In Su Cheon


Primary Appointment

Assistant Professor, Medicine- Infectious Diseases and International Health

Research Disciplines

Infectious Diseases/Biodefense

Research Interests

Infectious Diseases

Research Description

I completed my PhD in South Korea. After joining the Sun lab, I have focused on the underlying mechanisms by which tissue immune cells cause chronic disease following respiratory viral infection including respiratory syncytial virus, influenza or SARS-CoV-2. I am interested in the regulatory networks between memory T cells and alveolar macrophages, and the downstream consequences on memory T cell maintenance, protective immunity and chronic tissue sequelae.

Selected Publications


Canderan, G., Muehling, L. M., Kadl, A., Ladd, S., Bonham, C., Cross, C. E., . . . Woodfolk, J. A. (2024). Distinct Type 1 Immune Networks Underlie the Severity of Restrictive Lung Disease after COVID-19.. bioRxiv. doi:10.1101/2024.04.03.587929

Son, Y. M., Cheon, I. S., Li, C., & Sun, J. (2024). Persistent B Cell-Derived MHC Class II Signaling Is Required for the Optimal Maintenance of Tissue-Resident Helper T Cells.. ImmunoHorizons, 8(2), 163-171. doi:10.4049/immunohorizons.2300093


Jie, S., Narasimhan, H., Cheon, I. S., Qian, W., Hu, S., Parimon, T., . . . Chen, P. (2023). Proximal immune-epithelial progenitor interactions drive chronic tissue sequelae post COVID-19. doi:10.21203/

Narasimhan, H., Cheon, I. S., Qian, W., Hu, S., Parimon, T., Li, C., . . . Sun, J. (2023). Proximal immune-epithelial progenitor interactions drive chronic tissue sequelae post COVID-19.. bioRxiv. doi:10.1101/2023.09.13.557622

Zhu, B., Wei, X., Narasimhan, H., Qian, W., Zhang, R., Cheon, I. S., . . . Sun, J. (2023). Inhibition of the mitochondrial pyruvate carrier simultaneously mitigates hyperinflammation and hyperglycemia in COVID-19. SCIENCE IMMUNOLOGY, 8(82). doi:10.1126/sciimmunol.adf0348

Cheon, I. S., Son, Y. M., & Sun, J. (2023). Tissue-resident memory T cells and lung immunopathology. IMMUNOLOGICAL REVIEWS, 316(1), 63-83. doi:10.1111/imr.13201

Cable, J., Sun, J., Cheon, I. S., Vaughan, A. E., Castro, I. A., Stein, S. R., . . . Eddens, T. (2023). Respiratory viruses: New frontiers-a Keystone Symposia report. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1522(1), 60-73. doi:10.1111/nyas.14958


Tang, J., Zeng, C., Cox, T. M., Li, C., Son, Y. M., Cheon, I. S., . . . Sun, J. (2022). Respiratory mucosal immunity against SARS-CoV-2 after mRNA vaccination. SCIENCE IMMUNOLOGY, 7(76). doi:10.1126/sciimmunol.add4853


Cheon, I. S., Li, C., Son, Y. M., Goplen, N. P., Wu, Y., Cassmann, T., . . . Sun, J. (2021). Immune signatures underlying post-acute COVID-19 lung sequelae. SCIENCE IMMUNOLOGY, 6(65). doi:10.1126/sciimmunol.abk1741

Zhu, B., Wu, Y., Huang, S., Zhang, R., Son, Y. M., Li, C., . . . Sun, J. (2021). Uncoupling of macrophage inflammation from self-renewal modulates host recovery from respiratory viral infection. IMMUNITY, 54(6), 1200-+. doi:10.1016/j.immuni.2021.04.001

Goplen, N. P., Cheon, I. S., & Sun, J. (2021). Age-Related Dynamics of Lung-Resident Memory CD8+ T Cells in the Age of COVID-19. FRONTIERS IN IMMUNOLOGY, 12. doi:10.3389/fimmu.2021.636118


Goplen, N. P., Huang, S., Zhu, B., Cheon, I. S., Son, Y. M., Wang, Z., . . . Sun, J. (2019). Tissue-Resident Macrophages Limit Pulmonary CD8 Resident Memory T Cell Establishment. FRONTIERS IN IMMUNOLOGY, 10. doi:10.3389/fimmu.2019.02332

Cheon, I. S., Kim, J. Y., Choi, Y., Shim, B. -S., Choi, J. -A., Jung, D. -I., . . . Chang, J. (2019). Sublingual Immunization With an RSV G Glycoprotein Fragment Primes IL-17-Mediated Immunopathology Upon Respiratory Syncytial Virus Infection. FRONTIERS IN IMMUNOLOGY, 10. doi:10.3389/fimmu.2019.00567