Chaofan Li


Primary Appointment

Assistant Professor, Medicine- Infectious Diseases and International Health


  • PhD, Pathogenic Organisms, Fudan University

Research Disciplines

Infectious Diseases/Biodefense

Research Interests

Infectious Diseases

Research Description

Chaofan Li received his Ph.D. degree in Pathogenic Organisms from the Fudan University, China. From there, he joined the Sun lab at the Mayo Clinic as a research fellow/research associate before moving to the UVA. Chaofan is interested in understanding the transcriptional and metabolic regulation of T cell responses. He hopes to develop therapeutic targets for anti-viral infection and anti-tumor treatment based on the discoveries in basic mechanisms.

Selected Publications


Son, Y. M., Cheon, I. S., Li, C., & Sun, J. (2024). Persistent B Cell-Derived MHC Class II Signaling Is Required for the Optimal Maintenance of Tissue-Resident Helper T Cells.. ImmunoHorizons, 8(2), 163-171. doi:10.4049/immunohorizons.2300093


Jie, S., Narasimhan, H., Cheon, I. S., Qian, W., Hu, S., Parimon, T., . . . Chen, P. (2023). Proximal immune-epithelial progenitor interactions drive chronic tissue sequelae post COVID-19. doi:10.21203/

Narasimhan, H., Cheon, I. S., Qian, W., Hu, S., Parimon, T., Li, C., . . . Sun, J. (2023). Proximal immune-epithelial progenitor interactions drive chronic tissue sequelae post COVID-19.. bioRxiv. doi:10.1101/2023.09.13.557622

Zhu, B., Wei, X., Narasimhan, H., Qian, W., Zhang, R., Cheon, I. S., . . . Sun, J. (2023). Inhibition of the mitochondrial pyruvate carrier simultaneously mitigates hyperinflammation and hyperglycemia in COVID-19. SCIENCE IMMUNOLOGY, 8(82). doi:10.1126/sciimmunol.adf0348

Bingham, G. C., Muehling, L. M., Li, C., Huang, Y., Ma, S. -F., Abebayehu, D., . . . Bonham, C. A. (2024). High-dimensional comparison of monocytes and T cells in post-COVID and idiopathic pulmonary fibrosis. FRONTIERS IN IMMUNOLOGY, 14. doi:10.3389/fimmu.2023.1308594


Tang, J., Zeng, C., Cox, T. M., Li, C., Son, Y. M., Cheon, I. S., . . . Sun, J. (2022). Respiratory mucosal immunity against SARS-CoV-2 after mRNA vaccination. SCIENCE IMMUNOLOGY, 7(76). doi:10.1126/sciimmunol.add4853

Gao, X., Zhu, B., Wu, Y., Li, C., Zhou, X., Tang, J., & Sun, J. (2022). TFAM-Dependent Mitochondrial Metabolism Is Required for Alveolar Macrophage Maintenance and Homeostasis. JOURNAL OF IMMUNOLOGY, 208(6), 1456-1466. doi:10.4049/jimmunol.2100741


Cheon, I. S., Li, C., Son, Y. M., Goplen, N. P., Wu, Y., Cassmann, T., . . . Sun, J. (2021). Immune signatures underlying post-acute COVID-19 lung sequelae. SCIENCE IMMUNOLOGY, 6(65). doi:10.1126/sciimmunol.abk1741


Goplen, N. P., Wu, Y., Son, Y. M., Li, C., Wang, Z., Cheon, I. S., . . . Sun, J. (2020). Tissue-resident CD8+ T cells drive age-associated chronic lung sequelae after viral pneumonia. SCIENCE IMMUNOLOGY, 5(53). doi:10.1126/sciimmunol.abc4557


Zhang, S., Zhao, G., Su, C., Li, C., Zhou, X., Zhao, W., . . . Wang, B. (2020). Neonatal priming and infancy boosting with a novel respiratory syncytial virus vaccine induces protective immune responses without concomitant respiratory disease upon RSV challenge. HUMAN VACCINES & IMMUNOTHERAPEUTICS, 16(3), 664-672. doi:10.1080/21645515.2019.1671134

Li, C., Zhu, B., Son, Y. M., Wang, Z., Jiang, L., Xiang, M., . . . Sun, J. (2019). The Transcription Factor Bhlhe40 Programs Mitochondria! Regulation of Resident CD8+ T Cell Fitness and Functionality. IMMUNITY, 51(3), 491-+. doi:10.1016/j.immuni.2019.08.013

Wang, Z., Wang, S., Goplen, N. P., Li, C., Cheon, I. S., Dai, Q., . . . Sun, J. (2019). PD-1hi CD8+ resident memory T cells balance immunity and fibrotic sequelae. SCIENCE IMMUNOLOGY, 4(36). doi:10.1126/sciimmunol.aaw1217

Zhu, B., Zhang, R., Li, C., Jiang, L., Xiang, M., Ye, Z., . . . Sun, J. (2019). BCL6 modulates tissue neutrophil survival and exacerbates pulmonary inflammation following influenza virus infection. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116(24), 11888-11893. doi:10.1073/pnas.1902310116

Goplen, N. P., Huang, S., Zhu, B., Cheon, I. S., Son, Y. M., Wang, Z., . . . Sun, J. (2019). Tissue-Resident Macrophages Limit Pulmonary CD8 Resident Memory T Cell Establishment. FRONTIERS IN IMMUNOLOGY, 10. doi:10.3389/fimmu.2019.02332

Huang, S., Goplen, N. P., Zhu, B., Cheon, I. S., Son, Y., Wang, Z., . . . Sun, J. (2019). Macrophage PPAR-γ suppresses long-term lung fibrotic sequelae following acute influenza infection. PLOS ONE, 14(10). doi:10.1371/journal.pone.0223430


Zhou, C., Li, C., Gong, G. -Z., Wang, S., Zhang, J. -M., Xu, D. -Z., . . . Wang, B. (2017). Analysis of immunological mechanisms exerted by HBsAg-HBIG therapeutic vaccine combined with Adefovir in chronic hepatitis B patients. HUMAN VACCINES & IMMUNOTHERAPEUTICS, 13(9), 1989-1996. doi:10.1080/21645515.2017.1335840


Li, C., Zhou, X., Zhong, Y., Li, C., Dong, A., He, Z., . . . Wang, B. (2016). A Recombinant G Protein Plus Cyclosporine A-Based Respiratory Syncytial Virus Vaccine Elicits Humoral and Regulatory T Cell Responses against Infection without Vaccine-Enhanced Disease. JOURNAL OF IMMUNOLOGY, 196(4), 1721-1731. doi:10.4049/jimmunol.1502103


Geng, S., Zhang, H., Zhou, X., He, Y., Zhang, X., Xie, X., . . . Wang, B. (2015). Diabetes tolerogenic vaccines targeting antigen-specific inflammation. HUMAN VACCINES & IMMUNOTHERAPEUTICS, 11(2), 522-530. doi:10.1080/21645515.2014.1004024


Wang, S., Yu, Y., Geng, S., Wang, D., Zhang, L., Xie, X., . . . Wang, B. (2014). A coimmunization vaccine of Aβ42 ameliorates cognitive deficits without brain inflammation in an Alzheimer's disease model. ALZHEIMERS RESEARCH & THERAPY, 6(3). doi:10.1186/alzrt256

Xie, X., Geng, S., Liu, H., Li, C., Yang, Y., & Wang, B. (2014). Cimetidine synergizes with Praziquantel to enhance the immune response of HBV DNA vaccine via activating cytotoxic CD8+ T cell. HUMAN VACCINES & IMMUNOTHERAPEUTICS, 10(6), 1688-1699. doi:10.4161/hv.28517


Geng, S., Zhong, Y., Wang, S., Liu, H., Zou, Q., Xie, X., . . . Wang, B. (2012). Amiloride Enhances Antigen Specific CTL by Faciliting HBV DNA Vaccine Entry into Cells. PLOS ONE, 7(3). doi:10.1371/journal.pone.0033015