Sho Morioka

Primary Appointment

, Nephrology

Education

  • PhD, Biology, Nagoya University

Research Interests

Role of Programmed Cell Death in Kidney Injury

Research Description

My primary research focus includes regulation of programmed cell death (e.g. necroptosis, pyroptosis and apoptosis). After a brief post-doctoral stint my graduate thesis lab to complete some projects and publications (Blood 2012, Journal of Cell Biology 2014, Oncogene 2016), I moved to the University of Virginia as a Senior Research Scientist, focusing on identifying the endogenous regulatory pathways that control clearance of apoptotic cells (also termed âefferocytosisâ). Removal of apoptotic cells by phagocytes occurs at a rate of nearly one million cells per second in the body and defective clearance leads to inflammatory diseases; yet, there are still significant knowledge gaps in how a phagocyte achieves rapid corpse uptake and how the phagocytosis handles this stress on various aspects of its physiology such as energy metabolism, pH regulation, or volume regulation. I discovered that a novel gene program, solute carrier (SLC) program, is important for successful uptake of apoptotic cells (Nature 2018, Immunity 2019 and Nature Cell Biology 2019). During acute kidney injuries (AKI), it is known that phagocyte actively removes apoptotic cells. My current research focuses on the effect of enhancing efferocytosis on resolution of AKI. I am elucidating molecular mechanisms that enable phagocytes to efficiently remove apoptotic cells under kidney injury, using uniquely created super-engulfer transgenic mouse model.

Selected Publications

Rival CM, Xu W, Shankman LS, Morioka S, Arandjelovic S, Lee CS, Wheeler KM, Smith RP, Haney LB, Isakson BE, Purcell S, Lysiak JJ, Ravichandran KS, Phosphatidylserine on viable sperm and phagocytic machinery in oocytes regulate mammalian fertilization., 2019; Nature communications. 10(1) 4456. PMID: 31575859 | PMCID: PMC6773685

Morioka S, Maueröder C, Ravichandran KS, Living on the Edge: Efferocytosis at the Interface of Homeostasis and Pathology., 2019; Immunity. 50(5) 1149-1162. PMID: 31117011 | PMCID: PMC6721617

Morioka S, Perry JSA, Raymond MH, Medina CB, Zhu Y, Zhao L, Serbulea V, Onengut-Gumuscu S, Leitinger N, Kucenas S, Rathmell JC, Makowski L, Ravichandran KS, Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release., 2018; Nature. 563(7733) 714-718. PMID: 30464343 | PMCID: PMC6331005

Michaels AD, Newhook TE, Adair SJ, Morioka S, Goudreau BJ, Nagdas S, Mullen MG, Persily JB, Bullock T, Slingluff CL, Ravichandran KS, Parsons JT, Bauer TW, CD47 Blockade as an Adjuvant Immunotherapy for Resectable Pancreatic Cancer., 2017; Clinical cancer research : an official journal of the American Association for Cancer Research. () . PMID: 29288236 | PMCID: PMC6296745

Mihaly SR, Sakamachi Y, Ninomiya-Tsuji J, Morioka S, Erratum: Noncanonical cell death program independent of caspase activation cascade and necroptotic modules is elicited by loss of TGFβ-activated kinase 1., 2017; Scientific reports. 7(1) 10695. PMID: 28878387 | PMCID: PMC5587762

Mihaly SR, Sakamachi Y, Ninomiya-Tsuji J, Morioka S, Noncanonical cell death program independent of caspase activation cascade and necroptotic modules is elicited by loss of TGFβ-activated kinase 1., 2017; Scientific reports. 7(1) 2918. PMID: 28592892 | PMCID: PMC5462742