James C Zimring
- Email: jcz2k@virginia.edu
- Phone: 434-924-2427
Primary Appointment
, Pathology
Education
- BS, Emory University
- MD, Emory University
- PhD, Emory University
Research Disciplines
Experimental Pathology, Immunology, Metabolism, Microbiology
Research Interests
Alloimmunity in Transfusion and Transplantation , Oxidant Stress Biology in Health and Disease
Research Description
Training
- Interdisciplinary Training Program in Immunology
Selected Publications
2023
Dziewulska, K. H., Reisz, J. A., Hay, A. M., D'Alessandro, A., & Zimring, J. C. (2023). Hemolysis and Metabolic Lesion of G6PD Deficient RBCs in Response to Dapsone Hydroxylamine in a Humanized Mouse Model. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 386(3), 323-330. doi:10.1124/jpet.123.001634
Patel, S. R., Maier, C. L., & Zimring, J. C. (2023). Alloantigen Copy Number as a Critical Factor in RBC Alloimmunization. TRANSFUSION MEDICINE REVIEWS, 37(1), 21-26. doi:10.1016/j.tmrv.2022.12.009
Jash, A., Hay, A. M., Collins, J. B., Heo, J., Luckey, C. J., Hudson, K. E., & Zimring, J. C. (2023). The role of RBC antigen transgene integration sites on RBC biology in mice. TRANSFUSION, 63(1), 239-248. doi:10.1111/trf.17197
Jash, A., Howie, H. L., Hay, A. M., Luckey, C. J., Hudson, K. E., Thomson, P. C., . . . Zimring, J. C. (2023). Identification of multiple genetic loci associated with red blood cell alloimmunization in mice. HAEMATOLOGICA, 108(3), 905-908. doi:10.3324/haematol.2022.281767
2022
Zimring, J. C., Spitalnik, S. L., & Hudson, K. E. (2022). The senescent antigen hypothesis of RBC evanescence: 50 years of correlation without causation. TRANSFUSION, 62(11), 2414-2415. doi:10.1111/trf.17095
Moriconi, C., Dzieciatkowska, M., Roy, M., D'Alessandro, A., Roingeard, P., Lee, J. Y., . . . Hudson, K. E. (2022). Retention of functional mitochondria in mature red blood cells from patients with sickle cell disease. BRITISH JOURNAL OF HAEMATOLOGY, 198(3), 574-586. doi:10.1111/bjh.18287
Kim, C. Y., Johnson, H., Peltier, S., Spitalnik, S. L., Hod, E. A., Francis, R. O., . . . Thomas, T. (2022). Deuterated Linoleic Acid Attenuates the RBC Storage Lesion in a Mouse Model of Poor RBC Storage.. Frontiers in physiology, 13, 868578. doi:10.3389/fphys.2022.868578
Thangaraju, K., Katneni, U., Akpan, I. J., Tanaka, K., Thomas, T., Setua, S., . . . Buehler, P. W. (2022). The Impact of Age and BMI on the VWF/ADAMTS13 Axis and Simultaneous Thrombin and Plasmin Generation in Hospitalized COVID-19 Patients. FRONTIERS IN MEDICINE, 8. doi:10.3389/fmed.2021.817305
Soldatenko, A., Hoyt, L. R., Xu, L., Calabro, S., Lewis, S. M., Gallman, A. E., . . . Eisenbarth, S. C. (2022). Innate and Adaptive Immunity to Transfused Allogeneic RBCs in Mice Requires MyD88. JOURNAL OF IMMUNOLOGY, 208(4), 991-997. doi:10.4049/jimmunol.2100784
2021
D'Alessandro, A., Akpan, I., Thomas, T., Reisz, J., Cendali, F., Gamboni, F., . . . Francis, R. (2021). Biological and Clinical Factors contributing to the Metabolic Heterogeneity of Hospitalized Patients with and without COVID-19.. Res Sq. doi:10.21203/rs.3.rs-480167/v1
D'Alessandro, A., Thomas, T., Akpan, I. J., Reisz, J. A., Cendali, F. I., Gamboni, F., . . . Francis, R. O. (2021). Biological and Clinical Factors Contributing to the Metabolic Heterogeneity of Hospitalized Patients with and without COVID-19. CELLS, 10(9). doi:10.3390/cells10092293
Hay, A. M., Howie, H. L., Gorham, J. D., D'Alessandro, A., Spitalnik, S. L., Hudson, K. E., & Zimring, J. C. (2021). Mouse background genetics in biomedical research: The devil's in the details. TRANSFUSION, 61(10), 3017-3025. doi:10.1111/trf.16628
Escamilla-Rivera, V., Santhanakrishnan, M., Liu, J., Gibb, D. R., Forsmo, J. E., Foxman, E. F., . . . Hendrickson, J. E. (2021). Complement Plays a Critical Role in Inflammation-Induced Immunoprophylaxis Failure in Mice. FRONTIERS IN IMMUNOLOGY, 12. doi:10.3389/fimmu.2021.704072
Medved, J., Knott, B. M., Tarrah, S. N., Li, A. N., Shah, N., Moscovich, T. C., . . . Luckey, C. J. (2021). The lysophospholipid-binding molecule CD1D is not required for the alloimmunization response to fresh or stored RBCs in mice despite RBC storage driving alterations in lysophospholipids. TRANSFUSION, 61(7), 2169-2178. doi:10.1111/trf.16554
D'Alessandro, A., Howie, H. L., Hay, A. M., Dziewulska, K. H., Brown, B. C., Wither, M. J., . . . Zimring, J. C. (2021). Hematologic and systemic metabolic alterations due to Mediterranean class II G6PD deficiency in mice. JCI INSIGHT, 6(14). doi:10.1172/jci.insight.147056
Issaian, A., Hay, A., Dzieciatkowska, M., Roberti, D., Perrotta, S., Darula, Z., . . . D'Alessandro, A. (2021). The interactome of the N-terminus of band 3 regulates red blood cell metabolism and storage quality. HAEMATOLOGICA, 106(11), 2971-2985. doi:10.3324/haematol.2020.278252
D'Alessandro, A., Hay, A., Dzieciatkowska, M., Brown, B. C., Morrison, E. J., Hansen, K. C., & Zimring, J. C. (2021). Protein-L-isoaspartate O-methyltransferase is required for in vivo control of oxidative damage in red blood cells. HAEMATOLOGICA, 106(10), 2726-2739. doi:10.3324/haematol.2020.266676
D'Alessandro, A., Stefanoni, D., Slichter, S. J., Fu, X., & Zimring, J. C. (2021). The impact of donor sex and age on stored platelet metabolism and post-transfusion recovery. BLOOD TRANSFUSION, 19(3), 216-223. doi:10.2450/2020.0145-20
Thomas, T., Cendali, F., Fu, X., Gamboni, F., Morrison, E. J., Beirne, J., . . . D'Alessandro, A. (2021). Fatty acid desaturase activity in mature red blood cells and implications for blood storage quality. TRANSFUSION, 61(6), 1867-1883. doi:10.1111/trf.16402
Nemkov, T., Stefanoni, D., Bordbar, A., Issaian, A., Palsson, B. O., Dumont, L. J., . . . D'Alessandro, A. (2021). Blood donor exposome and impact of common drugs on red blood cell metabolism. JCI INSIGHT, 6(3). doi:10.1172/jci.insight.146175
Jash, A., Usaneerungrueng, C., Howie, H. L., Qiu, A., Luckey, C. J., Zimring, J. C., & Hudson, K. E. (2021). Antibodies to Low-Copy Number RBC Alloantigen Convert a Tolerogenic Stimulus to an Immunogenic Stimulus in Mice. FRONTIERS IN IMMUNOLOGY, 12. doi:10.3389/fimmu.2021.629608
Poston, J. N., Jash, A., Hannan, L. M., Hay, A. M., Usaneerungrueng, C., Howie, H. L., . . . Zimring, J. C. (2021). In utero exposure to alloantigens primes alloimmunization to platelet transfusion in mice. TRANSFUSION, 61(3), 687-691. doi:10.1111/trf.16224
Alessandro, A. D., Fu, X., Kanias, T., Reisz, J. A., Culp-Hill, R., Guo, Y., . . . Zimring, J. C. (2021). Donor sex, age and ethnicity impact stored red blood cell antioxidant metabolism through mechanisms in part explained by glucose 6-phosphate dehydrogenase levels and activity. HAEMATOLOGICA, 106(5), 1290-1302. doi:10.3324/haematol.2020.246603
2020
Thomas, T., Stefanoni, D., Dzieciatkowska, M., Issaian, A., Nemkov, T., Hill, R. C., . . . D'Alessandro, A. (2020). Evidence of Structural Protein Damage and Membrane Lipid Remodeling in Red Blood Cells from COVID-19 Patients. JOURNAL OF PROTEOME RESEARCH, 19(11), 4455-4469. doi:10.1021/acs.jproteome.0c00606
Temming, A. R., Bentlage, A. E. H., de Taeye, S. W., Bosman, G. P., Lissenberg-Thunnissen, S. N., Derksen, N. I. L., . . . Vidarsson, G. (2020). Cross-reactivity of mouse IgG subclasses to human Fc gamma receptors: Antibody deglycosylation only eliminates IgG2b binding. MOLECULAR IMMUNOLOGY, 127, 79-86. doi:10.1016/j.molimm.2020.08.015
D'Alessandro, A., Thomas, T., Dzieciatkowska, M., Hill, R. C., Francis, R. O., Hudson, K. E., . . . Hansen, K. C. (2020). Serum Proteomics in COVID-19 Patients: Altered Coagulation and Complement Status as a Function of IL-6 Level. JOURNAL OF PROTEOME RESEARCH, 19(11), 4417-4427. doi:10.1021/acs.jproteome.0c00365
Thomas, T., Stefanoni, D., Reisz, J. A., Nemkov, T., Bertolone, L., Francis, R. O., . . . D'Alessandro, A. (2020). COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status. JCI INSIGHT, 5(14). doi:10.1172/jci.insight.140327
Bertolone, L., Roy, M. K., Hay, A. M., Morrison, E. J., Stefanoni, D., Fu, X., . . . D'Alessandro, A. (2020). Impact of taurine on red blood cell metabolism and implications for blood storage. TRANSFUSION, 60(6), 1212-1226. doi:10.1111/trf.15810
Francis, R. O., D'Alessandro, A., Eisenberger, A., Soffing, M., Yeh, R., Coronel, E., . . . Hod, E. A. (2020). Donor glucose-6-phosphate dehydrogenase deficiency decreases blood quality for transfusion. JOURNAL OF CLINICAL INVESTIGATION, 130(5), 2270-2285. doi:10.1172/JCI133530
Zimring, J. C. (2020). Scientifically Thinking: How to Liberate Your Mind, Solve the World's Problems, and Embrace the Beauty of Science. AMERICAN JOURNAL OF PSYCHOLOGY, 133(4), 512-517. doi:10.5406/amerjpsyc.133.4.0512
Cleary, S. J., Kwaan, N., Tian, J. J., Calabrese, D. R., Mallavia, B., Magnen, M., . . . Looney, M. R. (2020). Complement activation on endothelium initiates antibody-mediated acute lung injury. JOURNAL OF CLINICAL INVESTIGATION, 130(11), 5909-5923. doi:10.1172/JCI138136
Bertolone, L., Shin, H. K., Stefanoni, D., Baek, J. H., Gao, Y., Morrison, E. J., . . . D'Alessandro, A. (2020). ZOOMICS: Comparative Metabolomics of Red Blood Cells From Old World Monkeys and Humans. FRONTIERS IN PHYSIOLOGY, 11. doi:10.3389/fphys.2020.593841
Zimring, J. C. (2020). Turning over a new leaf on turning over RBCs. BLOOD, 136(14), 1569-1570. doi:10.1182/blood.2020008463
Shinde, P., Howie, H. L., Stegmann, T. C., Hay, A. M., Waterman, H. R., Szittner, Z., . . . Zimring, J. C. (2020). IgG Subclass Determines Suppression Versus Enhancement of Humoral Alloimmunity to Kell RBC Antigens in Mice. FRONTIERS IN IMMUNOLOGY, 11. doi:10.3389/fimmu.2020.01516
Catala, A., Youssef, L. A., Reisz, J. A., Dzieciatkowska, M., Powers, N. E., Marchetti, C., . . . D'Alessandro, A. (2020). Metabolic Reprogramming of Mouse Bone Marrow Derived Macrophages Following Erythrophagocytosis. FRONTIERS IN PHYSIOLOGY, 11. doi:10.3389/fphys.2020.00396
Gruber, D. R., Richards, A. L., Howie, H. L., Hay, A. M., Lebedev, J. N., Wang, X., . . . Hudson, K. E. (2020). Passively transferred IgG enhances humoral immunity to a red blood cell alloantigen in mice. BLOOD ADVANCES, 4(7), 1526-1537. doi:10.1182/bloodadvances.2019001299
D'Alessandro, A., Fu, X., Reisz, J. A., Kanias, T., Page, G. P., Stone, M., . . . Busch, M. (2020). Stored RBC metabolism as a function of caffeine levels. TRANSFUSION, 60(6), 1197-1211. doi:10.1111/trf.15813
D'Alessandro, A., Fu, X., Reisz, J. A., Stone, M., Kleinman, S., Zimring, J. C., & Busch, M. (2020). Ethyl glucuronide, a marker of alcohol consumption, correlates with metabolic markers of oxidant stress but not with hemolysis in stored red blood cells from healthy blood donors. TRANSFUSION, 60(6), 1183-1196. doi:10.1111/trf.15811
Stefanoni, D., Fu, X., Reisz, J. A., Kanias, T., Nemkov, T., Page, G. P., . . . D'Alessandro, A. (2020). Nicotine exposure increases markers of oxidant stress in stored red blood cells from healthy donor volunteers. TRANSFUSION, 60(6), 1160-1174. doi:10.1111/trf.15812
Howie, H. L., Collins, B., Wang, X., Kapp, L., Delaney, M., Er, L. S., . . . Zimring, J. C. (2020). Characterization and refinement of monoclonal anti-human globulins that lack reactivity with human IgG4. TRANSFUSION, 60(5), 1060-1068. doi:10.1111/trf.15796
Escamilla-Rivera, V., Liu, J., Gibb, D. R., Santhanakrishnan, M., Liu, D., Forsmo, J. E., . . . Hendrickson, J. E. (2020). Poly(I:C) causes failure of immunoprophylaxis to red blood cells expressing the KEL glycoprotein in mice. BLOOD, 135(22), 1983-1993. doi:10.1182/blood.2020005018
Cen, S. Y., Holton, M. B., Binnington, B., Denomme, G. A., Howie, H. L., Lebedev, J. N., . . . Branch, D. R. (2020). IgG3 anti-Kell allotypic variation results in differential antigen binding and phagocytosis. TRANSFUSION, 60(4), 688-693. doi:10.1111/trf.15663
2019
Stefanoni, D., Shin, H. K. H., Baek, J. H., Champagne, D. P., Nemkov, T., Thomas, T., . . . D'Alessandro, A. (2020). Red blood cell metabolism in Rhesus macaques and humans: comparative biology of blood storage. HAEMATOLOGICA, 105(8), 2174-2186. doi:10.3324/haematol.2019.229930
D'Alessandro, A., Hansen, K. C., Eisenmesser, E. Z., & Zimring, J. C. (2019). Protect, repair, destroy or sacrifice: a role of oxidative stress biology in inter-donor variability of blood storage?. BLOOD TRANSFUSION, 17(4), 281-288. doi:10.2450/2019.0072-19
Poston, J. N., & Zimring, J. C. (n.d.). Refractoriness to platelet transfusion in the presence of anti-HLA antibodiesâreassessing the alloantibody hypothesis. Annals of Blood, 4, 8. doi:10.21037/aob.2019.04.01
Hudson, K. E., Wong, A. S. L., Richards, A. L., Kapp, L. M., & Zimring, J. C. (2019). Alloimmunogenicity of an isolated MHC allele is affected by the context of MHC mismatch in a murine model. TRANSFUSION, 59(2), 744-753. doi:10.1111/trf.15109
Temming, A. R., de Taeye, S. W., de Graaf, E. L., de Neef, L. A., Dekkers, G., Bruggeman, C. W., . . . Vidarsson, G. (2019). Functional Attributes of Antibodies, Effector Cells, and Target Cells Affecting NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity. JOURNAL OF IMMUNOLOGY, 203(12), 3126-3135. doi:10.4049/jimmunol.1900985
Zimring, J. C. (2019). The Pragmatic Truth of Scientific Claims. SCIENTIST, 33(12), 60.
Francis, R. O., Mahajan, S., Rapido, F., La Carpia, F., Soffing, M., Divgi, C., . . . Hod, E. A. (2019). Reexamination of the chromium-51-labeled posttransfusion red blood cell recovery method. TRANSFUSION, 59(7), 2264-2275. doi:10.1111/trf.15310
Howie, H. L., Hay, A. M., de Wolski, K., Waterman, H., Lebedev, J., Fu, X., . . . Zimring, J. C. (2019). Differences in Steap3 expression are a mechanism of genetic variation of RBC storage and oxidative damage in mice. BLOOD ADVANCES, 3(15), 2272-2285. doi:10.1182/bloodadvances.2019000605
Morrison, E. J., Champagne, D. P., Dzieciatkowska, M., Nemkov, T., Zimring, J. C., Hansen, K. C., . . . D'Alessandro, A. (2019). Parabiosis Incompletely Reverses Aging-Induced Metabolic Changes and Oxidant Stress in Mouse Red Blood Cells. NUTRIENTS, 11(6). doi:10.3390/nu11061337
D'Alessandro, A., Culp-Hill, R., Reisz, J. A., Anderson, M., Fu, X., Nemkov, T., . . . Cristman, A. M. (2019). Heterogeneity of blood processing and storage additives in different centers impacts stored red blood cell metabolism as much as storage time: lessons from REDS-III-Omics. TRANSFUSION, 59(1), 89-100. doi:10.1111/trf.14979
Stone, M., Keating, S. M., Kanias, T., Lanteri, M. C., Lebedeva, M., Sinchar, D., . . . Cristman, A. M. (2019). Piloting and implementation of quality assessment and quality control procedures in RBC-Omics: a large multi-center study of red blood cell hemolysis during storage. TRANSFUSION, 59(1), 57-66. doi:10.1111/trf.15099
D'Alessandro, A., Zimring, J. C., & Busch, M. (2019). Chronological storage age and metabolic age of stored red blood cells: are they the same?. TRANSFUSION, 59(5), 1620-1623. doi:10.1111/trf.15248
2018
Reisz, J. A., Nemkov, T., Dzieciatkowska, M., Culp-Hill, R., Stefanoni, D., Hill, R. C., . . . D'Alessandro, A. (2018). Methylation of protein aspartates and deamidated asparagines as a function of blood bank storage and oxidative stress in human red blood cells. TRANSFUSION, 58(12), 2978-2991. doi:10.1111/trf.14936
Howie, H. L., Wang, X., Kapp, L., Lebedev, J. N., & Zimring, J. C. (2018). Identification of IgG3-specific epitope that remedies problem in diagnostic IgG subclass determination due to human genetic variation. JOURNAL OF CLINICAL PATHOLOGY, 71(6), 559-561. doi:10.1136/jclinpath-2018-205001
Howie, H. L., Wang, X., Kapp, L., Lebedev, J., Hudson, K. E., & Zimring, J. C. (2018). Common murine immunoglobulin detection reagents have diminished reactivity with IgG3-A vulnerability to misinterpretation. JOURNAL OF IMMUNOLOGICAL METHODS, 455, 10-13. doi:10.1016/j.jim.2018.01.011
Gibb, D., Liu, J., Natarajan, P., Santhanakrishnan, M., Madrid, D., Eisenbarth, S., . . . Hendrickson, J. (2018). 1 Type I Interferon Is Necessary and Sufficient for Alloimmunization to Transfused KEL-Expressing RBCs in Mice. American Journal of Clinical Pathology, 149(suppl_1), S163. doi:10.1093/ajcp/aqx149.370
Gunasekera, D., Zimring, J. C., & Pratt, K. P. (2018). A unique major histocompatibility complex Class II-binding register correlates with HLA-DR11-associated immunogenicity of the major K blood group antigen. TRANSFUSION, 58(5), 1171-1181. doi:10.1111/trf.14525
Vostal, J. G., Buehler, P. W., Gelderman, M. P., Alayash, A. I., Doctor, A., Zimring, J. C., . . . Ness, P. M. (2018). Proceedings of the Food and Drug Administration's public workshop on new red blood cell product regulatory science 2016. TRANSFUSION, 58(1), 255-266. doi:10.1111/trf.14435
Hosoba, S., Waller, E. K., Shenvi, N., Graiser, M., Easley, K. A., Al-Kadhimi, Z., . . . Giver, C. R. (2018). Peritransplantation Red Blood Cell Transfusion Is Associated with Increased Risk of Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 24(5), 973-982. doi:10.1016/j.bbmt.2018.01.003
Karafin, M. S., Fu, X., D'Alessandro, A., Thomas, T., Hod, E. A., Zimring, J. C., . . . Francis, R. O. (2018). The clinical impact of glucose-6-phosphate dehydrogenase deficiency in patients with sickle cell disease. CURRENT OPINION IN HEMATOLOGY, 25(6), 494-499. doi:10.1097/MOH.0000000000000455
Nemkov, T., Reisz, J. A., Xia, Y., Zimring, J. C., & D'Alessandro, A. (2018). Red blood cells as an organ? How deep omics characterization of the most abundant cell in the human body highlights other systemic metabolic functions beyond oxygen transport. EXPERT REVIEW OF PROTEOMICS, 15(11), 855-864. doi:10.1080/14789450.2018.1531710
2017
Nemkov, T., Sun, K., Reisz, J. A., Song, A., Yoshida, T., Dunham, A., . . . D'Alessandro, A. (2018). Hypoxia modulates the purine salvage pathway and decreases red blood cell and supernatant levels of hypoxanthine during refrigerated storage. HAEMATOLOGICA, 103(2), 361-372. doi:10.3324/haematol.2017.178608
Hay, A., Howie, H. L., Waterman, H. R., de Wolski, K., & Zimring, J. C. (2017). Murine red blood cells from genetically distinct donors cross-regulate when stored together. TRANSFUSION, 57(11), 2657-2664. doi:10.1111/trf.14313
Howie, H. L., Delaney, M., Wang, X., Er, L. S., Kapp, L., Lebedev, J. N., & Zimring, J. C. (2017). Errors in data interpretation from genetic variation of human analytes. JCI INSIGHT, 2(13). doi:10.1172/jci.insight.94532
Bandyopadhyay, S., Brittenham, G. M., Francis, R. O., Zimring, J. C., Hod, E. A., & Spitalnik, S. L. (2017). Iron-deficient erythropoiesis in blood donors and red blood cell recovery after transfusion: initial studies with a mouse model. BLOOD TRANSFUSION, 15(2), 158-164. doi:10.2450/2017.0349-16
Zimring, J. C., & Spitalnik, S. L. (2017). Large retrospective effects, clear differences in animals, and multiple negative randomised controlled trials: this is exactly how it is supposed to work. BLOOD TRANSFUSION, 15(2), 104-106. doi:10.2450/2017.0307-16
Arthur, C. M., Patel, S. R., Smith, N. H., Bennett, A., Kamili, N. A., Mener, A., . . . Stowell, S. R. (2017). Antigen Density Dictates Immune Responsiveness following Red Blood Cell Transfusion. JOURNAL OF IMMUNOLOGY, 198(7), 2671-2680. doi:10.4049/jimmunol.1601736
Gibb, D. R., Liu, J., Natarajan, P., Santhanakrishnan, M., Madrid, D. J., Eisenbarth, S. C., . . . Hendrickson, J. E. (2017). Type I IFN Is Necessary and Sufficient for Inflammation-Induced Red Blood Cell Alloimmunization in Mice. JOURNAL OF IMMUNOLOGY, 199(3), 1041-1050. doi:10.4049/jimmunol.1700401
Hudson, K. E., de Wolski, K., Kapp, L. M., Richards, A. L., Schniederjan, M. J., & Zimring, J. C. (2017). Antibodies to Senescent Antigen and C3 Are Not Required for Normal Red Blood Cell Lifespan in a Murine Model. FRONTIERS IN IMMUNOLOGY, 8. doi:10.3389/fimmu.2017.01425
Richards, A. L., Howie, H. L., Kapp, L. M., Hendrickson, J. E., Zimring, J. C., & Hudson, K. E. (2017). Innate B-1 B Cells Are Not Enriched in Red Blood Cell Autoimmune Mice: Importance of B Cell Receptor Transgenic Selection. FRONTIERS IN IMMUNOLOGY, 8. doi:10.3389/fimmu.2017.01366
Dekkers, G., Bentlage, A. E. H., Stegmann, T. C., Howie, H. L., Lissenberg-Thunnissen, S., Zimring, J., . . . Vidarsson, G. (2017). Affinity of human IgG subclasses to mouse Fc gamma receptors. MABS, 9(5), 767-773. doi:10.1080/19420862.2017.1323159
2016
Howie, H. L., Delaney, M., Wang, X., Er, L. S., Vidarsson, G., Stegmann, T. C., . . . Zimring, J. C. (2016). Serological blind spots for variants of human IgG3 and IgG4 by a commonly used anti-immunoglobulin reagent. TRANSFUSION, 56(12), 2953-2962. doi:10.1111/trf.13812
Kanias, T., Sinchar, D., Osei-Hwedieh, D., Baust, J. J., Jordan, A., Zimring, J. C., . . . Gladwin, M. T. (2016). Testosterone-dependent sex differences in red blood cell hemolysis in storage, stress, and disease. TRANSFUSION, 56(10), 2571-2583. doi:10.1111/trf.13745
Waterman, H. R., Kapp, L. M., Munday, A., Odem-Davis, K., & Zimring, J. C. (2016). Transfusion-induced alloimmunization and platelet refractoriness in a mouse model: mechanisms and interventions. TRANSFUSION, 56(1), 91-100. doi:10.1111/trf.13270
Richards, A. L., Hendrickson, J. E., Zimring, J. C., & Hudson, K. E. (2016). Erythrophagocytosis by plasmacytoid dendritic cells and monocytes is enhanced during inflammation. TRANSFUSION, 56(4), 905-916. doi:10.1111/trf.13497
de Wolski, K., Fu, X., Dumont, L. J., Roback, J. D., Waterman, H., Odem-Davis, K., . . . Zimring, J. C. (2016). Metabolic pathways that correlate with post-transfusion circulation of stored murine red blood cells. HAEMATOLOGICA, 101(5), 578-586. doi:10.3324/haematol.2015.139139
Calabro, S., Gallman, A., Gowthaman, U., Liu, D., Chen, P., Liu, J., . . . Eisenbarth, S. C. (2016). Bridging channel dendritic cells induce immunity to transfused red blood cells. JOURNAL OF EXPERIMENTAL MEDICINE, 213(6), 887-896. doi:10.1084/jem.20151720
Gibb, D. R., Calabro, S., Liu, D., Tormey, C. A., Spitalnik, S. L., Zimring, J. C., . . . Eisenbarth, S. C. (2016). The Nlrp3 Inflammasome Does Not Regulate Alloimmunization to Transfused Red Blood Cells in Mice. EBIOMEDICINE, 9, 77-86. doi:10.1016/j.ebiom.2016.06.008
Zimring, J. C., Slichter, S., Odem-Davis, K., Felcyn, J. R., Kapp, L. M., Bell, L. N., . . . Fu, X. (2016). Metabolites in stored platelets associated with platelet recoveries and survivals. TRANSFUSION, 56(8), 1974-1983. doi:10.1111/trf.13631
Fu, X., Felcyn, J. R., Odem-Davis, K., & Zimring, J. C. (2016). Bioactive lipids accumulate in stored red blood cells despite leukoreduction: a targeted metabolomics study. TRANSFUSION, 56(10), 2560-2570. doi:10.1111/trf.13748
Zimring, J. C., & Hudson, K. E. (2016). Cellular immune responses in red blood cell alloimmunization. HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM, 452-456. doi:10.1182/asheducation-2016.1.452
Arneja, A., Salazar, J. E., Jiang, W., Hendrickson, J. E., Zimring, J. C., & Luckey, C. J. (2016). Interleukin-6 receptor-alpha signaling drives anti-RBC alloantibody production and T-follicular helper cell differentiation in a murine model of red blood cell alloimmunization. HAEMATOLOGICA, 101(11), E440-E444. doi:10.3324/haematol.2016.149278
2015
Zimring, J. C. (2015). Established and theoretical factors to consider in assessing the red cell storage lesion. BLOOD, 125(14), 2185-2190. doi:10.1182/blood-2014-11-567750
Zimring, J. C. (2015). Widening our gaze of red blood storage haze: a role for metabolomics. TRANSFUSION, 55(6), 1139-1142. doi:10.1111/trf.13071
Zimring, J. C. (2015). Do immune complexes play a role in hemolytic sequelae of intravenous immune globulin?. TRANSFUSION, 55, S86-S89. doi:10.1111/trf.13158
Waterman, H. R., Kapp, L. M., Howie, H. L., Hod, E. A., Spitalnik, S. L., & Zimring, J. C. (2015). Analysis of 24-h recovery of transfused stored RBCs in recipient mice of distinct genetic backgrounds. VOX SANGUINIS, 109(2), 148-154. doi:10.1111/vox.12270
Bernardo, L., Yu, H., Amash, A., Zimring, J. C., & Lazarus, A. H. (2015). IgG-Mediated Immune Suppression to Erythrocytes by Polyclonal Antibodies Can Occur in the Absence of Activating or Inhibitory Fcγ Receptors in a Full Mouse Model. JOURNAL OF IMMUNOLOGY, 195(5), 2224-2230. doi:10.4049/jimmunol.1500790
Stowell, S. R., Arthur, C. M., Girard-Pierce, K. R., Sullivan, H. C., Santhanakrishnan, M., Natarajan, P., . . . Hendrickson, J. E. (2015). Anti-KEL sera prevents alloimmunization to transfused KEL RBCs in a murine model. HAEMATOLOGICA, 100(10), E394-E397. doi:10.3324/haematol.2015.128603
2014
Wojczyk, B. S., Kim, N., Bandyopadhyay, S., Francis, R. O., Zimring, J. C., Hod, E. A., & Spitalnik, S. L. (2014). Macrophages clear refrigerator storage-damaged red blood cells and subsequently secrete cytokines in vivo, but not in vitro, in a murine model. TRANSFUSION, 54(12), 3186-3197. doi:10.1111/trf.12755
Roback, J. D., Josephson, C. D., Waller, E. K., Newman, J. L., Karatela, S., Uppal, K., . . . Dumont, L. J. (2014). Metabolomics of ADSOL (AS-1) Red Blood Cell Storage. TRANSFUSION MEDICINE REVIEWS, 28(2), 41-55. doi:10.1016/j.tmrv.2014.01.003
Zimring, J. C., Smith, N., Stowell, S. R., Johnsen, J. M., Bell, L. N., Francis, R. O., . . . Spitalnik, S. L. (2014). Strain-specific red blood cell storage, metabolism, and eicosanoid generation in a mouse model. TRANSFUSION, 54(1), 137-148. doi:10.1111/trf.12264
Yu, H., Stowell, S. R., Bernardo, L., Hendrickson, J. E., Zimring, J. C., Amash, A., . . . Lazarus, A. H. (2014). Antibody-Mediated Immune Suppression of Erythrocyte Alloimmunization Can Occur Independently from Red Cell Clearance or Epitope Masking in a Murine Model. JOURNAL OF IMMUNOLOGY, 193(6), 2902-2910. doi:10.4049/jimmunol.1302287
Zimring, J. C. (2014). The fat and the skinny on acute lung injury. BLOOD, 124(17), 2617-2618. doi:10.1182/blood-2014-09-597732
Drury-Stewart, D. N., Lannert, K. W., Chung, D. W., Teramura, G. T., Zimring, J. C., Konkle, B. A., . . . Johnsen, J. M. (2014). Complex Changes in von Willebrand Factor-Associated Parameters Are Acquired during Uncomplicated Pregnancy. PLOS ONE, 9(11). doi:10.1371/journal.pone.0112935
Ryder, A. B., Zimring, J. C., & Hendrickson, J. E. (2014). Factors Influencing RBC Alloimmunization: Lessons Learned from Murine Models. TRANSFUSION MEDICINE AND HEMOTHERAPY, 41(6), 406-419. doi:10.1159/000368995
2013
Patel, S. R., & Zimring, J. C. (2013). Transfusion-Induced Bone Marrow Transplant Rejection Due to Minor Histocompatibility Antigens. TRANSFUSION MEDICINE REVIEWS, 27(4), 241-248. doi:10.1016/j.tmrv.2013.08.002
Zimring, J. C. (2013). Regulation of immune responses by RBC transfusion. ISBT Science Series, 8(1), 181-184. doi:10.1111/voxs.12042
Stowell, S. R., Girard-Pierce, K. R., Smith, N. H., Henry, K. L., Arthur, C. M., Zimring, J. C., & Hendrickson, J. E. (2014). Transfusion of murine red blood cells expressing the human KEL glycoprotein induces clinically significant alloantibodies. TRANSFUSION, 54(1), 179-189. doi:10.1111/trf.12217
Zimring, J. C. (2013). Location, location, location: advancing veto cell therapies. BLOOD, 121(7), 1069-1070. doi:10.1182/blood-2012-12-472654
Liepkalns, J. S., Cadwell, C. M., Stowell, S. R., Hod, E. A., Spitalnik, S. L., & Zimring, J. C. (2013). Resistance of a subset of red blood cells to clearance by antibodies in a mouse model of incompatible transfusion. TRANSFUSION, 53(6), 1319-1327. doi:10.1111/j.1537-2995.2012.03910.x
Stowell, S. R., Henry, K. L., Smith, N. H., Hudson, K. E., Halverson, G. R., Park, J. C., . . . Hendrickson, J. E. (2013). Alloantibodies to a paternally derived RBC KEL antigen lead to hemolytic disease of the fetus/newborn in a murine model. BLOOD, 122(8), 1494-1504. doi:10.1182/blood-2013-03-488874
Girard-Pierce, K. R., Stowell, S. R., Smith, N. H., Arthur, C. M., Sullivan, H. C., Hendrickson, J. E., & Zimring, J. C. (2013). A novel role for C3 in antibody-induced red blood cell clearance and antigen modulation. BLOOD, 122(10), 1793-1801. doi:10.1182/blood-2013-06-508952
Stowell, S. R., Smith, N. H., Zimring, J. C., Fu, X., Palmer, A. F., Fontes, J., . . . Yazer, M. H. (2013). Addition of ascorbic acid solution to stored murine red blood cells increases posttransfusion recovery and decreases microparticles and alloimmunization. TRANSFUSION, 53(10), 2248-2257. doi:10.1111/trf.12106
Zimring, J. C., & Spitalnik, S. L. (2013). On the appropriate use and interpretation of animal models in transfusion medicine research. TRANSFUSION, 53(10), 2334-2339. doi:10.1111/trf.12131
Francis, R. O., Jhang, J. S., Pham, H. P., Hod, E. A., Zimring, J. C., & Spitalnik, S. L. (2013). Glucose-6-phosphate dehydrogenase deficiency in transfusion medicine: the unknown risks. VOX SANGUINIS, 105(4), 271-282. doi:10.1111/vox.12068
Stowell, S. R., Liepkalns, J. S., Hendrickson, J. E., Girard-Pierce, K. R., Smith, N. H., Arthur, C. M., & Zimring, J. C. (2013). Antigen Modulation Confers Protection to Red Blood Cells from Antibody through Fcγ Receptor Ligation. JOURNAL OF IMMUNOLOGY, 191(10), 5013-5025. doi:10.4049/jimmunol.1300885
Blacken, G. R., Zimring, J. C., & Fu, X. (2013). Resolution of translation start site for the human Kell glycoprotein. TRANSFUSION, 53(11), 2882-2886. doi:10.1111/trf.12267
Zimring, J. C. (2013). Fresh versus old blood: are there differences and do they matter?. HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM, 651-655. doi:10.1182/asheducation-2013.1.651
Zalpuri, S., Schonewille, H., Middelburg, R., van de Watering, L., de Vooght, K., Zimring, J., . . . Zwaginga, J. J. (2013). Effect of storage of red blood cells on alloimmunization. TRANSFUSION, 53(11), 2795-2800. doi:10.1111/trf.12156
2012
Francis, R. O., Jhang, J., Hendrickson, J. E., Zimring, J. C., Hod, E. A., & Spitalnik, S. L. (2013). Frequency of glucose-6-phosphate dehydrogenase-deficient red blood cell units in a metropolitan transfusion service. TRANSFUSION, 53(3), 606-611. doi:10.1111/j.1537-2995.2012.03765.x
Smith, N. H., Henry, K. L., Cadwell, C. M., Bennett, A., Hendrickson, J. E., Frame, T., & Zimring, J. C. (2012). Generation of transgenic mice with antithetical KEL1 and KEL2 human blood group antigens on red blood cells. TRANSFUSION, 52(12), 2620-2630. doi:10.1111/j.1537-2995.2012.03641.x
Gilson, C. R., Patel, S. R., & Zimring, J. C. (2012). CTLA4-Ig prevents alloantibody production and BMT rejection in response to platelet transfusions in mice. TRANSFUSION, 52(10), 2209-2219. doi:10.1111/j.1537-2995.2011.03550.x
Smith, N. H., Hod, E. A., Spitalnik, S. L., Zimring, J. C., & Hendrickson, J. E. (2012). Transfusion in the absence of inflammation induces antigen-specific tolerance to murine RBCs. BLOOD, 119(6), 1566-1569. doi:10.1182/blood-2011-09-382655
Patel, S. R., Smith, N. H., Kapp, L., & Zimring, J. C. (2012). Mechanisms of Alloimmunization and Subsequent Bone Marrow Transplantation Rejection Induced by Platelet Transfusion in a Murine Model. AMERICAN JOURNAL OF TRANSPLANTATION, 12(5), 1102-1112. doi:10.1111/j.1600-6143.2011.03959.x
Zimring, J. C., & Johnsen, J. M. (2012). Keeping the Kell away from immunity. BLOOD, 119(23), 5346-5348. doi:10.1182/blood-2012-04-423947
Zimring, J. C., Stowell, S. R., Johnsen, J. M., & Hendrickson, J. E. (2012). Effects of genetic, epigenetic, and environmental factors on alloimmunization to transfused antigens: Current paradigms and future considerations. TRANSFUSION CLINIQUE ET BIOLOGIQUE, 19(3), 125-131. doi:10.1016/j.tracli.2012.03.002
Stowell, S. R., Winkler, A. M., Maier, C. L., Arthur, C. M., Smith, N. H., Girard-Pierce, K. R., . . . Hendrickson, J. E. (2012). Initiation and Regulation of Complement during Hemolytic Transfusion Reactions. CLINICAL & DEVELOPMENTAL IMMUNOLOGY. doi:10.1155/2012/307093
Hudson, K. E., Hendrickson, J. E., Cadwell, C. M., Iwakoshi, N. N., & Zimring, J. C. (2012). Partial tolerance of autoreactive B and T cells to erythrocyte-specific self-antigens in mice. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 97(12), 1836-1844. doi:10.3324/haematol.2012.065144
Liepkalns, J. S., Hod, E. A., Stowell, S. R., Cadwell, C. M., Spitalnik, S. L., & Zimring, J. C. (2012). Biphasic clearance of incompatible red blood cells through a novel mechanism requiring neither complement nor Fcγ receptors in a murine model. TRANSFUSION, 52(12), 2631-2645. doi:10.1111/j.1537-2995.2012.03647.x
2011
Gilson, C. R., & Zimring, J. C. (2012). Alloimmunization to transfused platelets requires priming of CD4+ T cells in the splenic microenvironment in a murine model. TRANSFUSION, 52(4), 849-859. doi:10.1111/j.1537-2995.2011.03346.x
Hendrickson, J. E., Hod, E. A., Perry, J. R., Ghosh, S., Chappa, P., Adisa, O., . . . Zimring, J. C. (2012). Alloimmunization to transfused HOD red blood cells is not increased in mice with sickle cell disease. TRANSFUSION, 52(2), 231-240. doi:10.1111/j.1537-2995.2011.03255.x
Hendrickson, J. E., Hod, E. A., Hudson, K. E., Spitalnik, S. L., & Zimring, J. C. (2011). Transfusion of fresh murine red blood cells reverses adverse effects of older stored red blood cells. TRANSFUSION, 51(12), 2695-2702. doi:10.1111/j.1537-2995.2011.03197.x
Hendrickson, J. E., Hod, E. A., Cadwell, C. M., Eisenbarth, S. C., Spiegel, D. A., Tormey, C. A., . . . Zimring, J. C. (2011). Rapid clearance of transfused murine red blood cells is associated with recipient cytokine storm and enhanced alloimmunogenicity. TRANSFUSION, 51(11), 2445-2454. doi:10.1111/j.1537-2995.2011.03162.x
Zimring, J. (2011). Affirmative action in health care--the danger of waiting.. Health care law monthly, 2011(4), 2-10.
Josephson, C. D., Castillejo, M. -I., Caliendo, A. M., Waller, E. K., Zimring, J., Easley, K. A., . . . Roback, J. D. (2011). Prevention of Transfusion-Transmitted Cytomegalovirus in Low-Birth Weight Infants (â¤1500 g) Using Cytomegalovirus-Seronegative and Leukoreduced Transfusions. TRANSFUSION MEDICINE REVIEWS, 25(2), 125-132. doi:10.1016/j.tmrv.2010.11.004
Patel, S. R., Hendrickson, J. E., Smith, N. H., Cadwell, C. M., Ozato, K., Morse, H. C. I. I. I., . . . Zimring, J. C. (2011). Alloimmunization against RBC or PLT antigens is independent of TRIM21 expression in a murine model. MOLECULAR IMMUNOLOGY, 48(6-7), 909-913. doi:10.1016/j.molimm.2010.12.017
Zimring, J. C., Welniak, L., Semple, J. W., Ness, P. M., Slichter, S. J., & Spitalnik, S. L. (2011). Current problems and future directions of transfusion-induced alloimmunization: summary of an NHLBI working group. TRANSFUSION, 51(2), 435-441. doi:10.1111/j.1537-2995.2010.03024.x
Desmarets, M., Mylvaganam, G., Waller, E. K., Josephson, C. D., Pack, C., Lukacher, A. E., & Zimring, J. C. (2011). Minor Antigens on Transfused RBCs Crossprime CD8 T Cells but Do Not Induce Full Effector Function. AMERICAN JOURNAL OF TRANSPLANTATION, 11(9), 1825-1834. doi:10.1111/j.1600-6143.2011.03730.x
Hod, E. A., Brittenham, G. M., Billote, G. B., Francis, R. O., Ginzburg, Y. Z., Hendrickson, J. E., . . . Spitalnik, S. L. (2011). Transfusion of human volunteers with older, stored red blood cells produces extravascular hemolysis and circulating non-transferrin-bound iron. BLOOD, 118(25), 6675-6682. doi:10.1182/blood-2011-08-371849
2010
Gilson, C. R., Cadwell, C. M., Smith, N. H., Hendrickson, J. E., & Zimring, J. C. (2010). MHC II on transfused murine blood is not required for alloimmunization against MHC I. VOX SANGUINIS, 99(4), 369-374. doi:10.1111/j.1423-0410.2010.01351.x
Hudson, K. E., Lin, E., Hendrickson, J. E., Lukacher, A. E., & Zimring, J. C. (2010). Regulation of primary alloantibody response through antecedent exposure to a microbial T-cell epitope. BLOOD, 115(19), 3989-3996. doi:10.1182/blood-2009-08-238568
Hod, E. A., Zhang, N., Sokol, S. A., Wojczyk, B. S., Francis, R. O., Ansaldi, D., . . . Spitalnik, S. L. (2010). Transfusion of red blood cells after prolonged storage produces harmful effects that are mediated by iron and inflammation. BLOOD, 115(21), 4284-4292. doi:10.1182/blood-2009-10-245001
Zimring, J. C. (2010). Recent Developments and Future Directions of Alloimmunization to Transfused Blood Products. CLINICS IN LABORATORY MEDICINE, 30(2), 467-+. doi:10.1016/j.cll.2010.02.012
Hod, E. A., Arinsburg, S. A., Francis, R. O., Hendrickson, J. E., Zimring, J. C., & Spitalnik, S. L. (2010). Use of mouse models to study the mechanisms and consequences of RBC clearance. VOX SANGUINIS, 99(2), 99-111. doi:10.1111/j.1423-0410.2010.01327.x