James C Zimring

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Primary Appointment

, Pathology

Education

  • BS, Emory University
  • MD, Emory University
  • PhD, Emory University

Research Disciplines

Experimental Pathology, Immunology, Metabolism, Microbiology

Research Interests

Alloimmunity in Transfusion and Transplantation , Oxidant Stress Biology in Health and Disease

Research Description

Alloimmunity in Transfusion and Transplantation , Oxidant Stress Biology in Health and Disease

Training

  • Interdisciplinary Training Program in Immunology

Selected Publications

2022

Jash, A., Hay, A. M., Collins, J. B., Heo, J., Luckey, C. J., Hudson, K. E., & Zimring, J. C. (2022). The role of RBC antigen transgene integration sites on RBC biology in mice.. Transfusion. doi:10.1111/trf.17197

Jash, A., Howie, H. L., Hay, A. M., Luckey, C. J., Hudson, K. E., Thomson, P. C., . . . Zimring, J. C. (2022). Identification of multiple genetic loci associated with RBC alloimmunization in mice.. Haematologica. doi:10.3324/haematol.2022.281767

Zimring, J. C., Spitalnik, S. L., & Hudson, K. E. (2022). The senescent antigen hypothesis of RBC evanescence: 50 years of correlation without causation. TRANSFUSION, 62(11), 2414-2415. doi:10.1111/trf.17095

Moriconi, C., Dzieciatkowska, M., Roy, M., D'Alessandro, A., Roingeard, P., Lee, J. Y., . . . Hudson, K. E. (2022). Retention of functional mitochondria in mature red blood cells from patients with sickle cell disease. BRITISH JOURNAL OF HAEMATOLOGY, 198(3), 574-586. doi:10.1111/bjh.18287

Soldatenko, A., Hoyt, L. R., Xu, L., Calabro, S., Lewis, S. M., Gallman, A. E., . . . Eisenbarth, S. C. (2022). Innate and Adaptive Immunity to Transfused Allogeneic RBCs in Mice Requires MyD88. JOURNAL OF IMMUNOLOGY, 208(4), 991-997. doi:10.4049/jimmunol.2100784

Thangaraju, K., Katneni, U., Akpan, I. J., Tanaka, K., Thomas, T., Setua, S., . . . Buehler, P. W. (2022). The Impact of Age and BMI on the VWF/ADAMTS13 Axis and Simultaneous Thrombin and Plasmin Generation in Hospitalized COVID-19 Patients. FRONTIERS IN MEDICINE, 8. doi:10.3389/fmed.2021.817305

Kim, C. Y., Johnson, H., Peltier, S., Spitalnik, S. L., Hod, E. A., Francis, R. O., . . . Thomas, T. (2022). Deuterated Linoleic Acid Attenuates the RBC Storage Lesion in a Mouse Model of Poor RBC Storage.. Frontiers in physiology, 13, 868578. doi:10.3389/fphys.2022.868578

2021

Issaian, A., Hay, A., Dzieciatkowska, M., Roberti, D., Perrotta, S., Darula, Z., . . . D'Alessandro, A. (2021). The interactome of the N-terminus of band 3 regulates red blood cell metabolism and storage quality. HAEMATOLOGICA, 106(11), 2971-2985. doi:10.3324/haematol.2020.278252

Hay, A. M., Howie, H. L., Gorham, J. D., D'Alessandro, A., Spitalnik, S. L., Hudson, K. E., & Zimring, J. C. (2021). Mouse background genetics in biomedical research: The devil's in the details. TRANSFUSION, 61(10), 3017-3025. doi:10.1111/trf.16628

D'Alessandro, A., Hay, A., Dzieciatkowska, M., Brown, B. C., Morrison, E. J., Hansen, K. C., & Zimring, J. C. (2021). Protein-L-isoaspartate O-methyltransferase is required for in vivo control of oxidative damage in red blood cells. HAEMATOLOGICA, 106(10), 2726-2739. doi:10.3324/haematol.2020.266676

D'Alessandro, A., Thomas, T., Akpan, I. J., Reisz, J. A., Cendali, F. I., Gamboni, F., . . . Francis, R. O. (2021). Biological and Clinical Factors Contributing to the Metabolic Heterogeneity of Hospitalized Patients with and without COVID-19. CELLS, 10(9). doi:10.3390/cells10092293

D'Alessandro, A., Howie, H. L., Hay, A. M., Dziewulska, K. H., Brown, B. C., Wither, M. J., . . . Zimring, J. C. (2021). Hematologic and systemic metabolic alterations due to Mediterranean class II G6PD deficiency in mice. JCI INSIGHT, 6(14). doi:10.1172/jci.insight.147056

Medved, J., Knott, B. M., Tarrah, S. N., Li, A. N., Shah, N., Moscovich, T. C., . . . Luckey, C. J. (2021). The lysophospholipid-binding molecule CD1D is not required for the alloimmunization response to fresh or stored RBCs in mice despite RBC storage driving alterations in lysophospholipids. TRANSFUSION, 61(7), 2169-2178. doi:10.1111/trf.16554

Escamilla-Rivera, V., Santhanakrishnan, M., Liu, J., Gibb, D. R., Forsmo, J. E., Foxman, E. F., . . . Hendrickson, J. E. (2021). Complement Plays a Critical Role in Inflammation-Induced Immunoprophylaxis Failure in Mice. FRONTIERS IN IMMUNOLOGY, 12. doi:10.3389/fimmu.2021.704072

Thomas, T., Cendali, F., Fu, X., Gamboni, F., Morrison, E. J., Beirne, J., . . . D'Alessandro, A. (2021). Fatty acid desaturase activity in mature red blood cells and implications for blood storage quality. TRANSFUSION, 61(6), 1867-1883. doi:10.1111/trf.16402

D'Alessandro, A., Akpan, I., Thomas, T., Reisz, J., Cendali, F., Gamboni, F., . . . Francis, R. (2021). Biological and Clinical Factors contributing to the Metabolic Heterogeneity of Hospitalized Patients with and without COVID-19.. Res Sq. doi:10.21203/rs.3.rs-480167/v1

Alessandro, A. D., Fu, X., Kanias, T., Reisz, J. A., Culp-Hill, R., Guo, Y., . . . Zimring, J. C. (2021). Donor sex, age and ethnicity impact stored red blood cell antioxidant metabolism through mechanisms in part explained by glucose 6-phosphate dehydrogenase levels and activity. HAEMATOLOGICA, 106(5), 1290-1302. doi:10.3324/haematol.2020.246603

Jash, A., Usaneerungrueng, C., Howie, H. L., Qiu, A., Luckey, C. J., Zimring, J. C., & Hudson, K. E. (2021). Antibodies to Low-Copy Number RBC Alloantigen Convert a Tolerogenic Stimulus to an Immunogenic Stimulus in Mice. FRONTIERS IN IMMUNOLOGY, 12. doi:10.3389/fimmu.2021.629608

Poston, J. N., Jash, A., Hannan, L. M., Hay, A. M., Usaneerungrueng, C., Howie, H. L., . . . Zimring, J. C. (2021). In utero exposure to alloantigens primes alloimmunization to platelet transfusion in mice. TRANSFUSION, 61(3), 687-691. doi:10.1111/trf.16224

Nemkov, T., Stefanoni, D., Bordbar, A., Issaian, A., Palsson, B. O., Dumont, L. J., . . . Evalu, R. E. D. (2021). Blood donor exposome and impact of common drugs on red blood cell metabolism. JCI INSIGHT, 6(3). doi:10.1172/jci.insight.146175

D'Alessandro, A., Stefanoni, D., Slichter, S. J., Fu, X., & Zimring, J. C. (2021). The impact of donor sex and age on stored platelet metabolism and post-transfusion recovery. BLOOD TRANSFUSION, 19(3), 216-223. doi:10.2450/2020.0145-20

2020

Thomas, T., Stefanoni, D., Dzieciatkowska, M., Issaian, A., Nemkov, T., Hill, R. C., . . . D'Alessandro, A. (2020). Evidence of Structural Protein Damage and Membrane Lipid Remodeling in Red Blood Cells from COVID-19 Patients. JOURNAL OF PROTEOME RESEARCH, 19(11), 4455-4469. doi:10.1021/acs.jproteome.0c00606

D'Alessandro, A., Thomas, T., Dzieciatkowska, M., Hill, R. C., Francis, R. O., Hudson, K. E., . . . Hansen, K. C. (2020). Serum Proteomics in COVID-19 Patients: Altered Coagulation and Complement Status as a Function of IL-6 Level. JOURNAL OF PROTEOME RESEARCH, 19(11), 4417-4427. doi:10.1021/acs.jproteome.0c00365

Cleary, S. J., Kwaan, N., Tian, J. J., Calabrese, D. R., Mallavia, B., Magnen, M., . . . Looney, M. R. (2020). Complement activation on endothelium initiates antibody-mediated acute lung injury. JOURNAL OF CLINICAL INVESTIGATION, 130(11), 5909-5923. doi:10.1172/JCI138136

Temming, A. R., Bentlage, A. E. H., de Taeye, S. W., Bosman, G. P., Lissenberg-Thunnissen, S. N., Derksen, N. I. L., . . . Vidarsson, G. (2020). Cross-reactivity of mouse IgG subclasses to human Fc gamma receptors: Antibody deglycosylation only eliminates IgG2b binding. MOLECULAR IMMUNOLOGY, 127, 79-86. doi:10.1016/j.molimm.2020.08.015

Bertolone, L., Shin, H. K., Stefanoni, D., Baek, J. H., Gao, Y., Morrison, E. J., . . . D'Alessandro, A. (2020). ZOOMICS: Comparative Metabolomics of Red Blood Cells From Old World Monkeys and Humans. FRONTIERS IN PHYSIOLOGY, 11. doi:10.3389/fphys.2020.593841

Zimring, J. C. (2020). Turning over a new leaf on turning over RBCs. BLOOD, 136(14), 1569-1570. doi:10.1182/blood.2020008463

Stefanoni, D., Shin, H. K. H., Baek, J. H., Champagne, D. P., Nemkov, T., Thomas, T., . . . D'Alessandro, A. (2020). Red blood cell metabolism in Rhesus macaques and humans: comparative biology of blood storage. HAEMATOLOGICA, 105(8), 2174-2186. doi:10.3324/haematol.2019.229930

Thomas, T., Stefanoni, D., Reisz, J. A., Nemkov, T., Bertolone, L., Francis, R. O., . . . D'Alessandro, A. (2020). COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status. JCI INSIGHT, 5(14). doi:10.1172/jci.insight.140327

Shinde, P., Howie, H. L., Stegmann, T. C., Hay, A. M., Waterman, H. R., Szittner, Z., . . . Zimring, J. C. (2020). IgG Subclass Determines Suppression Versus Enhancement of Humoral Alloimmunity to Kell RBC Antigens in Mice. FRONTIERS IN IMMUNOLOGY, 11. doi:10.3389/fimmu.2020.01516

D'Alessandro, A., Fu, X., Reisz, J. A., Kanias, T., Page, G. P., Stone, M., . . . Evalu, R. E. D. (2020). Stored RBC metabolism as a function of caffeine levels. TRANSFUSION, 60(6), 1197-1211. doi:10.1111/trf.15813

D'Alessandro, A., Fu, X., Reisz, J. A., Stone, M., Kleinman, S., Zimring, J. C., . . . Evalu, R. E. D. (2020). Ethyl glucuronide, a marker of alcohol consumption, correlates with metabolic markers of oxidant stress but not with hemolysis in stored red blood cells from healthy blood donors. TRANSFUSION, 60(6), 1183-1196. doi:10.1111/trf.15811

Stefanoni, D., Fu, X., Reisz, J. A., Kanias, T., Nemkov, T., Page, G. P., . . . Evalu, R. E. D. (2020). Nicotine exposure increases markers of oxidant stress in stored red blood cells from healthy donor volunteers. TRANSFUSION, 60(6), 1160-1174. doi:10.1111/trf.15812

Bertolone, L., Roy, M. K., Hay, A. M., Morrison, E. J., Stefanoni, D., Fu, X., . . . D'Alessandro, A. (2020). Impact of taurine on red blood cell metabolism and implications for blood storage. TRANSFUSION, 60(6), 1212-1226. doi:10.1111/trf.15810

Escamilla-Rivera, V., Liu, J., Gibb, D. R., Santhanakrishnan, M., Liu, D., Forsmo, J. E., . . . Hendrickson, J. E. (2020). Poly(I:C) causes failure of immunoprophylaxis to red blood cells expressing the KEL glycoprotein in mice. BLOOD, 135(22), 1983-1993. doi:10.1182/blood.2020005018

Howie, H. L., Collins, B., Xiaohong, W., Kapp, L., Delaney, M., Er, L. S., . . . Zimring, J. C. (2020). Characterization and refinement of monoclonal anti-human globulins that lack reactivity with human IgG4. TRANSFUSION, 60(5), 1060-1068. doi:10.1111/trf.15796

Francis, R. O., D'Alessandro, A., Eisenberger, A., Soffing, M., Yeh, R., Coronel, E., . . . Hod, E. A. (2020). Donor glucose-6-phosphate dehydrogenase deficiency decreases blood quality for transfusion. JOURNAL OF CLINICAL INVESTIGATION, 130(5), 2270-2285. doi:10.1172/JCI133530

Catala, A., Youssef, L. A., Reisz, J. A., Dzieciatkowska, M., Powers, N. E., Marchetti, C., . . . D'Alessandro, A. (2020). Metabolic Reprogramming of Mouse Bone Marrow Derived Macrophages Following Erythrophagocytosis. FRONTIERS IN PHYSIOLOGY, 11. doi:10.3389/fphys.2020.00396

Gruber, D. R., Richards, A. L., Howie, H. L., Hay, A. M., Lebedev, J. N., Wang, X., . . . Hudson, K. E. (2020). Passively transferred IgG enhances humoral immunity to a red blood cell alloantigen in mice. BLOOD ADVANCES, 4(7), 1526-1537. doi:10.1182/bloodadvances.2019001299

Cen, S. Y., Holton, M. B., Binnington, B., Denomme, G. A., Howie, H. L., Lebedev, J. N., . . . Branch, D. R. (2020). IgG3 anti-Kell allotypic variation results in differential antigen binding and phagocytosis. TRANSFUSION, 60(4), 688-693. doi:10.1111/trf.15663

Zimring, J. C. (2020). Scientifically Thinking: How to Liberate Your Mind, Solve the World's Problems, and Embrace the Beauty of Science. AMERICAN JOURNAL OF PSYCHOLOGY, 133(4), 512-517. doi:10.5406/amerjpsyc.133.4.0512

2019

Temming, A. R., de Taeye, S. W., de Graaf, E. L., de Neef, L. A., Dekkers, G., Bruggeman, C. W., . . . Vidarsson, G. (2019). Functional Attributes of Antibodies, Effector Cells, and Target Cells Affecting NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity. JOURNAL OF IMMUNOLOGY, 203(12), 3126-3135. doi:10.4049/jimmunol.1900985

Zimring, J. C. (2019). The Pragmatic Truth of Scientific Claims. SCIENTIST, 33(12), 60. Retrieved from https://www.webofscience.com/

Howie, H. L., Hay, A. M., de Wolski, K., Waterman, H., Lebedev, J., Fu, X., . . . Zimring, J. C. (2019). Differences in Steap3 expression are a mechanism of genetic variation of RBC storage and oxidative damage in mice. BLOOD ADVANCES, 3(15), 2272-2285. doi:10.1182/bloodadvances.2019000605

Francis, R. O., Mahajan, S., Rapido, F., La Carpia, F., Soffing, M., Divgi, C., . . . Hod, E. A. (2019). Reexamination of the chromium-51-labeled posttransfusion red blood cell recovery method. TRANSFUSION, 59(7), 2264-2275. doi:10.1111/trf.15310

Morrison, E. J., Champagne, D. P., Dzieciatkowska, M., Nemkov, T., Zimring, J. C., Hansen, K. C., . . . D'Alessandro, A. (2019). Parabiosis Incompletely Reverses Aging-Induced Metabolic Changes and Oxidant Stress in Mouse Red Blood Cells. NUTRIENTS, 11(6). doi:10.3390/nu11061337

D'Alessandro, A., Zimring, J. C., & Busch, M. (2019). Chronological storage age and metabolic age of stored red blood cells: are they the same?. TRANSFUSION, 59(5), 1620-1623. doi:10.1111/trf.15248

Hudson, K. E., Wong, A. S. L., Richards, A. L., Kapp, L. M., & Zimring, J. C. (2019). Alloimmunogenicity of an isolated MHC allele is affected by the context of MHC mismatch in a murine model. TRANSFUSION, 59(2), 744-753. doi:10.1111/trf.15109

D'Alessandro, A., Hansen, K. C., Eisenmesser, E. Z., & Zimring, J. C. (2019). Protect, repair, destroy or sacrifice: a role of oxidative stress biology in inter-donor variability of blood storage?. BLOOD TRANSFUSION, 17(4), 281-288. doi:10.2450/2019.0072-19

D'Alessandro, A., Culp-Hill, R., Reisz, J. A., Anderson, M., Fu, X., Nemkov, T., . . . Donor, R. E. (2019). Heterogeneity of blood processing and storage additives in different centers impacts stored red blood cell metabolism as much as storage time: lessons from REDS-III-Omics. TRANSFUSION, 59(1), 89-100. doi:10.1111/trf.14979

Stone, M., Keating, S. M., Kanias, T., Lanteri, M. C., Lebedeva, M., Sinchar, D., . . . Inst, N. H. L. B. (2019). Piloting and implementation of quality assessment and quality control procedures in RBC-Omics: a large multi-center study of red blood cell hemolysis during storage. TRANSFUSION, 59(1), 57-66. doi:10.1111/trf.15099

2018

Reisz, J. A., Nemkov, T., Dzieciatkowska, M., Culp-Hill, R., Stefanoni, D., Hill, R. C., . . . D'Alessandro, A. (2018). Methylation of protein aspartates and deamidated asparagines as a function of blood bank storage and oxidative stress in human red blood cells. TRANSFUSION, 58(12), 2978-2991. doi:10.1111/trf.14936

Karafin, M. S., Fu, X., D'Alessandro, A., Thomas, T., Hod, E. A., Zimring, J. C., . . . Francis, R. O. (2018). The clinical impact of glucose-6-phosphate dehydrogenase deficiency in patients with sickle cell disease. CURRENT OPINION IN HEMATOLOGY, 25(6), 494-499. doi:10.1097/MOH.0000000000000455

Howie, H. L., Wang, X., Kapp, L., Lebedev, J. N., & Zimring, J. C. (2018). Identification of IgG3-specific epitope that remedies problem in diagnostic IgG subclass determination due to human genetic variation. JOURNAL OF CLINICAL PATHOLOGY, 71(6), 559-561. doi:10.1136/jclinpath-2018-205001

Gunasekera, D., Zimring, J. C., & Pratt, K. P. (2018). A unique major histocompatibility complex Class II-binding register correlates with HLA-DR11-associated immunogenicity of the major K blood group antigen. TRANSFUSION, 58(5), 1171-1181. doi:10.1111/trf.14525

Hosoba, S., Waller, E. K., Shenvi, N., Graiser, M., Easley, K. A., Al-Kadhimi, Z., . . . Giver, C. R. (2018). Peritransplantation Red Blood Cell Transfusion Is Associated with Increased Risk of Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 24(5), 973-982. doi:10.1016/j.bbmt.2018.01.003

Howie, H. L., Wang, X., Kapp, L., Lebedev, J., Hudson, K. E., & Zimring, J. C. (2018). Common murine immunoglobulin detection reagents have diminished reactivity with IgG3-A vulnerability to misinterpretation. JOURNAL OF IMMUNOLOGICAL METHODS, 455, 10-13. doi:10.1016/j.jim.2018.01.011

Nemkov, T., Sun, K., Reisz, J. A., Song, A., Yoshida, T., Dunham, A., . . . D'Alessandro, A. (2018). Hypoxia modulates the purine salvage pathway and decreases red blood cell and supernatant levels of hypoxanthine during refrigerated storage. HAEMATOLOGICA, 103(2), 361-372. doi:10.3324/haematol.2017.178608

Gibb, D., Liu, J., Natarajan, P., Santhanakrishnan, M., Madrid, D., Eisenbarth, S., . . . Hendrickson, J. (2018). 1 Type I Interferon Is Necessary and Sufficient for Alloimmunization to Transfused KEL-Expressing RBCs in Mice. American Journal of Clinical Pathology, 149(suppl_1), S163. doi:10.1093/ajcp/aqx149.370

Vostal, J. G., Buehler, P. W., Gelderman, M. P., Alayash, A. I., Doctor, A., Zimring, J. C., . . . Ness, P. M. (2018). Proceedings of the Food and Drug Administration's public workshop on new red blood cell product regulatory science 2016. TRANSFUSION, 58(1), 255-266. doi:10.1111/trf.14435

Nemkov, T., Reisz, J. A., Xia, Y., Zimring, J. C., & D'Alessandro, A. (2018). Red blood cells as an organ? How deep omics characterization of the most abundant cell in the human body highlights other systemic metabolic functions beyond oxygen transport. EXPERT REVIEW OF PROTEOMICS, 15(11), 855-864. doi:10.1080/14789450.2018.1531710

2017

Richards, A. L., Howie, H. L., Kapp, L. M., Hendrickson, J. E., Zimring, J. C., & Hudson, K. E. (2017). Innate B-1 B Cells Are Not Enriched in Red Blood Cell Autoimmune Mice: Importance of B Cell Receptor Transgenic Selection. FRONTIERS IN IMMUNOLOGY, 8. doi:10.3389/fimmu.2017.01366

Hay, A., Howie, H. L., Waterman, H. R., de Wolski, K., & Zimring, J. C. (2017). Murine red blood cells from genetically distinct donors cross-regulate when stored together. TRANSFUSION, 57(11), 2657-2664. doi:10.1111/trf.14313

Hudson, K. E., de Wolski, K., Kapp, L. M., Richards, A. L., Schniederjan, M. J., & Zimring, J. C. (2017). Antibodies to Senescent Antigen and C3 Are Not Required for Normal Red Blood Cell Lifespan in a Murine Model. FRONTIERS IN IMMUNOLOGY, 8. doi:10.3389/fimmu.2017.01425

Gibb, D. R., Liu, J., Natarajan, P., Santhanakrishnan, M., Madrid, D. J., Eisenbarth, S. C., . . . Hendrickson, J. E. (2017). Type I IFN Is Necessary and Sufficient for Inflammation-Induced Red Blood Cell Alloimmunization in Mice. JOURNAL OF IMMUNOLOGY, 199(3), 1041-1050. doi:10.4049/jimmunol.1700401

Howie, H. L., Delaney, M., Wang, X., Er, L. S., Kapp, L., Lebedev, J. N., & Zimring, J. C. (2017). Errors in data interpretation from genetic variation of human analytes. JCI INSIGHT, 2(13). doi:10.1172/jci.insight.94532

Arthur, C. M., Patel, S. R., Smith, N. H., Bennett, A., Kamili, N. A., Mener, A., . . . Stowell, S. R. (2017). Antigen Density Dictates Immune Responsiveness following Red Blood Cell Transfusion. JOURNAL OF IMMUNOLOGY, 198(7), 2671-2680. doi:10.4049/jimmunol.1601736

Bandyopadhyay, S., Brittenham, G. M., Francis, R. O., Zimring, J. C., Hod, E. A., & Spitalnik, S. L. (2017). Iron-deficient erythropoiesis in blood donors and red blood cell recovery after transfusion: initial studies with a mouse model. BLOOD TRANSFUSION, 15(2), 158-164. doi:10.2450/2017.0349-16

Zimring, J. C., & Spitalnik, S. L. (2017). Large retrospective effects, clear differences in animals, and multiple negative randomised controlled trials: this is exactly how it is supposed to work. BLOOD TRANSFUSION, 15(2), 104-106. doi:10.2450/2017.0307-16

Dekkers, G., Bentlage, A. E. H., Stegmann, T. C., Howie, H. L., Lissenberg-Thunnissen, S., Zimring, J., . . . Vidarsson, G. (2017). Affinity of human IgG subclasses to mouse Fc gamma receptors. MABS, 9(5), 767-773. doi:10.1080/19420862.2017.1323159

2016

Howie, H. L., Delaney, M., Wang, X., Er, L. S., Vidarsson, G., Stegmann, T. C., . . . Zimring, J. C. (2016). Serological blind spots for variants of human IgG3 and IgG4 by a commonly used anti-immunoglobulin reagent. TRANSFUSION, 56(12), 2953-2962. doi:10.1111/trf.13812

Zimring, J. C., & Hudson, K. E. (2016). Cellular immune responses in red blood cell alloimmunization. HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM, 452-456. doi:10.1182/asheducation-2016.1.452

Arneja, A., Salazar, J. E., Jiang, W., Hendrickson, J. E., Zimring, J. C., & Luckey, C. J. (2016). Interleukin-6 receptor-alpha signaling drives anti-RBC alloantibody production and T-follicular helper cell differentiation in a murine model of red blood cell alloimmunization. HAEMATOLOGICA, 101(11), E440-E444. doi:10.3324/haematol.2016.149278

Fu, X., Felcyn, J. R., Odem-Davis, K., & Zimring, J. C. (2016). Bioactive lipids accumulate in stored red blood cells despite leukoreduction: a targeted metabolomics study. TRANSFUSION, 56(10), 2560-2570. doi:10.1111/trf.13748

Kanias, T., Sinchar, D., Osei-Hwedieh, D., Baust, J. J., Jordan, A., Zimring, J. C., . . . Gladwin, M. T. (2016). Testosterone-dependent sex differences in red blood cell hemolysis in storage, stress, and disease. TRANSFUSION, 56(10), 2571-2583. doi:10.1111/trf.13745

Zimring, J. C., Slichter, S., Odem-Davis, K., Felcyn, J. R., Kapp, L. M., Bell, L. N., . . . Fu, X. (2016). Metabolites in stored platelets associated with platelet recoveries and survivals. TRANSFUSION, 56(8), 1974-1983. doi:10.1111/trf.13631

Gibb, D. R., Calabro, S., Liu, D., Tormey, C. A., Spitalnik, S. L., Zimring, J. C., . . . Eisenbarth, S. C. (2016). The Nlrp3 Inflammasome Does Not Regulate Alloimmunization to Transfused Red Blood Cells in Mice. EBIOMEDICINE, 9, 77-86. doi:10.1016/j.ebiom.2016.06.008

Calabro, S., Gallman, A., Gowthaman, U., Liu, D., Chen, P., Liu, J., . . . Eisenbarth, S. C. (2016). Bridging channel dendritic cells induce immunity to transfused red blood cells. JOURNAL OF EXPERIMENTAL MEDICINE, 213(6), 887-896. doi:10.1084/jem.20151720

de Wolski, K., Fu, X., Dumont, L. J., Roback, J. D., Waterman, H., Odem-Davis, K., . . . Zimring, J. C. (2016). Metabolic pathways that correlate with post-transfusion circulation of stored murine red blood cells. HAEMATOLOGICA, 101(5), 578-586. doi:10.3324/haematol.2015.139139

Richards, A. L., Hendrickson, J. E., Zimring, J. C., & Hudson, K. E. (2016). Erythrophagocytosis by plasmacytoid dendritic cells and monocytes is enhanced during inflammation. TRANSFUSION, 56(4), 905-916. doi:10.1111/trf.13497

Waterman, H. R., Kapp, L. M., Munday, A., Odem-Davis, K., & Zimring, J. C. (2016). Transfusion-induced alloimmunization and platelet refractoriness in a mouse model: mechanisms and interventions. TRANSFUSION, 56(1), 91-100. doi:10.1111/trf.13270

2015

Stowell, S. R., Arthur, C. M., Girard-Pierce, K. R., Sullivan, H. C., Santhanakrishnan, M., Natarajan, P., . . . Hendrickson, J. E. (2015). Anti-KEL sera prevents alloimmunization to transfused KEL RBCs in a murine model. HAEMATOLOGICA, 100(10), E394-E397. doi:10.3324/haematol.2015.128603

Bernardo, L., Yu, H., Amash, A., Zimring, J. C., & Lazarus, A. H. (2015). IgG-Mediated Immune Suppression to Erythrocytes by Polyclonal Antibodies Can Occur in the Absence of Activating or Inhibitory Fc gamma Receptors in a Full Mouse Model. JOURNAL OF IMMUNOLOGY, 195(5), 2224-2230. doi:10.4049/jimmunol.1500790

Waterman, H. R., Kapp, L. M., Howie, H. L., Hod, E. A., Spitalnik, S. L., & Zimring, J. C. (2015). Analysis of 24-h recovery of transfused stored RBCs in recipient mice of distinct genetic backgrounds. VOX SANGUINIS, 109(2), 148-154. doi:10.1111/vox.12270

Zimring, J. C. (2015). Do immune complexes play a role in hemolytic sequelae of intravenous immune globulin?. TRANSFUSION, 55, S86-S89. doi:10.1111/trf.13158

Zimring, J. C. (2015). Widening our gaze of red blood storage haze: a role for metabolomics. TRANSFUSION, 55(6), 1139-1142. doi:10.1111/trf.13071

Zimring, J. C. (2015). Established and theoretical factors to consider in assessing the red cell storage lesion. BLOOD, 125(14), 2185-2190. doi:10.1182/blood-2014-11-567750

2014

Wojczyk, B. S., Kim, N., Bandyopadhyay, S., Francis, R. O., Zimring, J. C., Hod, E. A., & Spitalnik, S. L. (2014). Macrophages clear refrigerator storage-damaged red blood cells and subsequently secrete cytokines in vivo, but not in vitro, in a murine model. TRANSFUSION, 54(12), 3186-3197. doi:10.1111/trf.12755

Drury-Stewart, D. N., Lannert, K. W., Chung, D. W., Teramura, G. T., Zimring, J. C., Konkle, B. A., . . . Johnsen, J. M. (2014). Complex Changes in von Willebrand Factor-Associated Parameters Are Acquired during Uncomplicated Pregnancy. PLOS ONE, 9(11). doi:10.1371/journal.pone.0112935

Zimring, J. C. (2014). The fat and the skinny on acute lung injury. BLOOD, 124(17), 2617-2618. doi:10.1182/blood-2014-09-597732

Yu, H., Stowell, S. R., Bernardo, L., Hendrickson, J. E., Zimring, J. C., Amash, A., . . . Lazarus, A. H. (2014). Antibody-Mediated Immune Suppression of Erythrocyte Alloimmunization Can Occur Independently from Red Cell Clearance or Epitope Masking in a Murine Model. JOURNAL OF IMMUNOLOGY, 193(6), 2902-2910. doi:10.4049/jimmunol.1302287

Roback, J. D., Josephson, C. D., Waller, E. K., Newman, J. L., Karatela, S., Uppal, K., . . . Dumont, L. J. (2014). Metabolomics of ADSOL (AS-1) Red Blood Cell Storage. TRANSFUSION MEDICINE REVIEWS, 28(2), 41-55. doi:10.1016/j.tmrv.2014.01.003

Stowell, S. R., Girard-Pierce, K. R., Smith, N. H., Henry, K. L., Arthur, C. M., Zimring, J. C., & Hendrickson, J. E. (2014). Transfusion of murine red blood cells expressing the human KEL glycoprotein induces clinically significant alloantibodies. TRANSFUSION, 54(1), 179-189. doi:10.1111/trf.12217

Zimring, J. C., Smith, N., Stowell, S. R., Johnsen, J. M., Bell, L. N., Francis, R. O., . . . Spitalnik, S. L. (2014). Strain-specific red blood cell storage, metabolism, and eicosanoid generation in a mouse model. TRANSFUSION, 54(1), 137-148. doi:10.1111/trf.12264

Ryder, A. B., Zimring, J. C., & Hendrickson, J. E. (2014). Factors Influencing RBC Alloimmunization: Lessons Learned from Murine Models. TRANSFUSION MEDICINE AND HEMOTHERAPY, 41(6), 406-419. doi:10.1159/000368995

2013

Zimring, J. C. (2013). Fresh versus old blood: are there differences and do they matter?. HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM, 651-655. doi:10.1182/asheducation-2013.1.651

Stowell, S. R., Liepkalns, J. S., Hendrickson, J. E., Girard-Pierce, K. R., Smith, N. H., Arthur, C. M., & Zimring, J. C. (2013). Antigen Modulation Confers Protection to Red Blood Cells from Antibody through Fc gamma Receptor Ligation. JOURNAL OF IMMUNOLOGY, 191(10), 5013-5025. doi:10.4049/jimmunol.1300885

Francis, R. O., Jhang, J. S., Pham, H. P., Hod, E. A., Zimring, J. C., & Spitalnik, S. L. (2013). Glucose-6-phosphate dehydrogenase deficiency in transfusion medicine: the unknown risks. VOX SANGUINIS, 105(4), 271-282. doi:10.1111/vox.12068

Blacken, G. R., Zimring, J. C., & Fu, X. (2013). Resolution of translation start site for the human Kell glycoprotein. TRANSFUSION, 53(11), 2882-2886. doi:10.1111/trf.12267

Zalpuri, S., Schonewille, H., Middelburg, R., van de Watering, L., de Vooght, K., Zimring, J., . . . Zwaginga, J. J. (2013). Effect of storage of red blood cells on alloimmunization. TRANSFUSION, 53(11), 2795-2800. doi:10.1111/trf.12156

Stowell, S. R., Smith, N. H., Zimring, J. C., Fu, X., Palmer, A. F., Fontes, J., . . . Yazer, M. H. (2013). Addition of ascorbic acid solution to stored murine red blood cells increases posttransfusion recovery and decreases microparticles and alloimmunization. TRANSFUSION, 53(10), 2248-2257. doi:10.1111/trf.12106

Zimring, J. C., & Spitalnik, S. L. (2013). On the appropriate use and interpretation of animal models in transfusion medicine research. TRANSFUSION, 53(10), 2334-2339. doi:10.1111/trf.12131

Patel, S. R., & Zimring, J. C. (2013). Transfusion-Induced Bone Marrow Transplant Rejection Due to Minor Histocompatibility Antigens. TRANSFUSION MEDICINE REVIEWS, 27(4), 241-248. doi:10.1016/j.tmrv.2013.08.002

Girard-Pierce, K. R., Stowell, S. R., Smith, N. H., Arthur, C. M., Sullivan, H. C., Hendrickson, J. E., & Zimring, J. C. (2013). A novel role for C3 in antibody-induced red blood cell clearance and antigen modulation. BLOOD, 122(10), 1793-1801. doi:10.1182/blood-2013-06-508952

Stowell, S. R., Henry, K. L., Smith, N. H., Hudson, K. E., Halverson, G. R., Park, J. C., . . . Hendrickson, J. E. (2013). Alloantibodies to a paternally derived RBC KEL antigen lead to hemolytic disease of the fetus/newborn in a murine model. BLOOD, 122(8), 1494-1504. doi:10.1182/blood-2013-03-488874

Zimring, J. C. (2013). Regulation of immune responses by RBC transfusion. ISBT Science Series, 8(1), 181-184. doi:10.1111/voxs.12042

Liepkalns, J. S., Cadwell, C. M., Stowell, S. R., Hod, E. A., Spitalnik, S. L., & Zimring, J. C. (2013). Resistance of a subset of red blood cells to clearance by antibodies in a mouse model of incompatible transfusion. TRANSFUSION, 53(6), 1319-1327. doi:10.1111/j.1537-2995.2012.03910.x

Francis, R. O., Jhang, J., Hendrickson, J. E., Zimring, J. C., Hod, E. A., & Spitalnik, S. L. (2013). Frequency of glucose-6-phosphate dehydrogenase-deficient red blood cell units in a metropolitan transfusion service. TRANSFUSION, 53(3), 606-611. doi:10.1111/j.1537-2995.2012.03765.x

Zimring, J. C. (2013). Location, location, location: advancing veto cell therapies. BLOOD, 121(7), 1069-1070. doi:10.1182/blood-2012-12-472654

2012

Hudson, K. E., Hendrickson, J. E., Cadwell, C. M., Iwakoshi, N. N., & Zimring, J. C. (2012). Partial tolerance of autoreactive B and T cells to erythrocyte-specific self-antigens in mice. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 97(12), 1836-1844. doi:10.3324/haematol.2012.065144

Liepkalns, J. S., Hod, E. A., Stowell, S. R., Cadwell, C. M., Spitalnik, S. L., & Zimring, J. C. (2012). Biphasic clearance of incompatible red blood cells through a novel mechanism requiring neither complement nor Fc gamma receptors in a murine model. TRANSFUSION, 52(12), 2631-2645. doi:10.1111/j.1537-2995.2012.03647.x

Smith, N. H., Henry, K. L., Cadwell, C. M., Bennett, A., Hendrickson, J. E., Frame, T., & Zimring, J. C. (2012). Generation of transgenic mice with antithetical KEL1 and KEL2 human blood group antigens on red blood cells. TRANSFUSION, 52(12), 2620-2630. doi:10.1111/j.1537-2995.2012.03641.x

Gilson, C. R., Patel, S. R., & Zimring, J. C. (2012). CTLA4-Ig prevents alloantibody production and BMT rejection in response to platelet transfusions in mice. TRANSFUSION, 52(10), 2209-2219. doi:10.1111/j.1537-2995.2011.03550.x

Zimring, J. C., & Johnsen, J. M. (2012). Keeping the Kell away from immunity. BLOOD, 119(23), 5346-5348. doi:10.1182/blood-2012-04-423947

Zimring, J. C., Stowell, S. R., Johnsen, J. M., & Hendrickson, J. E. (2012). Effects of genetic, epigenetic, and environmental factors on alloimmunization to transfused antigens: Current paradigms and future considerations. TRANSFUSION CLINIQUE ET BIOLOGIQUE, 19(3), 125-131. doi:10.1016/j.tracli.2012.03.002

Patel, S. R., Smith, N. H., Kapp, L., & Zimring, J. C. (2012). Mechanisms of Alloimmunization and Subsequent Bone Marrow Transplantation Rejection Induced by Platelet Transfusion in a Murine Model. AMERICAN JOURNAL OF TRANSPLANTATION, 12(5), 1102-1112. doi:10.1111/j.1600-6143.2011.03959.x

Gilson, C. R., & Zimring, J. C. (2012). Alloimmunization to transfused platelets requires priming of CD4+ T cells in the splenic microenvironment in a murine model. TRANSFUSION, 52(4), 849-859. doi:10.1111/j.1537-2995.2011.03346.x

Smith, N. H., Hod, E. A., Spitalnik, S. L., Zimring, J. C., & Hendrickson, J. E. (2012). Transfusion in the absence of inflammation induces antigen-specific tolerance to murine RBCs. BLOOD, 119(6), 1566-1569. doi:10.1182/blood-2011-09-382655

Hendrickson, J. E., Hod, E. A., Perry, J. R., Ghosh, S., Chappa, P., Adisa, O., . . . Zimring, J. C. (2012). Alloimmunization to transfused HOD red blood cells is not increased in mice with sickle cell disease. TRANSFUSION, 52(2), 231-240. doi:10.1111/j.1537-2995.2011.03255.x

Stowell, S. R., Winkler, A. M., Maier, C. L., Arthur, C. M., Smith, N. H., Girard-Pierce, K. R., . . . Hendrickson, J. E. (2012). Initiation and Regulation of Complement during Hemolytic Transfusion Reactions. CLINICAL & DEVELOPMENTAL IMMUNOLOGY. doi:10.1155/2012/307093

2011

Hod, E. A., Brittenham, G. M., Billote, G. B., Francis, R. O., Ginzburg, Y. Z., Hendrickson, J. E., . . . Spitalnik, S. L. (2011). Transfusion of human volunteers with older, stored red blood cells produces extravascular hemolysis and circulating non-transferrin-bound iron. BLOOD, 118(25), 6675-6682. doi:10.1182/blood-2011-08-371849

Hendrickson, J. E., Hod, E. A., Hudson, K. E., Spitalnik, S. L., & Zimring, J. C. (2011). Transfusion of fresh murine red blood cells reverses adverse effects of older stored red blood cells. TRANSFUSION, 51(12), 2695-2702. doi:10.1111/j.1537-2995.2011.03197.x

Hendrickson, J. E., Hod, E. A., Cadwell, C. M., Eisenbarth, S. C., Spiegel, D. A., Tormey, C. A., . . . Zimring, J. C. (2011). Rapid clearance of transfused murine red blood cells is associated with recipient cytokine storm and enhanced alloimmunogenicity. TRANSFUSION, 51(11), 2445-2454. doi:10.1111/j.1537-2995.2011.03162.x

Desmarets, M., Mylvaganam, G., Waller, E. K., Josephson, C. D., Pack, C., Lukacher, A. E., & Zimring, J. C. (2011). Minor Antigens on Transfused RBCs Crossprime CD8 T Cells but Do Not Induce Full Effector Function. AMERICAN JOURNAL OF TRANSPLANTATION, 11(9), 1825-1834. doi:10.1111/j.1600-6143.2011.03730.x

Zimring, J. (2011). Affirmative action in health care--the danger of waiting.. Health care law monthly, 2011(4), 2-10.

Josephson, C. D., Castillejo, M. -I., Caliendo, A. M., Waller, E. K., Zimring, J., Easley, K. A., . . . Roback, J. D. (2011). Prevention of Transfusion-Transmitted Cytomegalovirus in Low-Birth Weight Infants (<= 1500 g) Using Cytomegalovirus-Seronegative and Leukoreduced Transfusions. TRANSFUSION MEDICINE REVIEWS, 25(2), 125-132. doi:10.1016/j.tmrv.2010.11.004

Patel, S. R., Hendrickson, J. E., Smith, N. H., Cadwell, C. M., Ozato, K., III, M. H. C., . . . Zimring, J. C. (2011). Alloimmunization against RBC or PLT antigens is independent of TRIM21 expression in a murine model. MOLECULAR IMMUNOLOGY, 48(6-7), 909-913. doi:10.1016/j.molimm.2010.12.017

Zimring, J. C., Welniak, L., Semple, J. W., Ness, P. M., Slichter, S. J., Spitalnik, S. L., & Grp, N. H. L. B. I. A. W. (2011). Current problems and future directions of transfusion-induced alloimmunization: summary of an NHLBI working group. TRANSFUSION, 51(2), 435-441. doi:10.1111/j.1537-2995.2010.03024.x

2010

Hod, E. A., Arinsburg, S. A., Francis, R. O., Hendrickson, J. E., Zimring, J. C., & Spitalnik, S. L. (2010). Use of mouse models to study the mechanisms and consequences of RBC clearance. VOX SANGUINIS, 99(2), 99-111. doi:10.1111/j.1423-0410.2010.01327.x

Zimring, J. C. (2010). Recent Developments and Future Directions of Alloimmunization to Transfused Blood Products. CLINICS IN LABORATORY MEDICINE, 30(2), 467-+. doi:10.1016/j.cll.2010.02.012

Hod, E. A., Zhang, N., Sokol, S. A., Wojczyk, B. S., Francis, R. O., Ansaldi, D., . . . Spitalnik, S. L. (2010). Transfusion of red blood cells after prolonged storage produces harmful effects that are mediated by iron and inflammation. BLOOD, 115(21), 4284-4292. doi:10.1182/blood-2009-10-245001

Hudson, K. E., Lin, E., Hendrickson, J. E., Lukacher, A. E., & Zimring, J. C. (2010). Regulation of primary alloantibody response through antecedent exposure to a microbial T-cell epitope. BLOOD, 115(19), 3989-3996. doi:10.1182/blood-2009-08-238568

Hendrickson, J. E., Hod, E. A., Spitalnik, S. L., Hillyer, C. D., & Zimring, J. C. (2010). Storage of murine red blood cells enhances alloantibody responses to an erythroid-specific model antigen. TRANSFUSION, 50(3), 642-648. doi:10.1111/j.1537-2995.2009.02481.x

Gilson, C. R., Cadwell, C. M., Smith, N. H., Hendrickson, J. E., & Zimring, J. C. (2010). MHC II on transfused murine blood is not required for alloimmunization against MHC I. VOX SANGUINIS, 99(4), 369-374. doi:10.1111/j.1423-0410.2010.01351.x