William G Teague

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Primary Appointment

Professor, Pediatrics

Education

  • BS, Biology, Georgia State University
  • MD, Medicine, Medical College of Georgia

Research Disciplines

Development, Stem Cells & Regeneration, Immunology, Translational Science

Research Interests

Mucosal immunology in Children with Respiratory Disease

Personal Statement

We are dedicated to understanding the relationship between early life respiratory viral infections and the establishment of problematic wheeze and severe asthma in children. In work underway, we have discovered an unexpectedly prevalent syndrome of asymptomatic rhinovirus (RV) infection accompanied by significant infiltration of neutrophils and eosinophils into the airspaces of children with treatment-refractory wheeze. The prevalence of the syndrome is not enhanced by the establishment of allergen sensitization, but is associated with an increased in circulating blood eosinophils, which we propose have an anti-viral regulatory function. Further studies support a constitutional defect in interferon-induced mucosal gene responses as a potential mechanism, as well as defects in innate immune responses which drive formation of mucosal inflammasomes in affected children.

Selected Publications

2024

Teague, W. G., & Griffiths, C. (2024). Utility of T helper-2 biomarkers to predict outcomes and treatment response in children with asthma.. The Journal of allergy and clinical immunology, S0091-6749(24)00462-7. doi:10.1016/j.jaci.2024.04.023

2023

Qing, K., Altes, T. A., Mugler III, J. P., Mata, J. F., Tustison, N. J., Ruppert, K., . . . Mehrad, B. (2023). Hyperpolarized Xenon-129: A New Tool to Assess Pulmonary Physiology in Patients with Pulmonary Fibrosis. BIOMEDICINES, 11(6). doi:10.3390/biomedicines11061533

Alving, K., & Teague, W. G. (2023). Inflammatory Markers to Inform Treatment of Asthma With Biologicals: FeNO Versus Blood Eosinophils. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 11(4), 1221-1223. doi:10.1016/j.jaip.2023.02.001

Teague, W. G. (2023). Analysis of lung lavage granulocyte constituents and blood type 2 biomarkers does not support routine use of corticosteroids in children with problematic wheeze Reply to: Short courses of oral corticosteroids are effective, important, and safe for virus-triggered wheeze. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 130(4), 526. doi:10.1016/j.anai.2023.01.019

Teague, W. G. (2023). IgE-Specific Antibodies to Staphylococcal Enterotoxins: Novel Markers of Type 2 Inflammation in Children With Moderate to Severe Asthma. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 11(3), 797-798. doi:10.1016/j.jaip.2022.12.020

2022

Tang, J., Zeng, C., Cox, T. M., Li, C., Son, Y. M., Cheon, I. S., . . . Sun, J. (2022). Respiratory mucosal immunity against SARS-CoV-2 after mRNA vaccination. SCIENCE IMMUNOLOGY, 7(76). doi:10.1126/sciimmunol.add4853

Gaffin, J. M., Petty, C. R., Sorkness, R. L., Denlinger, L. C., Phillips, B. R., Ly, N. P., . . . Phipatanakul, W. (2023). Determinants of lung function across childhood in the Severe Asthma Research Program (SARP) 3. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 151(1), 138-+. doi:10.1016/j.jaci.2022.08.014

Teague, W. G. (2022). Lung lavage inflammatory patterns and pathogen profiles in preschool children with problematic wheeze. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 129(6), 674-675. doi:10.1016/j.anai.2022.07.001

Teague, W. G. (2022). Childhood Asthma Risk with Moderate Exercise: Good News for Most!. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 10(1), 240-241. doi:10.1016/j.jaip.2021.10.009

2021

Lawrence, M. G., Teague, W. G., Feng, X., Welch, C., Etter, E., Negri, J., . . . Borish, L. (2022). Interleukin-5 receptor alpha (CD125) expression on human blood and lung neutrophils. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 128(1), 53-+. doi:10.1016/j.anai.2021.08.004

Murray, C. S., Jackson, D. J., & Teague, W. G. (2021). Prevention and Outpatient Treatment of Asthma Exacerbations in Children. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 9(7), 2567-2576. doi:10.1016/j.jaip.2021.03.035

Teague, W. G., Lawrence, M. G., Williams, S., Garrod, A. S., Froh, D., Early, S. V., . . . Borish, L. (2021). Novel Treatment-Refractory Preschool Wheeze Phenotypes Identified by Cluster Analysis of Lung Lavage Constituents. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 9(7), 2792-+. doi:10.1016/j.jaip.2021.03.059

Teague, W. G., & Le, J. T. (2021). Love and a Cough Cannot Be Hid. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 9(4), 1638-1639. doi:10.1016/j.jaip.2020.12.046

Denlinger, L. C., Phillips, B. R., Sorkness, R. L., Bleecker, E. R., Castro, M., DeBoer, M. D., . . . Israel, E. (2021). Responsiveness to Parenteral Corticosteroids and Lung Function Trajectory in Adults with Moderate-to-Severe Asthma. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 203(7), 841-852. doi:10.1164/rccm.202002-0454OC

Teague, W. G. (2021). Hyperpolarized noble gas MRI of the chest in asthma: No longer an answer in need of a question. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 147(6), 2067-2068. doi:10.1016/j.jaci.2021.03.004

Israel, E., Denlinger, L. C., Bacharier, L. B., LaVange, L. M., Moore, W. C., Peters, M. C., . . . Ivanova, A. (2021). PrecISE: Precision Medicine in Severe Asthma: An adaptive platform trial with biomarker ascertainment. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 147(5), 1594-1601. doi:10.1016/j.jaci.2021.01.037

Teague, W. G., Mata, J., Qing, K., Tustison, N. J., Mugler, J. P., Meyer, C. H., . . . Altes, T. A. (2021). Measures of ventilation heterogeneity mapped with hyperpolarized helium-3 MRI demonstrate a T2-high phenotype in asthma. PEDIATRIC PULMONOLOGY, 56(6), 1440-1448. doi:10.1002/ppul.25303

2020

Ivanova, A., Israel, E., LaVange, L. M., Peters, M. C., Denlinger, L. C., Moore, W. C., . . . White, S. R. (2020). The precision interventions for severe and/or exacerbation-prone asthma (PrecISE) adaptive platform trial: statistical considerations.. Journal of biopharmaceutical statistics, 30(6), 1026-1037. doi:10.1080/10543406.2020.1821705

Teague, W. G., Iqbal, A., Ding, Y., Chipps, B. E., & Zazzali, J. L. (2021). The Added Burden of Allergen Sensitization Among Children with Severe or Poorly Controlled Asthma. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 9(2), 853-+. doi:10.1016/j.jaip.2020.08.063

Teague, W. G. (2020). Pediatric Severe Asthma in the Era of Biologic Treatments. PEDIATRIC ALLERGY IMMUNOLOGY AND PULMONOLOGY, 33(3), 118-120. doi:10.1089/ped.2020.1249

Steinke, J. W., Lawrence, M. G., Teague, W. G., Braciale, T. J., Patrie, J. T., & Borish, L. (2021). Bronchoalveolar lavage cytokine patterns in children with severe neutrophilic and paucigranulocytic asthma. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 147(2), 686-+. doi:10.1016/j.jaci.2020.05.039

Heymann, P. W., Platts-Mills, T. A. E., Woodfolk, J. A., Borish, L., Murphy, D. D., Carper, H. T., . . . Turner, R. B. (2020). Understanding the asthmatic response to an experimental rhinovirus infection: Exploring the effects of blocking IgE. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 146(3), 545-554. doi:10.1016/j.jaci.2020.01.035

Kuti, B. P., Kuti, D. K., & Teague, W. G. (2020). Determinants of severe exercise-induced bronchoconstriction in Nigerian children with asthma. PEDIATRIC PULMONOLOGY, 55, S51-S60. doi:10.1002/ppul.24609

Zein, J., Gaston, B., Bazeley, P., DeBoer, M. D., Igo, R. P. J., Bleecker, E. R., . . . Sharifi, N. (2020). HSD3B1 genotype identifies glucocorticoid responsiveness in severe asthma. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 117(4), 2187-2193. doi:10.1073/pnas.1918819117

Harris, D., Graham, L., McMurry, T. L., Esinhart, K., & Teague, W. G. (2020). Characteristics Relevant To Respiratory Health Among African Americans Attending Church-based Asthma Programs in Atlanta. JOURNAL OF HEALTH CARE FOR THE POOR AND UNDERSERVED, 31(2), 623-634. doi:10.1353/hpu.2020.0049

2019

Januska, M. N., Goldman, D. L., Webley, W., Teague, W. G., Cohen, R. T., Bunyavanich, S., & Vicencio, A. G. (2020). Bronchoscopy in severe childhood asthma: Irresponsible or irreplaceable?. PEDIATRIC PULMONOLOGY, 55(3), 795-802. doi:10.1002/ppul.24569

Ross, K. R., Gupta, R., DeBoer, M. D., Zein, J., Phillips, B. R., Mauger, D. T., . . . Gaston, B. (2020). Severe asthma during childhood and adolescence: A longitudinal study. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 145(1), 140-+. doi:10.1016/j.jaci.2019.09.030

Fitzpatrick, A. M., Szefler, S. J., Mauger, D. T., Phillips, B. R., Denlinger, L. C., Moore, W. C., . . . Jarjour, N. N. (2020). Development and initial validation of the Asthma Severity Scoring System (ASSESS). JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 145(1), 127-139. doi:10.1016/j.jaci.2019.09.018

Coverstone, A. M., Bacharier, L. B., Wilson, B. S., Fitzpatrick, A. M., Teague, W. G., Phipatanakul, W., . . . Castro, M. (2019). Clinical significance of the bronchodilator response in children with severe asthma. PEDIATRIC PULMONOLOGY, 54(11), 1694-1703. doi:10.1002/ppul.24473

Krishnan, S., Dozor, A. J., Bacharier, L., Lang, J. E., Irvin, C. G., Kaminsky, D., . . . American Lung Association Airway Clinical Research Centers (ALA-ACRC) Network. (2019). Clinical characterization of children with resistant airflow obstruction, a multicenter study.. The Journal of asthma : official journal of the Association for the Care of Asthma, 56(6), 611-617. doi:10.1080/02770903.2018.1477956

Schaefer, N., Li, X., Seibold, M. A., Jarjour, N. N., Denlinger, L. C., Castro, M., . . . Chu, H. W. (2019). The effect of BPIFA1/SPLUNC1 genetic variation on its expression and function in asthmatic airway epithelium. JCI INSIGHT, 4(8). doi:10.1172/jci.insight.127237

Harris, D., Graham, L., Teague, W. G., Mims, D., Montgomery, G. L., Stinson, M. S., . . . Warren, B. (2019). Not One More Life: A Health and Faith Partnership Engaging At-Risk African Americans with Asthma in Atlanta. ANNALS OF THE AMERICAN THORACIC SOCIETY, 16(4), 421-425. doi:10.1513/AnnalsATS.201803-166IP

Pal, K., Feng, X., Steinke, J. W., Burdick, M. D., Shim, Y. M., Sung, S. -S., . . . Borish, L. (2019). Leukotriene A4 Hydrolase Activation and Leukotriene B4 Production by Eosinophils in Severe Asthma. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 60(4), 413-419. doi:10.1165/rcmb.2018-0175OC

Kaminsky, D. A., Chapman, D. G., Holbrook, J. T., Henderson, R. J., Sugar, E. A., Mastronarde, J., . . . Irvin, C. G. (2019). Older age and obesity are associated with increased airway closure in response to methacholine in patients with asthma. RESPIROLOGY, 24(7), 638-645. doi:10.1111/resp.13496

Smith, C. J., Spaeder, M. C., Sorkness, R. L., & Teague, W. G. (2020). Disparate diagnostic accuracy of lung function tests as predictors of poor asthma control in children. JOURNAL OF ASTHMA, 57(3), 327-334. doi:10.1080/02770903.2019.1566471

Guilbert, T. W., Bacharier, L. B., Mauger, D. T., Phipatanakul, W., Szefler, S. J., Boehmer, S., . . . Martinez, F. D. (2019). Challenges in assessing the efficacy of systemic corticosteroids for severe wheezing episodes in preschool children. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 143(5), 1934-+. doi:10.1016/j.jaci.2018.10.071

Fitzpatrick, A. M., Gillespie, S. E., Mauger, D. T., Phillips, B. R., Bleecker, E. R., Israel, E., . . . Teague, W. G. (2019). Racial disparities in asthma-related health care use in the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 143(6), 2052-2061. doi:10.1016/j.jaci.2018.11.022

Hekking, P. -P., & Teague, W. G. (2019). . Disparate Eosinophilic Phenotypes with Age: Impact on Eligibility for AntieIL-5 Therapies in Severe Asthma. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 7(8), 2697-2698. doi:10.1016/j.jaip.2019.07.010

Teague, W. G. (2019). Tiotropium: An Effective Bronchodilator in Severe Asthma Independent of Type 2 Inflammation. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 7(7), 2296-2297. doi:10.1016/j.jaip.2019.05.005

Teague, W. G. (2019). Blood Eosinophilia May Not Adequately Estimate Lung Fluid Eosinophilia in Childhood Asthma. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 7(7), 2497-2498. doi:10.1016/j.jaip.2019.05.008

Gorski, S. A., Lawrence, M. G., Hinkelman, A., Spano, M. M., Steinke, J. W., Borish, L., . . . Braciale, T. J. (2019). Expression of IL-5 receptor alpha by murine and human lung neutrophils. PLOS ONE, 14(8). doi:10.1371/journal.pone.0221113

Teague, W. G., & Borish, L. C. (2019). Low Serum IgG: A Novel Predictor of Virus-Induced Asthma Exacerbations?. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 7(5), 1514-1515. doi:10.1016/j.jaip.2019.03.003

Teague, W. G., Lawrence, M. G., Shirley, D. -A. T., Garrod, A. S., Early, S. V., Payne, J. B., . . . Borish, L. (2019). Lung Lavage Granulocyte Patterns and Clinical Phenotypes in Children with Severe, Therapy-Resistant Asthma. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 7(6), 1803-+. doi:10.1016/j.jaip.2018.12.027

2018

Ross, K. R., Teague, W. G., & Gaston, B. M. (2019). Life Cycle of Childhood Asthma Prenatal, Infancy and Preschool, Childhood, and Adolescence. CLINICS IN CHEST MEDICINE, 40(1), 125-+. doi:10.1016/j.ccm.2018.10.008

Tang, M., Henderson, R. J., Holbrook, J. T., Que, L. G., Mathews, A. M., Wise, R. A., . . . Lang, J. E. (2019). Does Obesity Increase Respiratory Tract Infections in Patients with Asthma?. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 7(3), 954-+. doi:10.1016/j.jaip.2018.09.033

Chipps, B. E., Bacharier, L. B., Farrar, J. R., Jackson, D. J., Murphy, K. R., Phipatanakul, W., . . . Zeiger, R. S. (2018). The pediatric asthma yardstick Practical recommendations for a sustained step-up in asthma therapy for children with inadequately controlled asthma. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 120(6), 559-+. doi:10.1016/j.anai.2018.04.002

DeBoer, M. D., Phillips, B. R., Mauger, D. T., Zein, J., Erzurum, S. C., Fitzpatrick, A. M., . . . Teague, W. G. (2018). Effects of endogenous sex hormones on lung function and symptom control in adolescents with asthma. BMC PULMONARY MEDICINE, 18. doi:10.1186/s12890-018-0612-x

2017

Rogers, L., Sugar, E. A., Blake, K., Castro, M., Dimango, E., Hanania, N. A., . . . Holbrook, J. T. (2018). Step-Down Therapy for Asthma Well Controlled on Inhaled Corticosteroid and Long-Acting Beta-Agonist: A Randomized Clinical Trial. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 6(2), 633-+. doi:10.1016/j.jaip.2017.07.030

Wisniewski, J. A., Muehling, L. M., Eccles, J. D., Capaldo, B. J., Agrawal, R., Shirley, D. -A., . . . Woodfolk, J. A. (2018). TH1 signatures are present in the lower airways of children with severe asthma, regardless of allergic status. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 141(6), 2048-+. doi:10.1016/j.jaci.2017.08.020

Teague, W. G., Phillips, B. R., Fahy, J. V., Wenzel, S. E., Fitzpatrick, A. M., Moore, W. C., . . . Jarjour, N. N. (2018). Baseline Features of the Severe Asthma Research Program (SARP III) Cohort: Differences with Age. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 6(2), 545-+. doi:10.1016/j.jaip.2017.05.032

Phipatanakul, W., Mauger, D. T., Sorkness, R. L., Gaffin, J. M., Holguin, F., Woodruff, P. G., . . . Israel, E. (2017). Effects of Age and Disease Severity on Systemic Corticosteroid Responses in Asthma. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 195(11), 1439-1448. doi:10.1164/rccm.201607-1453OC

Denlinger, L. C., Phillips, B. R., Ramratnam, S., Ross, K., Bhakta, N. R., Cardet, J. C., . . . Jarjour, N. N. (2017). Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent Exacerbations. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 195(3), 302-313. doi:10.1164/rccm.201602-0419OC

Traina, G., Valluzzi, R. L., Fierro, V., Riccardi, C., Artesani, M. C., De Vuono, A., . . . Bodhankar, S. (2017). Proceedings of the 2017 WAO Symposium on Hot Topics in Allergy: Pediatric & Regulatory Aspects: Rome, Italy/Vatican City. 27-29 April 2017.. The World Allergy Organization journal, 10(Suppl 2), 39. doi:10.1186/s40413-017-0170-3

Teague, W. G. (2017). Up in Smoke: Accelerated Loss of Lung Function in Two Clusters of Smokers Identified in a Longitudinal Cohort Study of Adult-Onset Asthma. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 5(4), 979-980. doi:10.1016/j.jaip.2017.03.023

Altes, T. A., Meyer, C. H., Mata, J. F., Froh, D. K., Paget-Brown, A., Teague, W. G., . . . Mugler, J. P. I. I. I. (2017). Hyperpolarized helium-3 magnetic resonance lung imaging of non-sedated infants and young children: a proof-of-concept study. CLINICAL IMAGING, 45, 105-110. doi:10.1016/j.clinimag.2017.04.004

2016

Bime, C., Gerald, J. K., Wei, C. Y., Holbrook, J. T., Teague, W. G., Wise, R. A., & Gerald, L. B. (2016). Measurement characteristics of the childhood Asthma-Control Test and a shortened, child-only version. NPJ PRIMARY CARE RESPIRATORY MEDICINE, 26. doi:10.1038/npjpcrm.2016.75

Morrison, A. K., Patel, M., Johnson, S. L., LeGallo, R., Teague, W. G., & Vergales, B. (2016). Pulmonary interstitial glycogenosis in a patient with trisomy 21.. Journal of neonatal-perinatal medicine, 9(2), 227-231. doi:10.3233/npm-16915112

Lang, J. E., Hossain, J., Holbrook, J. T., Teague, W. G., Gold, B. D., Wise, R. A., & Lima, J. J. (2016). Gastro-oesophageal reflux and worse asthma control in obese children: a case of symptom misattribution?. THORAX, 71(3), 238-246. doi:10.1136/thoraxjnl-2015-207662

Zein, J. G., Udeh, B. L., Teague, W. G., Koroukian, S. M., Schlitz, N. K., Bleecker, E. R., . . . Erzurum, S. C. (2016). Impact of Age and Sex on Outcomes and Hospital Cost of Acute Asthma in the United States, 2011-2012. PLOS ONE, 11(6). doi:10.1371/journal.pone.0157301

2015

Quezada, W., Kwak, E. S., Reibman, J., Rogers, L., Mastronarde, J., Teague, W. G., . . . DiMango, E. (2016). Predictors of asthma exacerbation among patients with poorly controlled asthma despite inhaled corticosteroid treatment. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 116(2), 112-117. doi:10.1016/j.anai.2015.11.011

Bacharier, L. B., Guilbert, T. W., Mauger, D. T., Boehmer, S., Beigelman, A., Fitzpatrick, A. M., . . . Martinez, F. D. (2015). Early Administration of Azithromycin and Prevention of Severe Lower Respiratory Tract Illnesses in Preschool Children With a History of Such Illnesses A Randomized Clinical Trial. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 314(19), 2034-2044. doi:10.1001/jama.2015.13896

Altes, T. A., Mugler, J. P. I. I. I., Ruppert, K., Tustison, N. J., Gersbach, J., Szentpetery, S., . . . Teague, W. G. (2016). Clinical correlates of lung ventilation defects in asthmatic children. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 137(3), 789-+. doi:10.1016/j.jaci.2015.08.045

Shipe, R., Burdick, M. D., Strieter, B. A., Liu, L., Shim, Y. M., Sung, S. -S., . . . Rose, C. E. J. (2016). Number, activation, and differentiation of circulating fibrocytes correlate with asthma severity. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 137(3), 750-+. doi:10.1016/j.jaci.2015.07.037

Lang, J. E., Holbrook, J. T., Mougey, E. B., Wei, C. Y., Wise, R. A., Teague, W. G., & Lima, J. J. (2015). Lansoprazole Is Associated with Worsening Asthma Control in Children with the CYP2C19 Poor Metabolizer Phenotype. ANNALS OF THE AMERICAN THORACIC SOCIETY, 12(6), 878-885. doi:10.1513/AnnalsATS.201408-391OC

Riley, C. M., Wenzel, S. E., Castro, M., Erzurum, S. C., Chung, K. F., Fitzpatrick, A. M., . . . Holguin, F. (2015). Clinical Implications of Having Reduced Mid Forced Expiratory Flow Rates (FEF25-75), Independently of FEV1, in Adult Patients with Asthma. PLOS ONE, 10(12). doi:10.1371/journal.pone.0145476

Zein, J. G., Dweik, R. A., Comhair, S. A., Bleecker, E. R., Moore, W. C., Peters, S. P., . . . Erzurum, S. C. (2015). Asthma Is More Severe in Older Adults. PLOS ONE, 10(7). doi:10.1371/journal.pone.0133490

2014

Teague, W. G. (2015). Prednisone for acute virus-associated wheeze in children: Panacea or one more brick in the wall?. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 135(3), 699-700. doi:10.1016/j.jaci.2014.10.056

Marozkina, N. V., Wang, X. -Q., Stsiapura, V., Fitzpatrick, A., Carraro, S., Hawkins, G. A., . . . Gaston, B. (2015). Phenotype of asthmatics with increased airway S-nitrosoglutathione reductase activity. EUROPEAN RESPIRATORY JOURNAL, 45(1), 87-97. doi:10.1183/09031936.00042414

Teague, W. G., Tustison, N. J., & Altes, T. A. (2014). Ventilation heterogeneity in asthma. JOURNAL OF ASTHMA, 51(7), 677-684. doi:10.3109/02770903.2014.914535

Fitzpatrick, A. M., Holbrook, J. T., Wei, C. Y., Brown, M. S., Wise, R. A., & Teague, W. G. (2014). Exhaled Breath Condensate pH Does Not Discriminate Asymptomatic Gastroesophageal Reflux or the Response to Lansoprazole Treatment in Children with Poorly Controlled Asthma. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 2(5), 579-+. doi:10.1016/j.jaip.2014.04.006

2013

Teague, W. G. (2013). Trouble from the Start: Airway Structural Anomalies Present at Birth in the Cystic Fibrosis Piglet. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 188(12), 1391-1392. doi:10.1164/rccm.201311-1941ED

Chung, K. F., Wenzel, S. E., Brozek, J. L., Bush, A., Castro, M., Sterk, P. J., . . . Teague, W. G. (2014). International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. EUROPEAN RESPIRATORY JOURNAL, 43(2), 343-373. doi:10.1183/09031936.00202013

Wysocki, K., Park, S. Y., Bleecker, E., Busse, W., Castro, M., Chung, K. F., . . . Wenzel, S. (2014). Characterization of factors associated with systemic corticosteroid use in severe asthma: Data from the Severe Asthma Research Program. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 133(3), 915-918. doi:10.1016/j.jaci.2013.10.031

Nguyen, J. M., Holbrook, J. T., Wei, C. Y., Gerald, L. B., Teague, W. G., & Wise, R. A. (2014). Validation and psychometric properties of the Asthma Control Questionnaire among children. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 133(1), 91-+. doi:10.1016/j.jaci.2013.06.029

Phipatanakul, W., & Teague, W. G. (2013). Xenon ventilation computed tomography rules: new technology may open up further understanding in asthma. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 111(2), 81. doi:10.1016/j.anai.2013.05.025

Lima, J. J., Lang, J. E., Mougey, E. B., Blake, K. B., Gong, Y., Holbrook, J. T., . . . Teague, W. G. (2013). Association of CYP2C19 Polymorphisms and Lansoprazole-Associated Respiratory Adverse Effects in Children. JOURNAL OF PEDIATRICS, 163(3), 686-691. doi:10.1016/j.jpeds.2013.03.017

Mougey, E., Lang, J. E., Allayee, H., Teague, W. G., Dozor, A. J., Wise, R. A., & Lima, J. J. (2013). ALOX5 Polymorphism associates with increased leukotriene production and reduced lung function and asthma control in children with poorly controlled asthma. CLINICAL AND EXPERIMENTAL ALLERGY, 43(5), 512-520. doi:10.1111/cea.12076

Lang, J. E., Dozor, A. J., Holbrook, J. T., Mougey, E., Krishnan, S., Sweeten, S., . . . Lima, J. J. (2013). Biologic Mechanisms of Environmental Tobacco Smoke in Children with Poorly Controlled Asthma: Results from a Multicenter Clinical Trial. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 1(2), 172-U116. doi:10.1016/j.jaip.2012.11.006

Sah, P. K., Gerald Teague, W., Demuth, K. A., Whitlock, D. R., Brown, S. D., & Fitzpatrick, A. M. (2013). Poor asthma control in obese children may be overestimated because of enhanced perception of dyspnea.. The journal of allergy and clinical immunology. In practice, 1(1), 39-45. doi:10.1016/j.jaip.2012.10.006

Blake, K., & Teague, W. G. (2013). Gastroesophageal reflux disease and childhood asthma. CURRENT OPINION IN PULMONARY MEDICINE, 19(1), 24-29. doi:10.1097/MCP.0b013e32835b582b

2012

Holguin, F., Comhair, S. A. A., Hazen, S. L., Powers, R. W., Khatri, S. S., Bleecker, E. R., . . . Wenzel, S. E. (2013). An Association between L-Arginine/Asymmetric Dimethyl Arginine Balance, Obesity, and the Age of Asthma Onset Phenotype. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 187(2), 153-159. doi:10.1164/rccm.201207-1270OC

Lang, J. E., Holbrook, J. T., Wise, R. A., Dixon, A. E., Teague, W. G., Wei, C. Y., . . . Lima, J. J. (2013). Obesity in children with poorly controlled asthma: Sex differences. PEDIATRIC PULMONOLOGY, 48(9), 847-856. doi:10.1002/ppul.22707

Torgerson, D. G., Capurso, D., Ampleford, E. J., Li, X., Moore, W. C., Gignoux, C. R., . . . Nicolae, D. L. (2012). Genome-wide ancestry association testing identifies a common European variant on 6q14.1 as a risk factor for asthma in African American subjects. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 130(3), 622-+. doi:10.1016/j.jaci.2012.03.045

Fuhlbrigge, A., Peden, D., Apter, A. J., Boushey, H. A., Camargo, C. A. J., Gern, J., . . . Blaisdell, C. (2012). Asthma outcomes: Exacerbations. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 129(3), S34-S48. doi:10.1016/j.jaci.2011.12.983

Holbrook, J. T., Wise, R. A., Gold, B. D., Blake, K., Brown, E. D., Castro, M., . . . Teague, W. G. (2012). Lansoprazole for Children With Poorly Controlled Asthma A Randomized Controlled Trial. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 307(4), 373-381. doi:10.1001/jama.2011.2035

2011

Jarjour, N. N., Erzurum, S. C., Bleecker, E. R., Calhoun, W. J., Castro, M., Comhair, S. A. A., . . . Busse, W. W. (2012). Severe Asthma Lessons Learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 185(4), 356-362. doi:10.1164/rccm.201107-1317PP

Li, X., Ampleford, E. J., Howard, T. D., Moore, W. C., Li, H., Busse, W. W., . . . Meyers, D. A. (2012). The C11orf30-LRRC32 region is associated with total serum IgE levels in asthmatic patients. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 129(2), 575-578. doi:10.1016/j.jaci.2011.09.040

Kamat, P. P., Popler, J., Davis, J., Leong, T., Piland, S. C., Simon, D., . . . Fortenberry, J. D. (2011). Use of Flexible Bronchoscopy in Pediatric Patients Receiving Extracorporeal Membrane Oxygenation (ECMO) Support. PEDIATRIC PULMONOLOGY, 46(11), 1108-1113. doi:10.1002/ppul.21480

Holguin, F., Bleecker, E. R., Busse, W. W., Calhoun, W. J., Castro, M., Erzurum, S. C., . . . Wenzel, S. E. (2011). Obesity and asthma: An association modified by age of asthma onset. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 127(6), 1486-U249. doi:10.1016/j.jaci.2011.03.036

Comhair, S. A. A., Gaston, B. M., Ricci, K. S., Hammel, J., Dweik, R. A., Teague, W. G., . . . Erzurum, S. C. (2011). Detrimental Effects of Environmental Tobacco Smoke in Relation to Asthma Severity. PLOS ONE, 6(5). doi:10.1371/journal.pone.0018574

Sorkness, R. L., Teague, W. G., Penugonda, M., & Fitzpatrick, A. M. (2011). Sex dependence of airflow limitation and air trapping in children with severe asthma. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 127(4), 1073-1074. doi:10.1016/j.jaci.2010.12.1079

Li, X., Howard, T. D., Moore, W. C., Ampleford, E. J., Li, H., Busse, W. W., . . . Meyers, D. A. (2011). Importance of hedgehog interacting protein and other lung function genes in asthma. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 127(6), 1457-1465. doi:10.1016/j.jaci.2011.01.056

Clerisme-Beaty, E. M., Bartlett, S. J., Teague, W. G., Lima, J., Irvin, C. G., Cohen, R., . . . Rand, C. S. (2011). The Madison Avenue effect: How drug presentation style influences adherence and outcome in patients with asthma. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 127(2), 406-411. doi:10.1016/j.jaci.2010.11.038

Fitzpatrick, A. M., & Teague, W. G. (2011). Progressive airflow limitation is a feature of children with severe asthma. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 127(1), 282-284. doi:10.1016/j.jaci.2010.10.036

2010

Fitzpatrick, A. M., Teague, W. G., Meyers, D. A., Peters, S. P., Li, X., Li, H., . . . Moore, W. C. (2011). Heterogeneity of severe asthma in childhood: Confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 127(2), 382-U973. doi:10.1016/j.jaci.2010.11.015

Busse, W. W., Peters, S. P., Fenton, M. J., Mitchell, H., Bleecker, E. R., Castro, M., . . . Togias, A. (2011). Vaccination of patients with mild and severe asthma with a 2009 pandemic H1N1 influenza virus vaccine. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 127(1), 130-U215. doi:10.1016/j.jaci.2010.11.014

Liu, L., Teague, W. G., Erzurum, S., Fitzpatrick, A., Mantri, S., Dweik, R. A., . . . Gaston, B. (2011). Determinants of Exhaled Breath Condensate pH in a Large Population With Asthma. CHEST, 139(2), 328-336. doi:10.1378/chest.10-0163

Greenwald, R., Fitzpatrick, A. M., Gaston, B., Marozkina, N. V., Erzurum, S., & Teague, W. G. (2010). Breath Formate Is a Marker of Airway S-Nitrosothiol Depletion in Severe Asthma. PLOS ONE, 5(7). doi:10.1371/journal.pone.0011919

Fitzpatrick, A. M., & Teague, W. G. (2010). Severe Asthma in Children: Insights from the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. PEDIATRIC ALLERGY IMMUNOLOGY AND PULMONOLOGY, 23(2), 131-138. doi:10.1089/ped.2010.0021

Teague, W. G. (2010). Exhaled nitric oxide in wheezy infants: A marker of inflammation determined by airways acidification and S-nitrosothiol degradation?. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 125(6), 1235-1236. doi:10.1016/j.jaci.2010.04.012