Thomas A. Platts-Mills

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Primary Appointment

Professor, Medicine- Asthma, Allergy and Immunology

Research Interests

Common Allergic Diseases

Research Description

The studies in our laboratory are directed to understanding the role that immune responses to foreign proteins play in the common allergic diseases: asthma, rhinitis and atopic dermatitis. The research includes identification and purification of the proteins which give rise to the immune responses typical of allergic individuals. These proteins are used to both measure immune responses (IgE and IgG antibodies, as well as T cells), and to measure exposure to these common antigens in the environment of allergic individuals. The work has focused on indoor allergens and the main sources are dust mites, cats and cockroaches. For each of these, monoclonal antibodies have been developed which are used in two site immunometric assays to measure levels inside houses. Asthma is a very common problem: it affects 8 million Americans and is the most common reason for children being admitted to hospitals. Our studies on asthma have focused on several different aspects: 1. Studying random populations of asthmatics presenting to hospital to identify the relative role of IgE antibodies and exposure to allergens. 2. Detailed studies on the houses of patients to identify the form in which allergen become airborne and to develop detailed strategies for the control of exposure. 3. Studies on patients who have "intrinsic" asthma, i.e. are not allergic to inhalants, where there is increasing evidence that commensal fungi, e.g. Trichiphyton (athlete's foot) and Aspergillus (which can colonize the lung), can also act as allergens and can play a major role in asthma. The study of Trichophyton is particularly interesting because it can give rise to either immediate (IgE antibodies) or delayed hypersensitivity. Thus, there is the potential for studying in detail the factors that influence these two responses in man. In addition, these studies focus on a cause of "intrinsic asthma" which appears to be treatable, i.e. with specific antifungals.

Personal Statement

The studies in our laboratory are directed to understanding the role that immune responses to foreign proteins play in the common allergic diseases: asthma, rhinitis and atopic dermatitis. The research includes identification and purification of the proteins which give rise to the immune responses typical of allergic individuals. These proteins are used to both measure immune responses (IgE and IgG antibodies, as well as T cells), and to measure exposure to these common antigens in the environment of allergic individuals. The work has focused on indoor allergens and the main sources are dust mites, cats and cockroaches. For each of these, monoclonal antibodies have been developed which are used in two site immunometric assays to measure levels inside houses. Asthma is a very common problem: it affects 8 million Americans and is the most common reason for children being admitted to hospitals. Our studies on asthma have focused on several different aspects: 1. Studying random populations of asthmatics presenting to hospital to identify the relative role of IgE antibodies and exposure to allergens. 2. Detailed studies on the houses of patients to identify the form in which allergen become airborne and to develop detailed strategies for the control of exposure. 3. Studies on patients who have "intrinsic" asthma, i.e. are not allergic to inhalants, where there is increasing evidence that commensal fungi, e.g. Trichiphyton (athlete's foot) and Aspergillus (which can colonize the lung), can also act as allergens and can play a major role in asthma. The study of Trichophyton is particularly interesting because it can give rise to either immediate (IgE antibodies) or delayed hypersensitivity. Thus, there is the potential for studying in detail the factors that influence these two responses in man. In addition, these studies focus on a cause of "intrinsic asthma" which appears to be treatable, i.e. with specific antifungals.

Training

  • Interdisciplinary Training Program in Immunology

Selected Publications

2024

Keet, C., McGowan, E., Jacobs, D., Post, W., Platts-Mills, T., & Wilson, J. (2024). Reply.. The Journal of allergy and clinical immunology, S0091-6749(24)00004-6. doi:10.1016/j.jaci.2023.12.019

Wilson, J. M., Erickson, L., Levin, M., Ailsworth, S. M., Commins, S. P., & Platts-Mills, T. A. E. (2024). Tick bites, IgE to galactose-alpha-1,3-galactose and urticarial or anaphylactic reactions to mammalian meat: The alpha-gal syndrome. ALLERGY. doi:10.1111/all.16003

Ailsworth, S. M., Susi, A., Workman, L. J., Ji, Y. -S., Patel, J., Nelson, M. R., . . . Wilson, J. M. (2024). Alpha-Gal IgE Prevalence Patterns in the United States: An Investigation of 3,000 Military Recruits. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 12(1). doi:10.1016/j.jaip.2023.10.046

McGill, S. K., Levin, M. E., Shaheen, N. J., Cotton, C. C., Platts-Mills, T. A., & Commins, S. P. (2024). Gastrointestinal-isolated Distress is Common in Alpha-gal Allergic Patients on Mammalian Meat Challenge.. Journal of clinical gastroenterology, 58(1), 80-84. doi:10.1097/mcg.0000000000001827

2023

Keet, C., Mcgowan, E. C., Jacobs, D., Post, W. S., Richards, N. E., Workman, L. J., . . . Wilson, J. M. (2024). IgE to common food allergens is associated with cardiovascular mortality in the National Health and Examination Survey and the Multi-Ethnic of Atherosclerosis. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 153(2). doi:10.1016/j.jaci.2023.09.038

Rönmark, E., Bunne, J., Bjerg, A., Perzanowski, M., Winberg, A., Andersson, M., . . . Hedman, L. (2023). Prevalence and risk factors for allergic sensitization: 3 cross-sectional studies among schoolchildren from 1996 to 2017.. The journal of allergy and clinical immunology. Global, 2(4), 100150. doi:10.1016/j.jacig.2023.100150

Jutel, M., Agache, I., Zemelka-Wiacek, M., Akdis, M., Chivato, T., del Giacco, S., . . . Akdis, C. A. (2023). Nomenclature of allergic diseases and hypersensitivity reactions: Adapted to modern needs: An EAACI position paper. ALLERGY, 78(11), 2851-2874. doi:10.1111/all.15889

Dramburg, S., Hilger, C., Santos, A. F., de las Vecillas, L., Aalberse, R. C., Acevedo, N., . . . Hoffmann-Sommergruber, K. (2023). EAACI Molecular Allergology User's Guide 2.0. PEDIATRIC ALLERGY AND IMMUNOLOGY, 34. doi:10.1111/pai.13854

Melen, E., Lambrecht, B. N., Lloyd, C. M., Rothenberg, M. E., Kabashima, K., Luciani, F., . . . von Mutius, E. (2023). A conversation on allergy: recognizing the past and looking to the future. IMMUNOLOGY AND CELL BIOLOGY, 101(10), 936-946. doi:10.1111/imcb.12688

Medernach, J. G., Li, R. -C., Zhao, X. -Y., Yin, B., Noonan, E. A., Etter, E. F., . . . McGowan, E. C. (2023). Immunoglobulin G4 in eosinophilic esophagitis: Immune complex formation and correlation with disease activity. ALLERGY, 78(12), 3193-3203. doi:10.1111/all.15826

Reddy, S., Yi, L., Shields, B., Platts-Mills, T., Wilson, J., & Flowers, R. H. (2023). Alpha-gal syndrome: A review for the dermatologist. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 89(4), 750-757. doi:10.1016/j.jaad.2023.04.054

McGill, S. K., Hashash, J. G., & Platts-Mills, T. A. (2023). AGA Clinical Practice Update on Alpha-Gal Syndrome for the GI Clinician: Commentary. CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 21(4), 891-896. doi:10.1016/j.cgh.2022.12.035

Ailsworth, S. M., Keshavarz, B., Richards, N. E., Workman, L. J., Murphy, D. D., Nelson, M. R., . . . Wilson, J. M. (2023). Enhanced SARS-CoV-2 IgG durability following COVID-19 mRNA booster vaccination and comparison of BNT162b2 with mRNA-1273. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 130(1), 67-73. doi:10.1016/j.anai.2022.10.003

McGowan, E. C., Medernach, J., Keshavarz, B., Workman, L. J., Li, R. -C., Barnes, B. H., . . . Platts-Mills, T. A. E. (2023). Food antigen consumption and disease activity affect food-specific IgG4 levels in patients with eosinophilic esophagitis (EoE). CLINICAL AND EXPERIMENTAL ALLERGY, 53(3), 307-315. doi:10.1111/cea.14215

2022

Platts-Mills, T. A. E., Boyd, K. K., & Medernach, J. G. (2022). Can we alter the course of allergic disease?. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 129(3), 271-273. doi:10.1016/j.anai.2022.07.002

Muehling, L. M., Heymann, P. W., Carper, H., Murphy, D. D., Rajadhyaksha, E., Kennedy, J., . . . Woodfolk, J. A. (2022). Cluster analysis of nasal cytokines during rhinovirus infection identifies different immunophenotypes in both children and adults with allergic asthma. CLINICAL AND EXPERIMENTAL ALLERGY, 52(10), 1169-1182. doi:10.1111/cea.14176

Keshavarz, B., Richards, N. E., Workman, L. J., Patel, J., Muehling, L. M., Canderan, G., . . . Wilson, J. M. (2022). Trajectory of IgG to SARS-CoV-2 After Vaccination With BNT162b2 or mRNA-1273 in an Employee Cohort and Comparison With Natural Infection. FRONTIERS IN IMMUNOLOGY, 13. doi:10.3389/fimmu.2022.850987

Platts-Mills, T. (2022). Sensitisation of Forest workers to the oligosaccharide galactose alpha-1, 3-galactose (alpha-gal) is strongly associated with tick bites but not with evidence of tick borne infections. INFECTIOUS DISEASES, 54(8), 580-582. doi:10.1080/23744235.2022.2057584

Pattarabanjird, T., Wilson, J. M., Erickson, L. D., Workman, L. J., Qiao, H., Ghosheh, Y., . . . McNamara, C. A. (2022). Chemokine Receptor Activation Enhances Memory B Cell Class Switching Linked to IgE Sensitization to Alpha Gal and Cardiovascular Disease. FRONTIERS IN CARDIOVASCULAR MEDICINE, 8. doi:10.3389/fcvm.2021.791028

Bunne, J., Hedman, L., Perzanowski, M., Bjerg, A., Winberg, A., Andersson, M., . . . Ronmark, E. (2022). The Majority of Children Sensitized Before School-Age Develop Allergic Disease Before Adulthood: A Longitudinal Population-Based Study. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 10(2), 577-+. doi:10.1016/j.jaip.2021.10.023

Platts-Mills, T. A. E., Eid, R. C., & Keshavarz, B. (2022). Of mice and men, MMXXI: Anaphylaxis. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 149(1), 58-59. doi:10.1016/j.jaci.2021.08.029

Shi, Y., Tang, R., Luo, F., Li, H., Pan, Z., Xu, G., . . . Platts-Mills, T. A. E. (2022). The Diagnosis and Management of Allergic Reactions Caused by Chinese Materia Medica. CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY, 62(1), 103-122. doi:10.1007/s12016-020-08812-7

2021

Platts-Mills, T. A., Hilger, C., Jappe, U., van Hage, M., Gadermaier, G., Spillner, E., . . . Pomes, A. (2021). Carbohydrate epitopes currently recognized as targets for IgE antibodies. ALLERGY, 76(8), 2383-2394. doi:10.1111/all.14802

Keshavarz, B., Erickson, L. D. D., Platts-Mills, T. A. E., & Wilson, J. M. M. (2021). Lessons in Innate and Allergic Immunity From Dust Mite Feces and Tick Bites. FRONTIERS IN ALLERGY, 2. doi:10.3389/falgy.2021.692643

Richards, N. E., Keshavarz, B., Workman, L. J., Nelson, M. R., Platts-Mills, T. A. E., & Wilson, J. M. (2021). Comparison of SARS-CoV-2 Antibody Response by Age Among Recipients of the BNT162b2 vs the mRNA-1273 Vaccine. JAMA NETWORK OPEN, 4(9). doi:10.1001/jamanetworkopen.2021.24331

Platts-Mills, T. A. E., Keshavarz, B., Wilson, J. M., Li, R. -C., Heymann, P. W., Gold, D. R., . . . Erwin, E. A. (2021). An Overview of the Relevance of IgG4 Antibodies in Allergic Disease with a Focus on Food Allergens. CHILDREN-BASEL, 8(5). doi:10.3390/children8050418

Flashner, B. M., Rifas-Shiman, S. L., Oken, E., Camargo, C. A. J., Platts-Mills, T. A. E., Workman, L., . . . Rice, M. B. (2021). Contributions of asthma, rhinitis and IgE to exhaled nitric oxide in adolescents. ERJ OPEN RESEARCH, 7(2). doi:10.1183/23120541.00945-2020

Cooper, P. J., Chis Ster, I., Chico, M. E., Vaca, M., Oviedo, Y., Maldonado, A., . . . Strachan, D. P. (2021). Impact of early life geohelminths on wheeze, asthma and atopy in Ecuadorian children at 8 years. ALLERGY, 76(9), 2765-2775. doi:10.1111/all.14821

Wilson, J. M., Platts-Mills, T. A. E., & Keshavarz, B. (2021). Reply to: The antibody response to the glycan α-Gal correlates with COVID-19 symptoms. JOURNAL OF MEDICAL VIROLOGY, 93(9), 5219-5220. doi:10.1002/jmv.27022

Keshavarz, B., Wiencek, J. R., Workman, L. J., Straesser, M. D., Muehling, L. M., Canderan, G., . . . Wilson, J. M. (2021). Quantitative Measurement of IgG to Severe Acute Respiratory Syndrome Coronavirus-2 Proteins Using ImmunoCAP. INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 182(5), 417-424. doi:10.1159/000514203

Wilson, J. M., Keshavarz, B., James, H. R., Retterer, M. K. C., Schuyler, A. J., Knoedler, A., . . . Cooper, P. J. (2021). α-Gal specific-IgE prevalence and levels in Ecuador and Kenya: Relation to diet, parasites, and IgG4. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 147(4), 1393-+. doi:10.1016/j.jaci.2020.12.650

Keshavarz, B., Platts-Mills, T. A. E., & Wilson, J. M. (2021). The use of microarray and other multiplex technologies in the diagnosis of allergy. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 127(1), 10-18. doi:10.1016/j.anai.2021.01.003

Keshavarz, B., Wiencek, J., Bazydlo, L., Straesser, M., Workman, L., Platts-Mills, T., & Wilson, J. (2021). Quantitative Measurement of IgG to SARS-CoV-2 Proteins Using the Phadia ImmunoCAP 250. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 147(2), AB150.

Straesser, M., Keshavarz, B., Borish, L., Khokhar, D., Holian, A., Charlton, N. P., . . . Wilson, J. M. (2021). α-Gal on Crotalidae-polyvalent Fab antivenom (CroFab): Investigating the relevance to immediate hypersensitivity reactions. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 9(2), 1015-+. doi:10.1016/j.jaip.2020.10.026

Hawkins, R. B., Wilson, J. M., Mehaffey, J. H., Platts-Mills, T. A. E., & Ailawadi, G. (2021). Safety of Intravenous Heparin for Cardiac Surgery in Patients With Alpha-Gal Syndrome. ANNALS OF THORACIC SURGERY, 111(6), 1991-1997. doi:10.1016/j.athoracsur.2020.07.050

Wilson, J. M., Keshavarz, B., Retterer, M., Workman, L. J., Schuyler, A. J., McGowan, E. C., . . . Platts-Mills, T. A. E. (2021). A dynamic relationship between two regional causes of IgE-mediated anaphylaxis: α-Gal syndrome and imported fire ant. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 147(2), 643-+. doi:10.1016/j.jaci.2020.05.034

2020

Muehling, L. M., Heymann, P. W., Wright, P. W., Eccles, J. D., Agrawal, R., Carper, H. T., . . . Woodfolk, J. A. (2020). Human TH1 and TH2 cells targeting rhinovirus and allergen coordinately promote allergic asthma. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 146(3), 555-570. doi:10.1016/j.jaci.2020.03.037

Bacon, S. L., & Platts-Mills, T. A. E. (2020). Is It Time for Aerobic Exercise to be Included in Asthma Treatment Guidelines?. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 8(9), 2997-2998. doi:10.1016/j.jaip.2020.08.003

Shaker, M., & Platts-Mills, T. A. E. (2020). The Law of Unintended Consequences in Pertussis Vaccination: An Ounce of Prevention, a Pound of Cure, and ... Food Allergy?. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 8(6), 2015-2016. doi:10.1016/j.jaip.2020.01.005

Platts-Mills, T. A. E., Commins, S. P., Biedermann, T., van Hage, M., Levin, M., Beck, L. A., . . . Wilson, J. M. (2020). On the cause and consequences of IgE to galactose-α-1,3-galactose: A report from the National Institute of Allergy and Infectious Diseases Workshop on Understanding IgE-Mediated Mammalian Meat Allergy. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 145(4), 1061-1071. doi:10.1016/j.jaci.2020.01.047

Heymann, P. W., Platts-Mills, T. A. E., Woodfolk, J. A., Borish, L., Murphy, D. D., Carper, H. T., . . . Turner, R. B. (2020). Understanding the asthmatic response to an experimental rhinovirus infection: Exploring the effects of blocking IgE. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 146(3), 545-554. doi:10.1016/j.jaci.2020.01.035

Wilson, J. M., & Platts-Mills, T. A. E. (2020). α-Gal and other recent findings that have informed our understanding of anaphylaxis. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 124(2), 135-142. doi:10.1016/j.anai.2019.11.024

Erwin, E. A., Navalpakam, A., Singla, R., Bolender, J., Workman, L. J., & Platts-Mills, T. A. E. (2020). Distinct clinical characteristics of boys and girls with eosinophilic esophagitis. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 8(4), 1452-1455. doi:10.1016/j.jaip.2019.10.037

2019

Platts-Mills, T. A. E., Li, R. -C., Keshavarz, B., Smith, A. R., & Wilson, J. M. (2020). Diagnosis and Management of Patients with the α-Gal Syndrome. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 8(1), 15-+. doi:10.1016/j.jaip.2019.09.017

Kim, M. S., Straesser, M. D., Keshavarz, B., Workman, L., McGowan, E. C., Platts-Mills, T. A. E., & Wilson, J. M. (2020). IgE to galactose-α-1,3-galactose wanes over time in patients who avoid tick bites. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 8(1), 364-+. doi:10.1016/j.jaip.2019.08.045

Apostolovic, D., Mihailovic, J., Commins, S. P., Wijnveld, M., Kazimirova, M., Starkhammar, M., . . . van Hage, M. (2020). Allergenomics of the tick Ixodes ricinus reveals important α-Gal-carrying IgE-binding proteins in red meat allergy. ALLERGY, 75(1), 217-220. doi:10.1111/all.13978

Coulson, E., Rifas-Shiman, S. L., Sordillo, J., Bunyavanich, S., Camargo, C. A. J., Platts-Mills, T. A. E., . . . Rice, M. B. (2020). Racial, ethnic, and socioeconomic differences in adolescent food allergy. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 8(1), 336-+. doi:10.1016/j.jaip.2019.06.006

Wilson, J. M., & Platts-Mills, T. A. E. (2019). Red meat allergy in children and adults. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 19(3), 229-235. doi:10.1097/ACI.0000000000000523

McGowan, E. C., Platts-Mills, T. A. E., & Wilson, J. M. (2019). Food allergy, eosinophilic esophagitis, and the enigma of IgG4. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 122(6), 563-564. doi:10.1016/j.anai.2019.03.024

Cox, K. M., Commins, S. P., Capaldo, B. J., Workman, L. J., Platts-Mills, T. A. E., Amir, E. -A. D., . . . Erickson, L. D. (2019). An integrated framework using high-dimensional mass cytometry and fluorescent flow cytometry identifies discrete B cell subsets in patients with red meat allergy. CLINICAL AND EXPERIMENTAL ALLERGY, 49(5), 615-625. doi:10.1111/cea.13322

Ardura-Garcia, C., Arias, E., Hurtado, P., Bonnett, L. J., Sandoval, C., Maldonado, A., . . . Blakey, J. D. (2019). Predictors of severe asthma attack re-attendance in Ecuadorian children: a cohort study. EUROPEAN RESPIRATORY JOURNAL, 54(5). doi:10.1183/13993003.02419-2018

Sordillo, J. E., Rifas-Shiman, S. L., Switkowski, K., Coull, B., Gibson, H., Rice, M., . . . Oken, E. (2019). Prenatal oxidative balance and risk of asthma and allergic disease in adolescence. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 144(6), 1534-+. doi:10.1016/j.jaci.2019.07.044

Wilson, J. M., McNamara, C. A., & Platts-Mills, T. A. E. (2019). IgE, α-Gal and atherosclerosis. AGING-US, 11(7), 1900-1902. doi:10.18632/aging.101894

Wilson, J. M., Schuyler, A. J., Workman, L., Gupta, M., James, H. R., Posthumus, J., . . . Platts-Mills, T. A. E. (2019). Investigation into the α-Gal Syndrome: Characteristics of 261 Children and Adults Reporting Red Meat Allergy. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 7(7), 2348-+. doi:10.1016/j.jaip.2019.03.031

Levin, M., Apostolovic, D., Biedermann, T., Commins, S. P., Iweala, O. I., Platts-Mills, T. A. E., . . . Wilson, J. M. (2019). Galactose α-1,3-galactose phenotypes Lessons from various patient populations. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 122(6), 598-602. doi:10.1016/j.anai.2019.03.021

Peng, C., Van Meel, E. R., Cardenas, A., Rifas-Shiman, S. L., Sonawane, A. R., Glass, K. R., . . . DeMeo, D. L. (2019). Epigenome-wide association study reveals methylation pathways associated with childhood allergic sensitization. EPIGENETICS, 14(5), 445-466. doi:10.1080/15592294.2019.1590085

Peng, C., Cardenas, A., Rifas-Shiman, S. L., Hivert, M. -F., Gold, D. R., Platts-Mills, T. A., . . . DeMeo, D. L. (2019). Epigenetic age acceleration is associated with allergy and asthma in children in Project Viva. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 143(6), 2263-+. doi:10.1016/j.jaci.2019.01.034

Hamed, A., Preston, D. C., Eschenbacher, W., Khokhar, D., Workman, L., Steinke, J. W., . . . Borish, L. (2019). Nasal IgE production in allergic rhinitis: Impact of rhinovirus infection. CLINICAL AND EXPERIMENTAL ALLERGY, 49(6), 847-852. doi:10.1111/cea.13372

Pollack, K., Zlotoff, B. J., Borish, L. C., Commins, S. P., Platts-Mills, T. A. E., & Wilson, J. M. (2019). α-Gal Syndrome vs Chronic Urticaria. JAMA DERMATOLOGY, 155(1), 115-116. doi:10.1001/jamadermatol.2018.3970

Wilson, J. M., & Platts-Mills, T. A. E. (2019). IgE to galactose-α-1,3-galactose and the a-Gal syndrome: Insights from basophil activation testing. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 143(1), 101-103. doi:10.1016/j.jaci.2018.10.029

Platts-Mills, T. A. E. (2019). Dr. Kimishige Ishizaka: 1926-2018 The discovery of IgE and the revolution in the study of allergic disease. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 122(1), 2-7. doi:10.1016/j.anai.2018.09.464

2018

Maslova, E., Rifas-Shiman, S. L., Oken, E., Platts-Mills, T. A. E., & Gold, D. R. (2019). Fatty acids in pregnancy and risk of allergic sensitization and respiratory outcomes in childhood. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 122(1), 120-+. doi:10.1016/j.anai.2018.09.450

Stoltz, L. P., Cristiano, L. M., Dowling, A. P. G., Wilson, J. M., Platts-Mills, T. A. E., & Traister, R. S. (2019). Could chiggers be contributing to the prevalence of galactose-alpha-1, 3-galactose sensitization and mammalian meat allergy?. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 7(2), 664-666. doi:10.1016/j.jaip.2018.07.014

Wilson, J. M., & Platts-Mills, T. A. E. (2018). Meat allergy and allergens. MOLECULAR IMMUNOLOGY, 100, 107-112. doi:10.1016/j.molimm.2018.03.018

Lawrence, M. G., Palacios-Kibler, T. V., Workman, L. J., Schuyler, A. J., Steinke, J. W., Payne, S. C., . . . Borish, L. (2018). Low Serum IgE Is a Sensitive and Specific Marker for Common Variable Immunodeficiency (CVID). JOURNAL OF CLINICAL IMMUNOLOGY, 38(3), 225-233. doi:10.1007/s10875-018-0476-0

Platts-Mills, T. A. E., & Perzanowski, M. (2018). The use of machine learning to understand the relationship between IgE to specific allergens and asthma. PLOS MEDICINE, 15(11). doi:10.1371/journal.pmed.1002696

Aalberse, R. C., & Platts-Mills, T. A. (2018). Does a strong IgG response precede allergic sensitization?. ALLERGY, 73(9), 1924-1925. doi:10.1111/all.13441

Platts-Mills, T. A. E. (2018). The continuing effect of the discovery of IgE by Kimishige Ishizaka. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 142(3), 788-789. doi:10.1016/j.jaci.2018.07.017

Wilson, J. M., & Platts-Mills, T. A. E. (2018). Two ideas to improve mite allergen avoidance Reply. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 6(4), 1436-1437. doi:10.1016/j.jaip.2018.04.029

Aalberse, R. C., Lupinek, C., Siroux, V., Nadif, R., Just, J., Bousquet, J., . . . Platts-Mills, T. A. (2018). sIgE and sIgG to airborne atopic allergens: Coupled rather than inversely related responses. ALLERGY, 73(11), 2239-2242. doi:10.1111/all.13548

Wilson, J. M., Nguyen, A. T., Schuyler, A. J., Commins, S. P., Taylor, A. M., Platts-Mills, T. A. E., & McNamara, C. A. (2018). IgE to the Mammalian Oligosaccharide Galactose--1,3-Galactose Is Associated With Increased Atheroma Volume and Plaques With Unstable CharacteristicsBrief Report. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 38(7), 1665-1669. doi:10.1161/ATVBAHA.118.311222

Spergel, J. M., Aceves, S. S., Kliewer, K., Gonsalves, N., Chehade, M., Wechsler, J. B., . . . Rothenberg, M. E. (2018). New developments in patients with eosinophilic gastrointestinal diseases presented at the CEGIR/TIGERS Symposium at the 2018 American Academy of Allergy, Asthma & Immunology Meeting. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 142(1), 48-53. doi:10.1016/j.jaci.2018.05.005

Lochte, L., Petersen, P. E., Nielsen, K. G., Andersen, A., & Platts-Mills, T. A. E. (2018). Associations of physical activity with childhood asthma, a population study based on the WHO - health behaviour in school-aged children survey.. Asthma research and practice, 4, 6. doi:10.1186/s40733-018-0042-9

Peng, C., Cardenas, A., Rifas-Shiman, S. L., Hivert, M. -F., Gold, D. R., Platts-Mills, T. A., . . . DeMeo, D. L. (2018). Epigenome-wide association study of Iota serum immunoglobulin E in children: a life course approach. CLINICAL EPIGENETICS, 10. doi:10.1186/s13148-018-0488-x

Schuyler, A. J., Wilson, J. M., Tripathi, A., Commins, S. P., Ogbogu, P. U., Kruzsewski, P. G., . . . Erwin, E. A. (2018). Specific IgG4 antibodies to cow's milk proteins in pediatric patients with eosinophilic esophagitis. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 142(1), 139-+. doi:10.1016/j.jaci.2018.02.049

Retterer, M. K. C., Workman, L. J., Bacon, J. R., & Platts-Mills, T. A. E. (2018). Specific IgE to gelatin as a cause of anaphylaxis to zoster vaccine. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 141(5), 1956-1957. doi:10.1016/j.jaci.2017.08.047

Wilson, J. M., & Platts-Mills, T. A. E. (2018). Home Environmental Interventions for House Dust Mite. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 6(1), 1-7. doi:10.1016/j.jaip.2017.10.003

Amoah, A. S., Asuming-Brempong, E. K., Obeng, B. B., Versteeg, S. A., Larbi, I. A., Aryeetey, Y., . . . Yazdanbakhsh, M. (2018). Identification of dominant anti-glycan IgE responses in school children by glycan microarray. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 141(3), 1130-+. doi:10.1016/j.jaci.2017.09.040

Wilson, J. M., Workman, L., Schuyler, A. J., Rifas-Shiman, S. L., McGowan, E. C., Oken, E., . . . Platts-Mills, T. A. E. (2018). Allergen sensitization in a birth cohort at midchildhood: Focus on food component IgE and IgG4 responses. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 141(1), 419-+. doi:10.1016/j.jaci.2017.07.029

2017

Carter, M. C., Ruiz-Esteves, K. N., Workman, L., Lieberman, P., Platts-Mills, T. A. E., & Metcalfe, D. D. (2018). Identification of alpha-gal sensitivity in patients with a diagnosis of idiopathic anaphylaxis. ALLERGY, 73(5), 1131-1134. doi:10.1111/all.13366

Schuyler, A. J., Tripathi, A., Workman, L. J., Wilson, J. M., Erwin, E. A., Lawrence, M. G., . . . Platts-Mills, T. A. E. (2018). Underestimation of specific IgE measurements using extract-based assays on undiluted sera revealed through dilution. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 6(3), 1070-+. doi:10.1016/j.jaip.2017.10.037

Erwin, E. A., Rhoda, D. A., Redmond, M., Ly, J. B., Russo, J. M., Hill, I. D., & Platts-Mills, T. A. E. (2017). Using Serum IgE Antibodies to Predict Esophageal Eosinophilia in Children. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 65(5), 520-525. doi:10.1097/MPG.0000000000001553

Hoyt, A. E. W., Chapman, M. D., King, E. M., Platts-Mills, T. A. E., & Steinke, J. W. (2018). Food allergen component proteins are not detected in early-childhood vaccines. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 6(2), 677-679. doi:10.1016/j.jaip.2017.09.023

Jappe, U., Minge, S., Kreft, B., Ludwig, A., Przybilla, B., Walker, A., . . . Homann, A. (2018). Meat allergy associated with galactosyl--(1,3)-galactose (-Gal)Closing diagnostic gaps by anti--Gal IgE immune profiling. ALLERGY, 73(1), 93-105. doi:10.1111/all.13238

Homann, A., Roeckendorf, N., Kromminga, A., Frey, A., Platts-Mills, T. A., & Jappe, U. (2017). Glycan and Peptide IgE Epitopes of the TNF-alpha Blockers Infliximab and Adalimumab - Precision Diagnostics by Cross-Reactivity Immune Profiling of Patient Sera. THERANOSTICS, 7(19), 4699-4709. doi:10.7150/thno.20654

Platts-Mills, T. A. E., & Woodfolk, J. A. (2017). Mite Avoidance as a Logical Treatment for Severe Asthma in Childhood. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 196(2), 119-121. doi:10.1164/rccm.201703-0450ED

Heymann, P. W., Huyen-Tran, N., Steinke, J. W., Turner, R. B., Woodfolk, J. A., Platts-Mills, T. A. E., . . . Hershey, G. K. K. (2017). Rhinovirus infection results in stronger and more persistent genomic dysregulation: Evidence for altered innate immune response in asthmatics at baseline, early in infection, and during convalescence. PLOS ONE, 12(5). doi:10.1371/journal.pone.0178096

Wilson, J. M., Schuyler, A. J., Schroeder, N., & Platts-Mills, T. A. E. (2017). Galactose-α-1,3-Galactose: Atypical Food Allergen or Model IgE Hypersensitivity?. CURRENT ALLERGY AND ASTHMA REPORTS, 17(1). doi:10.1007/s11882-017-0672-7

Lawrence, M. G., Woodfolk, J. A., Schuyler, A. J., Stillman, L. C., Chapman, M. D., & Platts-Mills, T. A. E. (2017). Half-life of IgE in serum and skin: Consequences for anti-IgE therapy in patients with allergic disease. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 139(2), 422-428. doi:10.1016/j.jaci.2016.04.056

2016

For the Patient. (2016). Allergy and asthma proceedings, 37(6), 505. doi:10.2500/aap.2016.37.4012

Wisniewski, J. A., McLaughlin, A. P., Stenger, P. J., Patrie, J., Brown, M. A., El-Dahr, J. M., . . . Heymann, P. W. (2016). A comparison of seasonal trends in asthma exacerbations among children from geographic regions with different climates.. Allergy Asthma Proc, 37(6), 475-481. doi:10.2500/aap.2016.37.3994

Wisniewski, J. A., McLaughlin, A. P., Stenger, P. J., Patrie, J., Brown, M. A., El-Dahr, J. M., . . . Heymann, P. W. (2016). A comparison of seasonal trends in asthma exacerbations among children from geographic regions with different climates. ALLERGY AND ASTHMA PROCEEDINGS, 37(6), 475-481. doi:10.2500/aap.2016.37.3994

McGowan, E. C., & Platts-Mills, T. A. (2016). Eosinophilic Esophagitis From an Allergy Perspective: How to Optimally Pursue Allergy Testing & Dietary Modification in the Adult Population.. Current gastroenterology reports, 18(11), 58. doi:10.1007/s11894-016-0531-z

Aalberse, R. C., Platts-Mills, T. A., & Rispens, T. (2016). The Developmental History of IgE and IgG4 Antibodies in Relation to Atopy, Eosinophilic Esophagitis, and the Modified TH2 Response. CURRENT ALLERGY AND ASTHMA REPORTS, 16(6). doi:10.1007/s11882-016-0621-x

Commins, S. P., Jerath, M. R., & Platts-Mills, T. (2016). The glycan did it: how the α-gal story rescued carbohydrates for allergists â a US perspective. Allergo Journal International, 25(2), 44-48. doi:10.1007/s40629-016-0097-1

Bunyavanich, S., Rifas-Shiman, S. L., Platts-Mills, T. A., Workman, L., Sordillo, J. E., Camargo, C. A. J., . . . Litonjua, A. A. (2016). Prenatal, perinatal, and childhood vitamin D exposure and their association with childhood allergic rhinitis and allergic sensitization. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 137(4), 1063-+. doi:10.1016/j.jaci.2015.11.031

Wisniewski, J. A., McLaughlin, A. P., Stenger, P. J., Patrie, J., Brown, M. A., El-Dahr, J. M., . . . Heymann, P. W. (2016). Idiopathic CD4 lymphocytopenia. ALLERGY AND ASTHMA PROCEEDINGS, 37(6), 505.

Sporik, R., Squillace, S. P., Ingram, J. M., Rakes, G., Honsinger, R. W., & Platts-Mills, T. A. E. (2016). The novel structure of the cockroach allergen Bla g 1 has implications for allergenicity and exposure assessment' (vol 132, pg 1420, 2013). JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 137(1), 336.

Commins, S. P., Jerath, M. R., & Platts-Mills, T. (2016). The glycan did it: how the α-gal story rescued carbohydrates for allergists - a US perspective. ALLERGO JOURNAL, 25(2), 24-28. doi:10.1007/s15007-016-1043-8

Steinke, J. W., Pochan, S. L., James, H. R., Platts-Mills, T. A. E., & Commins, S. P. (2016). Altered metabolic profile in patients with IgE to galactose-alpha-1, 3-galactose following in vivo food challenge. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 138(5), 1465-1467. doi:10.1016/j.jaci.2016.05.021

Matricardi, P. M., Kleine-Tebbe, J., Hoffmann, H. J., Valenta, R., Hilger, C., Hofmaier, S., . . . Ollert, M. (2016). EAACI Molecular Allergology User's Guide. PEDIATRIC ALLERGY AND IMMUNOLOGY, 27, 1-250. doi:10.1111/pai.12563

Perzanowski, M. S., Ronmark, E., James, H. R., Hedman, L., Schuyler, A. J., Bjerg, A., . . . Platts-Mills, T. A. E. (2016). Relevance of specific IgE antibody titer to the prevalence, severity, and persistence of asthma among 19-year-olds in northern Sweden. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 138(6), 1582-1590. doi:10.1016/j.jaci.2016.05.017

Platts-Mills, T. A. E., Schuyler, A. J., Erwin, E. A., Commins, S. P., & Woodfolk, J. A. (2016). IgE in the diagnosis and treatment of allergic disease. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 137(6), 1662-1670. doi:10.1016/j.jaci.2016.04.010

Lochte, L., Nielsen, K. G., Petersen, P. E., & Platts-Mills, T. A. E. (2016). Childhood asthma and physical activity: a systematic review with meta-analysis and Graphic Appraisal Tool for Epidemiology assessment. BMC PEDIATRICS, 16. doi:10.1186/s12887-016-0571-4

Erwin, E. A., Kruszewski, P. G., Russo, J. M., Schuyler, A. J., & Platts-Mills, T. A. E. (2016). IgE antibodies and response to cow's milk elimination diet in pediatric eosinophilic esophagitis. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 138(2), 625-628. doi:10.1016/j.jaci.2016.01.048

Platts-Mills, T. A. E., Heymann, P. W., Commins, S. P., & Woodfolk, J. A. (2016). The discovery of IgE 50 years later. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 116(3), 179-182. doi:10.1016/j.anai.2016.01.003

Commins, S. P., Jerath, M. R., Cox, K., Erickson, L. D., & Platts-Mills, T. (2016). Delayed anaphylaxis to alpha-gal, an oligosaccharide in mammalian meat. ALLERGOLOGY INTERNATIONAL, 65(1), 16-20. doi:10.1016/j.alit.2015.10.001

Kruszewski, P. G., Russo, J. M., Franciosi, J. P., Varni, J. W., Platts-Mills, T. A. E., & Erwin, E. A. (2016). Prospective, comparative effectiveness trial of cow's milk elimination and swallowed fluticasone for pediatric eosinophilic esophagitis. DISEASES OF THE ESOPHAGUS, 29(4), 377-384. doi:10.1111/dote.12339

2015

Lawrence, M. G., Leiding, J. W., Lyons, J. J., Hsu, A. P., Nelson, C. C., Jones, N., . . . Holland, S. M. (2016). GATA3 haploinsufficiency does not block allergic sensitization or atopic disease. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 137(2), 627-+. doi:10.1016/j.jaci.2015.06.041

Wheatley, L. M., Plaut, M., Schwaninger, J. M., Banerji, A., Castells, M., Finkelman, F. D., . . . Trepanier, L. A. (2015). Report from the National Institute of Allergy and Infectious Diseases workshop on drug allergy. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 136(2), 262-+. doi:10.1016/j.jaci.2015.05.027

Malo, J. -L., Tarlo, S. M., Sastre, J., Martin, J., Jeebhay, M. F., Le Moual, N., . . . Cartier, A. (2015). An Official American Thoracic Society Workshop Report: Presentations and Discussion of the Fifth Jack Pepys Workshop on Asthma in the Workplace Comparisons between Asthma in the Workplace and Non-Work-related Asthma. ANNALS OF THE AMERICAN THORACIC SOCIETY, 12(7), S99-S110. doi:10.1513/AnnalsATS.201505-281ST

Platts-Mills, T. A. E. (2015). The allergy epidemics: 1870-2010. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 136(1), 3-13. doi:10.1016/j.jaci.2015.03.048

Wisniewski, J. A., Commins, S. P., Agrawal, R., Hulse, K. E., Yu, M. D., Cronin, J., . . . Woodfolk, J. A. (2015). Analysis of cytokine production by peanut-reactive T cells identifies residual Th2 effectors in highly allergic children who received peanut oral immunotherapy. CLINICAL AND EXPERIMENTAL ALLERGY, 45(7), 1201-1213. doi:10.1111/cea.12537

Slack, M. A., Ogbogu, P. U., Phillips, G., Platts-Mills, T. A. E., & Erwin, E. A. (2015). Serum vitamin D levels in a cohort of adult and pediatric patients with eosinophilic esophagitis. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 115(1), 45-50. doi:10.1016/j.anai.2015.04.016

Platts-Mills, T. A. E., Schuyler, A. J., Hoyt, A. E. W., & Commins, S. P. (2015). Delayed Anaphylaxis Involving IgE to Galactose-alpha-1,3-galactose. CURRENT ALLERGY AND ASTHMA REPORTS, 15(4). doi:10.1007/s11882-015-0512-6

Platts-Mills, T. A. E., Schuyler, A. J., Tripathi, A., & Commins, S. P. (2015). Anaphylaxis to the Carbohydrate Side Chain Alpha-gal. IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA, 35(2), 247-+. doi:10.1016/j.iac.2015.01.009

Steinke, J. W., Platts-Mills, T. A. E., & Commins, S. P. (2015). The alpha-gal story: Lessons learned from connecting the dots. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 135(3), 589-596. doi:10.1016/j.jaci.2014.12.1947

Endara, P., Vaca, M., Platts-Mills, T. A. E., Workman, L., Chico, M. E., Barreto, M. L., . . . Cooper, P. J. (2015). Effect of urban vs. rural residence on the association between atopy and wheeze in Latin America: findings from a case-control analysis. CLINICAL AND EXPERIMENTAL ALLERGY, 45(2), 438-447. doi:10.1111/cea.12399

Konradsen, J. R., van Hage, M., Hedlin, G., Hilger, C., Ronmark, E., & Platts-Mills, T. (2015). The risk of sensitization to furry animals in patients already sensitized to cat/dog: An in vitro evaluation using molecular-based allergy diagnostics Reply. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 135(6), 1666-1667. doi:10.1016/j.jaci.2015.03.020

Steinke, J. W., Platts-Mills, T. A. E., Schuyler, A., & Commins, S. P. (2015). The common food additive carrageenan and the alpha-gal epitope Reply. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 136(6), 1709-1710. doi:10.1016/j.jaci.2015.09.010

Woodfolk, J. A., Commins, S. P., Schuyler, A. J., Erwin, E. A., & Platts-Mills, T. A. E. (2015). Allergens, sources, particles, and molecules: Why do we make IgE responses?. ALLERGOLOGY INTERNATIONAL, 64(4), 295-303. doi:10.1016/j.alit.2015.06.001

Ardura-Garcia, C., Vaca, M., Oviedo, G., Sandoval, C., Workman, L., Schuyler, A. J., . . . Cooper, P. J. (2015). Risk factors for acute asthma in tropical America: a case-control study in the City of Esmeraldas, Ecuador. PEDIATRIC ALLERGY AND IMMUNOLOGY, 26(5), 423-430. doi:10.1111/pai.12401

Erwin, E. A., Tripathi, A., Ogbogu, P. U., Commins, S. P., Slack, M. A., Cho, C. B., . . . Platts-Mills, T. A. E. (2015). IgE Antibody Detection and Component Analysis in Patients with Eosinophilic Esophagitis. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 3(6), 896-+. doi:10.1016/j.jaip.2015.05.015

Word, C., Klaffky, E., Ortiz, C., Palacios, T., Pelletier, S., Oliveira, W., . . . Wisniewski, J. (2015). Management of acquired peanut allergy following solid-organ transplant. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 3(4), 612-614. doi:10.1016/j.jaip.2015.03.003

Nankervis, H., Pynn, E. V., Boyle, R. J., Rushton, L., Williams, H. C., Hewson, D. M., & Platts-Mills, T. (2015). House dust mite reduction and avoidance measures for treating eczema. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, (1). doi:10.1002/14651858.CD008426.pub2

Konradsen, J. R., Fujisawa, T., van Hage, M., Hedlin, G., Hilger, C., Kleine-Tebbe, J., . . . Platts-Mills, T. A. E. (2015). Allergy to furry animals: New insights, diagnostic approaches, and challenges. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 135(3), 616-625. doi:10.1016/j.jaci.2014.08.026

Maier, S., Chung, C. H., Morse, M., Platts-Mills, T., Townes, L., Mukhopadhyay, P., . . . Trifan, O. C. (2015). A retrospective analysis of cross-reacting cetuximab IgE antibody and its association with severe infusion reactions. CANCER MEDICINE, 4(1), 36-42. doi:10.1002/cam4.333

Tripathi, A., Commins, S. P., Heymann, P. W., & Platts-Mills, T. A. E. (2015). Diagnostic and experimental food challenges in patients with nonimmediate reactions to food. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 135(4), 985-987. doi:10.1016/j.jaci.2014.11.032

2014

Behbod, B., Sordillo, J. E., Hoffman, E. B., Datta, S., Webb, T. E., Kwan, D. L., . . . Gold, D. R. (2015). Asthma and allergy development: contrasting influences of yeasts and other fungal exposures. CLINICAL AND EXPERIMENTAL ALLERGY, 45(1), 154-163. doi:10.1111/cea.12401

Bunyavanich, S., Rifas-Shiman, S. L., Platts-Mills, T. A. E., Workman, L., Sordillo, J. E., Gillman, M. W., . . . Litonjua, A. A. (2014). Peanut allergy prevalence among school-age children in a US cohort not selected for any disease. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 134(3), 753-755. doi:10.1016/j.jaci.2014.05.050

Ring, J., Akdis, C., Lauener, R., Schaeppi, G., Traidl-Hoffmann, C., Akdis, M., . . . van Ree, R. (2014). Global Allergy Forum and Second Davos Declaration 2013 Allergy: Barriers to cure - challenges and actions to be taken. ALLERGY, 69(8), 978-982. doi:10.1111/all.12406

Cooper, P. J., Chico, M. E., Platts-Mills, T. A. E., Rodrigues, L. C., Strachan, D. P., & Barreto, M. L. (2015). Cohort Profile: The Ecuador Life (ECUAVIDA) study in Esmeraldas Province, Ecuador. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 44(5), 1517-1527. doi:10.1093/ije/dyu128

Erwin, E. A., Woodfolk, J. A., James, H. R., Satinover, S. M., & Platts-Mills, T. A. E. (2014). Changes in cat specific IgE and IgG antibodies with decreased cat exposure. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 112(6), 545-U164. doi:10.1016/j.anai.2014.03.007

Commins, S. P., James, H. R., Stevens, W., Pochan, S. L., Land, M. H., King, C., . . . Platts-Mills, T. A. E. (2014). Delayed clinical and ex vivo response to mammalian meat in patients with IgE to galactose-alpha-1,3-galactose. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 134(1), 108-+. doi:10.1016/j.jaci.2014.01.024

Kennedy, J. L., Shaker, M., McMeen, V., Gern, J., Carper, H., Murphy, D., . . . Heymann, P. W. (2014). Comparison of Viral Load in Individuals with and without Asthma during Infections with Rhinovirus. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 189(5), 532-539. doi:10.1164/rccm.201310-1767OC

Bunyavanich, S., Rifas-Shiman, S. L., Platts-Mills, T. A., Workman, L., Sordillo, J. E., Camargo, C. A. J., . . . Litonjua, A. A. (2014). Peanut, milk, and wheat intake during pregnancy is associated with reduced allergy and asthma in children. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 133(5), 1373-1382. doi:10.1016/j.jaci.2013.11.040

Mozzicato, S. M., Tripathi, A., Posthumus, J. B., Platts-Mills, T. A. E., & Commins, S. P. (2014). Porcine or bovine valve replacement in 3 patients with IgE antibodies to the mammalian oligosaccharide galactose-alpha-1,3-galactose. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 2(5), 637-638. doi:10.1016/j.jaip.2014.04.016

Fischer, J., Hebsaker, J., Caponetto, P., Platts-Mills, T. A. E., & Biedermann, T. (2014). Galactose-alpha-1,3-galactose sensitization is a prerequisite for pork-kidney allergy and cofactor-related mammalian meat anaphylaxis. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 134(3), 755-759. doi:10.1016/j.jaci.2014.05.051

Agrawal, R., Wisniewski, J., Yu, M. D., Kennedy, J. L., Platts-Mills, T., Heymann, P. W., & Woodfolk, J. A. (2014). Infection with human rhinovirus 16 promotes enhanced IgE responsiveness in basophils of atopic asthmatics. CLINICAL AND EXPERIMENTAL ALLERGY, 44(10), 1266-1273. doi:10.1111/cea.12390

Tripathi, A., Commins, S. P., Heymann, P. W., & Platts-Mills, T. A. E. (2014). Delayed Anaphylaxis to Red Meat Masquerading as Idiopathic Anaphylaxis. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 2(3), 259-265. doi:10.1016/j.jaip.2014.02.017

2013

Berg, E. A., Platts-Mills, T. A. E., & Commins, S. P. (2014). Drug allergens and food-the cetuximab and galactose-α-1,3-galactose story. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 112(2), 97-101. doi:10.1016/j.anai.2013.11.014

Behbod, B., Sordillo, J. E., Hoffman, E. B., Datta, S., Muilenberg, M. L., Scott, J. A., . . . Gold, D. R. (2013). Wheeze in infancy: protection associated with yeasts in house dust contrasts with increased risk associated with yeasts in indoor air and other fungal taxa. ALLERGY, 68(11), 1410-1418. doi:10.1111/all.12254

Platts-Mills, T. A. E., & Commins, S. P. (2013). Emerging antigens involved in allergic responses. CURRENT OPINION IN IMMUNOLOGY, 25(6), 769-774. doi:10.1016/j.coi.2013.09.002

Wisniewski, J. A., Agrawal, R., Minnicozzi, S., Xin, W., Patrie, J., Heymann, P. W., . . . Woodfolk, J. A. (2013). Sensitization to food and inhalant allergens in relation to age and wheeze among children with atopic dermatitis. CLINICAL AND EXPERIMENTAL ALLERGY, 43(10), 1160-1170. doi:10.1111/cea.12169

Commins, S. P., & Platts-Mills, T. A. E. (2013). Tick bites and red meat allergy. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 13(4), 354-359. doi:10.1097/ACI.0b013e3283624560

Kennedy, J. L., Stallings, A. P., Platts-Mills, T. A. E., Oliveira, W. M., Workman, L., James, H. R., . . . Commins, S. P. (2013). Galactose-α-1,3-galactose and Delayed Anaphylaxis, Angioedema, and Urticaria in Children. PEDIATRICS, 131(5), E1545-E1552. doi:10.1542/peds.2012-2585

Bortsov, A. V., Platts-Mills, T. F., Peak, D. A., Jones, J. S., Swor, R. A., Domeier, R. M., . . . McLean, S. A. (2013). Pain distribution and predictors of widespread pain in the immediate aftermath of motor vehicle collision. EUROPEAN JOURNAL OF PAIN, 17(8), 1243-1251. doi:10.1002/j.1532-2149.2013.00285.x

Platts-Mills, T. A. E., & Commins, S. P. (2013). Tick bite induced IgE antibodies to alpha-gal and delayed anaphylactic reactions to mammalian derived foods. ALLERGO JOURNAL, 22(8), 559-561. doi:10.1007/s15007-013-0445-0

King, E. M., Filep, S., Smith, B., Platts-Mills, T., Hamilton, R. G., Schmechel, D., . . . Chapman, M. D. (2013). A multi-center ring trial of allergen analysis using fluorescent multiplex array technology. JOURNAL OF IMMUNOLOGICAL METHODS, 387(1-2), 89-95. doi:10.1016/j.jim.2012.09.015

Platts-Mills, T. A. E. (2013). An overview of proposed mechanisms of specific immunotherapy (SIT).. Arbeiten aus dem Paul-Ehrlich-Institut (Bundesinstitut fur Impfstoffe und biomedizinische Arzneimittel) Langen/Hessen, 97, 115-118.

Davies, J. M., Platts-Mills, T. A., & Aalberse, R. C. (2013). The enigma of IgE+ B-cell memory in human subjects. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 131(4), 972-976. doi:10.1016/j.jaci.2012.12.1569

Shim, Y. M., Burnette, A., Lucas, S., Herring, R. C., Weltman, J., Patrie, J. T., . . . Platts-Mills, T. A. (2013). Physical Deconditioning as a Cause of Breathlessness among Obese Adolescents with a Diagnosis of Asthma. PLOS ONE, 8(4). doi:10.1371/journal.pone.0061022

Moncayo, A. -L., Vaca, M., Oviedo, G., Workman, L. J., Chico, M. E., Platts-Mills, T. A. E., . . . Cooper, P. J. (2013). Effects of geohelminth infection and age on the associations between allergen-specific IgE, skin test reactivity and wheeze: a case-control study. CLINICAL AND EXPERIMENTAL ALLERGY, 43(1), 60-72. doi:10.1111/cea.12040

Kennedy, J. L., Jeffus, S. K., Platts-Mills, T. A. E., Tripathi, A., Divjan, A., Perzanowski, M. S., & Heymann, P. W. (2013). Seventeen-year-old girl hospitalized for localized swelling, pruritus, tenderness, and lymphatic streaking with eosinophilia. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 1(3), 299-301. doi:10.1016/j.jaip.2013.01.008

Posthumus, J., James, H. R., Lane, C. J., Matos, L. A., Platts-Mills, T. A. E., & Commins, S. P. (2013). Initial description of pork-cat syndrome in the United States. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 131(3), 923-925. doi:10.1016/j.jaci.2012.12.665

Rispens, T., Derksen, N. I. L., Commins, S. P., Platts-Mills, T. A., & Aalberse, R. C. (2013). IgE Production to α-Gal Is Accompanied by Elevated Levels of Specific IgG1 Antibodies and Low Amounts of IgE to Blood Group B. PLOS ONE, 8(2). doi:10.1371/journal.pone.0055566

Hamsten, C., Tran, T. A. T., Starkhammar, M., Brauner, A., Commins, S. P., Platts-Mills, T. A. E., & van Hage, M. (2013). Red meat allergy in Sweden: Association with tick sensitization and B-negative blood groups. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 132(6), 1431-1434. doi:10.1016/j.jaci.2013.07.050

2012

Commins, S. P., & Platts-Mills, T. A. E. (2013). Delayed Anaphylaxis to Red Meat in Patients with IgE Specific for Galactose alpha-1,3-Galactose (alpha-gal). CURRENT ALLERGY AND ASTHMA REPORTS, 13(1), 72-77. doi:10.1007/s11882-012-0315-y

Rance, K., Oʼlaughlen, M., & Platts-Mills, T. (2012). Managing asthma in Black children.. The Nurse practitioner, 37(6), 46-52. doi:10.1097/01.npr.0000414596.39895.60

Kennedy, J. L., Heymann, P. W., & Platts-Mills, T. A. E. (2012). The role of allergy in severe asthma. CLINICAL AND EXPERIMENTAL ALLERGY, 42(5), 659-669. doi:10.1111/j.1365-2222.2011.03944.x

Mullins, R. J., James, H., Platts-Mills, T. A. E., & Commins, S. (2012). Relationship between red meat allergy and sensitization to gelatin and galactose-α-1,3-galactose. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 129(5), 1334-U217. doi:10.1016/j.jaci.2012.02.038

Peters, J. L., Cohen, S., Staudenmayer, J., Hosen, J., Platts-Mills, T. A. E., & Wright, R. J. (2012). Prenatal negative life events increases cord blood IgE: interactions with dust mite allergen and maternal atopy. ALLERGY, 67(4), 545-551. doi:10.1111/j.1398-9995.2012.02791.x

Ring, J., Akdis, C., Behrendt, H., Lauener, R. P., Schäppi, G., Akdis, M., . . . Rietschel, E. (2012). Davos declaration: allergy as a global problem.. Allergy, 67(2), 141-143. doi:10.1111/j.1398-9995.2011.02770.x

Cornmins, S. P., Kelly, L. A., Ronmark, E., James, H. R., Pochan, S. L., Peters, E. J., . . . Platts-Mills, T. A. E. (2012). Galactose-α-1,3-Galactose-Specific IgE Is Associated with Anaphylaxis but Not Asthma. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 185(7), 723-730. doi:10.1164/rccm.201111-2017OC

Ring, J., Akdis, C., Behrendt, H., Lauener, R. -P., Schaeppi, G., Akdis, M., . . . Rietschel, E. (2012). Davos declaration: allergy as a global problem (vol 67, pg 141, 2012). ALLERGY, 67(5), 712. doi:10.1111/j.1398-9995.2012.02814.x

Kennedy, J. L., Heymann, P. W., & Platts-Mills, T. A. (2012). The Role of Allergy in Severe Asthma.. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Kelly, L. A., Erwin, E. A., & Platts-Mills, T. A. E. (2012). The indoor air and asthma: the role of cat allergens. CURRENT OPINION IN PULMONARY MEDICINE, 18(1), 29-34. doi:10.1097/MCP.0b013e32834db10d

Platts-Mills, T. A. E. (2012). Allergy in Evolution. NEW TRENDS IN ALLERGY AND ATOPIC ECZEMA, 96, 1-6.

Heymann, P. W., & Platts-Mills, T. A. E. (2012). Deciphering the Importance of Host and Environmental Factors that Influence the Genesis of Asthma During Childhood. JOURNAL OF INFECTIOUS DISEASES, 206(9), 1331-1333. doi:10.1093/infdis/jis507

Soto-Quiros, M., Avila, L., Platts-Mills, T. A. E., Hunt, J. F., Erdman, D. D., Carper, H., . . . Heymann, P. W. (2012). High titers of IgE antibody to dust mite allergen and risk for wheezing among asthmatic children infected with rhinovirus. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 129(6), 1499-+. doi:10.1016/j.jaci.2012.03.040

Pointreau, Y., Commins, S. P., Calais, G., Watier, H., & Platts-Mills, T. A. E. (2012). Fatal Infusion Reactions to Cetuximab: Role of Immunoglobulin E-Mediated Anaphylaxis. JOURNAL OF CLINICAL ONCOLOGY, 30(3), 334. doi:10.1200/JCO.2011.38.4701

2011

Chruszcz, M., Pomes, A., Glesner, J., Vailes, L. D., Osinski, T., Porebski, P. J., . . . Chapman, M. D. (2012). Molecular Determinants for Antibody Binding on Group 1 House Dust Mite Allergens. JOURNAL OF BIOLOGICAL CHEMISTRY, 287(10), 7388-7398. doi:10.1074/jbc.M111.311159

Kwong, K. Y. C., Eghrari-Sabet, J. S., Mendoza, G. R., Platts-Mills, T., & Horn, R. (2011). The benefits of specific immunoglobulin E testing in the primary care setting.. The American journal of managed care, 17 Suppl 17, S447-S459.

van Bueren, J. J. L., Rispens, T., Verploegen, S., van der Palen-Merkus, T., Stapel, S., Workman, L. J., . . . Parren, P. W. H. I. (2011). Anti-galactose-α-1,3-galactose IgE from allergic patients does not bind α-galactosylated glycans on intact therapeutic antibody Fc domains. NATURE BIOTECHNOLOGY, 29(7), 574-576. doi:10.1038/nbt.1912

Cooper, P. J., Chico, M. E., Guadalupe, I., Sandoval, C. A., Mitre, E., Platts-Mills, T. A. E., . . . Griffin, G. E. (2011). Impact of early life exposures to geohelminth infections on the development of vaccine immunity, allergic sensitization, and allergic inflammatory diseases in children living in tropical Ecuador: the ECUAVIDA birth cohort study. BMC INFECTIOUS DISEASES, 11. doi:10.1186/1471-2334-11-184

Commins, S. P., James, H. R., Kelly, L. A., Pochan, S. L., Workman, L. J., Perzanowski, M. S., . . . Platts-Mills, T. A. E. (2011). The relevance of tick bites to the production of IgE antibodies to the mammalian oligosaccharide galactose-α-1,3-galactose. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 127(5), 1286-U310. doi:10.1016/j.jaci.2011.02.019

Buettel, I. C., Chamberlain, P., Chowers, Y., Ehmann, F., Greinacher, A., Jefferis, R., . . . Schneider, C. K. (2011). Taking immunogenicity assessment of therapeutic proteins to the next level. BIOLOGICALS, 39(2), 100-109. doi:10.1016/j.biologicals.2011.01.006

Stevens, W., Addo-Yobo, E., Roper, J., Woodcock, A., James, H., Platts-Mills, T., & Custovic, A. (2011). Differences in both prevalence and titre of specific immunoglobulin E among children with asthma in affluent and poor communities within a large town in Ghana. CLINICAL AND EXPERIMENTAL ALLERGY, 41(11), 1587-1594. doi:10.1111/j.1365-2222.2011.03832.x

Cox, L., Lieberman, P., Wallace, D., Simons, F. E. R., Finegold, I., Platts-Mills, T., & Schwartz, L. (2011). American Academy of Allergy, Asthma & Immunology/American College of Allergy, Asthma & Immunology Omalizumab-Associated Anaphylaxis Joint Task Force follow-up report. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 128(1), 210-212. doi:10.1016/j.jaci.2011.04.010

Erwin, E. A., Woodfolk, J. A., Ronmark, E., Perzanowski, M., & Platts-Mills, T. A. E. (2011). The long-term protective effects of domestic animals in the home. CLINICAL AND EXPERIMENTAL ALLERGY, 41(7), 920-922. doi:10.1111/j.1365-2222.2011.03787.x

Platts-Mills, T. A. E., & Woodfolk, J. A. (2011). Allergens and their role in the allergic immune response. IMMUNOLOGICAL REVIEWS, 242, 51-68. doi:10.1111/j.1600-065X.2011.01021.x

Erwin, E. A., Faust, R. A., Platts-Mills, T. A. E., & Borish, L. (2011). Epidemiological analysis of chronic rhinitis in pediatric patients. AMERICAN JOURNAL OF RHINOLOGY & ALLERGY, 25(5), 327-332. doi:10.2500/ajra.2011.25.3640

2010

Erwin, E. A., James, H. R., Gutekunst, H. M., Russo, J. M., Kelleher, K. J., & Platts-Mills, T. A. E. (2010). Serum IgE measurement and detection of food allergy in pediatric patients with eosinophilic esophagitis. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 104(6), 496-502. doi:10.1016/j.anai.2010.03.018

Enfield, K., Gammon, S., Floyd, J., Falt, C., Patrie, J., Platts-Mills, T. A., . . . Shim, Y. M. (2010). Six-Minute Walk Distance in Patients With Severe End-Stage COPD ASSOCIATION WITH SURVIVAL AFTER INPATIENT PULMONARY REHABILITATION. JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION, 30(3), 195-202. doi:10.1097/HCR.0b013e3181c565e4

Platts-Mills, T. A. E., & Cooper, P. J. (2010). Differences in asthma between rural and urban communities in South Africa and other developing countries. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 125(1), 106-107. doi:10.1016/j.jaci.2009.10.068