Jie Sun

GetPhoto.ashx?photo=js6re_1353

Primary Appointment

Professor of Medicine, Medicine- Infectious Diseases and International Health

Education

  • BA, Sichuan University
  • MS, Chinese Academy of Preventive Medicine
  • PhD, Cell and Molecular Biology, University of Pennsylvania
  • Postdoc, University of Virginia

Research Disciplines

Immunology, Microbiology

Research Interests

Viral immunology, T cells, Macrophages, Tissue repair

Research Description

My laboratory studies respiratory immunology under homeostasis and disease conditions.
The long-term goals of the laboratory are to develop novel ideas and methods for the induction of strong respiratory antiviral and anti-tumor immunity, and to target host immune regulatory networks for the control of acute and/or chronic disease (such as long COVID-19 symptom) development following respiratory viral infections including influenza, SARS-CoV-2 and respiratory syncytial virus (RSV). These research areas are of clinical relevance and may be translatable in the identification of novel preventive and therapeutic approaches.

Personal Statement

My laboratory studies respiratory immunology under homeostasis and disease conditions.
The long-term goals of the laboratory are to develop novel ideas and methods for the induction of strong respiratory antiviral and anti-tumor immunity, and to target host immune regulatory networks for the control of acute and/or chronic disease (such as long COVID-19 symptom) development following respiratory viral infections including influenza, SARS-CoV-2 and respiratory syncytial virus (RSV). These research areas are of clinical relevance and may be translatable in the identification of novel preventive and therapeutic approaches.

Selected Publications

2024

Nguyen, C., Kudek, M., Zander, R., Niu, H., Shen, J., Bauer, A., . . . Cui, W. (2024). Bhlhe40 Promotes CD4+ T Helper 1 Cell and Suppresses T Follicular Helper Cell Differentiation during Viral Infection.. Journal of immunology (Baltimore, Md. : 1950), 212(11), 1829-1842. doi:10.4049/jimmunol.2300355

Canderan, G., Muehling, L. M., Kadl, A., Ladd, S., Bonham, C., Cross, C. E., . . . Woodfolk, J. A. (2024). Distinct Type 1 Immune Networks Underlie the Severity of Restrictive Lung Disease after COVID-19.. bioRxiv. doi:10.1101/2024.04.03.587929

Zhu, X., Wu, Y., Li, Y., Zhou, X., Watzlawik, J. O., Chen, Y. M., . . . Zeng, H. (2024). Rag-GTPase-TFEB/TFE3 axis controls B cell mitochondrial fitness and humoral immunity independent of mTORC1.. Res Sq. doi:10.21203/rs.3.rs-3957355/v1

Zhu, X., Wu, Y., Li, Y., Zhou, X., Watzlawik, J. O., Chen, Y. M., . . . Zeng, H. (2024). The nutrient-sensing Rag-GTPase complex in B cells controls humoral immunity via TFEB/TFE3-dependent mitochondrial fitness.. bioRxiv. doi:10.1101/2024.02.26.582122

Ge, J., Shao, H., Ding, H., Huang, Y., Wu, X., Sun, J., & Que, J. (2024). Single Cell Analysis of Lung Lymphatic Endothelial Cells and Lymphatic Responses during Influenza Infection.. Journal of respiratory biology and translational medicine, 1(1), 10003. doi:10.35534/jrbtm.2024.10003

Son, Y. M., Cheon, I. S., Li, C., & Sun, J. (2024). Persistent B Cell-Derived MHC Class II Signaling Is Required for the Optimal Maintenance of Tissue-Resident Helper T Cells.. ImmunoHorizons, 8(2), 163-171. doi:10.4049/immunohorizons.2300093

Guo, K., Yombo, D. J. K., Wang, Z., Navaeiseddighi, Z., Xu, J., Schmit, T., . . . Khan, N. (2024). The chemokine receptor CXCR3 promotes CD8+ T cell-dependent lung pathology during influenza pathogenesis. SCIENCE ADVANCES, 10(1). doi:10.1126/sciadv.adj1120

2023

Jie, S., Narasimhan, H., Cheon, I. S., Qian, W., Hu, S., Parimon, T., . . . Chen, P. (2023). Proximal immune-epithelial progenitor interactions drive chronic tissue sequelae post COVID-19. doi:10.21203/rs.3.rs-3587418/v1

Narasimhan, H., Cheon, I. S., Qian, W., Hu, S., Parimon, T., Li, C., . . . Sun, J. (2023). Proximal immune-epithelial progenitor interactions drive chronic tissue sequelae post COVID-19.. bioRxiv. doi:10.1101/2023.09.13.557622

Kasmani, M. Y., Topchyan, P., Brown, A. K., Brown, R. J., Wu, X., Chen, Y., . . . Cui, W. (2023). A spatial sequencing atlas of age-induced changes in the lung during influenza infection. NATURE COMMUNICATIONS, 14(1). doi:10.1038/s41467-023-42021-y

Monroe, J. M., Quach, H. Q., Punia, S., Enninga, E. A. L., Fedyshyn, Y., Girsch, J. H., . . . Chakraborty, R. (2024). Vertical Transmission of SARS-CoV-2-Specific Antibodies and Cytokine Profiles in Pregnancy. JOURNAL OF INFECTIOUS DISEASES, 229(2), 473-484. doi:10.1093/infdis/jiad399

Fain, C. E., Zheng, J., Jin, F., Ayasoufi, K., Wu, Y., Lilley, M. T., . . . Johnson, A. J. (2024). Discrete class I molecules on brain endothelium differentially regulate neuropathology in experimental cerebral malaria. BRAIN, 147(2), 566-589. doi:10.1093/brain/awad319

Wu, Y., Hu, S. S., Zhang, R., Goplen, N. P., Gao, X., Narasimhan, H., . . . Sun, J. (2023). Single cell RNA sequencing unravels mechanisms underlying senescence-like phenotypes of alveolar macrophages. ISCIENCE, 26(7). doi:10.1016/j.isci.2023.107197

Zhu, B., Wei, X., Narasimhan, H., Qian, W., Zhang, R., Cheon, I. S., . . . Sun, J. (2023). Inhibition of the mitochondrial pyruvate carrier simultaneously mitigates hyperinflammation and hyperglycemia in COVID-19. SCIENCE IMMUNOLOGY, 8(82). doi:10.1126/sciimmunol.adf0348

Cheon, I. S., Son, Y. M., & Sun, J. (2023). Tissue-resident memory T cells and lung immunopathology. IMMUNOLOGICAL REVIEWS, 316(1), 63-83. doi:10.1111/imr.13201

Cable, J., Sun, J., Cheon, I. S., Vaughan, A. E., Castro, I. A., Stein, S. R., . . . Eddens, T. (2023). Respiratory viruses: New frontiers-a Keystone Symposia report. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1522(1), 60-73. doi:10.1111/nyas.14958

Wei, X., Narasimhan, H., Zhu, B., & Sun, J. (2023). Host Recovery from Respiratory Viral Infection. ANNUAL REVIEW OF IMMUNOLOGY, 41, 277-300. doi:10.1146/annurev-immunol-101921-040450

Arish, M., & Sun, J. (2023). Monocyte and macrophage function in respiratory viral infections. ANIMAL DISEASES, 3(1). doi:10.1186/s44149-023-00095-7

Bingham, G. C., Muehling, L. M., Li, C., Huang, Y., Ma, S. -F., Abebayehu, D., . . . Bonham, C. A. (2024). High-dimensional comparison of monocytes and T cells in post-COVID and idiopathic pulmonary fibrosis. FRONTIERS IN IMMUNOLOGY, 14. doi:10.3389/fimmu.2023.1308594

2022

Tang, J., & Sun, J. (2023). Lung tissue-resident memory T cells: the gatekeeper to respiratory viral (re)-infection.. Current opinion in immunology, 80, 102278. doi:10.1016/j.coi.2022.102278

Tang, J., Zeng, C., Cox, T. M., Li, C., Son, Y. M., Cheon, I. S., . . . Sun, J. (2022). Respiratory mucosal immunity against SARS-CoV-2 after mRNA vaccination. SCIENCE IMMUNOLOGY, 7(76). doi:10.1126/sciimmunol.add4853

Huang, H., Fang, Y., Jiang, M., Zhang, Y., Biermann, J., Melms, J. C., . . . Que, J. (2022). Contribution of Trp63CreERT2-labeled cells to alveolar regeneration is independent of tuft cells. ELIFE, 11. doi:10.7554/eLife.78217

Hajnik, R. L., Plante, J. A., Liang, Y., Alameh, M. -G., Tang, J., Bonam, S. R., . . . Hu, H. (2022). Dual spike and nucleocapsid mRNA vaccination confer protection against SARS-CoV-2 Omicron and Delta variants in preclinical models. SCIENCE TRANSLATIONAL MEDICINE, 14(662). doi:10.1126/scitranslmed.abq1945

Arish, M., Qian, W., Narasimhan, H., & Sun, J. (2023). COVID-19 immunopathology: From acute diseases to chronic sequelae. JOURNAL OF MEDICAL VIROLOGY, 95(1). doi:10.1002/jmv.28122

Narasimhan, H., Wu, Y., Goplen, N. P., & Sun, J. (2022). Immune determinants of chronic sequelae after respiratory viral infection. SCIENCE IMMUNOLOGY, 7(73). doi:10.1126/sciimmunol.abm7996

Fu, Y., Pajulas, A., Wang, J., Zhou, B., Cannon, A., Cheung, C. C. L., . . . Kaplan, M. H. (2022). Mouse pulmonary interstitial macrophages mediate the pro-tumorigenic effects of IL-9. NATURE COMMUNICATIONS, 13(1). doi:10.1038/s41467-022-31596-7

Ulrich, B. J., Kharwadkar, R., Chu, M., Pajulas, A., Muralidharan, C., Koh, B., . . . Kaplan, M. H. (2022). Allergic airway recall responses require IL-9 from resident memory CD4+ T cells. SCIENCE IMMUNOLOGY, 7(69). doi:10.1126/sciimmunol.abg9296

Fu, Y., Wang, J., Zhou, B., Pajulas, A., Gao, H., Ramdas, B., . . . Kaplan, M. H. (2022). An IL-9-pulmonary macrophage axis defines the allergic lung inflammatory environment. SCIENCE IMMUNOLOGY, 7(68). doi:10.1126/sciimmunol.abi9768

Gao, X., Zhu, B., Wu, Y., Li, C., Zhou, X., Tang, J., & Sun, J. (2022). TFAM-Dependent Mitochondrial Metabolism Is Required for Alveolar Macrophage Maintenance and Homeostasis. JOURNAL OF IMMUNOLOGY, 208(6), 1456-1466. doi:10.4049/jimmunol.2100741

Wu, X., Kasmani, M. Y., Zheng, S., Khatun, A., Chen, Y., Winkler, W., . . . Cui, W. (2022). BATF promotes group 2 innate lymphoid cell-mediated lung tissue protection during acute respiratory virus infection. SCIENCE IMMUNOLOGY, 7(67). doi:10.1126/sciimmunol.abc9934

2021

Cheon, I. S., Li, C., Son, Y. M., Goplen, N. P., Wu, Y., Cassmann, T., . . . Sun, J. (2021). Immune signatures underlying post-acute COVID-19 lung sequelae. SCIENCE IMMUNOLOGY, 6(65). doi:10.1126/sciimmunol.abk1741

Zhu, B., Wu, Y., Huang, S., Zhang, R., Son, Y. M., Li, C., . . . Sun, J. (2021). Uncoupling of macrophage inflammation from self-renewal modulates host recovery from respiratory viral infection. IMMUNITY, 54(6), 1200-+. doi:10.1016/j.immuni.2021.04.001

Son, Y. M., Cheon, I. S., Wu, Y., Li, C., Wang, Z., Gao, X., . . . Sun, J. (2021). Tissue-resident CD4+ T helper cells assist the development of protective respiratory B and CD8+ T cell memory responses. SCIENCE IMMUNOLOGY, 6(55). doi:10.1126/sciimmunol.abb6852

Goplen, N. P., Cheon, I. S., & Sun, J. (2021). Age-Related Dynamics of Lung-Resident Memory CD8+ T Cells in the Age of COVID-19. FRONTIERS IN IMMUNOLOGY, 12. doi:10.3389/fimmu.2021.636118

2020

Goplen, N. P., Wu, Y., Son, Y. M., Li, C., Wang, Z., Cheon, I. S., . . . Sun, J. (2020). Tissue-resident CD8+ T cells drive age-associated chronic lung sequelae after viral pneumonia. SCIENCE IMMUNOLOGY, 5(53). doi:10.1126/sciimmunol.abc4557

Fu, Y., Wang, J., Panangipalli, G., Ulrich, B. J., Koh, B., Xu, C., . . . Kaplan, M. H. (2020). STAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus. NATURE COMMUNICATIONS, 11(1). doi:10.1038/s41467-020-18648-6

Yang, S., Adaway, M., Du, J., Huang, S., Sun, J., Bidwell, J. P., & Zhou, B. (2021). NMP4 regulates the innate immune response to influenza A virus infection. MUCOSAL IMMUNOLOGY, 14(1), 209-218. doi:10.1038/s41385-020-0280-z

2019

Li, C., Zhu, B., Son, Y. M., Wang, Z., Jiang, L., Xiang, M., . . . Sun, J. (2019). The Transcription Factor Bhlhe40 Programs Mitochondria! Regulation of Resident CD8+ T Cell Fitness and Functionality. IMMUNITY, 51(3), 491-+. doi:10.1016/j.immuni.2019.08.013

Wang, Z., Wang, S., Goplen, N. P., Li, C., Cheon, I. S., Dai, Q., . . . Sun, J. (2019). PD-1hi CD8+ resident memory T cells balance immunity and fibrotic sequelae. SCIENCE IMMUNOLOGY, 4(36). doi:10.1126/sciimmunol.aaw1217

Zhu, B., Zhang, R., Li, C., Jiang, L., Xiang, M., Ye, Z., . . . Sun, J. (2019). BCL6 modulates tissue neutrophil survival and exacerbates pulmonary inflammation following influenza virus infection. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116(24), 11888-11893. doi:10.1073/pnas.1902310116

Huang, S., Jiang, L., Cheon, I. S., & Sun, J. (2019). Targeting Peroxisome Proliferator-Activated Receptor-Gamma Decreases Host Mortality After Influenza Infection in Obese Mice. VIRAL IMMUNOLOGY, 32(4), 161-169. doi:10.1089/vim.2019.0016

Huang, S., Zhu, B., Cheon, I. S., Goplen, N. P., Jiang, L., Zhang, R., . . . Sun, J. (2019). PPAR-γ in Macrophages Limits Pulmonary Inflammation and Promotes Host Recovery following Respiratory Viral Infection. JOURNAL OF VIROLOGY, 93(9). doi:10.1128/JVI.00030-19

2018

Gu, D., Lin, H., Zhang, X., Fan, Q., Chen, S., Shahda, S., . . . Xie, J. (2018). Simultaneous Inhibition of MEK and Hh Signaling Reduces Pancreatic Cancer Metastasis. CANCERS, 10(11). doi:10.3390/cancers10110403

2017

Cheon, I. S., Son, Y. M., Jiang, L., Goplen, N. P., Kaplan, M. H., Limper, A. H., . . . Sun, J. (2018). Neonatal hyperoxia promotes asthma-like features through IL-33-dependent ILC2 responses. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 142(4), 1100-1112. doi:10.1016/j.jaci.2017.11.025

Huang, S., Shen, Y., Pham, D., Jiang, L., Wang, Z., Kaplan, M. H., . . . Sun, J. (2017). IRF4 Modulates CD8+ T Cell Sensitivity to IL-2 Family Cytokines.. ImmunoHorizons, 1(6), 92-100. doi:10.4049/immunohorizons.1700020

Xie, M. M., Koh, B. -H., Hollister, K., Wu, H., Sun, J., Kaplan, M. H., & Dent, A. L. (2017). Bcl6 promotes follicular helper T-cell differentiation and PD-1 expression in a Blimp1-independent manner in mice. EUROPEAN JOURNAL OF IMMUNOLOGY, 47(7), 1136-1141. doi:10.1002/eji.201747034

Amet, T., Son, Y. M., Jiang, L., Cheon, I. S., Huang, S., Gupta, S. K., . . . Sun, J. (2017). BCL6 represses antiviral resistance in follicular T helper cells. JOURNAL OF LEUKOCYTE BIOLOGY, 102(2), 527-536. doi:10.1189/jlb.4A1216-513RR

Zhang, S., Sun, J., Fang, Y., Nassiri, M., Liu, L., Zhou, J., . . . Vance, G. H. (2017). Signet-ring cell lymphoma: clinicopathologic, immunohistochemical, and fluorescence in situ hybridization studies of 7 cases.. Annals of diagnostic pathology, 26, 38-42. doi:10.1016/j.anndiagpath.2016.10.002

2016

Belle, L., Agle, K., Zhou, V., Yin-Yuan, C., Komorowski, R., Eastwood, D., . . . Drobyski, W. R. (2016). Blockade of interleukin-27 signaling reduces GVHD in mice by augmenting Treg reconstitution and stabilizing Foxp3 expression. BLOOD, 128(16), 2068-2082. doi:10.1182/blood-2016-02-698241

2015

Mehrotra, P., Krishnamurthy, P., Sun, J., Goenka, S., & Kaplan, M. H. (2015). Poly-ADP-ribosyl polymerase-14 promotes T helper 17 and follicular T helper development. IMMUNOLOGY, 146(4), 537-546. doi:10.1111/imm.12515

2014

Tung, C. -Y., Lewis, D. E., Han, L., Jaja, M., Yao, S., Li, F., . . . Chang, H. -C. (2014). Activation of dendritic cell function by soypeptide lunasin as a novel vaccine adjuvant. VACCINE, 32(42), 5411-5419. doi:10.1016/j.vaccine.2014.07.103

2013

Yao, S., Buzo, B. F., Pham, D., Jiang, L., Taparowsky, E. J., Kaplan, M. H., & Sun, J. (2013). Interferon Regulatory Factor 4 Sustains CD8+ T Cell Expansion and Effector Differentiation. IMMUNITY, 39(5), 833-845. doi:10.1016/j.immuni.2013.10.007

Jabeen, R., Goswami, R., Awe, O., Kulkarni, A., Nguyen, E. T., Attenasio, A., . . . Kaplan, M. H. (2013). Th9 cell development requires a BATF-regulated transcriptional network. JOURNAL OF CLINICAL INVESTIGATION, 123(11), 4641-4653. doi:10.1172/JCI69489

Hua, L., Yao, S., Duy, P., Jiang, L., Wright, J., Sawant, D., . . . Sun, J. (2013). Cytokine-Dependent Induction of CD4+ T cells with Cytotoxic Potential during Influenza Virus Infection. JOURNAL OF VIROLOGY, 87(21), 11884-11893. doi:10.1128/JVI.01461-13

2011

Sun, J., Dodd, H., Moser, E. K., Sharma, R., & Braciale, T. J. (2011). CD4+ T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs. NATURE IMMUNOLOGY, 12(4), 327-U80. doi:10.1038/ni.1996