Jie Sun

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Primary Appointment

Harrison Distinguished Teaching Professor of Medicine, Division of Infectious Diseases and International Medicine, Associate Director for Scientific Programs, Carter Immunology Center University of Virginia School of Medicine, Medicine- Infectious Diseases and International Health

Education

  • BA, Sichuan University
  • MS, Chinese Academy of Preventive Medicine
  • Ph.D., University of Pennsylvania
  • Postdoc, University of Virginia

Research Disciplines

Immunology, Microbiology

Research Interests

Viral immunology, T cells, Macrophages, Tissue repair

Research Description

My laboratory studies respiratory immunology under homeostasis and disease conditions.
The long-term goals of the laboratory are to develop novel ideas and methods for the induction of strong respiratory antiviral and anti-tumor immunity, and to target host immune regulatory networks for the control of acute and/or chronic disease (such as long COVID-19 symptom) development following respiratory viral infections including influenza, SARS-CoV-2 and respiratory syncytial virus (RSV). These research areas are of clinical relevance and may be translatable in the identification of novel preventive and therapeutic approaches.

Personal Statement

My laboratory studies respiratory immunology under homeostasis and disease conditions.
The long-term goals of the laboratory are to develop novel ideas and methods for the induction of strong respiratory antiviral and anti-tumor immunity, and to target host immune regulatory networks for the control of acute and/or chronic disease (such as long COVID-19 symptom) development following respiratory viral infections including influenza, SARS-CoV-2 and respiratory syncytial virus (RSV). These research areas are of clinical relevance and may be translatable in the identification of novel preventive and therapeutic approaches.

Selected Publications

2022

Tang, J., Zeng, C., Cox, T. M., Li, C., Son, Y. M., Cheon, I. S., . . . Sun, J. (2022). Respiratory mucosal immunity against SARS-CoV-2 after mRNA vaccination.. Science immunology, 7(76), eadd4853. doi:10.1126/sciimmunol.add4853

Huang, H., Fang, Y., Jiang, M., Zhang, Y., Biermann, J., Melms, J. C., . . . Que, J. (2022). Contribution of Trp63(CreERT2)-labeled cells to alveolar regeneration is independent of tuft cells. ELIFE, 11. doi:10.7554/eLife.78217

Hajnik, R. L., Plante, J. A., Liang, Y., Alameh, M. -G., Tang, J., Bonam, S. R., . . . Hu, H. (2022). Dual spike and nucleocapsid mRNA vaccination confer protection against SARS-CoV-2 Omicron and Delta variants in preclinical models.. Science translational medicine, 14(662), eabq1945. doi:10.1126/scitranslmed.abq1945

Arish, M., Qian, W., Narasimhan, H., & Sun, J. (2022). COVID-19 immunopathology: From acute diseases to chronic sequelae. JOURNAL OF MEDICAL VIROLOGY. doi:10.1002/jmv.28122

Narasimhan, H., Wu, Y., Goplen, N. P., & Sun, J. (2022). Immune determinants of chronic sequelae after respiratory viral infection. SCIENCE IMMUNOLOGY, 7(73). doi:10.1126/sciimmunol.abm7996

Fu, Y., Pajulas, A., Wang, J., Zhou, B., Cannon, A., Cheung, C. C. L., . . . Kaplan, M. H. (2022). Mouse pulmonary interstitial macrophages mediate the pro-tumorigenic effects of IL-9. NATURE COMMUNICATIONS, 13(1). doi:10.1038/s41467-022-31596-7

Gao, X., Zhu, B., Wu, Y., Li, C., Zhou, X., Tang, J., & Sun, J. (2022). TFAM-Dependent Mitochondrial Metabolism Is Required for Alveolar Macrophage Maintenance and Homeostasis. JOURNAL OF IMMUNOLOGY, 208(6), 1456-1466. doi:10.4049/jimmunol.2100741

Ulrich, B. J., Kharwadkar, R., Chu, M., Pajulas, A., Muralidharan, C., Koh, B., . . . Kaplan, M. H. (2022). Allergic airway recall responses require IL-9 from resident memory CD4(+) T cells. SCIENCE IMMUNOLOGY, 7(69). doi:10.1126/sciimmunol.abg9296

Fu, Y., Wang, J., Zhou, B., Pajulas, A., Gao, H., Ramdas, B., . . . Kaplan, M. H. (2022). An IL-9-pulmonary macrophage axis defines the allergic lung inflammatory environment. SCIENCE IMMUNOLOGY, 7(68). doi:10.1126/sciimmunol.abi9768

Wu, X., Kasmani, M. Y., Zheng, S., Khatun, A., Chen, Y., Winkler, W., . . . Cui, W. (2022). BATF promotes group 2 innate lymphoid cell-mediated lung tissue protection during acute respiratory virus infection. SCIENCE IMMUNOLOGY, 7(67). doi:10.1126/sciimmunol.abc9934

2021

Cheon, I. S., Li, C., Son, Y. M., Goplen, N. P., Wu, Y., Cassmann, T., . . . Sun, J. (2021). Immune signatures underlying post-acute COVID-19 lung sequelae. SCIENCE IMMUNOLOGY, 6(65). doi:10.1126/sciimmunol.abk1741

Zhu, B., Wu, Y., Huang, S., Zhang, R., Son, Y. M., Li, C., . . . Sun, J. (2021). Uncoupling of macrophage inflammation from self-renewal modulates host recovery from respiratory viral infection. IMMUNITY, 54(6), 1200-+. doi:10.1016/j.immuni.2021.04.001

Son, Y. M., Cheon, I. S., Wu, Y., Li, C., Wang, Z., Gao, X., . . . Sun, J. (2021). Tissue-resident CD4(+) T helper cells assist the development of protective respiratory B and CD8(+) T cell memory responses. SCIENCE IMMUNOLOGY, 6(55). doi:10.1126/sciimmunol.abb6852

2020

Goplen, N. P., Wu, Y., Son, Y. M., Li, C., Wang, Z., Cheon, I. S., . . . Sun, J. (2020). Tissue-resident CD8(+) T cells drive age-associated chronic lung sequelae after viral pneumonia. SCIENCE IMMUNOLOGY, 5(53). doi:10.1126/sciimmunol.abc4557

2019

Li, C., Zhu, B., Son, Y. M., Wang, Z., Jiang, L., Xiang, M., . . . Sun, J. (2019). The Transcription Factor Bhlhe40 Programs Mitochondria! Regulation of Resident CD8(+) T Cell Fitness and Functionality. IMMUNITY, 51(3), 491-+. doi:10.1016/j.immuni.2019.08.013

Zhu, B., Zhang, R., Li, C., Jiang, L., Xiang, M., Ye, Z., . . . Sun, J. (2019). BCL6 modulates tissue neutrophil survival and exacerbates pulmonary inflammation following influenza virus infection. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116(24), 11888-11893. doi:10.1073/pnas.1902310116

Wang, Z., Wang, S., Goplen, N. P., Li, C., Cheon, I. S., Dai, Q., . . . Sun, J. (2019). PD-1(hi) CD8(+) resident memory T cells balance immunity and fibrotic sequelae. SCIENCE IMMUNOLOGY, 4(36). doi:10.1126/sciimmunol.aaw1217

2018

Cheon, I. S., Son, Y. M., Jiang, L., Goplen, N. P., Kaplan, M. H., Limper, A. H., . . . Sun, J. (2018). Neonatal hyperoxia promotes asthma-like features through IL-33-dependent ILC2 responses. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 142(4), 1100-1112. doi:10.1016/j.jaci.2017.11.025

2017

Amet, T., Son, Y. M., Jiang, L., Cheon, I. S., Huang, S., Gupta, S. K., . . . Sun, J. (2017). BCL6 represses antiviral resistance in follicular T helper cells. JOURNAL OF LEUKOCYTE BIOLOGY, 102(2), 527-536. doi:10.1189/jlb.4A1216-513RR

2013

Hua, L., Yao, S., Pham, D., Jiang, L., Wright, J., Sawant, D., . . . Sun, J. (2013). Cytokine-Dependent Induction of CD4(+) T cells with Cytotoxic Potential during Influenza Virus Infection. JOURNAL OF VIROLOGY, 87(21), 11884-11893. doi:10.1128/JVI.01461-13

2011

Sun, J., Dodd, H., Moser, E. K., Sharma, R., & Braciale, T. J. (2011). CD4(+) T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs. NATURE IMMUNOLOGY, 12(4), 327-U80. doi:10.1038/ni.1996