Disease Progression in Preclinical Murine Models of Acute Myeloid Leukemia. CANCERS, 13(19). doi:10.3390/cancers13194889

Olson, T. L., Cheon, H., Xing, J. C., Olson, K. C., Paila, U., Hamele, C. E., . . . Jr, L. T. P. (2021). Frequent somatic TET2 mutations in chronic NK-LGL leukemia with distinct patterns of cytopenias. BLOOD, 138(8), 662-673. doi:10.1182/blood.2020005831


Cherel, B., Humbert, M., LeBlanc, F. R., Zambello, R., Hamidou, M., Lifermann, F., . . . Lamy, T. (2020). Large Granular Lymphocyte Leukemia and Precapillary Pulmonary Hypertension. CHEST, 158(6), 2602-2609. doi:10.1016/j.chest.2020.07.094

Mittal, N., Jr, L. T., & Rivers, A. (2020). T-cell large granular lymphocytic leukemia successfully treated with oral cyclosporine in a child: Case report and review of literature. PEDIATRIC BLOOD & CANCER, 67(12). doi:10.1002/pbc.28487

Olson, K. C., Moosic, K. B., Jones, M. K., Larkin, P. M. K., Olson, T. L., Toro, M. F., . . . Jr, L. T. P. (2020). Large granular lymphocyte leukemia serum and corresponding hematological parameters reveal unique cytokine and sphingolipid biomarkers and associations with STAT3 mutations. CANCER MEDICINE, 9(18), 6533-6549. doi:10.1002/cam4.3246

Fox, J., He, M., Loughran, T., Synold, T., & Uthamanthil, R. (2020). Submitting Successful Cancer Center Support Grants (P30) from the Core Perspective.. Journal of biomolecular techniques : JBT, 31(Suppl), S41.

LeBlanc, F. R., Pearson, J. M., Tan, S. -F., Cheon, H., Xing, J. C., Dunton, W., . . . Jr, L. T. P. (2020). Sphingosine kinase-2 is overexpressed in large granular lymphocyte leukaemia and promotes survival through Mcl-1. BRITISH JOURNAL OF HAEMATOLOGY, 190(3), 405-417. doi:10.1111/bjh.16530

Annageldiyev, C., Tan, S. -F., Thakur, S., Dhanyamraju, P. K., Ramisetti, S. R., Bhadauria, P., . . . Sharma, A. (2020). The PI3K/AKT Pathway Inhibitor ISC-4 Induces Apoptosis and Inhibits Growth of Leukemia in Preclinical Models of Acute Myeloid Leukemia. FRONTIERS IN ONCOLOGY, 10. doi:10.3389/fonc.2020.00393

Cheon, H., Dziewulska, K. H., Moosic, K. B., Olson, K. C., Gru, A. A., Feith, D. J., & Jr, L. T. P. (2020). Advances in the Diagnosis and Treatment of Large Granular Lymphocytic Leukemia. CURRENT HEMATOLOGIC MALIGNANCY REPORTS, 15(2), 103-112. doi:10.1007/s11899-020-00565-6

Pearson, J. M., Tan, S. -F., Sharma, A., Annageldiyev, C., Fox, T. E., Abad, J. L., . . . Loughran, T. P. (2020). Ceramide Analogue SACLAC Modulates Sphingolipid Levels and MCL-1 Splicing to Induce Apoptosis in Acute Myeloid Leukemia. MOLECULAR CANCER RESEARCH, 18(3), 352-363. doi:10.1158/1541-7786.MCR-19-0619

Annageldiyev, C., Gowda, K., Patel, T., Bhattacharya, P., Tan, S. -F., Iyer, S., . . . Sharma, A. (2020). The novel Isatin analog KS99 targets stemness markers in acute myeloid leukemia. HAEMATOLOGICA, 105(3), 687-696. doi:10.3324/haematol.2018.212886

Nyland, S. B., Feith, D. J., Poss, M., Olson, T. L., Krissinger, D. J., Poiesz, B. J., . . . Loughran, T. P. (2020). Retroviral sero-reactivity in LGL leukaemia patients and family members. BRITISH JOURNAL OF HAEMATOLOGY, 188(4), 522-527. doi:10.1111/bjh.16223

Wang, T. T., Yang, J., Dighe, S., Schmachtenberg, M. W., Leigh, N. T., Farber, E., . . . Olson, T. L. (2020). Whole Genome Sequencing of Spontaneously Occurring Rat Natural Killer Large Granular Lymphocyte Leukemia Identifies JAK1 Somatic Activating Mutation. CANCERS, 12(1). doi:10.3390/cancers12010126


Barth, B. M., Wang, W., Toran, P. T., Fox, T. E., Annageldiyev, C., Ondrasik, R. M., . . . Claxton, D. F. (2019). Sphingolipid metabolism determines the therapeutic efficacy of nanoliposomal ceramide in acute myeloid leukemia. BLOOD ADVANCES, 3(17), 2598-2603. doi:10.1182/bloodadvances.2018021295

Lamy, T., & Loughran, T. P. (2019). Large granular lymphocytic and other rare lymphoid leukemias Preface. BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY, 32(3), 193-195. doi:10.1016/j.beha.2019.09.001

Kao, L. -P., Morad, S. A. F., Davis, T. S., MacDougall, M. R., Kassai, M., Abdelmageed, N., . . . Cabot, M. C. (2019). Chemotherapy selection pressure alters sphingolipid composition and mitochondrial bioenergetics in resistant HL-60 cells. JOURNAL OF LIPID RESEARCH, 60(9), 1590-1602. doi:10.1194/jlr.RA119000251

Moosic, K. B., Paila, U., Olson, K. C., Dziewulska, K., Wang, T. T., Xing, J. C., . . . Olson, T. L. (2019). Genomics of LGL leukemia and select other rare leukemia/lymphomas. BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY, 32(3), 196-206. doi:10.1016/j.beha.2019.06.003

Morad, S. A. F., MacDougall, M. R., Abdelmageed, N., Kao, L. -P., Feith, D. J., Tan, S. -F., . . . Cabot, M. C. (2019). Pivotal role of mitophagy in response of acute myelogenous leukemia to a ceramide-tamoxifen-containing drug regimen. EXPERIMENTAL CELL RESEARCH, 381(2), 256-264. doi:10.1016/j.yexcr.2019.05.021

Li, W., Yang, L., Harris, R. S., Lin, L., Olson, T. L., Hamele, C. E., . . . Poss, M. (2019). Retrovirus insertion site analysis of LGL leukemia patient genomes. BMC MEDICAL GENOMICS, 12. doi:10.1186/s12920-019-0549-9

Tan, S. -F., Dunton, W., Liu, X., Fox, T. E., Morad, S. A. F., Desai, D., . . . Loughran, T. P. (2019). Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-B-dependent P-glycoprotein upregulation. JOURNAL OF LIPID RESEARCH, 60(6), 1078-1086. doi:10.1194/jlr.M091876

Wang, T. T., Yang, J., Zhang, Y., Zhang, M., Dubois, S., Conlon, K. C., . . . Jr, L. T. P. (2019). IL-2 and IL-15 blockade by BNZ-1, an inhibitor of selective gamma-chain cytokines, decreases leukemic T-cell viability. LEUKEMIA, 33(5), 1243-1255. doi:10.1038/s41375-018-0290-y


Olson, K. C., Larkin, P. M. K., Signorelli, R., Hamele, C. E., Olson, T. L., Conaway, M. R., . . . Jr, L. T. P. (2018). Vitamin D pathway activation selectively deactivates signal transducer and activator of transcription (STAT) proteins and inflammatory cytokine production in natural killer leukemic large granular lymphocytes. CYTOKINE, 111, 551-562. doi:10.1016/j.cyto.2018.09.016

Olson, T. L., & Jr, L. T. P. (2018). Restoring the Long Noncoding RNA MEG3 Indicates a Potential Role for JAK-STAT Signaling in Chronic Myeloid Leukemia. EBIOMEDICINE, 35, 24. doi:10.1016/j.ebiom.2018.08.019

Yang, J., LeBlanc, F. R., Dighe, S. A., Hamele, C. E., Olson, T. L., Feith, D. J., & Jr, L. T. P. (2018). TRAIL mediates and sustains constitutive NF-kappa B activation in LGL leukemia. BLOOD, 131(25), 2803-2815. doi:10.1182/blood-2017-09-808816

Dufva, O., Kankainen, M., Kelkka, T., Sekiguchi, N., Awad, S. A., Eldfors, S., . . . Mustjoki, S. (2018). Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target. NATURE COMMUNICATIONS, 9. doi:10.1038/s41467-018-03987-2

Kulling, P. M., Olson, K. C., Olson, T. L., Hamele, C. E., Carter, K. N., Feith, D. J., & Jr, L. T. P. (2018). Calcitriol-mediated reduction in IFN-gamma output in T cell large granular lymphocytic leukemia requires vitamin D receptor upregulation. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 177, 140-148. doi:10.1016/j.jsbmb.2017.07.009

Kulling, P. M., Olson, K. C., Hamele, C. E., Toro, M. F., Tan, S. -F., Feith, D. J., & Jr, L. T. P. (2018). Dysregulation of the IFN-gamma-STAT1 signaling pathway in a cell line model of large granular lymphocyte leukemia. PLOS ONE, 13(2). doi:10.1371/journal.pone.0193429

Savola, P., Bruck, O., Olson, T., Kelkka, T., Kauppi, M. J., Kovanen, P. E., . . . Mustjoki, S. (2018). Somatic STAT3 mutations in Felty syndrome: an implication for a common pathogenesis with large granular lymphocyte leukemia. HAEMATOLOGICA, 103(2), 304-312. doi:10.3324/haematol.2017.175729


Gazitt, T., & Jr, L. T. P. (2017). Chronic neutropenia in LGL leukemia and rheumatoid arthritis. HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM, 181-186. doi:10.1182/asheducation-2017.1.181

Hengst, J. A., Dick, T. E., Sharma, A., Doi, K., Hegde, S., Tan, S. -F., . . . Yun, J. K. (2017). SKI-178: A Multitargeted Inhibitor of Sphingosine Kinase and Microtubule Dynamics Demonstrating Therapeutic Efficacy in Acute Myeloid Leukemia Models.. Cancer translational medicine, 3(4), 109-121. doi:10.4103/ctm.ctm_7_17

Morad, S. A. F., Davis, T. S., MacDougall, M. R., Tan, S. -F., Feith, D. J., Desai, D. H., . . . Cabot, M. G. (2017). Role of P-glycoprotein inhibitors in ceramide-based therapeutics for treatment of cancer. BIOCHEMICAL PHARMACOLOGY, 130, 21-33. doi:10.1016/j.bcp.2017.02.002

Salzberg, A. C., Harris-Becker, A., Popova, E. Y., Keasey, N., Loughran, T. P., Claxton, D. F., & Grigoryev, S. A. (2017). Genome-wide mapping of histone H3K9me2 in acute myeloid leukemia reveals large chromosomal domains associated with massive gene silencing and sites of genome instability. PLOS ONE, 12(3). doi:10.1371/journal.pone.0173723

Lamy, T., Moignet, A., & Jr, L. T. P. (2017). LGL leukemia: from pathogenesis to treatment. BLOOD, 129(9), 1082-1094. doi:10.1182/blood-2016-08-692590

Kulling, P. M., Olson, K. C., Olson, T. L., Feith, D. J., & Jr, L. T. P. (2017). Vitamin D in hematological disorders and malignancies. EUROPEAN JOURNAL OF HAEMATOLOGY, 98(3), 187-197. doi:10.1111/ejh.12818

Tan, S. -F., Pearson, J. M., Feith, D. J., & Jr, L. T. P. (2017). The emergence of acid ceramidase as a therapeutic target for acute myeloid leukemia. EXPERT OPINION ON THERAPEUTIC TARGETS, 21(6), 583-590. doi:10.1080/14728222.2017.1322065

Salzberg, A. C., Harris-Becker, A., Popova, E. Y., Keasey, N., Loughran, T. P., Claxton, D. F., & Grigoryev, S. A. (2017). Genome-wide mapping of histone H3K9me2 in acute myeloid leukemia reveals large chromosomal domains associated with massive gene silencing and sites of genome instability.. PloS one, 12(3), e0173723. doi:10.1371/journal.pone.0173723

Olson, K. C., Kulling, P. M., Olson, T. L., Tan, S. -F., Rainbow, R. J., Feith, D. J., & Jr, L. T. P. (2017). Vitamin D decreases STAT phosphorylation and inflammatory cytokine output in T-LGL leukemia. CANCER BIOLOGY & THERAPY, 18(5), 290-303. doi:10.1080/15384047.2016.1235669


Tan, S. -F., Liu, X., Fox, T. E., Barth, B. M., Sharma, A., Turner, S. D., . . . Jr, L. T. P. (2016). Acid ceramidase is upregulated in AML and represents a novel therapeutic target. ONCOTARGET, 7(50), 83208-83222. doi:10.18632/oncotarget.13079

Andersson, E. I., Tanahashi, T., Sekiguchi, N., Gasparini, V. R., Bortoluzzi, S., Kawakami, T., . . . Ishida, F. (2016). High incidence of activating STAT5B mutations in CD4-positive T-cell large granular lymphocyte leukemia. BLOOD, 128(20), 2465-2468. doi:10.1182/blood-2016-06-724856

Gazitt, T., Lood, C., Sun, X., Feith, D., Ledbetter, J., Starkebaum, G., . . . Elkon, K. B. (2016). Cell-Mediated Neutrophil Lysis-a Mechanism Promoting Hypercitrullination in Rheumatoid Arthritis?. ARTHRITIS & RHEUMATOLOGY, 68. Retrieved from

Morad, S. A. F., Ryan, T. E., Neufer, P. D., Zeczycki, T. N., Davis, T. S., MacDougall, M. R., . . . Cabot, M. C. (2016). Ceramide-tamoxifen regimen targets bioenergetic elements in acute myelogenous leukemia. JOURNAL OF LIPID RESEARCH, 57(7), 1231-1242. doi:10.1194/jlr.M067389

Andersson, E., Kuusanmaki, H., Bortoluzzi, S., Lagstrom, S., Parsons, A., Rajala, H., . . . Mustjoki, S. (2016). Activating somatic mutations outside the SH2-domain of STAT3 in LGL leukemia. LEUKEMIA, 30(5), 1204-1208. doi:10.1038/leu.2015.263

Sang, W., Wang, Y., Zhang, C., Yan, D., Niu, M., Yang, C., . . . Xu, K. (2016). Fludarabine, idarubicin, and cytarabine regimen together with TKI followed by haploidentical hematopoietic stem cell transplantation, a success for relapsed Ph+ acute lymphoblastic leukemia. CLINICAL CASE REPORTS, 4(4), 390-395. doi:10.1002/ccr3.438

Sang, W., Wang, Y., Zhang, C., Zhang, D., Sun, C., Niu, M., . . . Xu, K. (2016). MiR-150 impairs inflammatory cytokine production by targeting ARRB-2 after blocking CD28/B7 costimulatory pathway. IMMUNOLOGY LETTERS, 172, 1-10. doi:10.1016/j.imlet.2015.11.001

Epner, E. M., Saroya, B. S., Hasanali, Z. S., & Jr, L. T. P. (2016). Combination epigenetic and immunotherapy overcomes resistance to monoclonal antibodies in hematologic malignancies: A new therapeutic approach. EXPERIMENTAL HEMATOLOGY, 44(3), 157-160. doi:10.1016/j.exphem.2015.12.011

Sang, W., Sun, C., Zhang, C., Zhang, D., Wang, Y., Xu, L., . . . Xu, K. (2016). MicroRNA-150 negatively regulates the function of CD4(+) T cells through AKT3/Bim signaling pathway. CELLULAR IMMUNOLOGY, 306, 35-40. doi:10.1016/j.cellimm.2016.05.007


LeBlanc, F. R., Liu, X., Hengst, J., Fox, T., Calvert, V., III, P. E. F., . . . Jr, L. T. P. (2015). Sphingosine kinase inhibitors decrease viability and induce cell death in natural killer-large granular lymphocyte leukemia. CANCER BIOLOGY & THERAPY, 16(12), 1830-1840. doi:10.1080/15384047.2015.1078949

Sang, W., Zhang, C., Zhang, D., Wang, Y., Sun, C., Niu, M., . . . Xu, K. (2015). MicroRNA-181a, a potential diagnosis marker, alleviates acute graft versus host disease by regulating IFN- production. AMERICAN JOURNAL OF HEMATOLOGY, 90(11), 998-1007. doi:10.1002/ajh.24136

Morad, S. A. F., Davis, T. S., Kester, M., Jr, L. T. P., & Cabot, M. C. (2015). Dynamics of ceramide generation and metabolism in response to fenretinide - Diversity within and among leukemia. LEUKEMIA RESEARCH, 39(10), 1071-1078. doi:10.1016/j.leukres.2015.06.009

Morad, S. A. F., Tan, S. -F., Feith, D. J., Kester, M., Claxton, D. F., Jr, L. T. P., . . . Cabot, M. C. (2015). Modification of sphingolipid metabolism by tamoxifen and N-desmethyltamoxifen in acute myelogenous leukemia-Impact on enzyme activity and response to cytotoxics. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1851(7), 919-928. doi:10.1016/j.bbalip.2015.03.001

Hasanali, Z. S., Saroya, B. S., Stuart, A., Shimko, S., Evans, J., Shah, M. V., . . . Epner, E. M. (2015). Epigenetic therapy overcomes treatment resistance in T cell prolymphocytic leukemia. SCIENCE TRANSLATIONAL MEDICINE, 7(293). doi:10.1126/scitranslmed.aaa5079

Steinway, S. N., Biggs, M. B., Jr, L. T. P., Papin, J. A., & Albert, R. (2015). Inference of Network Dynamics and Metabolic Interactions in the Gut Microbiome. PLOS COMPUTATIONAL BIOLOGY, 11(6). doi:10.1371/journal.pcbi.1004338

Jr, L. T. P., Zickl, L., Olson, T. L., Wang, V., Zhang, D., Rajala, H. L. M., . . . Tallman, M. S. (2015). Immunosuppressive therapy of LGL leukemia: prospective multicenter phase II study by the Eastern Cooperative Oncology Group (E5998). LEUKEMIA, 29(4), 886-894. doi:10.1038/leu.2014.298

Dick, T. E., Hengst, J. A., Fox, T. E., Colledge, A. L., Kale, V. P., Sung, S. -S., . . . Yun, J. K. (2015). The Apoptotic Mechanism of Action of the Sphingosine Kinase 1 Selective Inhibitor SKI-178 in Human Acute Myeloid Leukemia Cell Lines. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 352(3), 494-508. doi:10.1124/jpet.114.219659

Murphy, P. W., Brett, L. K., Verla-Tebit, E., Macik, B. G., & Jr, L. T. P. (2015). Acquired inhibitors to factor VIII and fibrinogen in the setting of T-cell large granular lymphocyte leukemia: a case report and review of the literature. BLOOD COAGULATION & FIBRINOLYSIS, 26(2), 211-213. doi:10.1097/MBC.0000000000000209

Ratan, A., Olson, T. L., Jr, L. T. P., & Miller, W. (2015). Identification of indels in next-generation sequencing data. BMC BIOINFORMATICS, 16. doi:10.1186/s12859-015-0483-6

Perzova, R., Graziano, E., Sanghi, S., Welch, C., Benz, P., Abbott, L., . . . Poiesz, B. J. (2015). Increased Seroreactivity to Human T Cell Lymphoma/Leukemia Virus-Related Endogenous Sequence-1 Gag Peptides in Patients with Human T Cell Lymphoma/Leukemia Virus Myelopathy. AIDS RESEARCH AND HUMAN RETROVIRUSES, 31(2), 242-249. doi:10.1089/aid.2014.0171

Sun, X., Hasanali, Z. S., Chen, A., Zhang, D., Liu, X., Wang, H. -G., . . . Xu, K. (2015). Suberoylanilide hydroxamic acid (SAHA) and cladribine synergistically induce apoptosis in NK-LGL leukaemia. BRITISH JOURNAL OF HAEMATOLOGY, 168(3), 371-383. doi:10.1111/bjh.13143

Ren, T., Takahashi, Y., Liu, X., Loughran, T. P., Sun, S. -C., Wang, H. -G., & Cheng, H. (2015). HTLV-1 Tax deregulates autophagy by recruiting autophagic molecules into lipid raft microdomains. ONCOGENE, 34(3), 373-384. doi:10.1038/onc.2013.552

Steinway, S. N., Zanudo, J. G. T., Michel, P. J., Feith, D. J., Loughran, T. P., & Albert, R. (2015). Combinatorial interventions inhibit TGF beta-driven epithelial-to-mesenchymal transition and support hybrid cellular phenotypes. NPJ SYSTEMS BIOLOGY AND APPLICATIONS, 1. doi:10.1038/npjsba.2015.14

LeBlanc, F. R., & Jr, L. T. P. (2015). Large granular lymphocyte leukemia: clinical background, molecular pathogenesis and treatment. EXPERT OPINION ON ORPHAN DRUGS, 3(8), 859-867. doi:10.1517/21678707.2015.1062362

Yan, Y., Olson, T. L., Nyland, S. B., Feith, D. J., & Loughran, T. P. (2015). Emergence of a STAT3 mutated NK clone in LGL leukemia.. Leukemia research reports, 4(1), 4-7. doi:10.1016/j.lrr.2014.12.001

Rajala, H. L. M., Olson, T., Clemente, M. J., Lagstrom, S., Ellonen, P., Lundan, T., . . . Mustjoki, S. (2015). The analysis of clonal diversity and therapy responses using STAT3 mutations as a molecular marker in large granular lymphocytic leukemia. HAEMATOLOGICA, 100(1), 91-99. doi:10.3324/haematol.2014.113142


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Hasanali, Z., Sharma, K., Shimko, S., Stuart, A., Liu, X., Epner, E. E., & Loughran, T. P. (2012). Epigenetically induced expression of CD30 in T-PLL: A rationale for the use of brentuximab vedotin. JOURNAL OF CLINICAL ONCOLOGY, 30(15). Retrieved from

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Saadatpour, A., Wang, R. -S., Liao, A., Liu, X., Loughran, T. P., Albert, I., & Albert, R. (2011). Dynamical and Structural Analysis of a T Cell Survival Network Identifies Novel Candidate Therapeutic Targets for Large Granular Lymphocyte Leukemia. PLOS COMPUTATIONAL BIOLOGY, 7(11). doi:10.1371/journal.pcbi.1002267

Clemente, M. J., Wlodarski, M. W., Makishima, H., Viny, A. D., Bretschneider, I., Shaik, M., . . . Maciejewski, J. P. (2011). Clonal drift demonstrates unexpected dynamics of the T-cell repertoire in T-large granular lymphocyte leukemia. BLOOD, 118(16), 4384-4393. doi:10.1182/blood-2011-02-338517

Liao, A., Broeg, K., Fox, T., Tan, S. -F., Watters, R., Shah, M. V., . . . Liu, X. (2011). Therapeutic efficacy of FTY720 in a rat model of NK-cell leukemia. BLOOD, 118(10), 2793-2800. doi:10.1182/blood-2011-01-331447

Liu, X., & Jr, L. T. P. (2011). The spectrum of large granular lymphocyte leukemia and Felty's syndrome. CURRENT OPINION IN HEMATOLOGY, 18(4), 254-259. doi:10.1097/MOH.0b013e32834760fb

Barth, B. M., Altinoglu, E. I., Shanmugavelandy, S. S., Kaiser, J. M., Crespo-Gonzalez, D., DiVittore, N. A., . . . Kester, M. (2011). Targeted Indocyanine-Green-Loaded Calcium Phosphosilicate Nanoparticles for In Vivo Photodynamic Therapy of Leukemia. ACS NANO, 5(7), 5325-5337. doi:10.1021/nn2005766

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Yu, J., Mitsui, T., Wei, M., Mao, H., Butchar, J. P., Shah, M. V., . . . Caligiuri, M. A. (2011). NKp46 identifies an NKT cell subset susceptible to leukemic transformation in mouse and human. JOURNAL OF CLINICAL INVESTIGATION, 121(4), 1456-1470. doi:10.1172/JCI43242

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Ryland, L. K., Fox, T. E., Liu, X., Loughran, T. P., & Kester, M. (2011). Dysregulation of sphingolipid metabolism in cancer. CANCER BIOLOGY & THERAPY, 11(2), 138-149. doi:10.4161/cbt.11.2.14624

Campbell, C., Zhang, R., Haley, J. S., Liu, X., Loughran, T., Schell, T. D., . . . Thakar, J. (2011). Why do CD8+T cells become indifferent to tumors: a dynamic modeling approach. FRONTIERS IN PHYSIOLOGY, 2. doi:10.3389/fphys.2011.00032

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Liu, X., Ryland, L., Yang, J., Liao, A., Aliaga, C., Watts, R., . . . Jr, L. T. P. (2010). Targeting of survivin by nanoliposomal ceramide induces complete remission in a rat model of NK-LGL leukemia. BLOOD, 116(20), 4192-4201. doi:10.1182/blood-2010-02-271080

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Abbi, K. K. S., Rizvi, S. M., Sivik, J., Thyagarajan, S., Loughran, T., & Drabick, J. J. (2010). Guillain-Barre syndrome after use of alemtuzumab (Campath) in a patient with T-cell prolymphocytic leukemia: A case report and review of the literature. LEUKEMIA RESEARCH, 34(7), E154-E156. doi:10.1016/j.leukres.2010.02.036

Abbi, K. K., Wagner, H., Drabick, J. J., Loughran, T. P., & Talamo, G. (2010). The role of radiation therapy for multiple myeloma in the era of novel agents. JOURNAL OF CLINICAL ONCOLOGY, 28(15). doi:10.1200/jco.2010.28.15_suppl.e18557

Sekeres, M. A., List, A. F., Cuthbertson, D., Paquette, R., Ganetsky, R., Latham, D., . . . Maciejewski, J. P. (2010). Phase I Combination Trial of Lenalidomide and Azacitidine in Patients With Higher-Risk Myelodysplastic Syndromes. JOURNAL OF CLINICAL ONCOLOGY, 28(13), 2253-2258. doi:10.1200/JCO.2009.26.0745

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Pastor, D. M., Eggers, A. D., Drabick, J. J., Loughran, T. P., Bayerl, M. G., & Shope, T. R. (2010). Retroperitoneal Diffuse Large B-Cell Lymphoma Presenting As Pseudoachalasia. JOURNAL OF CLINICAL ONCOLOGY, 28(12), E184-E187. doi:10.1200/JCO.2009.25.8715

Talamo, G., Barochia, A., Zangari, M., & Loughran, T. P. (2010). Multiple myeloma presenting as CEA-producing rectal cancer.. Rare tumors, 2(1), e4. doi:10.4081/rt.2010.e4

Yang, J., Liu, X., Nyland, S. B., Zhang, R., Ryland, L. K., Broeg, K., . . . Jr, L. T. P. (2010). Platelet-derived growth factor mediates survival of leukemic large granular lymphocytes via an autocrine regulatory pathway. BLOOD, 115(1), 51-60. doi:10.1182/blood-2009-06-223719

Thomas, A., Perzova, R., Abbott, L., Benz, P., Poiesz, M. J., Dube, S., . . . Poiesz, B. J. (2010). LGL Leukemia and HTLV. AIDS RESEARCH AND HUMAN RETROVIRUSES, 26(1), 33-40. doi:10.1089/aid.2009.0124

Wozney, J. L., Damluji, A. A., Ahmed, F., Zangari, M., Jr, L. T. P., & Talamo, G. (2010). Estimation of Daily Proteinuria in Patients with Multiple Myeloma by Using the Protein-to-Creatinine Ratio in Random Urine Samples. ACTA HAEMATOLOGICA, 123(4), 226-229. doi:10.1159/000313448